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P08218

- CEL2B_HUMAN

UniProt

P08218 - CEL2B_HUMAN

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Protein
Chymotrypsin-like elastase family member 2B
Gene
CELA2B, ELA2B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Acts upon elastin.

Catalytic activityi

Preferential cleavage: Leu-|-Xaa, Met-|-Xaa and Phe-|-Xaa. Hydrolyzes elastin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731Charge relay system By similarity
Active sitei121 – 1211Charge relay system By similarity
Active sitei216 – 2161Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: ProtInc
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.206.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chymotrypsin-like elastase family member 2B (EC:3.4.21.71)
    Alternative name(s):
    Elastase-2B
    Gene namesi
    Name:CELA2B
    Synonyms:ELA2B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:29995. CELA2B.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: ProtInc
    Complete GO annotation...

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165750841.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616
    Add
    BLAST
    Propeptidei17 – 2812Activation peptide
    PRO_0000027695Add
    BLAST
    Chaini29 – 269241Chymotrypsin-like elastase family member 2B
    PRO_0000027696Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi58 ↔ 74 By similarity
    Disulfide bondi155 ↔ 222 By similarity
    Disulfide bondi186 ↔ 202 By similarity
    Disulfide bondi212 ↔ 243 By similarity

    Keywords - PTMi

    Disulfide bond, Zymogen

    Proteomic databases

    PaxDbiP08218.
    PRIDEiP08218.

    Miscellaneous databases

    PMAP-CutDBP08218.

    Expressioni

    Tissue specificityi

    Pancreas.

    Gene expression databases

    ArrayExpressiP08218.
    BgeeiP08218.
    GenevestigatoriP08218.

    Organism-specific databases

    HPAiHPA047270.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000365075.

    Structurei

    3D structure databases

    ProteinModelPortaliP08218.
    SMRiP08218. Positions 29-269.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 267239Peptidase S1
    Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.
    KOiK01346.
    OMAiHIWETVE.
    OrthoDBiEOG75B84T.
    PhylomeDBiP08218.
    TreeFamiTF330455.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P08218-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIRTLLLSTL VAGALSCGVS TYAPDMSRML GGEEARPNSW PWQVSLQYSS    50
    NGQWYHTCGG SLIANSWVLT AAHCISSSGI YRVMLGQHNL YVAESGSLAV 100
    SVSKIVVHKD WNSDQVSKGN DIALLKLANP VSLTDKIQLA CLPPAGTILP 150
    NNYPCYVTGW GRLQTNGALP DDLKQGQLLV VDYATCSSSG WWGSTVKTNM 200
    ICAGGDGVIC TCNGDSGGPL NCQASDGRWE VHGIGSLTSV LGCNYYYKPS 250
    IFTRVSNYND WINSVIANN 269
    Length:269
    Mass (Da):28,810
    Last modified:July 22, 2008 - v2
    Checksum:iCC81C1D18B918B5F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti79 – 791G → R.2 Publications
    Corresponds to variant rs3820071 [ dbSNP | Ensembl ].
    VAR_044534
    Natural varianti114 – 1141D → N.2 Publications
    Corresponds to variant rs3766160 [ dbSNP | Ensembl ].
    VAR_044535
    Natural varianti177 – 1771Q → R.2 Publications
    Corresponds to variant rs6429745 [ dbSNP | Ensembl ].
    VAR_044536
    Natural varianti235 – 2351G → S.
    Corresponds to variant rs3737703 [ dbSNP | Ensembl ].
    VAR_044537

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16653 mRNA. Translation: AAA52381.1.
    AL512883 Genomic DNA. Translation: CAC42422.1.
    CH471167 Genomic DNA. Translation: EAW51728.1.
    BC069455 mRNA. Translation: AAH69455.1.
    BC113540 mRNA. Translation: AAI13541.1.
    BC113542 mRNA. Translation: AAI13543.1.
    CCDSiCCDS30605.1.
    PIRiC26823.
    RefSeqiNP_056933.2. NM_015849.2.
    UniGeneiHs.631871.

    Genome annotation databases

    EnsembliENST00000375910; ENSP00000365075; ENSG00000215704.
    GeneIDi51032.
    KEGGihsa:51032.
    UCSCiuc001awl.3. human.

    Polymorphism databases

    DMDMi212288098.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16653 mRNA. Translation: AAA52381.1 .
    AL512883 Genomic DNA. Translation: CAC42422.1 .
    CH471167 Genomic DNA. Translation: EAW51728.1 .
    BC069455 mRNA. Translation: AAH69455.1 .
    BC113540 mRNA. Translation: AAI13541.1 .
    BC113542 mRNA. Translation: AAI13543.1 .
    CCDSi CCDS30605.1.
    PIRi C26823.
    RefSeqi NP_056933.2. NM_015849.2.
    UniGenei Hs.631871.

    3D structure databases

    ProteinModelPortali P08218.
    SMRi P08218. Positions 29-269.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000365075.

    Chemistry

    BindingDBi P08218.

    Protein family/group databases

    MEROPSi S01.206.

    Polymorphism databases

    DMDMi 212288098.

    Proteomic databases

    PaxDbi P08218.
    PRIDEi P08218.

    Protocols and materials databases

    DNASUi 51032.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000375910 ; ENSP00000365075 ; ENSG00000215704 .
    GeneIDi 51032.
    KEGGi hsa:51032.
    UCSCi uc001awl.3. human.

    Organism-specific databases

    CTDi 51032.
    GeneCardsi GC01P015792.
    HGNCi HGNC:29995. CELA2B.
    HPAi HPA047270.
    MIMi 609444. gene.
    neXtProti NX_P08218.
    PharmGKBi PA165750841.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.
    KOi K01346.
    OMAi HIWETVE.
    OrthoDBi EOG75B84T.
    PhylomeDBi P08218.
    TreeFami TF330455.

    Miscellaneous databases

    GeneWikii CELA2B.
    GenomeRNAii 51032.
    NextBioi 53589.
    PMAP-CutDB P08218.
    PROi P08218.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P08218.
    Bgeei P08218.
    Genevestigatori P08218.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas."
      Kawashima I., Tani T., Shimoda K., Takiguchi Y.
      DNA 6:163-172(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ARG-79; ASN-114 AND ARG-177.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-79; ASN-114 AND ARG-177.

    Entry informationi

    Entry nameiCEL2B_HUMAN
    AccessioniPrimary (citable) accession number: P08218
    Secondary accession number(s): Q14D16, Q6ISM5, Q96QV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: July 22, 2008
    Last modified: July 9, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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