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Protein

L-arabinose isomerase

Gene

araA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of L-arabinose to L-ribulose.

Catalytic activityi

L-arabinose = L-ribulose.

Cofactori

Mn2+Note: Binds 1 Mn2+ ion per subunit.

Pathwayi: L-arabinose degradation via L-ribulose

This protein is involved in step 1 of the subpathway that synthesizes D-xylulose 5-phosphate from L-arabinose (bacterial route).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. L-arabinose isomerase (araA)
  2. Ribulokinase (araB)
  3. L-ribulose-5-phosphate 4-epimerase AraD (araD)
This subpathway is part of the pathway L-arabinose degradation via L-ribulose, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-xylulose 5-phosphate from L-arabinose (bacterial route), the pathway L-arabinose degradation via L-ribulose and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi306Manganese1
Metal bindingi333Manganese1
Metal bindingi350Manganese1
Metal bindingi450Manganese1

GO - Molecular functioni

  • L-arabinose isomerase activity Source: EcoCyc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • arabinose catabolic process Source: EcoliWiki
  • L-arabinose catabolic process to xylulose 5-phosphate Source: EcoCyc

Keywordsi

Molecular functionIsomerase
Biological processArabinose catabolism, Carbohydrate metabolism
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:ARABISOM-MONOMER
MetaCyc:ARABISOM-MONOMER
BRENDAi5.3.1.4 2026
UniPathwayiUPA00145; UER00565

Names & Taxonomyi

Protein namesi
Recommended name:
L-arabinose isomerase (EC:5.3.1.4)
Gene namesi
Name:araA
Ordered Locus Names:b0062, JW0061
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10052 araA

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001983851 – 500L-arabinose isomeraseAdd BLAST500

Proteomic databases

PaxDbiP08202
PRIDEiP08202

Interactioni

Subunit structurei

Homohexamer.2 Publications

Protein-protein interaction databases

BioGridi4259464, 1 interactor
DIPiDIP-9123N
IntActiP08202, 4 interactors
STRINGi316407.85674308

Structurei

Secondary structure

1500
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 6Combined sources4
Beta strandi8 – 14Combined sources7
Beta strandi17 – 19Combined sources3
Helixi23 – 41Combined sources19
Beta strandi45 – 50Combined sources6
Helixi57 – 69Combined sources13
Beta strandi73 – 79Combined sources7
Helixi87 – 95Combined sources9
Beta strandi100 – 104Combined sources5
Beta strandi107 – 110Combined sources4
Turni113 – 115Combined sources3
Helixi118 – 123Combined sources6
Helixi126 – 139Combined sources14
Beta strandi144 – 149Combined sources6
Helixi154 – 173Combined sources20
Beta strandi177 – 182Combined sources6
Helixi195 – 202Combined sources8
Beta strandi205 – 209Combined sources5
Helixi211 – 219Combined sources9
Helixi223 – 236Combined sources14
Beta strandi237 – 239Combined sources3
Helixi241 – 243Combined sources3
Helixi250 – 270Combined sources21
Beta strandi273 – 276Combined sources4
Helixi291 – 298Combined sources8
Beta strandi302 – 305Combined sources4
Helixi309 – 321Combined sources13
Turni322 – 324Combined sources3
Beta strandi325 – 327Combined sources3
Beta strandi329 – 338Combined sources10
Beta strandi345 – 349Combined sources5
Helixi356 – 358Combined sources3
Beta strandi361 – 363Combined sources3
Beta strandi365 – 368Combined sources4
Turni372 – 375Combined sources4
Beta strandi380 – 383Combined sources4
Beta strandi389 – 398Combined sources10
Beta strandi400 – 412Combined sources13
Beta strandi427 – 433Combined sources7
Helixi435 – 444Combined sources10
Beta strandi449 – 456Combined sources8
Helixi459 – 468Combined sources10
Beta strandi472 – 477Combined sources6
Helixi482 – 496Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AJTX-ray2.60A/B/C1-500[»]
2HXGX-ray2.80A/B/C1-500[»]
4F2DX-ray2.30A/B/C1-500[»]
ProteinModelPortaliP08202
SMRiP08202
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08202

Family & Domainsi

Sequence similaritiesi

Belongs to the arabinose isomerase family.Curated

Phylogenomic databases

eggNOGiENOG4105CAC Bacteria
COG2160 LUCA
HOGENOMiHOG000252817
InParanoidiP08202
KOiK01804
OMAiHMLEICP
PhylomeDBiP08202

Family and domain databases

Gene3Di3.40.50.10940, 1 hit
HAMAPiMF_00519 Arabinose_Isome, 1 hit
InterProiView protein in InterPro
IPR024664 Ara_Isoase_C
IPR038583 AraA_N_sf
IPR004216 Fuc/Ara_isomerase_C
IPR009015 Fucose_isomerase_N/cen_sf
IPR003762 Lara_isomerase
PANTHERiPTHR38464 PTHR38464, 1 hit
PfamiView protein in Pfam
PF11762 Arabinose_Iso_C, 1 hit
PF02610 Arabinose_Isome, 1 hit
PIRSFiPIRSF001478 L-ara_isomerase, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD018364 Lara_isomerase, 1 hit
SUPFAMiSSF50443 SSF50443, 1 hit
SSF53743 SSF53743, 1 hit

Sequencei

Sequence statusi: Complete.

P08202-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIFDNYEVW FVIGSQHLYG PETLRQVTQH AEHVVNALNT EAKLPCKLVL
60 70 80 90 100
KPLGTTPDEI TAICRDANYD DRCAGLVVWL HTFSPAKMWI NGLTMLNKPL
110 120 130 140 150
LQFHTQFNAA LPWDSIDMDF MNLNQTAHGG REFGFIGARM RQQHAVVTGH
160 170 180 190 200
WQDKQAHERI GSWMRQAVSK QDTRHLKVCR FGDNMREVAV TDGDKVAAQI
210 220 230 240 250
KFGFSVNTWA VGDLVQVVNS ISDGDVNALV DEYESCYTMT PATQIHGKKR
260 270 280 290 300
QNVLEAARIE LGMKRFLEQG GFHAFTTTFE DLHGLKQLPG LAVQRLMQQG
310 320 330 340 350
YGFAGEGDWK TAALLRIMKV MSTGLQGGTS FMEDYTYHFE KGNDLVLGSH
360 370 380 390 400
MLEVCPSIAA EEKPILDVQH LGIGGKDDPA RLIFNTQTGP AIVASLIDLG
410 420 430 440 450
DRYRLLVNCI DTVKTPHSLP KLPVANALWK AQPDLPTASE AWILAGGAHH
460 470 480 490 500
TVFSHALNLN DMRQFAEMHD IEITVIDNDT RLPAFKDALR WNEVYYGFRR
Length:500
Mass (Da):56,074
Last modified:June 27, 2006 - v3
Checksum:iE427A145A3455D36
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72R → P in AAA23463 (PubMed:3549454).Curated1
Sequence conflicti248K → E in AAA23463 (PubMed:3549454).Curated1
Sequence conflicti360A → V in AAA23463 (PubMed:3549454).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15263 Genomic DNA Translation: AAA23463.1
U00096 Genomic DNA Translation: AAC73173.1
AP009048 Genomic DNA Translation: BAB96631.2
X74279 Genomic DNA Translation: CAA52340.1
PIRiF64727 ISECAB
RefSeqiNP_414604.1, NC_000913.3
WP_000151748.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73173; AAC73173; b0062
BAB96631; BAB96631; BAB96631
GeneIDi947511
KEGGiecj:JW0061
eco:b0062
PATRICifig|1411691.4.peg.2221

Similar proteinsi

Entry informationi

Entry nameiARAA_ECOLI
AccessioniPrimary (citable) accession number: P08202
Secondary accession number(s): P78040
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: June 27, 2006
Last modified: March 28, 2018
This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health