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Reviewed, UniProtKB/Swiss-Prot P08247 (SYPH_HUMAN)

Last modified June 16, 2009. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Synaptophysin
Alternative name(s):
    Major synaptic vesicle protein p38
Gene names
Name: SYP
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane.

Subunit structure

Homohexamer or homotetramer.

Subcellular location

Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Multi-pass membrane protein. Cell junction › synapse › synaptosome.

Tissue specificity

Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.

Domain

The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.

Post-translational modification

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation By similarity.

Sequence similarities

Belongs to the synaptophysin/synaptobrevin family.

Contains 1 MARVEL domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Synaptophysin
PRO_0000179161

Regions

Topological domain1 – 2525Cytoplasmic Potential
Transmembrane26 – 4924 Potential
Topological domain50 – 10657Vesicular Potential
Transmembrane107 – 13024 Potential
Topological domain131 – 1377Cytoplasmic Potential
Transmembrane138 – 16124 Potential
Topological domain162 – 19938Vesicular Potential
Transmembrane200 – 22324 Potential
Topological domain224 – 31390Cytoplasmic Potential
Domain21 – 227207MARVEL
Region254 – 30552Repeats, Gly-rich

Amino acid modifications

Modified residue811Phosphotyrosine By similarity
Glycosylation591N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1961P → L in AAH64550. Ref.4

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Sequences

Sequence LengthMass (Da)Tools
P08247-1 [UniParc].

Last modified August 1, 1991. Version 3.
Checksum: 592289C43B12EFA7

FASTA31333,845
        10         20         30         40         50         60 
MLLLADMDVV NQLVAGGQFR VVKEPLGFVK VLQWVFAIFA FATCGSYSGE LQLSVDCANK 

        70         80         90        100        110        120 
TESDLSIEVE FEYPFRLHQV YFDAPTCRGG TTKVFLVGDY SSSAEFFVTV AVFAFLYSMG 

       130        140        150        160        170        180 
ALATYIFLQN KYRENNKGPM LDFLATAVFA FMWLVSSSAW AKGLSDVKMA TDPENIIKEM 

       190        200        210        220        230        240 
PVCRQTGNTC KELRDPVTSG LNTSVVFGFL NLVLWVGNLW FVFKETGWAA PFLRAPPGAP 

       250        260        270        280        290        300 
EKQPAPGDAY GDAGYGQGPG GYGPQDSYGP QGGYQPDYGQ PAGSGGSGYG PQGDYGQQGY 

       310 
GPQGAPTSFS NQM

« Hide

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References

« Hide 'large scale' references
[1]"The cDNA and derived amino acid sequences for rat and human synaptophysin."
Suedhof T.C., Lottspeich F., Greengard P., Mehl E., Jahn R.
Nucleic Acids Res. 15:9607-9607(1987) [PubMed: 3120152] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Synaptophysin: structure of the human gene and assignment to the X chromosome in man and mouse."
Oezcelik T., Lafreniere R.G., Archer B.T. III, Johnston P.A., Willard H.F., Francke U., Suedhof T.C.
Am. J. Hum. Genet. 47:551-561(1990) [PubMed: 1975480] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp."
Fisher S.E., Ciccodicola A., Tanaka K., Curci A., Desicato S., D'Urso M., Craig I.W.
Genomics 45:340-347(1997) [PubMed: 9344658] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

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Web resources

Wikipedia

Synaptophysin entry

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Cross-references

Sequence databases

X06389 mRNA. Translation: CAA29686.1.
U93305 Genomic DNA. Translation: AAB92358.1.
BC064550 mRNA. Translation: AAH64550.1.
IPIIPI00027770.
PIRA35699.
RefSeqNP_003170.1.
UniGeneHs.632804

3D structure databases

ModBaseSearch...

PTM databases

PhosphoSiteP08247.

Proteomic databases

PRIDEP08247.

Genome annotation databases

EnsemblENSG00000102003. Homo sapiens. [Contig view]
GeneID6855.
KEGGhsa:6855.

Organism-specific databases

GeneCardsGC0XM048931.
H-InvDBHIX0016771.
HGNCHGNC:11506. SYP.
HPACAB000076.
HPA002858.
MIM313475. gene.
PharmGKBPA36288.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP08247.
HOVERGENP08247.
OMAP08247. TGNTCKE.

Gene expression databases

ArrayExpressP08247.
BgeeP08247.
CleanExHS_SYP.
GermOnlineENSG00000102003. Homo sapiens.

Family and domain databases

InterProIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
IPR015457. Synaptophysin_.
[Graphical view]
PANTHERPTHR10306. Synaptophysin. 1 hit.
PTHR10306:SF2. Synaptophysin_. 1 hit.
PfamPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSPR00220. SYNAPTOPHYSN.
PROSITEPS51225. MARVEL. 1 hit.
PS00604. SYNAPTOP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio26757.
SOURCESearch...

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Entry information

Entry nameSYPH_HUMAN
AccessionPrimary (citable) accession number: P08247
Secondary accession number(s): Q6P2F7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1991
Last modified: June 16, 2009
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents