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Protein

Protein FimG

Gene

fimG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Involved in the integration of FimH in the fimbriae.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei166Required for stability and transportBy similarity1

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:EG10314-MONOMER.
ECOL316407:JW4282-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FimG
Gene namesi
Name:fimG
Ordered Locus Names:b4319, JW4282
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10314. fimG.

Subcellular locationi

GO - Cellular componenti

  • pilus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Fimbrium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000921024 – 167Protein FimGAdd BLAST144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 77Curated

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP08190.
PRIDEiP08190.

Interactioni

Protein-protein interaction databases

BioGridi4262750. 9 interactors.
DIPiDIP-9615N.
IntActiP08190. 1 interactor.
STRINGi511145.b4319.

Structurei

Secondary structure

1167
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 34Combined sources9
Beta strandi40 – 42Combined sources3
Beta strandi44 – 53Combined sources10
Helixi55 – 57Combined sources3
Beta strandi68 – 75Combined sources8
Beta strandi83 – 89Combined sources7
Beta strandi96 – 99Combined sources4
Beta strandi108 – 112Combined sources5
Beta strandi114 – 116Combined sources3
Beta strandi124 – 128Combined sources5
Turni131 – 134Combined sources4
Beta strandi135 – 145Combined sources11
Beta strandi147 – 149Combined sources3
Beta strandi153 – 166Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BFQX-ray1.34G36-167[»]
3BFWX-ray1.80A/C36-167[»]
3JWNX-ray2.69G/M24-167[»]
4J3OX-ray3.80G24-167[»]
4XO9X-ray1.14B24-37[»]
4XOAX-ray2.54B/D/F/H24-37[»]
4XODX-ray1.14B24-37[»]
5IQMX-ray1.50A/G36-167[»]
5IQNX-ray1.00A/G36-167[»]
5IQOX-ray1.30A/C36-167[»]
ProteinModelPortaliP08190.
SMRiP08190.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08190.

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108T65. Bacteria.
ENOG4111FMS. LUCA.
HOGENOMiHOG000260127.
InParanoidiP08190.
KOiK07349.
OMAiFTHEAKF.
PhylomeDBiP08190.

Family and domain databases

Gene3Di2.60.40.1090. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08190-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWCKRGYVL AAILALASAT IQAADVTITV NGKVVAKPCT VSTTNATVDL
60 70 80 90 100
GDLYSFSLMS AGAASAWHDV ALELTNCPVG TSRVTASFSG AADSTGYYKN
110 120 130 140 150
QGTAQNIQLE LQDDSGNTLN TGATKTVQVD DSSQSAHFPL QVRALTVNGG
160
ATQGTIQAVI SITYTYS
Length:167
Mass (Da):17,317
Last modified:February 1, 1995 - v2
Checksum:i8C3EF95FD442E22C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61A → S in CAA29155 (PubMed:2890081).Curated1
Sequence conflicti148 – 149NG → KV in CAA29155 (PubMed:2890081).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05672 Genomic DNA. Translation: CAA29155.1.
U14003 Genomic DNA. Translation: AAA97215.1.
U00096 Genomic DNA. Translation: AAC77275.1.
AP009048 Genomic DNA. Translation: BAE78312.1.
PIRiS56544.
RefSeqiNP_418739.1. NC_000913.3.
WP_000870592.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77275; AAC77275; b4319.
BAE78312; BAE78312; BAE78312.
GeneIDi948846.
KEGGiecj:JW4282.
eco:b4319.
PATRICi32124234. VBIEscCol129921_4460.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05672 Genomic DNA. Translation: CAA29155.1.
U14003 Genomic DNA. Translation: AAA97215.1.
U00096 Genomic DNA. Translation: AAC77275.1.
AP009048 Genomic DNA. Translation: BAE78312.1.
PIRiS56544.
RefSeqiNP_418739.1. NC_000913.3.
WP_000870592.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BFQX-ray1.34G36-167[»]
3BFWX-ray1.80A/C36-167[»]
3JWNX-ray2.69G/M24-167[»]
4J3OX-ray3.80G24-167[»]
4XO9X-ray1.14B24-37[»]
4XOAX-ray2.54B/D/F/H24-37[»]
4XODX-ray1.14B24-37[»]
5IQMX-ray1.50A/G36-167[»]
5IQNX-ray1.00A/G36-167[»]
5IQOX-ray1.30A/C36-167[»]
ProteinModelPortaliP08190.
SMRiP08190.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262750. 9 interactors.
DIPiDIP-9615N.
IntActiP08190. 1 interactor.
STRINGi511145.b4319.

Proteomic databases

PaxDbiP08190.
PRIDEiP08190.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77275; AAC77275; b4319.
BAE78312; BAE78312; BAE78312.
GeneIDi948846.
KEGGiecj:JW4282.
eco:b4319.
PATRICi32124234. VBIEscCol129921_4460.

Organism-specific databases

EchoBASEiEB0310.
EcoGeneiEG10314. fimG.

Phylogenomic databases

eggNOGiENOG4108T65. Bacteria.
ENOG4111FMS. LUCA.
HOGENOMiHOG000260127.
InParanoidiP08190.
KOiK07349.
OMAiFTHEAKF.
PhylomeDBiP08190.

Enzyme and pathway databases

BioCyciEcoCyc:EG10314-MONOMER.
ECOL316407:JW4282-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP08190.
PROiP08190.

Family and domain databases

Gene3Di2.60.40.1090. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFIMG_ECOLI
AccessioniPrimary (citable) accession number: P08190
Secondary accession number(s): Q2M5Z4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.