Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein S100-A10

Gene

S100a10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-75205. Dissolution of Fibrin Clot.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A10
Alternative name(s):
Calpactin I light chain
Calpactin-1 light chain
Cellular ligand of annexin II
S100 calcium-binding protein A10
p10 protein
p11
Gene namesi
Name:S100a10
Synonyms:Cal1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1339468. S100a10.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • extrinsic component of plasma membrane Source: MGI
  • membrane raft Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001440042 – 97Protein S100-A10Add BLAST96

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23N6-acetyllysineCombined sources1
Modified residuei28N6-acetyllysineBy similarity1
Modified residuei54N6-acetyllysineBy similarity1
Modified residuei57N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP08207.
PaxDbiP08207.
PeptideAtlasiP08207.
PRIDEiP08207.

PTM databases

iPTMnetiP08207.
PhosphoSitePlusiP08207.

Expressioni

Gene expression databases

BgeeiENSMUSG00000041959.
CleanExiMM_S100A10.
ExpressionAtlasiP08207. baseline and differential.
GenevisibleiP08207. MM.

Interactioni

Subunit structurei

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Anxa2P073562EBI-643986,EBI-738510

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203049. 4 interactors.
IntActiP08207. 8 interactors.
MINTiMINT-4133605.
STRINGi10090.ENSMUSP00000036949.

Structurei

3D structure databases

ProteinModelPortaliP08207.
SMRiP08207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni60 – 71Ancestral calcium siteAdd BLAST12

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IXW9. Eukaryota.
ENOG410YSSI. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP08207.
KOiK17274.
OMAiAMETLMF.
OrthoDBiEOG091G10QT.
PhylomeDBiP08207.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR028476. S100-A10.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERiPTHR11639:SF74. PTHR11639:SF74. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSQMEHAME TMMLTFHRFA GDKDHLTKED LRVLMEREFP GFLENQKDPL
60 70 80 90
AVDKIMKDLD QCRDGKVGFQ SFLSLVAGLT IACNDYFVVN MKQKGKK
Length:97
Mass (Da):11,186
Last modified:January 23, 2007 - v2
Checksum:iE7F092D4DAF6B43E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16465 mRNA. Translation: AAA37363.1.
BC025044 mRNA. Translation: AAH25044.1.
CCDSiCCDS38526.1.
PIRiA28489.
RefSeqiNP_033138.1. NM_009112.2.
UniGeneiMm.1.

Genome annotation databases

EnsembliENSMUST00000045756; ENSMUSP00000036949; ENSMUSG00000041959.
ENSMUST00000170612; ENSMUSP00000130712; ENSMUSG00000041959.
GeneIDi20194.
KEGGimmu:20194.
UCSCiuc008qfk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16465 mRNA. Translation: AAA37363.1.
BC025044 mRNA. Translation: AAH25044.1.
CCDSiCCDS38526.1.
PIRiA28489.
RefSeqiNP_033138.1. NM_009112.2.
UniGeneiMm.1.

3D structure databases

ProteinModelPortaliP08207.
SMRiP08207.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203049. 4 interactors.
IntActiP08207. 8 interactors.
MINTiMINT-4133605.
STRINGi10090.ENSMUSP00000036949.

PTM databases

iPTMnetiP08207.
PhosphoSitePlusiP08207.

Proteomic databases

EPDiP08207.
PaxDbiP08207.
PeptideAtlasiP08207.
PRIDEiP08207.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045756; ENSMUSP00000036949; ENSMUSG00000041959.
ENSMUST00000170612; ENSMUSP00000130712; ENSMUSG00000041959.
GeneIDi20194.
KEGGimmu:20194.
UCSCiuc008qfk.1. mouse.

Organism-specific databases

CTDi6281.
MGIiMGI:1339468. S100a10.

Phylogenomic databases

eggNOGiENOG410IXW9. Eukaryota.
ENOG410YSSI. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP08207.
KOiK17274.
OMAiAMETLMF.
OrthoDBiEOG091G10QT.
PhylomeDBiP08207.
TreeFamiTF332727.

Enzyme and pathway databases

ReactomeiR-MMU-75205. Dissolution of Fibrin Clot.

Miscellaneous databases

PROiP08207.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041959.
CleanExiMM_S100A10.
ExpressionAtlasiP08207. baseline and differential.
GenevisibleiP08207. MM.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR028476. S100-A10.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERiPTHR11639:SF74. PTHR11639:SF74. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS10AA_MOUSE
AccessioniPrimary (citable) accession number: P08207
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.