Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P08207 (S10AA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein S100-A10
Alternative name(s):
Calpactin I light chain
Calpactin-1 light chain
Cellular ligand of annexin II
S100 calcium-binding protein A10
p10 protein
p11
Gene names
Name:S100a10
Synonyms:Cal1l
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length97 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

Subunit structure

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A By similarity.

Miscellaneous

Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.

Sequence similarities

Belongs to the S-100 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Anxa2P073562EBI-643986,EBI-738510

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 9796Protein S100-A10
PRO_0000144004

Regions

Region60 – 7112Ancestral calcium site

Amino acid modifications

Modified residue231N6-acetyllysine Ref.3
Modified residue281N6-acetyllysine By similarity
Modified residue541N6-acetyllysine By similarity
Modified residue571N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P08207 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: E7F092D4DAF6B43E

FASTA9711,186
        10         20         30         40         50         60 
MPSQMEHAME TMMLTFHRFA GDKDHLTKED LRVLMEREFP GFLENQKDPL AVDKIMKDLD 

        70         80         90 
QCRDGKVGFQ SFLSLVAGLT IACNDYFVVN MKQKGKK 

« Hide

References

« Hide 'large scale' references
[1]"cDNA sequence and tissue distribution of the mRNA for bovine and murine p11, the S100-related light chain of the protein-tyrosine kinase substrate p36 (calpactin I)."
Saris C.J.M., Kristensen T., D'Eustachio P., Hicks L.J., Noonan D.J., Glenney J.R. Jr., Hunter T., Tack B.F.
J. Biol. Chem. 262:10663-10671(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary gland.
[3]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M16465 mRNA. Translation: AAA37363.1.
BC025044 mRNA. Translation: AAH25044.1.
CCDSCCDS38526.1.
PIRA28489.
RefSeqNP_033138.1. NM_009112.2.
UniGeneMm.1.

3D structure databases

ProteinModelPortalP08207.
SMRP08207. Positions 2-93.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP08207. 8 interactions.
MINTMINT-4133605.
STRING10090.ENSMUSP00000036949.

PTM databases

PhosphoSiteP08207.

Proteomic databases

MaxQBP08207.
PaxDbP08207.
PRIDEP08207.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000045756; ENSMUSP00000036949; ENSMUSG00000041959.
ENSMUST00000170612; ENSMUSP00000130712; ENSMUSG00000041959.
GeneID20194.
KEGGmmu:20194.
UCSCuc008qfk.1. mouse.

Organism-specific databases

CTD6281.
MGIMGI:1339468. S100a10.

Phylogenomic databases

eggNOGNOG26977.
HOGENOMHOG000246968.
HOVERGENHBG001479.
InParanoidP08207.
KOK17274.
OMAAMETLMF.
OrthoDBEOG7R833W.
PhylomeDBP08207.
TreeFamTF332727.

Gene expression databases

ArrayExpressP08207.
BgeeP08207.
CleanExMM_S100A10.
GenevestigatorP08207.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR028476. S100-A10.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERPTHR11639:SF56. PTHR11639:SF56. 1 hit.
PfamPF01023. S_100. 1 hit.
[Graphical view]
PROSITEPS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio297751.
PROP08207.
SOURCESearch...

Entry information

Entry nameS10AA_MOUSE
AccessionPrimary (citable) accession number: P08207
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot