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P08185

- CBG_HUMAN

UniProt

P08185 - CBG_HUMAN

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Protein

Corticosteroid-binding globulin

Gene

SERPINA6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei250 – 2501Conserved cysteine within steroid binding domain
Binding sitei254 – 2541Corticosteroid
Binding sitei286 – 2861Corticosteroid
Binding sitei390 – 3901Corticosteroid
Binding sitei393 – 3931Corticosteroid

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: RefGenome
  2. steroid binding Source: UniProtKB

GO - Biological processi

  1. glucocorticoid metabolic process Source: Ensembl
  2. negative regulation of endopeptidase activity Source: RefGenome
  3. regulation of proteolysis Source: RefGenome
  4. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding, Steroid-binding

Protein family/group databases

MEROPSiI04.954.

Names & Taxonomyi

Protein namesi
Recommended name:
Corticosteroid-binding globulin
Short name:
CBG
Alternative name(s):
Serpin A6
Transcortin
Gene namesi
Name:SERPINA6
Synonyms:CBG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:1540. SERPINA6.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProt
  2. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Corticosteroid-binding globulin deficiency (CBG deficiency) [MIM:611489]: Extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.4 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti115 – 1151L → H in CBG deficiency; Leuven; decreased cortisol-binding affinity. 2 Publications
Corresponds to variant rs28929488 [ dbSNP | Ensembl ].
VAR_007111
Natural varianti389 – 3891D → N in CBG deficiency; Lyon; decreased cortisol-binding affinity. 2 Publications
Corresponds to variant rs28929488 [ dbSNP | Ensembl ].
VAR_016223

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi611489. phenotype.
Orphaneti199247. Corticosteroid-binding globulin deficiency.
PharmGKBiPA35033.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 405383Corticosteroid-binding globulinPRO_0000032429Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi31 – 311N-linked (GlcNAc...)1 Publication
Glycosylationi96 – 961N-linked (GlcNAc...)3 Publications
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi260 – 2601N-linked (GlcNAc...)
Glycosylationi330 – 3301N-linked (GlcNAc...)2 Publications
Glycosylationi369 – 3691N-linked (GlcNAc...)1 Publication

Post-translational modificationi

N-glycosylated; binds 5 oligosaccharide chains.
Glycosylation in position Asn-260 is needed for steroid binding.

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP08185.
PaxDbiP08185.
PeptideAtlasiP08185.
PRIDEiP08185.

Expressioni

Tissue specificityi

Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.

Gene expression databases

BgeeiP08185.
CleanExiHS_SERPINA6.
ExpressionAtlasiP08185. baseline and differential.
GenevestigatoriP08185.

Organism-specific databases

HPAiHPA017864.

Interactioni

Protein-protein interaction databases

BioGridi107314. 9 interactions.
STRINGi9606.ENSP00000342850.

Structurei

Secondary structure

1
405
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi39 – 5719Combined sources
Beta strandi59 – 613Combined sources
Beta strandi63 – 653Combined sources
Helixi67 – 7812Combined sources
Helixi83 – 9210Combined sources
Turni97 – 993Combined sources
Helixi102 – 11716Combined sources
Beta strandi124 – 13411Combined sources
Helixi141 – 15111Combined sources
Beta strandi154 – 1585Combined sources
Helixi163 – 17715Combined sources
Turni178 – 1803Combined sources
Beta strandi188 – 1903Combined sources
Beta strandi194 – 20916Combined sources
Helixi213 – 2153Combined sources
Beta strandi217 – 2248Combined sources
Beta strandi227 – 24418Combined sources
Beta strandi246 – 26823Combined sources
Helixi273 – 2786Combined sources
Helixi282 – 29110Combined sources
Beta strandi293 – 30210Combined sources
Beta strandi305 – 3117Combined sources
Helixi313 – 3186Combined sources
Helixi323 – 3253Combined sources
Turni332 – 3343Combined sources
Beta strandi335 – 3384Combined sources
Beta strandi340 – 35314Combined sources
Beta strandi355 – 3573Combined sources
Beta strandi375 – 3784Combined sources
Beta strandi383 – 3897Combined sources
Turni390 – 3923Combined sources
Beta strandi395 – 4028Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VDXX-ray1.84A/B33-357[»]
A/B372-405[»]
2VDYX-ray2.30A/B33-405[»]
4BB2X-ray2.48A33-371[»]
B372-405[»]
4C41X-ray1.80A33-405[»]
4C49X-ray2.70A/B/C/D33-405[»]
ProteinModelPortaliP08185.
SMRiP08185. Positions 35-371, 373-405.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08185.

Family & Domainsi

Domaini

Proteolytic cleavage leads to an important conformation change. This reduces the affinity for steroids.1 Publication

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238521.
HOVERGENiHBG005957.
InParanoidiP08185.
OMAiSTREENF.
PhylomeDBiP08185.
TreeFamiTF343201.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08185-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLLLYTCLL WLPTSGLWTV QAMDPNAAYV NMSNHHRGLA SANVDFAFSL
60 70 80 90 100
YKHLVALSPK KNIFISPVSI SMALAMLSLG TCGHTRAQLL QGLGFNLTER
110 120 130 140 150
SETEIHQGFQ HLHQLFAKSD TSLEMTMGNA LFLDGSLELL ESFSADIKHY
160 170 180 190 200
YESEVLAMNF QDWATASRQI NSYVKNKTQG KIVDLFSGLD SPAILVLVNY
210 220 230 240 250
IFFKGTWTQP FDLASTREEN FYVDETTVVK VPMMLQSSTI SYLHDSELPC
260 270 280 290 300
QLVQMNYVGN GTVFFILPDK GKMNTVIAAL SRDTINRWSA GLTSSQVDLY
310 320 330 340 350
IPKVTISGVY DLGDVLEEMG IADLFTNQAN FSRITQDAQL KSSKVVHKAV
360 370 380 390 400
LQLNEEGVDT AGSTGVTLNL TSKPIILRFN QPFIIMIFDH FTWSSLFLAR

VMNPV
Length:405
Mass (Da):45,141
Last modified:August 1, 1988 - v1
Checksum:iF0E36EFC3B3C08A1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti115 – 1151L → H in CBG deficiency; Leuven; decreased cortisol-binding affinity. 2 Publications
Corresponds to variant rs28929488 [ dbSNP | Ensembl ].
VAR_007111
Natural varianti246 – 2461S → A.1 Publication
Corresponds to variant rs2228541 [ dbSNP | Ensembl ].
VAR_024350
Natural varianti389 – 3891D → N in CBG deficiency; Lyon; decreased cortisol-binding affinity. 2 Publications
Corresponds to variant rs28929488 [ dbSNP | Ensembl ].
VAR_016223

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02943 mRNA. Translation: AAB59523.1.
AK290821 mRNA. Translation: BAF83510.1.
CH471061 Genomic DNA. Translation: EAW81568.1.
BC056259 mRNA. Translation: AAH56259.1.
BC058021 mRNA. Translation: AAH58021.1.
CCDSiCCDS9924.1.
PIRiA28321.
RefSeqiNP_001747.2. NM_001756.3.
UniGeneiHs.532635.

Genome annotation databases

EnsembliENST00000341584; ENSP00000342850; ENSG00000170099.
ENST00000621384; ENSP00000484501; ENSG00000277405.
GeneIDi866.
KEGGihsa:866.
UCSCiuc001ycv.3. human.

Polymorphism databases

DMDMi115851.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Transcortin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02943 mRNA. Translation: AAB59523.1 .
AK290821 mRNA. Translation: BAF83510.1 .
CH471061 Genomic DNA. Translation: EAW81568.1 .
BC056259 mRNA. Translation: AAH56259.1 .
BC058021 mRNA. Translation: AAH58021.1 .
CCDSi CCDS9924.1.
PIRi A28321.
RefSeqi NP_001747.2. NM_001756.3.
UniGenei Hs.532635.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2VDX X-ray 1.84 A/B 33-357 [» ]
A/B 372-405 [» ]
2VDY X-ray 2.30 A/B 33-405 [» ]
4BB2 X-ray 2.48 A 33-371 [» ]
B 372-405 [» ]
4C41 X-ray 1.80 A 33-405 [» ]
4C49 X-ray 2.70 A/B/C/D 33-405 [» ]
ProteinModelPortali P08185.
SMRi P08185. Positions 35-371, 373-405.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107314. 9 interactions.
STRINGi 9606.ENSP00000342850.

Chemistry

ChEMBLi CHEMBL2421.
DrugBanki DB00240. Alclometasone.
DB00394. Beclomethasone.
DB01410. Ciclesonide.
DB00663. Flumethasone Pivalate.
DB00180. Flunisolide.
DB00591. Fluocinolone Acetonide.
DB01047. Fluocinonide.
DB00324. Fluorometholone.
DB00846. Flurandrenolide.
DB00588. Fluticasone Propionate.
DB00596. Halobetasol Propionate.
DB00253. Medrysone.
DB00648. Mitotane.
DB01384. Paramethasone.
DB00860. Prednisolone.
DB00896. Rimexolone.
DB00620. Triamcinolone.

Protein family/group databases

MEROPSi I04.954.

Polymorphism databases

DMDMi 115851.

Proteomic databases

MaxQBi P08185.
PaxDbi P08185.
PeptideAtlasi P08185.
PRIDEi P08185.

Protocols and materials databases

DNASUi 866.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000341584 ; ENSP00000342850 ; ENSG00000170099 .
ENST00000621384 ; ENSP00000484501 ; ENSG00000277405 .
GeneIDi 866.
KEGGi hsa:866.
UCSCi uc001ycv.3. human.

Organism-specific databases

CTDi 866.
GeneCardsi GC14M094770.
HGNCi HGNC:1540. SERPINA6.
HPAi HPA017864.
MIMi 122500. gene.
611489. phenotype.
neXtProti NX_P08185.
Orphaneti 199247. Corticosteroid-binding globulin deficiency.
PharmGKBi PA35033.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4826.
GeneTreei ENSGT00760000118839.
HOGENOMi HOG000238521.
HOVERGENi HBG005957.
InParanoidi P08185.
OMAi STREENF.
PhylomeDBi P08185.
TreeFami TF343201.

Miscellaneous databases

EvolutionaryTracei P08185.
GeneWikii Transcortin.
GenomeRNAii 866.
NextBioi 3614.
PROi P08185.
SOURCEi Search...

Gene expression databases

Bgeei P08185.
CleanExi HS_SERPINA6.
ExpressionAtlasi P08185. baseline and differential.
Genevestigatori P08185.

Family and domain databases

InterProi IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors."
    Hammond G.L., Smith C.L., Goping I.S., Underhill D.A., Harley M.J., Reventos J., Musto N.A., Gunsalus G.L., Bardin C.W.
    Proc. Natl. Acad. Sci. U.S.A. 84:5153-5157(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver and Lung.
  2. "Corticosteroid binding globulin, testosterone-estradiol binding globulin, and androgen binding protein belong to protein families distinct from steroid receptors."
    Bardin C.W., Gunsalus G.L., Musto N.A., Cheng C.Y., Reventos J., Smith C., Underhill D.A., Hammond G.
    J. Steroid Biochem. 30:131-139(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-246.
  6. "Comparative structural analyses of corticosteroid binding globulin."
    Kato E.A., Hsu B.R.-S., Kuhn R.W.
    J. Steroid Biochem. 29:213-220(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-30.
  7. "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
    Bunkenborg J., Pilch B.J., Podtelejnikov A.V., Wisniewski J.R.
    Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96.
    Tissue: Plasma.
  8. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-31; ASN-96; ASN-330 AND ASN-369.
    Tissue: Plasma.
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96 AND ASN-330.
    Tissue: Liver.
  10. "The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release."
    Zhou A., Wei Z., Stanley P.L., Read R.J., Stein P.E., Carrell R.W.
    J. Mol. Biol. 380:244-251(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.84 ANGSTROMS) OF 33-405 IN COMPLEX WITH CORTISOL, FUNCTION, DOMAIN.
  11. "A Leu-->His substitution at residue 93 in human corticosteroid binding globulin results in reduced affinity for cortisol."
    Smith C.L., Power S.G.A., Hammond G.L.
    J. Steroid Biochem. Mol. Biol. 42:671-676(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CBG DEFICIENCY HIS-115.
  12. "Decreased cortisol-binding affinity of transcortin Leuven is associated with an amino acid substitution at residue-93."
    van Baelen H., Power S.G.A., Hammond G.L.
    Steroids 58:275-277(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CBG DEFICIENCY HIS-115.
  13. "Novel human corticosteroid-binding globulin variant with low cortisol-binding affinity."
    Emptoz-Bonneton A., Cousin P., Seguchi K., Avvakumov G.V., Bully C., Hammond G.L., Pugeat M.
    J. Clin. Endocrinol. Metab. 85:361-367(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CBG DEFICIENCY ASN-389.
  14. "Haploinsufficiency of the SERPINA6 gene is associated with severe muscle fatigue: A de novo mutation in corticosteroid-binding globulin deficiency."
    Buss C., Schuelter U., Hesse J., Moser D., Phillips D.I., Hellhammer D., Meyer J.
    J. Neural Transm. 114:563-569(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CBG DEFICIENCY ASN-389.

Entry informationi

Entry nameiCBG_HUMAN
AccessioniPrimary (citable) accession number: P08185
Secondary accession number(s): A8K456, Q7Z2Q9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 26, 2014
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3