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P08207

- S10AA_MOUSE

UniProt

P08207 - S10AA_MOUSE

Protein

Protein S100-A10

Gene

S100a10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. protein binding Source: IntAct

    GO - Biological processi

    1. cellular response to acid chemical Source: MGI
    2. positive regulation of binding Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein S100-A10
    Alternative name(s):
    Calpactin I light chain
    Calpactin-1 light chain
    Cellular ligand of annexin II
    S100 calcium-binding protein A10
    p10 protein
    p11
    Gene namesi
    Name:S100a10
    Synonyms:Cal1l
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1339468. S100a10.

    Subcellular locationi

    GO - Cellular componenti

    1. extrinsic component of plasma membrane Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 9796Protein S100-A10PRO_0000144004Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei23 – 231N6-acetyllysine1 Publication
    Modified residuei28 – 281N6-acetyllysineBy similarity
    Modified residuei54 – 541N6-acetyllysineBy similarity
    Modified residuei57 – 571N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP08207.
    PaxDbiP08207.
    PRIDEiP08207.

    PTM databases

    PhosphoSiteiP08207.

    Expressioni

    Gene expression databases

    ArrayExpressiP08207.
    BgeeiP08207.
    CleanExiMM_S100A10.
    GenevestigatoriP08207.

    Interactioni

    Subunit structurei

    Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Anxa2P073562EBI-643986,EBI-738510

    Protein-protein interaction databases

    IntActiP08207. 8 interactions.
    MINTiMINT-4133605.
    STRINGi10090.ENSMUSP00000036949.

    Structurei

    3D structure databases

    ProteinModelPortaliP08207.
    SMRiP08207. Positions 2-93.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni60 – 7112Ancestral calcium siteAdd
    BLAST

    Sequence similaritiesi

    Belongs to the S-100 family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG26977.
    HOGENOMiHOG000246968.
    HOVERGENiHBG001479.
    InParanoidiP08207.
    KOiK17274.
    OMAiAMETLMF.
    OrthoDBiEOG7R833W.
    PhylomeDBiP08207.
    TreeFamiTF332727.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR028476. S100-A10.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    [Graphical view]
    PANTHERiPTHR11639:SF56. PTHR11639:SF56. 1 hit.
    PfamiPF01023. S_100. 1 hit.
    [Graphical view]
    PROSITEiPS50222. EF_HAND_2. 1 hit.
    PS00303. S100_CABP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P08207-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSQMEHAME TMMLTFHRFA GDKDHLTKED LRVLMEREFP GFLENQKDPL   50
    AVDKIMKDLD QCRDGKVGFQ SFLSLVAGLT IACNDYFVVN MKQKGKK 97
    Length:97
    Mass (Da):11,186
    Last modified:January 23, 2007 - v2
    Checksum:iE7F092D4DAF6B43E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16465 mRNA. Translation: AAA37363.1.
    BC025044 mRNA. Translation: AAH25044.1.
    CCDSiCCDS38526.1.
    PIRiA28489.
    RefSeqiNP_033138.1. NM_009112.2.
    UniGeneiMm.1.

    Genome annotation databases

    EnsembliENSMUST00000045756; ENSMUSP00000036949; ENSMUSG00000041959.
    ENSMUST00000170612; ENSMUSP00000130712; ENSMUSG00000041959.
    GeneIDi20194.
    KEGGimmu:20194.
    UCSCiuc008qfk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16465 mRNA. Translation: AAA37363.1 .
    BC025044 mRNA. Translation: AAH25044.1 .
    CCDSi CCDS38526.1.
    PIRi A28489.
    RefSeqi NP_033138.1. NM_009112.2.
    UniGenei Mm.1.

    3D structure databases

    ProteinModelPortali P08207.
    SMRi P08207. Positions 2-93.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P08207. 8 interactions.
    MINTi MINT-4133605.
    STRINGi 10090.ENSMUSP00000036949.

    PTM databases

    PhosphoSitei P08207.

    Proteomic databases

    MaxQBi P08207.
    PaxDbi P08207.
    PRIDEi P08207.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000045756 ; ENSMUSP00000036949 ; ENSMUSG00000041959 .
    ENSMUST00000170612 ; ENSMUSP00000130712 ; ENSMUSG00000041959 .
    GeneIDi 20194.
    KEGGi mmu:20194.
    UCSCi uc008qfk.1. mouse.

    Organism-specific databases

    CTDi 6281.
    MGIi MGI:1339468. S100a10.

    Phylogenomic databases

    eggNOGi NOG26977.
    HOGENOMi HOG000246968.
    HOVERGENi HBG001479.
    InParanoidi P08207.
    KOi K17274.
    OMAi AMETLMF.
    OrthoDBi EOG7R833W.
    PhylomeDBi P08207.
    TreeFami TF332727.

    Miscellaneous databases

    NextBioi 297751.
    PROi P08207.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P08207.
    Bgeei P08207.
    CleanExi MM_S100A10.
    Genevestigatori P08207.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR028476. S100-A10.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    [Graphical view ]
    PANTHERi PTHR11639:SF56. PTHR11639:SF56. 1 hit.
    Pfami PF01023. S_100. 1 hit.
    [Graphical view ]
    PROSITEi PS50222. EF_HAND_2. 1 hit.
    PS00303. S100_CABP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA sequence and tissue distribution of the mRNA for bovine and murine p11, the S100-related light chain of the protein-tyrosine kinase substrate p36 (calpactin I)."
      Saris C.J.M., Kristensen T., D'Eustachio P., Hicks L.J., Noonan D.J., Glenney J.R. Jr., Hunter T., Tack B.F.
      J. Biol. Chem. 262:10663-10671(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.
    3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiS10AA_MOUSE
    AccessioniPrimary (citable) accession number: P08207
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3