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P08207

- S10AA_MOUSE

UniProt

P08207 - S10AA_MOUSE

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Protein

Protein S100-A10

Gene

S100a10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. establishment of protein localization to plasma membrane Source: Ensembl
  2. membrane budding Source: Ensembl
  3. membrane raft assembly Source: Ensembl
  4. positive regulation of binding Source: MGI
  5. positive regulation of focal adhesion assembly Source: Ensembl
  6. positive regulation of Rac GTPase activity Source: Ensembl
  7. positive regulation of stress fiber assembly Source: Ensembl
  8. positive regulation of substrate adhesion-dependent cell spreading Source: Ensembl
  9. protein heterotetramerization Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A10
Alternative name(s):
Calpactin I light chain
Calpactin-1 light chain
Cellular ligand of annexin II
S100 calcium-binding protein A10
p10 protein
p11
Gene namesi
Name:S100a10
Synonyms:Cal1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1339468. S100a10.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. extrinsic component of plasma membrane Source: MGI
  3. membrane raft Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 9796Protein S100-A10PRO_0000144004Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231N6-acetyllysine1 Publication
Modified residuei28 – 281N6-acetyllysineBy similarity
Modified residuei54 – 541N6-acetyllysineBy similarity
Modified residuei57 – 571N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP08207.
PaxDbiP08207.
PRIDEiP08207.

PTM databases

PhosphoSiteiP08207.

Expressioni

Gene expression databases

BgeeiP08207.
CleanExiMM_S100A10.
ExpressionAtlasiP08207. baseline and differential.
GenevestigatoriP08207.

Interactioni

Subunit structurei

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Anxa2P073562EBI-643986,EBI-738510

Protein-protein interaction databases

IntActiP08207. 8 interactions.
MINTiMINT-4133605.
STRINGi10090.ENSMUSP00000036949.

Structurei

3D structure databases

ProteinModelPortaliP08207.
SMRiP08207. Positions 2-93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni60 – 7112Ancestral calcium siteAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG26977.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP08207.
KOiK17274.
OMAiAMETLMF.
OrthoDBiEOG7R833W.
PhylomeDBiP08207.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR028476. S100-A10.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERiPTHR11639:SF56. PTHR11639:SF56. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08207-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSQMEHAME TMMLTFHRFA GDKDHLTKED LRVLMEREFP GFLENQKDPL
60 70 80 90
AVDKIMKDLD QCRDGKVGFQ SFLSLVAGLT IACNDYFVVN MKQKGKK
Length:97
Mass (Da):11,186
Last modified:January 23, 2007 - v2
Checksum:iE7F092D4DAF6B43E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16465 mRNA. Translation: AAA37363.1.
BC025044 mRNA. Translation: AAH25044.1.
CCDSiCCDS38526.1.
PIRiA28489.
RefSeqiNP_033138.1. NM_009112.2.
UniGeneiMm.1.

Genome annotation databases

EnsembliENSMUST00000045756; ENSMUSP00000036949; ENSMUSG00000041959.
ENSMUST00000170612; ENSMUSP00000130712; ENSMUSG00000041959.
GeneIDi20194.
KEGGimmu:20194.
UCSCiuc008qfk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16465 mRNA. Translation: AAA37363.1 .
BC025044 mRNA. Translation: AAH25044.1 .
CCDSi CCDS38526.1.
PIRi A28489.
RefSeqi NP_033138.1. NM_009112.2.
UniGenei Mm.1.

3D structure databases

ProteinModelPortali P08207.
SMRi P08207. Positions 2-93.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P08207. 8 interactions.
MINTi MINT-4133605.
STRINGi 10090.ENSMUSP00000036949.

PTM databases

PhosphoSitei P08207.

Proteomic databases

MaxQBi P08207.
PaxDbi P08207.
PRIDEi P08207.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000045756 ; ENSMUSP00000036949 ; ENSMUSG00000041959 .
ENSMUST00000170612 ; ENSMUSP00000130712 ; ENSMUSG00000041959 .
GeneIDi 20194.
KEGGi mmu:20194.
UCSCi uc008qfk.1. mouse.

Organism-specific databases

CTDi 6281.
MGIi MGI:1339468. S100a10.

Phylogenomic databases

eggNOGi NOG26977.
HOGENOMi HOG000246968.
HOVERGENi HBG001479.
InParanoidi P08207.
KOi K17274.
OMAi AMETLMF.
OrthoDBi EOG7R833W.
PhylomeDBi P08207.
TreeFami TF332727.

Miscellaneous databases

NextBioi 297751.
PROi P08207.
SOURCEi Search...

Gene expression databases

Bgeei P08207.
CleanExi MM_S100A10.
ExpressionAtlasi P08207. baseline and differential.
Genevestigatori P08207.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR028476. S100-A10.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view ]
PANTHERi PTHR11639:SF56. PTHR11639:SF56. 1 hit.
Pfami PF01023. S_100. 1 hit.
[Graphical view ]
PROSITEi PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA sequence and tissue distribution of the mRNA for bovine and murine p11, the S100-related light chain of the protein-tyrosine kinase substrate p36 (calpactin I)."
    Saris C.J.M., Kristensen T., D'Eustachio P., Hicks L.J., Noonan D.J., Glenney J.R. Jr., Hunter T., Tack B.F.
    J. Biol. Chem. 262:10663-10671(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiS10AA_MOUSE
AccessioniPrimary (citable) accession number: P08207
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3