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Protein

Chymotrypsin-like elastase family member 2B

Gene

CELA2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acts upon elastin.

Catalytic activityi

Preferential cleavage: Leu-|-Xaa, Met-|-Xaa and Phe-|-Xaa. Hydrolyzes elastin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73Charge relay systemBy similarity1
Active sitei121Charge relay systemBy similarity1
Active sitei216Charge relay systemBy similarity1

GO - Molecular functioni

  • serine-type endopeptidase activity Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciZFISH:HS05704-MONOMER.

Protein family/group databases

MEROPSiS01.206.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-like elastase family member 2B (EC:3.4.21.71)
Alternative name(s):
Elastase-2B
Gene namesi
Name:CELA2B
Synonyms:ELA2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29995. CELA2B.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: ProtInc
  • extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000215704.
PharmGKBiPA165750841.

Polymorphism and mutation databases

BioMutaiCELA2B.
DMDMi212288098.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Add BLAST16
PropeptideiPRO_000002769517 – 28Activation peptideAdd BLAST12
ChainiPRO_000002769629 – 269Chymotrypsin-like elastase family member 2BAdd BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 74PROSITE-ProRule annotation
Disulfide bondi155 ↔ 222PROSITE-ProRule annotation
Disulfide bondi186 ↔ 202PROSITE-ProRule annotation
Disulfide bondi212 ↔ 243PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP08218.
PeptideAtlasiP08218.
PRIDEiP08218.

Miscellaneous databases

PMAP-CutDBP08218.

Expressioni

Tissue specificityi

Pancreas.

Gene expression databases

BgeeiENSG00000215704.
ExpressionAtlasiP08218. baseline and differential.
GenevisibleiP08218. HS.

Interactioni

Protein-protein interaction databases

BioGridi119238. 15 interactors.
IntActiP08218. 2 interactors.
STRINGi9606.ENSP00000365075.

Structurei

3D structure databases

ProteinModelPortaliP08218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 267Peptidase S1PROSITE-ProRule annotationAdd BLAST239

Sequence similaritiesi

Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119027.
HOGENOMiHOG000251820.
InParanoidiP08218.
KOiK01346.
OMAiHKDWNSD.
OrthoDBiEOG091G0DF7.
PhylomeDBiP08218.
TreeFamiTF330455.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08218-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRTLLLSTL VAGALSCGVS TYAPDMSRML GGEEARPNSW PWQVSLQYSS
60 70 80 90 100
NGQWYHTCGG SLIANSWVLT AAHCISSSGI YRVMLGQHNL YVAESGSLAV
110 120 130 140 150
SVSKIVVHKD WNSDQVSKGN DIALLKLANP VSLTDKIQLA CLPPAGTILP
160 170 180 190 200
NNYPCYVTGW GRLQTNGALP DDLKQGQLLV VDYATCSSSG WWGSTVKTNM
210 220 230 240 250
ICAGGDGVIC TCNGDSGGPL NCQASDGRWE VHGIGSLTSV LGCNYYYKPS
260
IFTRVSNYND WINSVIANN
Length:269
Mass (Da):28,810
Last modified:July 22, 2008 - v2
Checksum:iCC81C1D18B918B5F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04453479G → R.2 PublicationsCorresponds to variant rs3820071dbSNPEnsembl.1
Natural variantiVAR_044535114D → N.2 PublicationsCorresponds to variant rs3766160dbSNPEnsembl.1
Natural variantiVAR_044536177Q → R.2 PublicationsCorresponds to variant rs6429745dbSNPEnsembl.1
Natural variantiVAR_044537235G → S.Corresponds to variant rs3737703dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16653 mRNA. Translation: AAA52381.1.
AL512883 Genomic DNA. Translation: CAC42422.1.
CH471167 Genomic DNA. Translation: EAW51728.1.
BC069455 mRNA. Translation: AAH69455.1.
BC113540 mRNA. Translation: AAI13541.1.
BC113542 mRNA. Translation: AAI13543.1.
CCDSiCCDS30605.1.
PIRiC26823.
RefSeqiNP_056933.2. NM_015849.2.
UniGeneiHs.631871.

Genome annotation databases

EnsembliENST00000375910; ENSP00000365075; ENSG00000215704.
GeneIDi51032.
KEGGihsa:51032.
UCSCiuc001awl.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16653 mRNA. Translation: AAA52381.1.
AL512883 Genomic DNA. Translation: CAC42422.1.
CH471167 Genomic DNA. Translation: EAW51728.1.
BC069455 mRNA. Translation: AAH69455.1.
BC113540 mRNA. Translation: AAI13541.1.
BC113542 mRNA. Translation: AAI13543.1.
CCDSiCCDS30605.1.
PIRiC26823.
RefSeqiNP_056933.2. NM_015849.2.
UniGeneiHs.631871.

3D structure databases

ProteinModelPortaliP08218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119238. 15 interactors.
IntActiP08218. 2 interactors.
STRINGi9606.ENSP00000365075.

Protein family/group databases

MEROPSiS01.206.

Polymorphism and mutation databases

BioMutaiCELA2B.
DMDMi212288098.

Proteomic databases

PaxDbiP08218.
PeptideAtlasiP08218.
PRIDEiP08218.

Protocols and materials databases

DNASUi51032.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375910; ENSP00000365075; ENSG00000215704.
GeneIDi51032.
KEGGihsa:51032.
UCSCiuc001awl.3. human.

Organism-specific databases

CTDi51032.
GeneCardsiCELA2B.
HGNCiHGNC:29995. CELA2B.
MIMi609444. gene.
neXtProtiNX_P08218.
OpenTargetsiENSG00000215704.
PharmGKBiPA165750841.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119027.
HOGENOMiHOG000251820.
InParanoidiP08218.
KOiK01346.
OMAiHKDWNSD.
OrthoDBiEOG091G0DF7.
PhylomeDBiP08218.
TreeFamiTF330455.

Enzyme and pathway databases

BioCyciZFISH:HS05704-MONOMER.

Miscellaneous databases

GeneWikiiCELA2B.
GenomeRNAii51032.
PMAP-CutDBP08218.
PROiP08218.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000215704.
ExpressionAtlasiP08218. baseline and differential.
GenevisibleiP08218. HS.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCEL2B_HUMAN
AccessioniPrimary (citable) accession number: P08218
Secondary accession number(s): Q14D16, Q6ISM5, Q96QV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: July 22, 2008
Last modified: November 30, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.