Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P08218

- CEL2B_HUMAN

UniProt

P08218 - CEL2B_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Chymotrypsin-like elastase family member 2B

Gene

CELA2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Acts upon elastin.

Catalytic activityi

Preferential cleavage: Leu-|-Xaa, Met-|-Xaa and Phe-|-Xaa. Hydrolyzes elastin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731Charge relay systemBy similarity
Active sitei121 – 1211Charge relay systemBy similarity
Active sitei216 – 2161Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.206.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-like elastase family member 2B (EC:3.4.21.71)
Alternative name(s):
Elastase-2B
Gene namesi
Name:CELA2B
Synonyms:ELA2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:29995. CELA2B.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165750841.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Add
BLAST
Propeptidei17 – 2812Activation peptidePRO_0000027695Add
BLAST
Chaini29 – 269241Chymotrypsin-like elastase family member 2BPRO_0000027696Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi58 ↔ 74PROSITE-ProRule annotation
Disulfide bondi155 ↔ 222PROSITE-ProRule annotation
Disulfide bondi186 ↔ 202PROSITE-ProRule annotation
Disulfide bondi212 ↔ 243PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP08218.
PRIDEiP08218.

Miscellaneous databases

PMAP-CutDBP08218.

Expressioni

Tissue specificityi

Pancreas.

Gene expression databases

BgeeiP08218.
ExpressionAtlasiP08218. baseline and differential.
GenevestigatoriP08218.

Organism-specific databases

HPAiHPA047270.

Interactioni

Protein-protein interaction databases

BioGridi119238. 14 interactions.
STRINGi9606.ENSP00000365075.

Structurei

3D structure databases

ProteinModelPortaliP08218.
SMRiP08218. Positions 29-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 267239Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000119027.
HOGENOMiHOG000251820.
InParanoidiP08218.
KOiK01346.
OMAiHIWETVE.
OrthoDBiEOG75B84T.
PhylomeDBiP08218.
TreeFamiTF330455.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08218-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIRTLLLSTL VAGALSCGVS TYAPDMSRML GGEEARPNSW PWQVSLQYSS
60 70 80 90 100
NGQWYHTCGG SLIANSWVLT AAHCISSSGI YRVMLGQHNL YVAESGSLAV
110 120 130 140 150
SVSKIVVHKD WNSDQVSKGN DIALLKLANP VSLTDKIQLA CLPPAGTILP
160 170 180 190 200
NNYPCYVTGW GRLQTNGALP DDLKQGQLLV VDYATCSSSG WWGSTVKTNM
210 220 230 240 250
ICAGGDGVIC TCNGDSGGPL NCQASDGRWE VHGIGSLTSV LGCNYYYKPS
260
IFTRVSNYND WINSVIANN
Length:269
Mass (Da):28,810
Last modified:July 22, 2008 - v2
Checksum:iCC81C1D18B918B5F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti79 – 791G → R.2 Publications
Corresponds to variant rs3820071 [ dbSNP | Ensembl ].
VAR_044534
Natural varianti114 – 1141D → N.2 Publications
Corresponds to variant rs3766160 [ dbSNP | Ensembl ].
VAR_044535
Natural varianti177 – 1771Q → R.2 Publications
Corresponds to variant rs6429745 [ dbSNP | Ensembl ].
VAR_044536
Natural varianti235 – 2351G → S.
Corresponds to variant rs3737703 [ dbSNP | Ensembl ].
VAR_044537

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16653 mRNA. Translation: AAA52381.1.
AL512883 Genomic DNA. Translation: CAC42422.1.
CH471167 Genomic DNA. Translation: EAW51728.1.
BC069455 mRNA. Translation: AAH69455.1.
BC113540 mRNA. Translation: AAI13541.1.
BC113542 mRNA. Translation: AAI13543.1.
CCDSiCCDS30605.1.
PIRiC26823.
RefSeqiNP_056933.2. NM_015849.2.
UniGeneiHs.631871.

Genome annotation databases

EnsembliENST00000375910; ENSP00000365075; ENSG00000215704.
GeneIDi51032.
KEGGihsa:51032.
UCSCiuc001awl.3. human.

Polymorphism databases

DMDMi212288098.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16653 mRNA. Translation: AAA52381.1 .
AL512883 Genomic DNA. Translation: CAC42422.1 .
CH471167 Genomic DNA. Translation: EAW51728.1 .
BC069455 mRNA. Translation: AAH69455.1 .
BC113540 mRNA. Translation: AAI13541.1 .
BC113542 mRNA. Translation: AAI13543.1 .
CCDSi CCDS30605.1.
PIRi C26823.
RefSeqi NP_056933.2. NM_015849.2.
UniGenei Hs.631871.

3D structure databases

ProteinModelPortali P08218.
SMRi P08218. Positions 29-269.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119238. 14 interactions.
STRINGi 9606.ENSP00000365075.

Protein family/group databases

MEROPSi S01.206.

Polymorphism databases

DMDMi 212288098.

Proteomic databases

PaxDbi P08218.
PRIDEi P08218.

Protocols and materials databases

DNASUi 51032.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375910 ; ENSP00000365075 ; ENSG00000215704 .
GeneIDi 51032.
KEGGi hsa:51032.
UCSCi uc001awl.3. human.

Organism-specific databases

CTDi 51032.
GeneCardsi GC01P015792.
HGNCi HGNC:29995. CELA2B.
HPAi HPA047270.
MIMi 609444. gene.
neXtProti NX_P08218.
PharmGKBi PA165750841.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00760000119027.
HOGENOMi HOG000251820.
InParanoidi P08218.
KOi K01346.
OMAi HIWETVE.
OrthoDBi EOG75B84T.
PhylomeDBi P08218.
TreeFami TF330455.

Miscellaneous databases

GeneWikii CELA2B.
GenomeRNAii 51032.
NextBioi 53589.
PMAP-CutDB P08218.
PROi P08218.
SOURCEi Search...

Gene expression databases

Bgeei P08218.
ExpressionAtlasi P08218. baseline and differential.
Genevestigatori P08218.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas."
    Kawashima I., Tani T., Shimoda K., Takiguchi Y.
    DNA 6:163-172(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ARG-79; ASN-114 AND ARG-177.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-79; ASN-114 AND ARG-177.

Entry informationi

Entry nameiCEL2B_HUMAN
AccessioniPrimary (citable) accession number: P08218
Secondary accession number(s): Q14D16, Q6ISM5, Q96QV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: July 22, 2008
Last modified: November 26, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3