Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein FimF

Gene

fimF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Involved in the integration of FimH in the fimbriae.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei175Required for stability and transportBy similarity1

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:EG10313-MONOMER.
ECOL316407:JW4281-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FimF
Gene namesi
Name:fimF
Ordered Locus Names:b4318, JW4281
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10313. fimF.

Subcellular locationi

GO - Cellular componenti

  • pilus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Fimbrium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000000920721 – 176Protein FimFAdd BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 78Curated

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP08189.
PRIDEiP08189.

Interactioni

Protein-protein interaction databases

BioGridi4262749. 3 interactors.
DIPiDIP-9614N.
IntActiP08189. 1 interactor.
MINTiMINT-6491069.
STRINGi511145.b4318.

Structurei

Secondary structure

1176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 33Combined sources8
Beta strandi35 – 37Combined sources3
Beta strandi38 – 42Combined sources5
Beta strandi46 – 49Combined sources4
Helixi52 – 55Combined sources4
Helixi56 – 58Combined sources3
Beta strandi69 – 78Combined sources10
Beta strandi84 – 90Combined sources7
Beta strandi100 – 102Combined sources3
Beta strandi106 – 109Combined sources4
Beta strandi111 – 118Combined sources8
Beta strandi127 – 129Combined sources3
Helixi131 – 133Combined sources3
Beta strandi136 – 138Combined sources3
Beta strandi141 – 143Combined sources3
Beta strandi145 – 159Combined sources15
Beta strandi166 – 175Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JMRNMR-A23-176[»]
3BFQX-ray1.34F23-37[»]
3BFWX-ray1.80B/D23-37[»]
3BWUX-ray1.76F35-176[»]
3JWNX-ray2.69E/F/K/L23-176[»]
4J3OX-ray3.80F23-176[»]
4XOBX-ray3.00B/D/F/H23-37[»]
5IQMX-ray1.50B/F23-37[»]
5IQNX-ray1.00B/F25-34[»]
5IQOX-ray1.30B/D23-37[»]
ProteinModelPortaliP08189.
SMRiP08189.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08189.

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108SQA. Bacteria.
ENOG4111HFM. LUCA.
HOGENOMiHOG000260127.
InParanoidiP08189.
KOiK07348.
OMAiYVRDNAC.
PhylomeDBiP08189.

Family and domain databases

Gene3Di2.60.40.1090. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
PfamiPF00419. Fimbrial. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08189-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNKPFYLLC AFLWLAVSHA LAADSTITIR GYVRDNGCSV AAESTNFTVD
60 70 80 90 100
LMENAAKQFN NIGATTPVVP FRILLSPCGN AVSAVKVGFT GVADSHNANL
110 120 130 140 150
LALENTVSAA SGLGIQLLNE QQNQIPLNAP SSALSWTTLT PGKPNTLNFY
160 170
ARLMATQVPV TAGHINATAT FTLEYQ
Length:176
Mass (Da):18,715
Last modified:February 1, 1995 - v2
Checksum:i38692EFE6A40121F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70P → S in CAA29154 (PubMed:2890081).Curated1
Sequence conflicti76S → L in CAA29154 (PubMed:2890081).Curated1
Sequence conflicti81A → V in CAA29154 (PubMed:2890081).Curated1
Sequence conflicti84 – 92AVKVGFTGV → RRKGWVYWR in CAA29154 (PubMed:2890081).Curated9
Sequence conflicti107V → A in CAA29154 (PubMed:2890081).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05672 Genomic DNA. Translation: CAA29154.1.
U14003 Genomic DNA. Translation: AAA97214.1.
U00096 Genomic DNA. Translation: AAC77274.1.
AP009048 Genomic DNA. Translation: BAE78311.1.
X51655 Genomic DNA. Translation: CAA35969.1.
PIRiS56543.
RefSeqiNP_418738.1. NC_000913.3.
WP_001244827.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77274; AAC77274; b4318.
BAE78311; BAE78311; BAE78311.
GeneIDi948845.
KEGGiecj:JW4281.
eco:b4318.
PATRICi32124232. VBIEscCol129921_4459.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05672 Genomic DNA. Translation: CAA29154.1.
U14003 Genomic DNA. Translation: AAA97214.1.
U00096 Genomic DNA. Translation: AAC77274.1.
AP009048 Genomic DNA. Translation: BAE78311.1.
X51655 Genomic DNA. Translation: CAA35969.1.
PIRiS56543.
RefSeqiNP_418738.1. NC_000913.3.
WP_001244827.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JMRNMR-A23-176[»]
3BFQX-ray1.34F23-37[»]
3BFWX-ray1.80B/D23-37[»]
3BWUX-ray1.76F35-176[»]
3JWNX-ray2.69E/F/K/L23-176[»]
4J3OX-ray3.80F23-176[»]
4XOBX-ray3.00B/D/F/H23-37[»]
5IQMX-ray1.50B/F23-37[»]
5IQNX-ray1.00B/F25-34[»]
5IQOX-ray1.30B/D23-37[»]
ProteinModelPortaliP08189.
SMRiP08189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262749. 3 interactors.
DIPiDIP-9614N.
IntActiP08189. 1 interactor.
MINTiMINT-6491069.
STRINGi511145.b4318.

Proteomic databases

PaxDbiP08189.
PRIDEiP08189.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77274; AAC77274; b4318.
BAE78311; BAE78311; BAE78311.
GeneIDi948845.
KEGGiecj:JW4281.
eco:b4318.
PATRICi32124232. VBIEscCol129921_4459.

Organism-specific databases

EchoBASEiEB0309.
EcoGeneiEG10313. fimF.

Phylogenomic databases

eggNOGiENOG4108SQA. Bacteria.
ENOG4111HFM. LUCA.
HOGENOMiHOG000260127.
InParanoidiP08189.
KOiK07348.
OMAiYVRDNAC.
PhylomeDBiP08189.

Enzyme and pathway databases

BioCyciEcoCyc:EG10313-MONOMER.
ECOL316407:JW4281-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP08189.
PROiP08189.

Family and domain databases

Gene3Di2.60.40.1090. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
PfamiPF00419. Fimbrial. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFIMF_ECOLI
AccessioniPrimary (citable) accession number: P08189
Secondary accession number(s): Q2M5Z5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.