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Protein

Glycerol-3-phosphate transporter

Gene

glpT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for glycerol-3-phosphate uptake.

GO - Molecular functioni

  • glycerol-3-phosphate transmembrane transporter activity Source: InterPro
  • glycerol-phosphate:inorganic phosphate antiporter activity Source: EcoCyc
  • organophosphate:inorganic phosphate antiporter activity Source: EcoCyc

GO - Biological processi

  • glycerol-3-phosphate transport Source: EcoCyc
  • glycerol metabolic process Source: UniProtKB-KW
  • glycerol transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Glycerol metabolism, Transport

Enzyme and pathway databases

BioCyciEcoCyc:GLPT-MONOMER.
ECOL316407:JW2234-MONOMER.
MetaCyc:GLPT-MONOMER.

Protein family/group databases

TCDBi2.A.1.4.3. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate transporter
Short name:
G-3-P transporter
Alternative name(s):
G-3-P permease
Gene namesi
Name:glpT
Ordered Locus Names:b2240, JW2234
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10401. glpT.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicAdd BLAST36
Transmembranei37 – 57Helical; Name=1Add BLAST21
Topological domaini58 – 63Periplasmic6
Transmembranei64 – 84Helical; Name=2Add BLAST21
Topological domaini85 – 93Cytoplasmic9
Transmembranei94 – 112Helical; Name=3Add BLAST19
Topological domaini113 – 120Periplasmic8
Transmembranei121 – 141Helical; Name=4Add BLAST21
Topological domaini142 – 160CytoplasmicAdd BLAST19
Transmembranei161 – 180Helical; Name=5Add BLAST20
Topological domaini181 – 189Periplasmic9
Transmembranei190 – 207Helical; Name=6Add BLAST18
Topological domaini208 – 261CytoplasmicAdd BLAST54
Transmembranei262 – 282Helical; Name=7Add BLAST21
Topological domaini283 – 287Periplasmic5
Transmembranei288 – 308Helical; Name=8Add BLAST21
Topological domaini309 – 321CytoplasmicAdd BLAST13
Transmembranei322 – 341Helical; Name=9Add BLAST20
Topological domaini342 – 346Periplasmic5
Transmembranei347 – 368Helical; Name=10Add BLAST22
Topological domaini369 – 387CytoplasmicAdd BLAST19
Transmembranei388 – 409Helical; Name=11Add BLAST22
Topological domaini410 – 414Periplasmic5
Transmembranei415 – 435Helical; Name=12Add BLAST21
Topological domaini436 – 452CytoplasmicAdd BLAST17

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001998781 – 452Glycerol-3-phosphate transporterAdd BLAST452

Proteomic databases

PaxDbiP08194.
PRIDEiP08194.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi4261310. 156 interactors.
IntActiP08194. 1 interactor.
STRINGi511145.b2240.

Structurei

Secondary structure

1452
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi20 – 45Combined sources26
Helixi48 – 54Combined sources7
Helixi65 – 89Combined sources25
Helixi92 – 112Combined sources21
Helixi114 – 117Combined sources4
Beta strandi118 – 121Combined sources4
Helixi122 – 136Combined sources15
Helixi138 – 146Combined sources9
Turni150 – 152Combined sources3
Helixi153 – 169Combined sources17
Helixi172 – 182Combined sources11
Helixi191 – 207Combined sources17
Turni213 – 215Combined sources3
Turni221 – 223Combined sources3
Helixi243 – 248Combined sources6
Helixi253 – 279Combined sources27
Helixi288 – 315Combined sources28
Helixi321 – 338Combined sources18
Helixi347 – 361Combined sources15
Helixi363 – 374Combined sources12
Helixi380 – 409Combined sources30
Helixi414 – 443Combined sources30
Helixi444 – 448Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PW4X-ray3.30A3-448[»]
ProteinModelPortaliP08194.
SMRiP08194.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08194.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CXY. Bacteria.
COG2271. LUCA.
HOGENOMiHOG000274729.
InParanoidiP08194.
KOiK02445.
OMAiWSTHERG.
PhylomeDBiP08194.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR005267. G3P_transporter.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR021159. Sugar-P_transporter_CS.
IPR000849. Sugar_P_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002808. Hexose_phosphate_transp. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00712. glpT. 1 hit.
PROSITEiPS00942. GLPT. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08194-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSIFKPAPH KARLPAAEID PTYRRLRWQI FLGIFFGYAA YYLVRKNFAL
60 70 80 90 100
AMPYLVEQGF SRGDLGFALS GISIAYGFSK FIMGSVSDRS NPRVFLPAGL
110 120 130 140 150
ILAAAVMLFM GFVPWATSSI AVMFVLLFLC GWFQGMGWPP CGRTMVHWWS
160 170 180 190 200
QKERGGIVSV WNCAHNVGGG IPPLLFLLGM AWFNDWHAAL YMPAFCAILV
210 220 230 240 250
ALFAFAMMRD TPQSCGLPPI EEYKNDYPDD YNEKAEQELT AKQIFMQYVL
260 270 280 290 300
PNKLLWYIAI ANVFVYLLRY GILDWSPTYL KEVKHFALDK SSWAYFLYEY
310 320 330 340 350
AGIPGTLLCG WMSDKVFRGN RGATGVFFMT LVTIATIVYW MNPAGNPTVD
360 370 380 390 400
MICMIVIGFL IYGPVMLIGL HALELAPKKA AGTAAGFTGL FGYLGGSVAA
410 420 430 440 450
SAIVGYTVDF FGWDGGFMVM IGGSILAVIL LIVVMIGEKR RHEQLLQERN

GG
Length:452
Mass (Da):50,310
Last modified:August 1, 1988 - v1
Checksum:i0DE70D08D40AD445
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00536 Genomic DNA. Translation: CAA68598.1.
U00096 Genomic DNA. Translation: AAC75300.1.
AP009048 Genomic DNA. Translation: BAA16059.1.
PIRiS00868. JNECGT.
RefSeqiNP_416743.1. NC_000913.3.
WP_000948731.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75300; AAC75300; b2240.
BAA16059; BAA16059; BAA16059.
GeneIDi946704.
KEGGiecj:JW2234.
eco:b2240.
PATRICi32119839. VBIEscCol129921_2329.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00536 Genomic DNA. Translation: CAA68598.1.
U00096 Genomic DNA. Translation: AAC75300.1.
AP009048 Genomic DNA. Translation: BAA16059.1.
PIRiS00868. JNECGT.
RefSeqiNP_416743.1. NC_000913.3.
WP_000948731.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PW4X-ray3.30A3-448[»]
ProteinModelPortaliP08194.
SMRiP08194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261310. 156 interactors.
IntActiP08194. 1 interactor.
STRINGi511145.b2240.

Protein family/group databases

TCDBi2.A.1.4.3. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP08194.
PRIDEiP08194.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75300; AAC75300; b2240.
BAA16059; BAA16059; BAA16059.
GeneIDi946704.
KEGGiecj:JW2234.
eco:b2240.
PATRICi32119839. VBIEscCol129921_2329.

Organism-specific databases

EchoBASEiEB0396.
EcoGeneiEG10401. glpT.

Phylogenomic databases

eggNOGiENOG4105CXY. Bacteria.
COG2271. LUCA.
HOGENOMiHOG000274729.
InParanoidiP08194.
KOiK02445.
OMAiWSTHERG.
PhylomeDBiP08194.

Enzyme and pathway databases

BioCyciEcoCyc:GLPT-MONOMER.
ECOL316407:JW2234-MONOMER.
MetaCyc:GLPT-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP08194.
PROiP08194.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR005267. G3P_transporter.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR021159. Sugar-P_transporter_CS.
IPR000849. Sugar_P_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002808. Hexose_phosphate_transp. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00712. glpT. 1 hit.
PROSITEiPS00942. GLPT. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLPT_ECOLI
AccessioniPrimary (citable) accession number: P08194
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 2, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.