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Protein

Gamma-crystallin D

Gene

CRYGD

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Eye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-crystallin D
Alternative name(s):
Gamma-D-crystallin
Gamma-crystallin IIIB
Gene namesi
Name:CRYGD
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 174173Gamma-crystallin DPRO_0000057582Add
BLAST

Proteomic databases

PaxDbiP08209.
PRIDEiP08209.

Structurei

Secondary structure

1
174
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 97Combined sources
Helixi10 – 123Combined sources
Beta strandi13 – 219Combined sources
Turni27 – 293Combined sources
Beta strandi34 – 418Combined sources
Beta strandi43 – 497Combined sources
Beta strandi53 – 586Combined sources
Beta strandi60 – 656Combined sources
Helixi66 – 694Combined sources
Beta strandi72 – 743Combined sources
Beta strandi78 – 814Combined sources
Beta strandi89 – 957Combined sources
Turni96 – 983Combined sources
Beta strandi99 – 1079Combined sources
Helixi112 – 1154Combined sources
Beta strandi123 – 1297Combined sources
Beta strandi131 – 1366Combined sources
Turni137 – 1393Combined sources
Beta strandi140 – 1467Combined sources
Beta strandi148 – 1536Combined sources
Helixi154 – 1574Combined sources
Beta strandi160 – 1634Combined sources
Beta strandi166 – 1694Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ELPX-ray1.95A/B2-174[»]
ProteinModelPortaliP08209.
SMRiP08209. Positions 2-174.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08209.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 4039Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd
BLAST
Domaini41 – 8343Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd
BLAST
Domaini88 – 12841Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd
BLAST
Domaini129 – 17143Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni84 – 874Connecting peptide

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated
Contains 4 beta/gamma crystallin 'Greek key' domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IWCR. Eukaryota.
ENOG411298R. LUCA.
HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiP08209.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08209-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKITFYEDR GFQGRHYECS SDHSNLQPYL GRCNSVRVDS GCWMIYEQPN
60 70 80 90 100
YLGPQYFLRR GDYPDYQQWM GLNDSVRSCR LIPHAGSHRL RLYEREDYRG
110 120 130 140 150
QMIEITEDCS SLQDRFHFNE IHSLNVLEGS WVLYELPNYR GRQYLLRPGE
160 170
YRRYHDWGAM NAKVGSLRRV IDIY
Length:174
Mass (Da):20,866
Last modified:January 23, 2007 - v4
Checksum:i6B13F1A266AA4BBF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti76 – 761V → I in AAB59282 (PubMed:3606621).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27070 mRNA. Translation: AAA98995.1.
M16895 mRNA. Translation: AAB59282.1.
PIRiB29655.
RefSeqiNP_776716.1. NM_174291.2.
UniGeneiBt.537.

Genome annotation databases

GeneIDi281723.
KEGGibta:281723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27070 mRNA. Translation: AAA98995.1.
M16895 mRNA. Translation: AAB59282.1.
PIRiB29655.
RefSeqiNP_776716.1. NM_174291.2.
UniGeneiBt.537.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ELPX-ray1.95A/B2-174[»]
ProteinModelPortaliP08209.
SMRiP08209. Positions 2-174.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiP08209.
PRIDEiP08209.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281723.
KEGGibta:281723.

Organism-specific databases

CTDi1421.

Phylogenomic databases

eggNOGiENOG410IWCR. Eukaryota.
ENOG411298R. LUCA.
HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiP08209.

Miscellaneous databases

EvolutionaryTraceiP08209.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of recombinant bovine gamma B-, gamma C- and gamma D-crystallins and correlation with native proteins."
    Hay R.E., Andley U.P., Petrash J.M.
    Exp. Eye Res. 58:573-584(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Lens.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-157.
    Tissue: Lens.
  3. "Structure of bovine eye lens gammaD (gammaIIIb)-crystallin at 1.95 A."
    Chirgadze Y.N., Driessen H.P.C., Wright G., Slingsby C., Hay R.E., Lindley P.F.
    Acta Crystallogr. D 52:712-721(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS).

Entry informationi

Entry nameiCRGD_BOVIN
AccessioniPrimary (citable) accession number: P08209
Secondary accession number(s): Q28089
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 120 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.