P08190 (FIMG_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FimG

Gene names

Name:	fimG
Ordered Locus Names:	b4319, JW4282

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	167 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Involved in the integration of FimH in the fimbriae.
Subcellular location	Fimbrium.
Sequence similarities	Belongs to the fimbrial protein family.

Ontologies

Keywords
Cellular component	Fimbrium
Domain	Signal
PTM	Disulfide bond
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: InterPro
Cellular_component	pilus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 23

23

Potential

Chain

24 – 167

144

Protein FimG

PRO_0000009210

Sites

Site

166

1

Required for stability and transport By similarity

Amino acid modifications

Disulfide bond

39 ↔ 77

Probable

Experimental info

Sequence conflict

61

1

A → S in CAA29155. Ref.1

Sequence conflict

148 – 149

2

NG → KV in CAA29155. Ref.1

Secondary structure

1

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167

Helix Strand Turn

Details...

Beta strand

26 – 34

9

Beta strand

40 – 42

3

Beta strand

44 – 54

11

Helix

56 – 58

3

Beta strand

68 – 75

8

Beta strand

83 – 89

7

Beta strand

96 – 99

4

Beta strand

108 – 113

6

Beta strand

114 – 116

3

Beta strand

124 – 128

5

Turn

131 – 134

4

Beta strand

135 – 145

11

Beta strand

147 – 149

3

Beta strand

153 – 167

15

Sequences

	Sequence		Length	Mass (Da)
	P08190 [UniParc]. Last modified February 1, 1995. Version 2. Checksum: 8C3EF95FD442E22C	FASTA	167	17,317
	10 20 30 40 50 60 MKWCKRGYVL AAILALASAT IQAADVTITV NGKVVAKPCT VSTTNATVDL GDLYSFSLMS 70 80 90 100 110 120 AGAASAWHDV ALELTNCPVG TSRVTASFSG AADSTGYYKN QGTAQNIQLE LQDDSGNTLN 130 140 150 160 TGATKTVQVD DSSQSAHFPL QVRALTVNGG ATQGTIQAVI SITYTYS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Three fim genes required for the regulation of length and mediation of adhesion of Escherichia coli type 1 fimbriae." Klemm P., Christiansen G. Mol. Gen. Genet. 208:439-445(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes." Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R. Nucleic Acids Res. 23:2105-2119(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X05672 Genomic DNA. Translation: CAA29155.1.
U14003 Genomic DNA. Translation: AAA97215.1.
U00096 Genomic DNA. Translation: AAC77275.1.
AP009048 Genomic DNA. Translation: BAE78312.1.

PIR

S56544.

RefSeq

NP_418739.1. NC_000913.2.
YP_492453.1. NC_007779.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3BFQ	X-ray	1.34	G	36-167	[»]
3BFW	X-ray	1.80	A/C	36-167	[»]
3JWN	X-ray	2.69	G/M	24-167	[»]
4J3O	X-ray	3.80	G	24-167	[»]

ProteinModelPortal

P08190.

SMR

P08190. Positions 24-167.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-9615N.

IntAct

P08190. 1 interaction.

STRING

511145.b4319.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAC77275; AAC77275; b4319.
BAE78312; BAE78312; BAE78312.

GeneID

12933756.
948846.

KEGG

ecj:Y75_p4205.
eco:b4319.

PATRIC

32124234. VBIEscCol129921_4460.

Organism-specific databases

EchoBASE

EB0310.

EcoGene

EG10314. fimG.

Phylogenomic databases

eggNOG

COG3539.

HOGENOM

HOG000260127.

KO

K07349.

OMA

WCKRGYL.

ProtClustDB

CLSK880033.

Enzyme and pathway databases

BioCyc

EcoCyc:EG10314-MONOMER.
ECOL316407:JW4282-MONOMER.

Gene expression databases

Genevestigator

P08190.

Family and domain databases

Gene3D

2.60.40.1090. 1 hit.

InterPro

IPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]

Pfam

PF00419. Fimbrial. 1 hit.
[Graphical view]

SUPFAM

SSF49401. Adhes_bact. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

P08190.

Entry information

Entry name

FIMG_ECOLI

Accession

Primary (citable) accession number: P08190
Secondary accession number(s): Q2M5Z4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	February 1, 1995
Last modified:	May 29, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program