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Protein

Signal recognition particle receptor subunit alpha

Gene

SRPRA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi425 – 432GTPBy similarity8
Nucleotide bindingi520 – 524GTPBy similarity5
Nucleotide bindingi588 – 591GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: UniProtKB-KW
  • poly(A) RNA binding Source: UniProtKB
  • signal recognition particle binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:G66-30738-MONOMER.
ReactomeiR-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-381038. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle receptor subunit alpha
Short name:
SR-alpha
Alternative name(s):
Docking protein alpha
Short name:
DP-alpha
Gene namesi
Name:SRPRAImported
Synonyms:SRPR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:11307. SRPRA.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: ProtInc
  • endoplasmic reticulum membrane Source: Reactome
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: ProtInc
  • membrane Source: MGI
  • signal recognition particle receptor complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6734.
OpenTargetsiENSG00000182934.
PharmGKBiPA36131.

Polymorphism and mutation databases

BioMutaiSRPR.
DMDMi20455516.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001012131 – 638Signal recognition particle receptor subunit alphaAdd BLAST638

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei177PhosphoserineCombined sources1
Modified residuei284PhosphothreonineCombined sources1
Modified residuei296PhosphoserineCombined sources1
Modified residuei297PhosphoserineCombined sources1
Modified residuei298PhosphoserineCombined sources1
Modified residuei473PhosphoserineCombined sources1
Modified residuei578PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP08240.
MaxQBiP08240.
PaxDbiP08240.
PeptideAtlasiP08240.
PRIDEiP08240.

PTM databases

iPTMnetiP08240.
PhosphoSitePlusiP08240.
SwissPalmiP08240.

Expressioni

Gene expression databases

BgeeiENSG00000182934.
CleanExiHS_SRPR.
GenevisibleiP08240. HS.

Organism-specific databases

HPAiHPA053860.

Interactioni

Subunit structurei

Heterodimer with SRPRB.1 Publication

Protein-protein interaction databases

BioGridi112612. 40 interactors.
IntActiP08240. 42 interactors.
MINTiMINT-1404634.
STRINGi9606.ENSP00000328023.

Structurei

Secondary structure

1638
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 9Combined sources7
Beta strandi12 – 19Combined sources8
Turni20 – 22Combined sources3
Helixi28 – 35Combined sources8
Helixi37 – 39Combined sources3
Beta strandi53 – 59Combined sources7
Turni60 – 63Combined sources4
Beta strandi64 – 71Combined sources8
Helixi73 – 75Combined sources3
Helixi76 – 93Combined sources18
Helixi95 – 99Combined sources5
Beta strandi100 – 102Combined sources3
Helixi104 – 107Combined sources4
Helixi114 – 127Combined sources14
Helixi335 – 351Combined sources17
Helixi356 – 370Combined sources15
Helixi381 – 397Combined sources17
Helixi405 – 414Combined sources10
Beta strandi419 – 424Combined sources6
Helixi431 – 444Combined sources14
Beta strandi449 – 454Combined sources6
Helixi461 – 475Combined sources15
Helixi478 – 480Combined sources3
Turni481 – 483Combined sources3
Beta strandi487 – 490Combined sources4
Helixi498 – 512Combined sources15
Beta strandi515 – 521Combined sources7
Helixi529 – 542Combined sources14
Beta strandi545 – 552Combined sources8
Helixi558 – 572Combined sources15
Beta strandi576 – 578Combined sources3
Beta strandi584 – 588Combined sources5
Helixi590 – 592Combined sources3
Helixi599 – 606Combined sources8
Beta strandi611 – 615Combined sources5
Beta strandi617 – 619Combined sources3
Helixi628 – 637Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FH5X-ray2.45A3-176[»]
2GO5electron microscopy7.4013-176[»]
5L3QX-ray3.20B/D1-638[»]
ProteinModelPortaliP08240.
SMRiP08240.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08240.

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP-binding SRP family.Curated

Phylogenomic databases

eggNOGiKOG0781. Eukaryota.
COG0552. LUCA.
GeneTreeiENSGT00550000074936.
HOGENOMiHOG000201671.
HOVERGENiHBG047566.
InParanoidiP08240.
KOiK13431.
OMAiEEFMQKH.
OrthoDBiEOG091G05TG.
PhylomeDBiP08240.
TreeFamiTF106189.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011012. Longin-like_dom.
IPR027417. P-loop_NTPase.
IPR007222. Sig_recog_particle_rcpt_asu_N.
IPR013822. Signal_recog_particl_SRP54_hlx.
IPR000897. SRP54_GTPase_dom.
[Graphical view]
PfamiPF04086. SRP-alpha_N. 1 hit.
PF00448. SRP54. 1 hit.
PF02881. SRP54_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00962. SRP54. 1 hit.
SM00963. SRP54_N. 1 hit.
[Graphical view]
SUPFAMiSSF47364. SSF47364. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00300. SRP54. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P08240-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLDFFTIFSK GGLVLWCFQG VSDSCTGPVN ALIRSVLLQE RGGNNSFTHE
60 70 80 90 100
ALTLKYKLDN QFELVFVVGF QKILTLTYVD KLIDDVHRLF RDKYRTEIQQ
110 120 130 140 150
QSALSLLNGT FDFQNDFLRL LREAEESSKI RAPTTMKKFE DSEKAKKPVR
160 170 180 190 200
SMIETRGEKP KEKAKNSKKK GAKKEGSDGP LATSKPVPAE KSGLPVGPEN
210 220 230 240 250
GVELSKEELI RRKREEFIQK HGRGMEKSNK STKSDAPKEK GKKAPRVWEL
260 270 280 290 300
GGCANKEVLD YSTPTTNGTP EAALSEDINL IRGTGSGGQL QDLDCSSSDD
310 320 330 340 350
EGAAQNSTKP SATKGTLGGM FGMLKGLVGS KSLSREDMES VLDKMRDHLI
360 370 380 390 400
AKNVAADIAV QLCESVANKL EGKVMGTFST VTSTVKQALQ ESLVQILQPQ
410 420 430 440 450
RRVDMLRDIM DAQRRQRPYV VTFCGVNGVG KSTNLAKISF WLLENGFSVL
460 470 480 490 500
IAACDTFRAG AVEQLRTHTR RLSALHPPEK HGGRTMVQLF EKGYGKDAAG
510 520 530 540 550
IAMEAIAFAR NQGFDVVLVD TAGRMQDNAP LMTALAKLIT VNTPDLVLFV
560 570 580 590 600
GEALVGNEAV DQLVKFNRAL ADHSMAQTPR LIDGIVLTKF DTIDDKVGAA
610 620 630
ISMTYITSKP IVFVGTGQTY CDLRSLNAKA VVAALMKA
Length:638
Mass (Da):69,811
Last modified:May 2, 2002 - v2
Checksum:i967F943CEE3FA79E
GO
Isoform 2 (identifier: P08240-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-67: Missing.

Note: No experimental confirmation available.
Show »
Length:610
Mass (Da):66,559
Checksum:i7A561BCA1C06A29E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81K → R in CAA29608 (PubMed:3340536).Curated1
Sequence conflicti201G → E in CAA29608 (PubMed:3340536).Curated1
Sequence conflicti306 – 307NS → TL in CAA29608 (PubMed:3340536).Curated2
Sequence conflicti632V → L in BAG64435 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04605540 – 67Missing in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06272 mRNA. Translation: CAA29608.1.
AK303379 mRNA. Translation: BAG64435.1.
AK312377 mRNA. Translation: BAG35295.1.
AP001318 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67686.1.
BC001162 mRNA. Translation: AAH01162.1.
BC009110 mRNA. Translation: AAH09110.1.
BC013583 mRNA. Translation: AAH13583.1.
CCDSiCCDS31717.1. [P08240-1]
CCDS53722.1. [P08240-2]
PIRiA29440.
RefSeqiNP_001171313.1. NM_001177842.1. [P08240-2]
NP_003130.2. NM_003139.3. [P08240-1]
UniGeneiHs.368376.

Genome annotation databases

EnsembliENST00000332118; ENSP00000328023; ENSG00000182934. [P08240-1]
ENST00000532259; ENSP00000435508; ENSG00000182934. [P08240-2]
GeneIDi6734.
KEGGihsa:6734.
UCSCiuc001qdh.4. human. [P08240-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06272 mRNA. Translation: CAA29608.1.
AK303379 mRNA. Translation: BAG64435.1.
AK312377 mRNA. Translation: BAG35295.1.
AP001318 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67686.1.
BC001162 mRNA. Translation: AAH01162.1.
BC009110 mRNA. Translation: AAH09110.1.
BC013583 mRNA. Translation: AAH13583.1.
CCDSiCCDS31717.1. [P08240-1]
CCDS53722.1. [P08240-2]
PIRiA29440.
RefSeqiNP_001171313.1. NM_001177842.1. [P08240-2]
NP_003130.2. NM_003139.3. [P08240-1]
UniGeneiHs.368376.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FH5X-ray2.45A3-176[»]
2GO5electron microscopy7.4013-176[»]
5L3QX-ray3.20B/D1-638[»]
ProteinModelPortaliP08240.
SMRiP08240.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112612. 40 interactors.
IntActiP08240. 42 interactors.
MINTiMINT-1404634.
STRINGi9606.ENSP00000328023.

PTM databases

iPTMnetiP08240.
PhosphoSitePlusiP08240.
SwissPalmiP08240.

Polymorphism and mutation databases

BioMutaiSRPR.
DMDMi20455516.

Proteomic databases

EPDiP08240.
MaxQBiP08240.
PaxDbiP08240.
PeptideAtlasiP08240.
PRIDEiP08240.

Protocols and materials databases

DNASUi6734.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332118; ENSP00000328023; ENSG00000182934. [P08240-1]
ENST00000532259; ENSP00000435508; ENSG00000182934. [P08240-2]
GeneIDi6734.
KEGGihsa:6734.
UCSCiuc001qdh.4. human. [P08240-1]

Organism-specific databases

CTDi6734.
DisGeNETi6734.
GeneCardsiSRPR.
HGNCiHGNC:11307. SRPRA.
HPAiHPA053860.
MIMi182180. gene.
neXtProtiNX_P08240.
OpenTargetsiENSG00000182934.
PharmGKBiPA36131.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0781. Eukaryota.
COG0552. LUCA.
GeneTreeiENSGT00550000074936.
HOGENOMiHOG000201671.
HOVERGENiHBG047566.
InParanoidiP08240.
KOiK13431.
OMAiEEFMQKH.
OrthoDBiEOG091G05TG.
PhylomeDBiP08240.
TreeFamiTF106189.

Enzyme and pathway databases

BioCyciZFISH:G66-30738-MONOMER.
ReactomeiR-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-381038. XBP1(S) activates chaperone genes.

Miscellaneous databases

ChiTaRSiSRPR. human.
EvolutionaryTraceiP08240.
GenomeRNAii6734.
PROiP08240.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182934.
CleanExiHS_SRPR.
GenevisibleiP08240. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011012. Longin-like_dom.
IPR027417. P-loop_NTPase.
IPR007222. Sig_recog_particle_rcpt_asu_N.
IPR013822. Signal_recog_particl_SRP54_hlx.
IPR000897. SRP54_GTPase_dom.
[Graphical view]
PfamiPF04086. SRP-alpha_N. 1 hit.
PF00448. SRP54. 1 hit.
PF02881. SRP54_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00962. SRP54. 1 hit.
SM00963. SRP54_N. 1 hit.
[Graphical view]
SUPFAMiSSF47364. SSF47364. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00300. SRP54. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRPRA_HUMAN
AccessioniPrimary (citable) accession number: P08240
Secondary accession number(s): A6NIB3
, B2R5Z8, B4E0H3, E9PJS4, Q9BVJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: May 2, 2002
Last modified: November 30, 2016
This is version 170 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.