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P08185

- CBG_HUMAN

UniProt

P08185 - CBG_HUMAN

Protein

Corticosteroid-binding globulin

Gene

SERPINA6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 148 (01 Oct 2014)
      Sequence version 1 (01 Aug 1988)
      Previous versions | rss
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    Functioni

    Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei250 – 2501Conserved cysteine within steroid binding domain
    Binding sitei254 – 2541Corticosteroid
    Binding sitei286 – 2861Corticosteroid
    Binding sitei390 – 3901Corticosteroid
    Binding sitei393 – 3931Corticosteroid

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: RefGenome
    2. steroid binding Source: UniProtKB

    GO - Biological processi

    1. glucocorticoid metabolic process Source: Ensembl
    2. negative regulation of endopeptidase activity Source: RefGenome
    3. regulation of proteolysis Source: RefGenome
    4. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Lipid-binding, Steroid-binding

    Protein family/group databases

    MEROPSiI04.954.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Corticosteroid-binding globulin
    Short name:
    CBG
    Alternative name(s):
    Serpin A6
    Transcortin
    Gene namesi
    Name:SERPINA6
    Synonyms:CBG
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:1540. SERPINA6.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProt
    2. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Corticosteroid-binding globulin deficiency (CBG deficiency) [MIM:611489]: Extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.4 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti115 – 1151L → H in CBG deficiency; Leuven; decreased cortisol-binding affinity. 2 Publications
    Corresponds to variant rs28929488 [ dbSNP | Ensembl ].
    VAR_007111
    Natural varianti389 – 3891D → N in CBG deficiency; Lyon; decreased cortisol-binding affinity. 2 Publications
    Corresponds to variant rs28929488 [ dbSNP | Ensembl ].
    VAR_016223

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi611489. phenotype.
    Orphaneti199247. Corticosteroid-binding globulin deficiency.
    PharmGKBiPA35033.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 22221 PublicationAdd
    BLAST
    Chaini23 – 405383Corticosteroid-binding globulinPRO_0000032429Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi31 – 311N-linked (GlcNAc...)1 Publication
    Glycosylationi96 – 961N-linked (GlcNAc...)3 Publications
    Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi260 – 2601N-linked (GlcNAc...)
    Glycosylationi330 – 3301N-linked (GlcNAc...)2 Publications
    Glycosylationi369 – 3691N-linked (GlcNAc...)1 Publication

    Post-translational modificationi

    N-glycosylated; binds 5 oligosaccharide chains.
    Glycosylation in position Asn-260 is needed for steroid binding.

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP08185.
    PaxDbiP08185.
    PeptideAtlasiP08185.
    PRIDEiP08185.

    Expressioni

    Tissue specificityi

    Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.

    Gene expression databases

    ArrayExpressiP08185.
    BgeeiP08185.
    CleanExiHS_SERPINA6.
    GenevestigatoriP08185.

    Organism-specific databases

    HPAiHPA017864.

    Interactioni

    Protein-protein interaction databases

    BioGridi107314. 1 interaction.
    STRINGi9606.ENSP00000342850.

    Structurei

    Secondary structure

    1
    405
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi39 – 5719
    Beta strandi59 – 613
    Beta strandi63 – 653
    Helixi67 – 7812
    Helixi83 – 9210
    Turni97 – 993
    Helixi102 – 11716
    Beta strandi124 – 13411
    Helixi141 – 15111
    Beta strandi154 – 1585
    Helixi163 – 17715
    Turni178 – 1803
    Beta strandi188 – 1903
    Beta strandi194 – 20916
    Helixi213 – 2153
    Beta strandi217 – 2248
    Beta strandi227 – 24418
    Beta strandi246 – 26823
    Helixi273 – 2786
    Helixi282 – 29110
    Beta strandi293 – 30210
    Beta strandi305 – 3117
    Helixi313 – 3186
    Helixi323 – 3253
    Turni332 – 3343
    Beta strandi335 – 3384
    Beta strandi340 – 35314
    Beta strandi355 – 3573
    Beta strandi375 – 3784
    Beta strandi383 – 3897
    Turni390 – 3923
    Beta strandi395 – 4028

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2VDXX-ray1.84A/B33-357[»]
    A/B372-405[»]
    2VDYX-ray2.30A/B33-357[»]
    A/B372-405[»]
    4BB2X-ray2.48A33-371[»]
    B372-405[»]
    ProteinModelPortaliP08185.
    SMRiP08185. Positions 35-371, 373-405.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP08185.

    Family & Domainsi

    Domaini

    Proteolytic cleavage leads to an important conformation change. This reduces the affinity for steroids.1 Publication

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    HOGENOMiHOG000238521.
    HOVERGENiHBG005957.
    InParanoidiP08185.
    OMAiSTREENF.
    PhylomeDBiP08185.
    TreeFamiTF343201.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P08185-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLLLYTCLL WLPTSGLWTV QAMDPNAAYV NMSNHHRGLA SANVDFAFSL    50
    YKHLVALSPK KNIFISPVSI SMALAMLSLG TCGHTRAQLL QGLGFNLTER 100
    SETEIHQGFQ HLHQLFAKSD TSLEMTMGNA LFLDGSLELL ESFSADIKHY 150
    YESEVLAMNF QDWATASRQI NSYVKNKTQG KIVDLFSGLD SPAILVLVNY 200
    IFFKGTWTQP FDLASTREEN FYVDETTVVK VPMMLQSSTI SYLHDSELPC 250
    QLVQMNYVGN GTVFFILPDK GKMNTVIAAL SRDTINRWSA GLTSSQVDLY 300
    IPKVTISGVY DLGDVLEEMG IADLFTNQAN FSRITQDAQL KSSKVVHKAV 350
    LQLNEEGVDT AGSTGVTLNL TSKPIILRFN QPFIIMIFDH FTWSSLFLAR 400
    VMNPV 405
    Length:405
    Mass (Da):45,141
    Last modified:August 1, 1988 - v1
    Checksum:iF0E36EFC3B3C08A1
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti115 – 1151L → H in CBG deficiency; Leuven; decreased cortisol-binding affinity. 2 Publications
    Corresponds to variant rs28929488 [ dbSNP | Ensembl ].
    VAR_007111
    Natural varianti246 – 2461S → A.1 Publication
    Corresponds to variant rs2228541 [ dbSNP | Ensembl ].
    VAR_024350
    Natural varianti389 – 3891D → N in CBG deficiency; Lyon; decreased cortisol-binding affinity. 2 Publications
    Corresponds to variant rs28929488 [ dbSNP | Ensembl ].
    VAR_016223

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02943 mRNA. Translation: AAB59523.1.
    AK290821 mRNA. Translation: BAF83510.1.
    CH471061 Genomic DNA. Translation: EAW81568.1.
    BC056259 mRNA. Translation: AAH56259.1.
    BC058021 mRNA. Translation: AAH58021.1.
    CCDSiCCDS9924.1.
    PIRiA28321.
    RefSeqiNP_001747.2. NM_001756.3.
    UniGeneiHs.532635.

    Genome annotation databases

    EnsembliENST00000341584; ENSP00000342850; ENSG00000170099.
    GeneIDi866.
    KEGGihsa:866.
    UCSCiuc001ycv.3. human.

    Polymorphism databases

    DMDMi115851.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Transcortin entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02943 mRNA. Translation: AAB59523.1 .
    AK290821 mRNA. Translation: BAF83510.1 .
    CH471061 Genomic DNA. Translation: EAW81568.1 .
    BC056259 mRNA. Translation: AAH56259.1 .
    BC058021 mRNA. Translation: AAH58021.1 .
    CCDSi CCDS9924.1.
    PIRi A28321.
    RefSeqi NP_001747.2. NM_001756.3.
    UniGenei Hs.532635.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2VDX X-ray 1.84 A/B 33-357 [» ]
    A/B 372-405 [» ]
    2VDY X-ray 2.30 A/B 33-357 [» ]
    A/B 372-405 [» ]
    4BB2 X-ray 2.48 A 33-371 [» ]
    B 372-405 [» ]
    ProteinModelPortali P08185.
    SMRi P08185. Positions 35-371, 373-405.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107314. 1 interaction.
    STRINGi 9606.ENSP00000342850.

    Chemistry

    ChEMBLi CHEMBL2421.
    DrugBanki DB00240. Alclometasone.
    DB00394. Beclomethasone.
    DB01410. Ciclesonide.
    DB00663. Flumethasone Pivalate.
    DB00180. Flunisolide.
    DB00591. Fluocinolone Acetonide.
    DB01047. Fluocinonide.
    DB00324. Fluorometholone.
    DB00846. Flurandrenolide.
    DB00588. Fluticasone Propionate.
    DB00596. Halobetasol Propionate.
    DB00253. Medrysone.
    DB00648. Mitotane.
    DB01384. Paramethasone.
    DB00860. Prednisolone.
    DB00896. Rimexolone.
    DB00620. Triamcinolone.

    Protein family/group databases

    MEROPSi I04.954.

    Polymorphism databases

    DMDMi 115851.

    Proteomic databases

    MaxQBi P08185.
    PaxDbi P08185.
    PeptideAtlasi P08185.
    PRIDEi P08185.

    Protocols and materials databases

    DNASUi 866.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000341584 ; ENSP00000342850 ; ENSG00000170099 .
    GeneIDi 866.
    KEGGi hsa:866.
    UCSCi uc001ycv.3. human.

    Organism-specific databases

    CTDi 866.
    GeneCardsi GC14M094770.
    HGNCi HGNC:1540. SERPINA6.
    HPAi HPA017864.
    MIMi 122500. gene.
    611489. phenotype.
    neXtProti NX_P08185.
    Orphaneti 199247. Corticosteroid-binding globulin deficiency.
    PharmGKBi PA35033.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4826.
    HOGENOMi HOG000238521.
    HOVERGENi HBG005957.
    InParanoidi P08185.
    OMAi STREENF.
    PhylomeDBi P08185.
    TreeFami TF343201.

    Miscellaneous databases

    EvolutionaryTracei P08185.
    GeneWikii Transcortin.
    GenomeRNAii 866.
    NextBioi 3614.
    PROi P08185.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P08185.
    Bgeei P08185.
    CleanExi HS_SERPINA6.
    Genevestigatori P08185.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors."
      Hammond G.L., Smith C.L., Goping I.S., Underhill D.A., Harley M.J., Reventos J., Musto N.A., Gunsalus G.L., Bardin C.W.
      Proc. Natl. Acad. Sci. U.S.A. 84:5153-5157(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver and Lung.
    2. "Corticosteroid binding globulin, testosterone-estradiol binding globulin, and androgen binding protein belong to protein families distinct from steroid receptors."
      Bardin C.W., Gunsalus G.L., Musto N.A., Cheng C.Y., Reventos J., Smith C., Underhill D.A., Hammond G.
      J. Steroid Biochem. 30:131-139(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-246.
    6. "Comparative structural analyses of corticosteroid binding globulin."
      Kato E.A., Hsu B.R.-S., Kuhn R.W.
      J. Steroid Biochem. 29:213-220(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 23-30.
    7. "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
      Bunkenborg J., Pilch B.J., Podtelejnikov A.V., Wisniewski J.R.
      Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96.
      Tissue: Plasma.
    8. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-31; ASN-96; ASN-330 AND ASN-369.
      Tissue: Plasma.
    9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96 AND ASN-330.
      Tissue: Liver.
    10. "The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release."
      Zhou A., Wei Z., Stanley P.L., Read R.J., Stein P.E., Carrell R.W.
      J. Mol. Biol. 380:244-251(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.84 ANGSTROMS) OF 33-405 IN COMPLEX WITH CORTISOL, FUNCTION, DOMAIN.
    11. "A Leu-->His substitution at residue 93 in human corticosteroid binding globulin results in reduced affinity for cortisol."
      Smith C.L., Power S.G.A., Hammond G.L.
      J. Steroid Biochem. Mol. Biol. 42:671-676(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT CBG DEFICIENCY HIS-115.
    12. "Decreased cortisol-binding affinity of transcortin Leuven is associated with an amino acid substitution at residue-93."
      van Baelen H., Power S.G.A., Hammond G.L.
      Steroids 58:275-277(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT CBG DEFICIENCY HIS-115.
    13. "Novel human corticosteroid-binding globulin variant with low cortisol-binding affinity."
      Emptoz-Bonneton A., Cousin P., Seguchi K., Avvakumov G.V., Bully C., Hammond G.L., Pugeat M.
      J. Clin. Endocrinol. Metab. 85:361-367(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT CBG DEFICIENCY ASN-389.
    14. "Haploinsufficiency of the SERPINA6 gene is associated with severe muscle fatigue: A de novo mutation in corticosteroid-binding globulin deficiency."
      Buss C., Schuelter U., Hesse J., Moser D., Phillips D.I., Hellhammer D., Meyer J.
      J. Neural Transm. 114:563-569(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT CBG DEFICIENCY ASN-389.

    Entry informationi

    Entry nameiCBG_HUMAN
    AccessioniPrimary (citable) accession number: P08185
    Secondary accession number(s): A8K456, Q7Z2Q9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: August 1, 1988
    Last modified: October 1, 2014
    This is version 148 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3