P08207 (S10AA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein S100-A10

Alternative name(s):
Calpactin I light chain
Calpactin-1 light chain
Cellular ligand of annexin II
S100 calcium-binding protein A10
p10 protein
p11

Gene names

Name:	S100a10
Synonyms:	Cal1l

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	97 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.
Subunit structure	Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A By similarity.
Miscellaneous	Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.
Sequence similarities	Belongs to the S-100 family.

Ontologies

Keywords
Domain	Repeat
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to acid Inferred from direct assay PubMed 17690254. Source: MGI positive regulation of binding Inferred from mutant phenotype PubMed 17690254. Source: MGI
Cellular_component	extrinsic to plasma membrane Inferred from direct assay PubMed 17690254. Source: MGI
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 97	96	Protein S100-A10		PRO_0000144004
Regions
	Region	60 – 71	12	Ancestral calcium site
Amino acid modifications
	Modified residue	23	1	N6-acetyllysine By similarity
	Modified residue	28	1	N6-acetyllysine By similarity
	Modified residue	54	1	N6-acetyllysine By similarity
	Modified residue	57	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P08207 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: E7F092D4DAF6B43E	FASTA	97	11,186
	10 20 30 40 50 60 MPSQMEHAME TMMLTFHRFA GDKDHLTKED LRVLMEREFP GFLENQKDPL AVDKIMKDLD 70 80 90 QCRDGKVGFQ SFLSLVAGLT IACNDYFVVN MKQKGKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA sequence and tissue distribution of the mRNA for bovine and murine p11, the S100-related light chain of the protein-tyrosine kinase substrate p36 (calpactin I)." Saris C.J.M., Kristensen T., D'Eustachio P., Hicks L.J., Noonan D.J., Glenney J.R. Jr., Hunter T., Tack B.F. J. Biol. Chem. 262:10663-10671(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M16465 mRNA. Translation: AAA37363.1. BC025044 mRNA. Translation: AAH25044.1.
IPI	IPI00222555.
PIR	A28489.
RefSeq	NP_033138.1. NM_009112.2.
UniGene	Mm.1.
3D structure databases
ProteinModelPortal	P08207.
SMR	P08207. Positions 2-93.
ModBase	Search...
Protein-protein interaction databases
IntAct	P08207. 3 interactions.
STRING	10090.ENSMUSP00000036949.
PTM databases
PhosphoSite	P08207.
Proteomic databases
PaxDb	P08207.
PRIDE	P08207.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000045756; ENSMUSP00000036949; ENSMUSG00000041959. ENSMUST00000170612; ENSMUSP00000130712; ENSMUSG00000041959.
GeneID	20194.
KEGG	mmu:20194.
Organism-specific databases
CTD	6281.
MGI	MGI:1339468. S100a10.
Phylogenomic databases
eggNOG	NOG26977.
HOGENOM	HOG000246968.
HOVERGEN	HBG001479.
InParanoid	P08207.
OMA	AMETLMF.
OrthoDB	EOG4DNF5Z.
Gene expression databases
ArrayExpress	P08207.
Bgee	P08207.
CleanEx	MM_S100A10.
Genevestigator	P08207.
GermOnline	ENSMUSG00000041959. Mus musculus.
Family and domain databases
Gene3D	1.10.238.10. 1 hit.
InterPro	IPR011992. EF-hand-like_dom. IPR002048. EF_hand_dom. IPR001751. S100/CaBP-9k_CS. IPR013787. S100_Ca-bd_sub. [Graphical view]
Pfam	PF01023. S_100. 1 hit. [Graphical view]
PROSITE	PS50222. EF_HAND_2. 1 hit. PS00303. S100_CABP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	297751.
SOURCE	Search...

Entry information

Entry name

S10AA_MOUSE

Accession

Primary (citable) accession number: P08207

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program