##gff-version 3 P08237 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00511 P08237 UniProtKB Chain 2 780 . . . ID=PRO_0000112016;Note=ATP-dependent 6-phosphofructokinase%2C muscle type P08237 UniProtKB Region 2 390 . . . Note=N-terminal catalytic PFK domain 1 P08237 UniProtKB Region 391 401 . . . Note=Interdomain linker P08237 UniProtKB Region 402 780 . . . Note=C-terminal regulatory PFK domain 2 P08237 UniProtKB Active site 166 166 . . . Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184 P08237 UniProtKB Binding site 25 25 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184 P08237 UniProtKB Binding site 88 89 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184 P08237 UniProtKB Binding site 118 121 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184 P08237 UniProtKB Binding site 119 119 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184 P08237 UniProtKB Binding site 164 166 . . . Note=In other chain;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184 P08237 UniProtKB Binding site 201 201 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184 P08237 UniProtKB Binding site 208 210 . . . Note=In other chain;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184 P08237 UniProtKB Binding site 264 264 . . . Note=In other chain;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184 P08237 UniProtKB Binding site 292 292 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184 P08237 UniProtKB Binding site 298 301 . . . Note=In other chain;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184 P08237 UniProtKB Binding site 471 471 . . . Note=In other chain;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184 P08237 UniProtKB Binding site 528 532 . . . Note=In other chain;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184 P08237 UniProtKB Binding site 566 566 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184 P08237 UniProtKB Binding site 573 575 . . . Note=In other chain;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184 P08237 UniProtKB Binding site 629 629 . . . Note=In other chain;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184 P08237 UniProtKB Binding site 655 655 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184 P08237 UniProtKB Binding site 661 664 . . . Note=In other chain;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184 P08237 UniProtKB Binding site 735 735 . . . Note=In other chain;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184 P08237 UniProtKB Modified residue 2 2 . . . Note=N-acetylthreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00511 P08237 UniProtKB Modified residue 133 133 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P47858 P08237 UniProtKB Modified residue 377 377 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P47857 P08237 UniProtKB Modified residue 557 557 . . . Note=N6-(2-hydroxyisobutyryl)lysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29775581;Dbxref=PMID:29775581 P08237 UniProtKB Modified residue 667 667 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163 P08237 UniProtKB Modified residue 775 775 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00511 P08237 UniProtKB Glycosylation 530 530 . . . Note=O-linked (GlcNAc) serine;Ontology_term=ECO:0000250;evidence=ECO:0000250 P08237 UniProtKB Alternative sequence 1 1 . . . ID=VSP_046125;Note=In isoform 3. M->MHKDEFHLKFFMCVIQSRQLVRTPQRTAGEASTSSMLIPKPPPKTDILKSLDTMDDPDTVGSIPVFKTEWIM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 P08237 UniProtKB Alternative sequence 282 312 . . . ID=VSP_004667;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2140567;Dbxref=PMID:2140567 P08237 UniProtKB Natural variant 39 39 . . . ID=VAR_006063;Note=In GSD7%3B Ashkenazi. R->L;Dbxref=dbSNP:rs121918193 P08237 UniProtKB Natural variant 39 39 . . . ID=VAR_006064;Note=In GSD7%3B Italian. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7513946;Dbxref=dbSNP:rs121918193,PMID:7513946 P08237 UniProtKB Natural variant 57 57 . . . ID=VAR_072239;Note=In GSD7%3B Italian. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22133655;Dbxref=PMID:22133655 P08237 UniProtKB Natural variant 100 100 . . . ID=VAR_006065;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7825568;Dbxref=dbSNP:rs2228500,PMID:7825568 P08237 UniProtKB Natural variant 180 180 . . . ID=VAR_072240;Note=In GSD7%3B Italian. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22133655;Dbxref=PMID:22133655 P08237 UniProtKB Natural variant 209 209 . . . ID=VAR_006066;Note=In GSD7%3B loss of activity shown by complementation assays in yeast. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7825568;Dbxref=dbSNP:rs767265360,PMID:7825568 P08237 UniProtKB Natural variant 309 309 . . . ID=VAR_072241;Note=In GSD7%3B Spanish%3B complete loss of enzyme activity. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24427140;Dbxref=dbSNP:rs1169383137,PMID:24427140 P08237 UniProtKB Natural variant 543 543 . . . ID=VAR_006067;Note=In GSD7%3B Italian. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7513946;Dbxref=dbSNP:rs121918194,PMID:7513946 P08237 UniProtKB Natural variant 591 591 . . . ID=VAR_072242;Note=In GSD7%3B Italian. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22133655;Dbxref=PMID:22133655 P08237 UniProtKB Natural variant 686 686 . . . ID=VAR_006068;Note=In GSD7%3B Japanese. W->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8889589;Dbxref=dbSNP:rs121918196,PMID:8889589 P08237 UniProtKB Natural variant 696 696 . . . ID=VAR_006069;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7825568;Dbxref=dbSNP:rs41291971,PMID:7825568 P08237 UniProtKB Sequence conflict 670 670 . . . Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 P08237 UniProtKB Sequence conflict 2 2 . . . Note=H->L;Ontology_term=ECO:0000305;evidence=ECO:0000305