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Protein

Protein S100-A10

Gene

S100a10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. ion channel binding Source: MGI
  3. protein homodimerization activity Source: MGI

GO - Biological processi

  1. establishment of protein localization to plasma membrane Source: MGI
  2. membrane budding Source: MGI
  3. membrane raft assembly Source: MGI
  4. positive regulation of binding Source: MGI
  5. positive regulation of focal adhesion assembly Source: MGI
  6. positive regulation of Rac GTPase activity Source: MGI
  7. positive regulation of stress fiber assembly Source: MGI
  8. positive regulation of substrate adhesion-dependent cell spreading Source: MGI
  9. protein heterotetramerization Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_289519. Dissolution of Fibrin Clot.
REACT_297274. Orphan transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A10
Alternative name(s):
Calpactin I light chain
Calpactin-1 light chain
Cellular ligand of annexin II
S100 calcium-binding protein A10
p10 protein
p11
Gene namesi
Name:S100a10
Synonyms:Cal1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1339468. S100a10.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: MGI
  2. extrinsic component of plasma membrane Source: MGI
  3. membrane raft Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 9796Protein S100-A10PRO_0000144004Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231N6-acetyllysine1 Publication
Modified residuei28 – 281N6-acetyllysineBy similarity
Modified residuei54 – 541N6-acetyllysineBy similarity
Modified residuei57 – 571N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP08207.
PaxDbiP08207.
PRIDEiP08207.

PTM databases

PhosphoSiteiP08207.

Expressioni

Gene expression databases

BgeeiP08207.
CleanExiMM_S100A10.
ExpressionAtlasiP08207. baseline and differential.
GenevestigatoriP08207.

Interactioni

Subunit structurei

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Anxa2P073562EBI-643986,EBI-738510

Protein-protein interaction databases

IntActiP08207. 8 interactions.
MINTiMINT-4133605.
STRINGi10090.ENSMUSP00000036949.

Structurei

3D structure databases

ProteinModelPortaliP08207.
SMRiP08207. Positions 2-93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni60 – 7112Ancestral calcium siteAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG26977.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP08207.
KOiK17274.
OMAiAMETLMF.
OrthoDBiEOG7R833W.
PhylomeDBiP08207.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR028476. S100-A10.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERiPTHR11639:SF56. PTHR11639:SF56. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSQMEHAME TMMLTFHRFA GDKDHLTKED LRVLMEREFP GFLENQKDPL
60 70 80 90
AVDKIMKDLD QCRDGKVGFQ SFLSLVAGLT IACNDYFVVN MKQKGKK
Length:97
Mass (Da):11,186
Last modified:January 23, 2007 - v2
Checksum:iE7F092D4DAF6B43E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16465 mRNA. Translation: AAA37363.1.
BC025044 mRNA. Translation: AAH25044.1.
CCDSiCCDS38526.1.
PIRiA28489.
RefSeqiNP_033138.1. NM_009112.2.
UniGeneiMm.1.

Genome annotation databases

EnsembliENSMUST00000045756; ENSMUSP00000036949; ENSMUSG00000041959.
ENSMUST00000170612; ENSMUSP00000130712; ENSMUSG00000041959.
GeneIDi20194.
KEGGimmu:20194.
UCSCiuc008qfk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16465 mRNA. Translation: AAA37363.1.
BC025044 mRNA. Translation: AAH25044.1.
CCDSiCCDS38526.1.
PIRiA28489.
RefSeqiNP_033138.1. NM_009112.2.
UniGeneiMm.1.

3D structure databases

ProteinModelPortaliP08207.
SMRiP08207. Positions 2-93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP08207. 8 interactions.
MINTiMINT-4133605.
STRINGi10090.ENSMUSP00000036949.

PTM databases

PhosphoSiteiP08207.

Proteomic databases

MaxQBiP08207.
PaxDbiP08207.
PRIDEiP08207.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045756; ENSMUSP00000036949; ENSMUSG00000041959.
ENSMUST00000170612; ENSMUSP00000130712; ENSMUSG00000041959.
GeneIDi20194.
KEGGimmu:20194.
UCSCiuc008qfk.1. mouse.

Organism-specific databases

CTDi6281.
MGIiMGI:1339468. S100a10.

Phylogenomic databases

eggNOGiNOG26977.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP08207.
KOiK17274.
OMAiAMETLMF.
OrthoDBiEOG7R833W.
PhylomeDBiP08207.
TreeFamiTF332727.

Enzyme and pathway databases

ReactomeiREACT_289519. Dissolution of Fibrin Clot.
REACT_297274. Orphan transporters.

Miscellaneous databases

NextBioi297751.
PROiP08207.
SOURCEiSearch...

Gene expression databases

BgeeiP08207.
CleanExiMM_S100A10.
ExpressionAtlasiP08207. baseline and differential.
GenevestigatoriP08207.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR028476. S100-A10.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERiPTHR11639:SF56. PTHR11639:SF56. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA sequence and tissue distribution of the mRNA for bovine and murine p11, the S100-related light chain of the protein-tyrosine kinase substrate p36 (calpactin I)."
    Saris C.J.M., Kristensen T., D'Eustachio P., Hicks L.J., Noonan D.J., Glenney J.R. Jr., Hunter T., Tack B.F.
    J. Biol. Chem. 262:10663-10671(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiS10AA_MOUSE
AccessioniPrimary (citable) accession number: P08207
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: April 1, 2015
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.