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Protein

4F2 cell-surface antigen heavy chain

Gene

SLC3A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier.15 Publications

Kineticsi

  1. KM=295 µM for glutamine (in the presence of NaCl)1 Publication
  2. KM=236 µM for leucine (in the presence of NaCl)1 Publication
  3. KM=120 µM for arginine (in the presence of NaCl)1 Publication
  4. KM=138 µM for arginine (in the absence of NaCl)1 Publication

    GO - Molecular functioni

    • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
    • calcium:sodium antiporter activity Source: UniProtKB
    • catalytic activity Source: InterPro
    • double-stranded RNA binding Source: MGI
    • neutral amino acid transmembrane transporter activity Source: UniProtKB
    • poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    • amino acid transport Source: UniProtKB
    • calcium ion transport Source: UniProtKB
    • carbohydrate metabolic process Source: InterPro
    • cell growth Source: UniProtKB
    • leucine import Source: UniProtKB
    • leukocyte migration Source: Reactome
    • response to exogenous dsRNA Source: MGI
    • tryptophan transport Source: UniProtKB
    Complete GO annotation...

    Keywords - Biological processi

    Amino-acid transport, Transport

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000168003-MONOMER.
    ZFISH:ENSG00000168003-MONOMER.
    ReactomeiR-HSA-210991. Basigin interactions.
    R-HSA-352230. Amino acid transport across the plasma membrane.
    SABIO-RKP08195.

    Protein family/group databases

    CAZyiGH13. Glycoside Hydrolase Family 13.
    TCDBi8.A.9.2.2. the rbat transport accessory protein (rbat) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4F2 cell-surface antigen heavy chain
    Short name:
    4F2hc
    Alternative name(s):
    4F2 heavy chain antigen
    Lymphocyte activation antigen 4F2 large subunit
    Solute carrier family 3 member 2
    CD_antigen: CD98
    Gene namesi
    Name:SLC3A2
    Synonyms:MDU1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:11026. SLC3A2.

    Subcellular locationi

    • Apical cell membrane; Single-pass type II membrane protein
    • Melanosome

    • Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localized to the plasma membrane when associated with SLC7A5 or SLC7A8. Localized to the placental apical membrane. Located selectively at cell-cell adhesion sites (By similarity). Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity).By similarity

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini102 – 184CytoplasmicSequence analysisAdd BLAST83
    Transmembranei185 – 205Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
    Topological domaini206 – 630ExtracellularSequence analysisAdd BLAST425

    GO - Cellular componenti

    • apical plasma membrane Source: UniProtKB-SubCell
    • cell-cell adherens junction Source: BHF-UCL
    • cell surface Source: UniProtKB
    • cytoplasm Source: HPA
    • extracellular exosome Source: UniProtKB
    • integral component of membrane Source: UniProtKB
    • melanosome Source: UniProtKB-SubCell
    • membrane Source: UniProtKB
    • nucleus Source: HPA
    • plasma membrane Source: HPA
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi210C → S: Abolishes dimerization, leucine uptake and interaction with beta-1 integrins. 3 Publications1
    Mutagenesisi431C → S: No effect on dimerization, leucine uptake or interaction with beta-1 integrins. 2 Publications1

    Organism-specific databases

    DisGeNETi6520.
    OpenTargetsiENSG00000168003.
    PharmGKBiPA35894.

    Chemistry databases

    GuidetoPHARMACOLOGYi890.

    Polymorphism and mutation databases

    BioMutaiSLC3A2.
    DMDMi257051063.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000643831 – 6304F2 cell-surface antigen heavy chainAdd BLAST630
    Isoform 2 (identifier: P08195-2)
    Initiator methionineiRemovedCombined sources

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei1N-acetylmethionineCombined sources1 Publication1
    Modified residuei103PhosphoserineCombined sources1
    Modified residuei106PhosphothreonineBy similarity1
    Modified residuei134PhosphoserineCombined sources1
    Cross-linki147Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
    Modified residuei165PhosphoserineCombined sources1
    Cross-linki166Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
    Disulfide bondi210Interchain (with light chain)1 Publication
    Glycosylationi365N-linked (GlcNAc...)3 Publications1
    Glycosylationi381N-linked (GlcNAc...)4 Publications1
    Modified residuei406Phosphoserine1 Publication1
    Modified residuei408Phosphoserine1 Publication1
    Modified residuei410Phosphoserine1 Publication1
    Glycosylationi424N-linked (GlcNAc...) (complex)4 Publications1
    Glycosylationi506N-linked (GlcNAc...)2 Publications1
    Modified residuei527Phosphoserine1 Publication1
    Modified residuei531Phosphoserine1 Publication1
    Isoform 2 (identifier: P08195-2)
    Modified residuei2N-acetylserineCombined sources1
    Modified residuei2PhosphoserineCombined sources1

    Post-translational modificationi

    Phosphorylation on Ser-406; Ser-408 or Ser-410 and on Ser-527 or Ser-531 by ecto-protein kinases favors heterotypic cell-cell interactions.1 Publication

    Keywords - PTMi

    Acetylation, Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    EPDiP08195.
    MaxQBiP08195.
    PaxDbiP08195.
    PeptideAtlasiP08195.
    PRIDEiP08195.

    PTM databases

    iPTMnetiP08195.
    PhosphoSitePlusiP08195.
    SwissPalmiP08195.

    Expressioni

    Tissue specificityi

    Expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. Also expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line C2BBe1.9 Publications

    Inductioni

    Expression is induced in resting peripheral blood T-lymphocytes following PHA stimulation. Expression increases at the time of maximal DNA synthesis, in fibroblasts stimulated to divide. Expression and the uptake of leucine is stimulated in mononuclear, cytotrophoblast-like choriocarcinoma cells by combined treatment with PMA and calcium ionophore.3 Publications

    Gene expression databases

    BgeeiENSG00000168003.
    CleanExiHS_SLC3A2.
    ExpressionAtlasiP08195. baseline and differential.
    GenevisibleiP08195. HS.

    Organism-specific databases

    HPAiCAB010455.
    HPA017980.

    Interactioni

    Subunit structurei

    Disulfide-linked heterodimer of a glycosylated heavy chain and a non-glycosylated light chain (SLC7A5, SLC7A6, SLCA7A7, SLC7A8, SLC7A10 or SLCA7A11). Colocalizes with cadherins (By similarity). Interacts with FAM57A/CT120 and ICAM1. Constitutively and specifically associates with beta-1 integrins (alpha-2/beta-1, alpha-3/beta-1, alpha-5/beta-1 and alpha-6/beta-1), but minimally with alpha-4/beta-1.By similarity14 Publications

    GO - Molecular functioni

    • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

    Protein-protein interaction databases

    BioGridi112411. 48 interactors.
    IntActiP08195. 29 interactors.
    MINTiMINT-4999018.
    STRINGi9606.ENSP00000367123.

    Structurei

    Secondary structure

    1630
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Helixi218 – 220Combined sources3
    Beta strandi224 – 227Combined sources4
    Helixi230 – 234Combined sources5
    Helixi241 – 245Combined sources5
    Helixi248 – 253Combined sources6
    Beta strandi257 – 261Combined sources5
    Beta strandi265 – 267Combined sources3
    Beta strandi275 – 280Combined sources6
    Helixi282 – 284Combined sources3
    Helixi287 – 299Combined sources13
    Beta strandi303 – 307Combined sources5
    Turni310 – 313Combined sources4
    Beta strandi314 – 316Combined sources3
    Beta strandi319 – 321Combined sources3
    Helixi323 – 340Combined sources18
    Beta strandi344 – 347Combined sources4
    Helixi350 – 352Combined sources3
    Helixi356 – 370Combined sources15
    Beta strandi375 – 379Combined sources5
    Helixi385 – 391Combined sources7
    Turni392 – 394Combined sources3
    Beta strandi399 – 401Combined sources3
    Turni404 – 407Combined sources4
    Helixi412 – 426Combined sources15
    Beta strandi437 – 439Combined sources3
    Helixi441 – 443Combined sources3
    Helixi447 – 449Combined sources3
    Helixi450 – 457Combined sources8
    Beta strandi460 – 467Combined sources8
    Helixi470 – 472Combined sources3
    Helixi476 – 478Combined sources3
    Beta strandi479 – 481Combined sources3
    Beta strandi484 – 486Combined sources3
    Helixi493 – 495Combined sources3
    Helixi500 – 502Combined sources3
    Helixi505 – 507Combined sources3
    Helixi509 – 513Combined sources5
    Helixi519 – 532Combined sources14
    Helixi534 – 538Combined sources5
    Beta strandi540 – 545Combined sources6
    Beta strandi550 – 556Combined sources7
    Beta strandi562 – 568Combined sources7
    Beta strandi570 – 572Combined sources3
    Beta strandi581 – 583Combined sources3
    Helixi585 – 587Combined sources3
    Beta strandi591 – 603Combined sources13
    Beta strandi607 – 610Combined sources4
    Helixi611 – 613Combined sources3
    Beta strandi621 – 626Combined sources6

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2DH2X-ray2.10A212-630[»]
    2DH3X-ray2.80A/B212-630[»]
    ProteinModelPortaliP08195.
    SMRiP08195.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP08195.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SLC3A transporter family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG0471. Eukaryota.
    COG0366. LUCA.
    GeneTreeiENSGT00860000133843.
    HOGENOMiHOG000233529.
    HOVERGENiHBG000023.
    InParanoidiP08195.
    KOiK06519.
    PhylomeDBiP08195.

    Family and domain databases

    Gene3Di2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR015902. Glyco_hydro_13.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR013780. Glyco_hydro_b.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR031984. SLC3A2_N.
    [Graphical view]
    PANTHERiPTHR10357. PTHR10357. 1 hit.
    PfamiPF00128. Alpha-amylase. 1 hit.
    PF16028. SLC3A2_N. 1 hit.
    [Graphical view]
    SMARTiSM00642. Aamy. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: P08195-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MELQPPEASI AVVSIPRQLP GSHSEAGVQG LSAGDDSELG SHCVAQTGLE
    60 70 80 90 100
    LLASGDPLPS ASQNAEMIET GSDCVTQAGL QLLASSDPPA LASKNAEVTG
    110 120 130 140 150
    TMSQDTEVDM KEVELNELEP EKQPMNAASG AAMSLAGAEK NGLVKIKVAE
    160 170 180 190 200
    DEAEAAAAAK FTGLSKEELL KVAGSPGWVR TRWALLLLFW LGWLGMLAGA
    210 220 230 240 250
    VVIIVRAPRC RELPAQKWWH TGALYRIGDL QAFQGHGAGN LAGLKGRLDY
    260 270 280 290 300
    LSSLKVKGLV LGPIHKNQKD DVAQTDLLQI DPNFGSKEDF DSLLQSAKKK
    310 320 330 340 350
    SIRVILDLTP NYRGENSWFS TQVDTVATKV KDALEFWLQA GVDGFQVRDI
    360 370 380 390 400
    ENLKDASSFL AEWQNITKGF SEDRLLIAGT NSSDLQQILS LLESNKDLLL
    410 420 430 440 450
    TSSYLSDSGS TGEHTKSLVT QYLNATGNRW CSWSLSQARL LTSFLPAQLL
    460 470 480 490 500
    RLYQLMLFTL PGTPVFSYGD EIGLDAAALP GQPMEAPVML WDESSFPDIP
    510 520 530 540 550
    GAVSANMTVK GQSEDPGSLL SLFRRLSDQR SKERSLLHGD FHAFSAGPGL
    560 570 580 590 600
    FSYIRHWDQN ERFLVVLNFG DVGLSAGLQA SDLPASASLP AKADLLLSTQ
    610 620 630
    PGREEGSPLE LERLKLEPHE GLLLRFPYAA
    Length:630
    Mass (Da):67,994
    Last modified:September 1, 2009 - v3
    Checksum:iAE427F8204CC10B0
    GO
    Isoform 2 (identifier: P08195-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-101: Missing.

    Show »
    Length:529
    Mass (Da):57,945
    Checksum:i82F26856737E8F31
    GO
    Isoform 3 (identifier: P08195-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         38-99: Missing.

    Show »
    Length:568
    Mass (Da):61,816
    Checksum:iF2B9400F95F2E1BD
    GO
    Isoform 4 (identifier: P08195-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         98-98: V → VTETGFHHVSQADIEFLTSIDPTASASGSAGI

    Show »
    Length:661
    Mass (Da):71,123
    Checksum:i06C2CDFD6B1D93F5
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti137G → E in AAA35536 (PubMed:3480538).Curated1
    Sequence conflicti158A → P in AAA51540 (PubMed:3036867).Curated1
    Sequence conflicti223A → P in AAA35536 (PubMed:3480538).Curated1
    Sequence conflicti315E → D in AAA35536 (PubMed:3480538).Curated1
    Sequence conflicti320S → F in AAA35489 (PubMed:3265470).Curated1
    Sequence conflicti372E → G in AAA35536 (PubMed:3480538).Curated1
    Sequence conflicti412 – 413GE → PQ in AAA35536 (PubMed:3480538).Curated2
    Sequence conflicti465V → L in AAA35536 (PubMed:3480538).Curated1
    Sequence conflicti481G → P in AAA35536 (PubMed:3480538).Curated1
    Sequence conflicti549G → E in AAA35489 (PubMed:3265470).Curated1
    Sequence conflicti609L → P in AAA35536 (PubMed:3480538).Curated1
    Sequence conflicti612E → G in AAA35536 (PubMed:3480538).Curated1

    Mass spectrometryi

    Molecular mass is 57944.93 Da from positions 1 - 529. Determined by MALDI. 1 Publication

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0379071 – 101Missing in isoform 2. 4 PublicationsAdd BLAST101
    Alternative sequenceiVSP_03790838 – 99Missing in isoform 3. 1 PublicationAdd BLAST62
    Alternative sequenceiVSP_03790998V → VTETGFHHVSQADIEFLTSI DPTASASGSAGI in isoform 4. 1 Publication1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    J02939 mRNA. Translation: AAA52497.1.
    J02769 mRNA. Translation: AAA51540.1.
    J03569 mRNA. Translation: AAA35536.1.
    M21904
    , M21898, M21899, M21900, M21901, M21902, M21903 Genomic DNA. Translation: AAA35489.1.
    AB018010 mRNA. Translation: BAA84649.1.
    AP001160 Genomic DNA. No translation available.
    BC001061 mRNA. Translation: AAH01061.2.
    BC003000 mRNA. Translation: AAH03000.2.
    BE794697 mRNA. No translation available.
    CCDSiCCDS31589.1. [P08195-3]
    CCDS31590.1. [P08195-2]
    CCDS8039.2. [P08195-1]
    PIRiA28455. SAHU4F.
    RefSeqiNP_001012680.1. NM_001012662.2.
    NP_001012682.1. NM_001012664.2. [P08195-3]
    NP_001013269.1. NM_001013251.2. [P08195-2]
    NP_002385.3. NM_002394.5. [P08195-1]
    UniGeneiHs.502769.

    Genome annotation databases

    EnsembliENST00000338663; ENSP00000340815; ENSG00000168003. [P08195-2]
    ENST00000377889; ENSP00000367121; ENSG00000168003. [P08195-3]
    ENST00000377890; ENSP00000367122; ENSG00000168003. [P08195-1]
    GeneIDi6520.
    KEGGihsa:6520.
    UCSCiuc001nwd.4. human. [P08195-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    J02939 mRNA. Translation: AAA52497.1.
    J02769 mRNA. Translation: AAA51540.1.
    J03569 mRNA. Translation: AAA35536.1.
    M21904
    , M21898, M21899, M21900, M21901, M21902, M21903 Genomic DNA. Translation: AAA35489.1.
    AB018010 mRNA. Translation: BAA84649.1.
    AP001160 Genomic DNA. No translation available.
    BC001061 mRNA. Translation: AAH01061.2.
    BC003000 mRNA. Translation: AAH03000.2.
    BE794697 mRNA. No translation available.
    CCDSiCCDS31589.1. [P08195-3]
    CCDS31590.1. [P08195-2]
    CCDS8039.2. [P08195-1]
    PIRiA28455. SAHU4F.
    RefSeqiNP_001012680.1. NM_001012662.2.
    NP_001012682.1. NM_001012664.2. [P08195-3]
    NP_001013269.1. NM_001013251.2. [P08195-2]
    NP_002385.3. NM_002394.5. [P08195-1]
    UniGeneiHs.502769.

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2DH2X-ray2.10A212-630[»]
    2DH3X-ray2.80A/B212-630[»]
    ProteinModelPortaliP08195.
    SMRiP08195.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi112411. 48 interactors.
    IntActiP08195. 29 interactors.
    MINTiMINT-4999018.
    STRINGi9606.ENSP00000367123.

    Chemistry databases

    GuidetoPHARMACOLOGYi890.

    Protein family/group databases

    CAZyiGH13. Glycoside Hydrolase Family 13.
    TCDBi8.A.9.2.2. the rbat transport accessory protein (rbat) family.

    PTM databases

    iPTMnetiP08195.
    PhosphoSitePlusiP08195.
    SwissPalmiP08195.

    Polymorphism and mutation databases

    BioMutaiSLC3A2.
    DMDMi257051063.

    Proteomic databases

    EPDiP08195.
    MaxQBiP08195.
    PaxDbiP08195.
    PeptideAtlasiP08195.
    PRIDEiP08195.

    Protocols and materials databases

    DNASUi6520.
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000338663; ENSP00000340815; ENSG00000168003. [P08195-2]
    ENST00000377889; ENSP00000367121; ENSG00000168003. [P08195-3]
    ENST00000377890; ENSP00000367122; ENSG00000168003. [P08195-1]
    GeneIDi6520.
    KEGGihsa:6520.
    UCSCiuc001nwd.4. human. [P08195-1]

    Organism-specific databases

    CTDi6520.
    DisGeNETi6520.
    GeneCardsiSLC3A2.
    HGNCiHGNC:11026. SLC3A2.
    HPAiCAB010455.
    HPA017980.
    MIMi158070. gene.
    neXtProtiNX_P08195.
    OpenTargetsiENSG00000168003.
    PharmGKBiPA35894.
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG0471. Eukaryota.
    COG0366. LUCA.
    GeneTreeiENSGT00860000133843.
    HOGENOMiHOG000233529.
    HOVERGENiHBG000023.
    InParanoidiP08195.
    KOiK06519.
    PhylomeDBiP08195.

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000168003-MONOMER.
    ZFISH:ENSG00000168003-MONOMER.
    ReactomeiR-HSA-210991. Basigin interactions.
    R-HSA-352230. Amino acid transport across the plasma membrane.
    SABIO-RKP08195.

    Miscellaneous databases

    ChiTaRSiSLC3A2. human.
    EvolutionaryTraceiP08195.
    GeneWikiiSLC3A2.
    GenomeRNAii6520.
    PROiP08195.
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000168003.
    CleanExiHS_SLC3A2.
    ExpressionAtlasiP08195. baseline and differential.
    GenevisibleiP08195. HS.

    Family and domain databases

    Gene3Di2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR015902. Glyco_hydro_13.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR013780. Glyco_hydro_b.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR031984. SLC3A2_N.
    [Graphical view]
    PANTHERiPTHR10357. PTHR10357. 1 hit.
    PfamiPF00128. Alpha-amylase. 1 hit.
    PF16028. SLC3A2_N. 1 hit.
    [Graphical view]
    SMARTiSM00642. Aamy. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    ProtoNetiSearch...

    Entry informationi

    Entry namei4F2_HUMAN
    AccessioniPrimary (citable) accession number: P08195
    Secondary accession number(s): Q13543
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: September 1, 2009
    Last modified: November 30, 2016
    This is version 194 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Arginine uptake is inhibited by increasing concentrations of leucine in the presence of Na+.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.