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Protein

Gamma-crystallin D

Gene

CRYGD

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

Keywordsi

Molecular functionEye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-crystallin D
Alternative name(s):
Gamma-D-crystallin
Gamma-crystallin IIIB
Gene namesi
Name:CRYGD
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000575821 – 174Gamma-crystallin DAdd BLAST174

Proteomic databases

PaxDbiP08209.
PRIDEiP08209.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029019.

Structurei

Secondary structure

1174
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 9Combined sources7
Helixi10 – 12Combined sources3
Beta strandi13 – 21Combined sources9
Turni27 – 29Combined sources3
Beta strandi34 – 41Combined sources8
Beta strandi43 – 49Combined sources7
Beta strandi53 – 58Combined sources6
Beta strandi60 – 65Combined sources6
Helixi66 – 69Combined sources4
Beta strandi72 – 74Combined sources3
Beta strandi78 – 81Combined sources4
Beta strandi89 – 95Combined sources7
Turni96 – 98Combined sources3
Beta strandi99 – 107Combined sources9
Helixi112 – 115Combined sources4
Beta strandi123 – 129Combined sources7
Beta strandi131 – 136Combined sources6
Turni137 – 139Combined sources3
Beta strandi140 – 146Combined sources7
Beta strandi148 – 153Combined sources6
Helixi154 – 157Combined sources4
Beta strandi160 – 163Combined sources4
Beta strandi166 – 169Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ELPX-ray1.95A/B2-174[»]
ProteinModelPortaliP08209.
SMRiP08209.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08209.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 40Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST39
Domaini41 – 83Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST43
Domaini88 – 128Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST41
Domaini129 – 171Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 87Connecting peptide4

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IWCR. Eukaryota.
ENOG411298R. LUCA.
HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiP08209.

Family and domain databases

InterProiView protein in InterPro
IPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
PfamiView protein in Pfam
PF00030. Crystall. 2 hits.
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiView protein in SMART
SM00247. XTALbg. 2 hits.
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiView protein in PROSITE
PS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.

Sequencei

Sequence statusi: Complete.

P08209-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKITFYEDR GFQGRHYECS SDHSNLQPYL GRCNSVRVDS GCWMIYEQPN
60 70 80 90 100
YLGPQYFLRR GDYPDYQQWM GLNDSVRSCR LIPHAGSHRL RLYEREDYRG
110 120 130 140 150
QMIEITEDCS SLQDRFHFNE IHSLNVLEGS WVLYELPNYR GRQYLLRPGE
160 170
YRRYHDWGAM NAKVGSLRRV IDIY
Length:174
Mass (Da):20,866
Last modified:January 23, 2007 - v4
Checksum:i6B13F1A266AA4BBF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti76V → I in AAB59282 (PubMed:3606621).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27070 mRNA. Translation: AAA98995.1.
M16895 mRNA. Translation: AAB59282.1.
PIRiB29655.
RefSeqiNP_776716.1. NM_174291.2.
UniGeneiBt.537.

Genome annotation databases

GeneIDi281723.
KEGGibta:281723.

Similar proteinsi

Entry informationi

Entry nameiCRGD_BOVIN
AccessioniPrimary (citable) accession number: P08209
Secondary accession number(s): Q28089
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 125 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families