ID   S10AA_MOUSE             Reviewed;          97 AA.
AC   P08207;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   24-JAN-2024, entry version 183.
DE   RecName: Full=Protein S100-A10;
DE   AltName: Full=Calpactin I light chain;
DE   AltName: Full=Calpactin-1 light chain;
DE   AltName: Full=Cellular ligand of annexin II;
DE   AltName: Full=S100 calcium-binding protein A10;
DE   AltName: Full=p10 protein;
DE   AltName: Full=p11;
GN   Name=S100a10; Synonyms=Cal1l;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3038891; DOI=10.1016/s0021-9258(18)61015-4;
RA   Saris C.J.M., Kristensen T., D'Eustachio P., Hicks L.J., Noonan D.J.,
RA   Glenney J.R. Jr., Hunter T., Tack B.F.;
RT   "cDNA sequence and tissue distribution of the mRNA for bovine and murine
RT   p11, the S100-related light chain of the protein-tyrosine kinase substrate
RT   p36 (calpactin I).";
RL   J. Biol. Chem. 262:10663-10671(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung,
RC   Pancreas, Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [4]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-23, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Embryonic fibroblast;
RX   PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA   Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA   Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT   "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT   pathways.";
RL   Mol. Cell 50:919-930(2013).
RN   [5]
RP   INTERACTION WITH TASOR.
RX   PubMed=31112734; DOI=10.1016/j.yexcr.2019.05.018;
RA   Gresakova V., Novosadova V., Prochazkova M., Bhargava S., Jenickova I.,
RA   Prochazka J., Sedlacek R.;
RT   "Fam208a orchestrates interaction protein network essential for early
RT   embryonic development and cell division.";
RL   Exp. Cell Res. 382:111437-111437(2019).
CC   -!- FUNCTION: Because S100A10 induces the dimerization of ANXA2/p36, it may
CC       function as a regulator of protein phosphorylation in that the ANXA2
CC       monomer is the preferred target (in vitro) of tyrosine-specific kinase.
CC   -!- SUBUNIT: Heterotetramer containing 2 light chains of S100A10/p11 and 2
CC       heavy chains of ANXA2/p36 (By similarity). Interacts with SCN10A (By
CC       similarity). Interacts with TASOR (PubMed:31112734).
CC       {ECO:0000250|UniProtKB:P05943, ECO:0000250|UniProtKB:P60903,
CC       ECO:0000269|PubMed:31112734}.
CC   -!- INTERACTION:
CC       P08207; P07356: Anxa2; NbExp=2; IntAct=EBI-643986, EBI-738510;
CC   -!- MISCELLANEOUS: Does not appear to bind calcium. Contains 2 ancestral
CC       calcium site related to EF-hand domains that have lost their ability to
CC       bind calcium.
CC   -!- SIMILARITY: Belongs to the S-100 family. {ECO:0000305}.
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DR   EMBL; M16465; AAA37363.1; -; mRNA.
DR   EMBL; BC025044; AAH25044.1; -; mRNA.
DR   CCDS; CCDS38526.1; -.
DR   PIR; A28489; A28489.
DR   RefSeq; NP_033138.1; NM_009112.2.
DR   AlphaFoldDB; P08207; -.
DR   SMR; P08207; -.
DR   BioGRID; 203049; 11.
DR   ComplexPortal; CPX-898; Annexin A2 - S100-A10 complex.
DR   ComplexPortal; CPX-899; SMARCA3 - Annexin A2 - S100-A10 complex.
DR   ComplexPortal; CPX-905; AHNAK - Annexin A2 - S100-A10 complex.
DR   CORUM; P08207; -.
DR   IntAct; P08207; 7.
DR   STRING; 10090.ENSMUSP00000036949; -.
DR   GlyGen; P08207; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; P08207; -.
DR   PhosphoSitePlus; P08207; -.
DR   EPD; P08207; -.
DR   jPOST; P08207; -.
DR   PaxDb; 10090-ENSMUSP00000036949; -.
DR   PeptideAtlas; P08207; -.
DR   ProteomicsDB; 255435; -.
DR   Pumba; P08207; -.
DR   Antibodypedia; 1093; 545 antibodies from 39 providers.
DR   DNASU; 20194; -.
DR   Ensembl; ENSMUST00000045756.14; ENSMUSP00000036949.8; ENSMUSG00000041959.15.
DR   Ensembl; ENSMUST00000170612.2; ENSMUSP00000130712.2; ENSMUSG00000041959.15.
DR   GeneID; 20194; -.
DR   KEGG; mmu:20194; -.
DR   UCSC; uc008qfk.1; mouse.
DR   AGR; MGI:1339468; -.
DR   CTD; 6281; -.
DR   MGI; MGI:1339468; S100a10.
DR   VEuPathDB; HostDB:ENSMUSG00000041959; -.
DR   eggNOG; ENOG502S6TB; Eukaryota.
DR   GeneTree; ENSGT00940000154197; -.
DR   HOGENOM; CLU_138624_2_1_1; -.
DR   InParanoid; P08207; -.
DR   OMA; ENCAISE; -.
DR   OrthoDB; 619060at2759; -.
DR   PhylomeDB; P08207; -.
DR   TreeFam; TF332727; -.
DR   Reactome; R-MMU-75205; Dissolution of Fibrin Clot.
DR   BioGRID-ORCS; 20194; 1 hit in 79 CRISPR screens.
DR   ChiTaRS; S100a10; mouse.
DR   PRO; PR:P08207; -.
DR   Proteomes; UP000000589; Chromosome 3.
DR   RNAct; P08207; Protein.
DR   Bgee; ENSMUSG00000041959; Expressed in conjunctival fornix and 305 other cell types or tissues.
DR   ExpressionAtlas; P08207; baseline and differential.
DR   GO; GO:1990665; C:AnxA2-p11 complex; ISO:MGI.
DR   GO; GO:0009986; C:cell surface; IDA:MGI.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0045121; C:membrane raft; IEA:Ensembl.
DR   GO; GO:0016363; C:nuclear matrix; NAS:ComplexPortal.
DR   GO; GO:0005886; C:plasma membrane; IDA:ComplexPortal.
DR   GO; GO:0098797; C:plasma membrane protein complex; IPI:ComplexPortal.
DR   GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IPI:ComplexPortal.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0048306; F:calcium-dependent protein binding; IBA:GO_Central.
DR   GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR   GO; GO:0044325; F:transmembrane transporter binding; ISO:MGI.
DR   GO; GO:0001765; P:membrane raft assembly; ISO:MGI.
DR   GO; GO:0042789; P:mRNA transcription by RNA polymerase II; IDA:ComplexPortal.
DR   GO; GO:0045921; P:positive regulation of exocytosis; NAS:ComplexPortal.
DR   GO; GO:0051894; P:positive regulation of focal adhesion assembly; ISO:MGI.
DR   GO; GO:1905686; P:positive regulation of plasma membrane repair; NAS:ComplexPortal.
DR   GO; GO:0010756; P:positive regulation of plasminogen activation; ISO:MGI.
DR   GO; GO:0051496; P:positive regulation of stress fiber assembly; ISO:MGI.
DR   GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; ISO:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:ComplexPortal.
DR   GO; GO:0072659; P:protein localization to plasma membrane; ISO:MGI.
DR   GO; GO:0050767; P:regulation of neurogenesis; IDA:ComplexPortal.
DR   GO; GO:0006900; P:vesicle budding from membrane; ISO:MGI.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR001751; S100/CaBP7/8-like_CS.
DR   InterPro; IPR013787; S100_Ca-bd_sub.
DR   PANTHER; PTHR11639:SF74; PROTEIN S100-A10; 1.
DR   PANTHER; PTHR11639; S100 CALCIUM-BINDING PROTEIN; 1.
DR   Pfam; PF01023; S_100; 1.
DR   SMART; SM01394; S_100; 1.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS00303; S100_CABP; 1.
DR   Genevisible; P08207; MM.
PE   1: Evidence at protein level;
KW   Acetylation; Reference proteome; Repeat.
FT   CHAIN           1..97
FT                   /note="Protein S100-A10"
FT                   /id="PRO_0000144004"
FT   DOMAIN          47..82
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   REGION          60..71
FT                   /note="Ancestral calcium site"
FT   MOD_RES         23
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0007744|PubMed:23806337"
FT   MOD_RES         28
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P60903"
FT   MOD_RES         54
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P60903"
FT   MOD_RES         57
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P60903"
SQ   SEQUENCE   97 AA;  11186 MW;  E7F092D4DAF6B43E CRC64;
     MPSQMEHAME TMMLTFHRFA GDKDHLTKED LRVLMEREFP GFLENQKDPL AVDKIMKDLD
     QCRDGKVGFQ SFLSLVAGLT IACNDYFVVN MKQKGKK
//