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UniProtKB - P08183 (MDR1_HUMAN)

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Protein

Multidrug resistance protein 1

Gene

ABCB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

Catalytic activityi

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi427 – 434ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1070 – 1077ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: ProtInc
  • ATP binding Source: ProtInc
  • ceramide-translocating ATPase activity Source: BHF-UCL
  • phosphatidylcholine-translocating ATPase activity Source: BHF-UCL
  • phosphatidylethanolamine-translocating ATPase activity Source: BHF-UCL
  • transporter activity Source: ProtInc
  • xenobiotic-transporting ATPase activity Source: Reactome
Complete GO annotation...

GO - Biological processi

  • ceramide translocation Source: BHF-UCL
  • G2/M transition of mitotic cell cycle Source: DFLAT
  • phospholipid translocation Source: BHF-UCL
  • positive regulation of anion channel activity Source: CAFA
  • regulation of chloride transport Source: CAFA
  • regulation of response to osmotic stress Source: CAFA
  • response to drug Source: ProtInc
  • stem cell proliferation Source: DFLAT
  • transmembrane transport Source: Reactome
  • transport Source: ProtInc
Complete GO annotation...

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.3.44. 2681.
ReactomeiR-HSA-2161517. Abacavir transmembrane transport.
R-HSA-382556. ABC-family proteins mediated transport.

Protein family/group databases

MoonProtiP08183.
TCDBi3.A.1.201.1. the atp-binding cassette (abc) superfamily.

Chemistry databases

SwissLipidsiSLP:000000385.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein 1 (EC:3.6.3.44)
Alternative name(s):
ATP-binding cassette sub-family B member 1
P-glycoprotein 1
CD_antigen: CD243
Gene namesi
Name:ABCB1
Synonyms:MDR1, PGY1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:40. ABCB1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44CytoplasmicBy similarityAdd BLAST44
Transmembranei45 – 67HelicalPROSITE-ProRule annotationAdd BLAST23
Topological domaini68 – 116ExtracellularBy similarityAdd BLAST49
Transmembranei117 – 137HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini138 – 186CytoplasmicBy similarityAdd BLAST49
Transmembranei187 – 208HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini209 – 215ExtracellularBy similarity7
Transmembranei216 – 236HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini237 – 292CytoplasmicBy similarityAdd BLAST56
Transmembranei293 – 316HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini317 – 330ExtracellularBy similarityAdd BLAST14
Transmembranei331 – 352HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini353 – 711CytoplasmicBy similarityAdd BLAST359
Transmembranei712 – 732HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini733 – 756ExtracellularBy similarityAdd BLAST24
Transmembranei757 – 777HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini778 – 832CytoplasmicBy similarityAdd BLAST55
Transmembranei833 – 853HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini854ExtracellularBy similarity1
Transmembranei855 – 874HelicalPROSITE-ProRule annotationAdd BLAST20
Topological domaini875 – 934CytoplasmicBy similarityAdd BLAST60
Transmembranei935 – 957HelicalPROSITE-ProRule annotationAdd BLAST23
Topological domaini958 – 973ExtracellularBy similarityAdd BLAST16
Transmembranei974 – 995HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini996 – 1280CytoplasmicBy similarityAdd BLAST285

GO - Cellular componenti

  • apical plasma membrane Source: BHF-UCL
  • cell surface Source: DFLAT
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: ProtInc
  • membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Inflammatory bowel disease 13 (IBD13)
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
See also OMIM:612244
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013361893S → A Common allele; associated with susceptibility to IBD13; has decreased enzyme activity. 8 PublicationsCorresponds to variant dbSNP:rs2032582Ensembl.1

Organism-specific databases

DisGeNETi5243.
MalaCardsiABCB1.
MIMi612244. phenotype.
OpenTargetsiENSG00000085563.
Orphaneti771. Ulcerative colitis.
PharmGKBiPA267.

Chemistry databases

ChEMBLiCHEMBL4302.
DrugBankiDB01193. Acebutolol.
DB00316. Acetaminophen.
DB00945. Acetylsalicylic acid.
DB00171. Adenosine triphosphate.
DB08916. Afatinib.
DB00518. Albendazole.
DB04630. Aldosterone.
DB11363. Alectinib.
DB00802. Alfentanil.
DB00523. Alitretinoin.
DB00915. Amantadine.
DB06403. Ambrisentan.
DB00345. Aminohippuric acid.
DB01118. Amiodarone.
DB00321. Amitriptyline.
DB00381. Amlodipine.
DB00701. Amprenavir.
DB00276. Amsacrine.
DB06605. Apixaban.
DB01169. Arsenic trioxide.
DB00637. Astemizole.
DB01072. Atazanavir.
DB00335. Atenolol.
DB01076. Atorvastatin.
DB06626. Axitinib.
DB00972. Azelastine.
DB00207. Azithromycin.
DB01086. Benzocaine.
DB01244. Bepridil.
DB00443. Betamethasone.
DB00810. Biperiden.
DB08873. Boceprevir.
DB06616. Bosutinib.
DB08870. Brentuximab vedotin.
DB01200. Bromocriptine.
DB00921. Buprenorphine.
DB00490. Buspirone.
DB06772. Cabazitaxel.
DB00201. Caffeine.
DB04690. Camptothecin.
DB08907. Canagliflozin.
DB00796. Candesartan.
DB01197. Captopril.
DB00564. Carbamazepine.
DB08889. Carfilzomib.
DB01136. Carvedilol.
DB00520. Caspofungin.
DB09063. Ceritinib.
DB00439. Cerivastatin.
DB00608. Chloroquine.
DB00477. Chlorpromazine.
DB00672. Chlorpropamide.
DB01239. Chlorprothixene.
DB04540. Cholesterol.
DB02659. Cholic Acid.
DB01340. Cilazapril.
DB00501. Cimetidine.
DB00537. Ciprofloxacin.
DB00515. Cisplatin.
DB00215. Citalopram.
DB01211. Clarithromycin.
DB00349. Clobazam.
DB00845. Clofazimine.
DB00882. Clomifene.
DB01242. Clomipramine.
DB00575. Clonidine.
DB00758. Clopidogrel.
DB00257. Clotrimazole.
DB00363. Clozapine.
DB09065. Cobicistat.
DB05239. Cobimetinib.
DB01394. Colchicine.
DB02587. Colforsin.
DB00286. Conjugated Equine Estrogens.
DB08865. Crizotinib.
DB00531. Cyclophosphamide.
DB00091. Cyclosporine.
DB06695. Dabigatran etexilate.
DB08912. Dabrafenib.
DB09102. Daclatasvir.
DB00970. Dactinomycin.
DB06292. Dapagliflozin.
DB01254. Dasatinib.
DB00694. Daunorubicin.
DB04840. Debrisoquin.
DB01151. Desipramine.
DB00967. Desloratadine.
DB01234. Dexamethasone.
DB00514. Dextromethorphan.
DB00829. Diazepam.
DB00586. Diclofenac.
DB00255. Diethylstilbestrol.
DB01396. Digitoxin.
DB00390. Digoxin.
DB00320. Dihydroergotamine.
DB02901. Dihydrotestosterone.
DB00343. Diltiazem.
DB00975. Dipyridamole.
DB01248. Docetaxel.
DB01184. Domperidone.
DB00590. Doxazosin.
DB01142. Doxepin.
DB00997. Doxorubicin.
DB00470. Dronabinol.
DB04855. Dronedarone.
DB09075. Edoxaban.
DB04881. Elacridar.
DB11574. Elbasvir.
DB00216. Eletriptan.
DB00584. Enalapril.
DB08899. Enzalutamide.
DB00751. Epinastine.
DB01253. Ergonovine.
DB00696. Ergotamine.
DB00530. Erlotinib.
DB00199. Erythromycin.
DB00783. Estradiol.
DB01196. Estramustine.
DB04573. Estriol.
DB00655. Estrone.
DB00977. Ethinyl Estradiol.
DB00773. Etoposide.
DB06414. Etravirine.
DB00973. Ezetimibe.
DB01023. Felodipine.
DB00813. Fentanyl.
DB06702. Fesoterodine.
DB00950. Fexofenadine.
DB08874. Fidaxomicin.
DB00196. Fluconazole.
DB00472. Fluoxetine.
DB00875. Flupentixol.
DB00623. Fluphenazine.
DB00690. Flurazepam.
DB08906. Fluticasone furoate.
DB00176. Fluvoxamine.
DB05449. FM-VP4.
DB00317. Gefitinib.
DB00441. Gemcitabine.
DB01645. Genistein.
DB01016. Glyburide.
DB09462. Glycerin.
DB04077. Glycerol.
DB00027. Gramicidin D.
DB11575. Grazoprevir.
DB00365. Grepafloxacin.
DB00502. Haloperidol.
DB00741. Hydrocortisone.
DB01050. Ibuprofen.
DB09054. Idelalisib.
DB00619. Imatinib.
DB00458. Imipramine.
DB05039. Indacaterol.
DB00224. Indinavir.
DB00328. Indomethacin.
DB00762. Irinotecan.
DB06636. Isavuconazonium.
DB01167. Itraconazole.
DB08820. Ivacaftor.
DB00602. Ivermectin.
DB01221. Ketamine.
DB01587. Ketazolam.
DB01026. Ketoconazole.
DB00709. Lamivudine.
DB00555. Lamotrigine.
DB00448. Lansoprazole.
DB01259. Lapatinib.
DB00480. Lenalidomide.
DB09078. Lenvatinib.
DB01202. Levetiracetam.
DB01137. Levofloxacin.
DB08918. Levomilnacipran.
DB00451. Levothyroxine.
DB00281. Lidocaine.
DB08882. Linagliptin.
DB00279. Liothyronine.
DB01583. Liotrix.
DB00722. Lisinopril.
DB08827. Lomitapide.
DB00836. Loperamide.
DB01601. Lopinavir.
DB00455. Loratadine.
DB00678. Losartan.
DB00227. Lovastatin.
DB00742. Mannitol.
DB00934. Maprotiline.
DB00643. Mebendazole.
DB00358. Mefloquine.
DB00351. Megestrol acetate.
DB00371. Meprobamate.
DB00333. Methadone.
DB00563. Methotrexate.
DB00959. Methylprednisolone.
DB00264. Metoprolol.
DB01388. Mibefradil.
DB01110. Miconazole.
DB00683. Midazolam.
DB00834. Mifepristone.
DB08893. Mirabegron.
DB00305. Mitomycin.
DB01204. Mitoxantrone.
DB00295. Morphine.
DB00688. Mycophenolate mofetil.
DB01203. Nadolol.
DB01183. Naloxone.
DB00704. Naltrexone.
DB03467. Naringenin.
DB01149. Nefazodone.
DB00220. Nelfinavir.
DB01400. Neostigmine.
DB00622. Nicardipine.
DB01115. Nifedipine.
DB04868. Nilotinib.
DB09079. Nintedanib.
DB00401. Nisoldipine.
DB01595. Nitrazepam.
DB01054. Nitrendipine.
DB00585. Nizatidine.
DB00717. Norethisterone.
DB00334. Olanzapine.
DB09296. Ombitasvir.
DB00338. Omeprazole.
DB09330. Osimertinib.
DB04417. P-Nitrophenol.
DB01229. Paclitaxel.
DB03796. Palmitic Acid.
DB06603. Panobinostat.
DB00213. Pantoprazole.
DB00715. Paroxetine.
DB06589. Pazopanib.
DB00790. Perindopril.
DB01174. Phenobarbital.
DB00252. Phenytoin.
DB01100. Pimozide.
DB08860. Pitavastatin.
DB02261. Platelet Activating Factor.
DB08910. Pomalidomide.
DB08901. Ponatinib.
DB01263. Posaconazole.
DB00175. Pravastatin.
DB00457. Prazosin.
DB00860. Prednisolone.
DB00635. Prednisone.
DB01032. Probenecid.
DB00396. Progesterone.
DB01069. Promethazine.
DB01182. Propafenone.
DB00571. Propranolol.
DB00344. Protriptyline.
DB04216. Quercetin.
DB01224. Quetiapine.
DB01103. Quinacrine.
DB00908. Quinidine.
DB00468. Quinine.
DB00863. Ranitidine.
DB00234. Reboxetine.
DB08896. Regorafenib.
DB00206. Reserpine.
DB01045. Rifampicin.
DB08864. Rilpivirine.
DB00734. Risperidone.
DB00503. Ritonavir.
DB06228. Rivaroxaban.
DB09291. Rolapitant.
DB06176. Romidepsin.
DB00778. Roxithromycin.
DB00936. Salicylic acid.
DB01232. Saquinavir.
DB00747. Scopolamine.
DB01037. Selegiline.
DB11362. Selexipag.
DB01104. Sertraline.
DB06207. Silodosin.
DB06290. Simeprevir.
DB00641. Simvastatin.
DB00877. Sirolimus.
DB01261. Sitagliptin.
DB08934. Sofosbuvir.
DB00398. Sorafenib.
DB01208. Sparfloxacin.
DB03203. Sphingosine.
DB00421. Spironolactone.
DB01323. St. John's Wort.
DB02010. Staurosporine.
DB00428. Streptozocin.
DB01138. Sulfinpyrazone.
DB00669. Sumatriptan.
DB01268. Sunitinib.
DB00382. Tacrine.
DB00864. Tacrolimus.
DB00675. Tamoxifen.
DB04348. Taurocholic Acid.
DB09161. Technetium Tc-99m sestamibi.
DB05521. Telaprevir.
DB00966. Telmisartan.
DB06287. Temsirolimus.
DB01162. Terazosin.
DB00342. Terfenadine.
DB04905. Tesmilifene.
DB00624. Testosterone.
DB08816. Ticagrelor.
DB00373. Timolol.
DB06212. Tolvaptan.
DB01030. Topotecan.
DB00539. Toremifene.
DB05773. Trastuzumab emtansine.
DB00656. Trazodone.
DB00831. Trifluoperazine.
DB00508. Triflupromazine.
DB00440. Trimethoprim.
DB00726. Trimipramine.
DB01361. Troleandomycin.
DB08867. Ulipristal.
DB09076. Umeclidinium.
DB01339. Vecuronium.
DB11581. Venetoclax.
DB00285. Venlafaxine.
DB00661. Verapamil.
DB00570. Vinblastine.
DB00541. Vincristine.
DB00361. Vinorelbine.
DB08828. Vismodegib.
DB04877. Voacamine.
DB00495. Zidovudine.
DB04832. Zimelidine.

Polymorphism and mutation databases

BioMutaiABCB1.
DMDMi238054374.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933321 – 1280Multidrug resistance protein 1Add BLAST1280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP08183.
MaxQBiP08183.
PaxDbiP08183.
PeptideAtlasiP08183.
PRIDEiP08183.

PTM databases

iPTMnetiP08183.
PhosphoSitePlusiP08183.

Expressioni

Tissue specificityi

Expressed in liver, kidney, small intestine and brain.

Gene expression databases

BgeeiENSG00000085563.
CleanExiHS_ABCB1.
ExpressionAtlasiP08183. baseline and differential.
GenevisibleiP08183. HS.

Organism-specific databases

HPAiCAB001716.
HPA002199.

Interactioni

Subunit structurei

Interacts with PSMB5. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi111262. 14 interactors.
IntActiP08183. 6 interactors.
MINTiMINT-5000901.
STRINGi9606.ENSP00000265724.

Chemistry databases

BindingDBiP08183.

Structurei

3D structure databases

ProteinModelPortaliP08183.
SMRiP08183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 357ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST307
Domaini392 – 628ABC transporter 1PROSITE-ProRule annotationAdd BLAST237
Domaini711 – 1000ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST290
Domaini1035 – 1273ABC transporter 2PROSITE-ProRule annotationAdd BLAST239

Sequence similaritiesi

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00530000062896.
HOVERGENiHBG080809.
InParanoidiP08183.
KOiK05658.
OMAiMQTRGNE.
OrthoDBiEOG091G0HVA.
PhylomeDBiP08183.
TreeFamiTF105193.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P08183-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLEGDRNGG AKKKNFFKLN NKSEKDKKEK KPTVSVFSMF RYSNWLDKLY 
        60         70         80         90        100
MVVGTLAAII HGAGLPLMML VFGEMTDIFA NAGNLEDLMS NITNRSDIND 
       110        120        130        140        150
TGFFMNLEED MTRYAYYYSG IGAGVLVAAY IQVSFWCLAA GRQIHKIRKQ 
       160        170        180        190        200
FFHAIMRQEI GWFDVHDVGE LNTRLTDDVS KINEGIGDKI GMFFQSMATF 
       210        220        230        240        250
FTGFIVGFTR GWKLTLVILA ISPVLGLSAA VWAKILSSFT DKELLAYAKA 
       260        270        280        290        300
GAVAEEVLAA IRTVIAFGGQ KKELERYNKN LEEAKRIGIK KAITANISIG 
       310        320        330        340        350
AAFLLIYASY ALAFWYGTTL VLSGEYSIGQ VLTVFFSVLI GAFSVGQASP 
       360        370        380        390        400
SIEAFANARG AAYEIFKIID NKPSIDSYSK SGHKPDNIKG NLEFRNVHFS 
       410        420        430        440        450
YPSRKEVKIL KGLNLKVQSG QTVALVGNSG CGKSTTVQLM QRLYDPTEGM 
       460        470        480        490        500
VSVDGQDIRT INVRFLREII GVVSQEPVLF ATTIAENIRY GRENVTMDEI 
       510        520        530        540        550
EKAVKEANAY DFIMKLPHKF DTLVGERGAQ LSGGQKQRIA IARALVRNPK 
       560        570        580        590        600
ILLLDEATSA LDTESEAVVQ VALDKARKGR TTIVIAHRLS TVRNADVIAG 
       610        620        630        640        650
FDDGVIVEKG NHDELMKEKG IYFKLVTMQT AGNEVELENA ADESKSEIDA 
       660        670        680        690        700
LEMSSNDSRS SLIRKRSTRR SVRGSQAQDR KLSTKEALDE SIPPVSFWRI 
       710        720        730        740        750
MKLNLTEWPY FVVGVFCAII NGGLQPAFAI IFSKIIGVFT RIDDPETKRQ 
       760        770        780        790        800
NSNLFSLLFL ALGIISFITF FLQGFTFGKA GEILTKRLRY MVFRSMLRQD 
       810        820        830        840        850
VSWFDDPKNT TGALTTRLAN DAAQVKGAIG SRLAVITQNI ANLGTGIIIS 
       860        870        880        890        900
FIYGWQLTLL LLAIVPIIAI AGVVEMKMLS GQALKDKKEL EGSGKIATEA 
       910        920        930        940        950
IENFRTVVSL TQEQKFEHMY AQSLQVPYRN SLRKAHIFGI TFSFTQAMMY 
       960        970        980        990       1000
FSYAGCFRFG AYLVAHKLMS FEDVLLVFSA VVFGAMAVGQ VSSFAPDYAK 
      1010       1020       1030       1040       1050
AKISAAHIIM IIEKTPLIDS YSTEGLMPNT LEGNVTFGEV VFNYPTRPDI 
      1060       1070       1080       1090       1100
PVLQGLSLEV KKGQTLALVG SSGCGKSTVV QLLERFYDPL AGKVLLDGKE 
      1110       1120       1130       1140       1150
IKRLNVQWLR AHLGIVSQEP ILFDCSIAEN IAYGDNSRVV SQEEIVRAAK 
      1160       1170       1180       1190       1200
EANIHAFIES LPNKYSTKVG DKGTQLSGGQ KQRIAIARAL VRQPHILLLD 
      1210       1220       1230       1240       1250
EATSALDTES EKVVQEALDK AREGRTCIVI AHRLSTIQNA DLIVVFQNGR 
      1260       1270       1280
VKEHGTHQQL LAQKGIYFSM VSVQAGTKRQ
Length:1,280
Mass (Da):141,479
Last modified:May 26, 2009 - v3
Checksum:iF0230744AB288C73
GO
Isoform 2 (identifier: P08183-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-177: RYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTD → S

Show »
Length:1,216
Mass (Da):134,032
Checksum:i227233F5F2259A8C
GO

Sequence cautioni

The sequence AAM49149 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23S → R in CAA41558 (PubMed:2568832).Curated1
Sequence conflicti336Missing in AAB69423 (PubMed:9038218).Curated1

Polymorphismi

Genetic variation in ABCB1 may play a role in patients who do not respond to drug treatment.3 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02227617F → L1 PublicationCorresponds to variant dbSNP:rs28381804Ensembl.1
Natural variantiVAR_01470421N → D5 PublicationsCorresponds to variant dbSNP:rs9282564Ensembl.1
Natural variantiVAR_05542344N → S. Corresponds to variant dbSNP:rs1202183Ensembl.1
Natural variantiVAR_05542480A → E. Corresponds to variant dbSNP:rs9282565Ensembl.1
Natural variantiVAR_015001103F → L Rare polymorphism. 1 Publication1
Natural variantiVAR_018351108E → K1 Publication1
Natural variantiVAR_015002185G → V in a colchicine-selected multidrug-resistant cell line; confers increased resistance to colchicine. 3 PublicationsCorresponds to variant dbSNP:rs1128501Ensembl.1
Natural variantiVAR_055425261I → V. Corresponds to variant dbSNP:rs36008564Ensembl.1
Natural variantiVAR_015003400S → N3 PublicationsCorresponds to variant dbSNP:rs2229109Ensembl.1
Natural variantiVAR_022277566E → K1 PublicationCorresponds to variant dbSNP:rs28381902Ensembl.1
Natural variantiVAR_022278593R → C1 PublicationCorresponds to variant dbSNP:rs28381914Ensembl.1
Natural variantiVAR_055426599A → T. Corresponds to variant dbSNP:rs2235036Ensembl.1
Natural variantiVAR_055427669R → C. Corresponds to variant dbSNP:rs35023033Ensembl.1
Natural variantiVAR_055428801V → M. Corresponds to variant dbSNP:rs2235039Ensembl.1
Natural variantiVAR_055429829I → V. Corresponds to variant dbSNP:rs2032581Ensembl.1
Natural variantiVAR_022279836I → V1 PublicationCorresponds to variant dbSNP:rs28381967Ensembl.1
Natural variantiVAR_035737887K → N in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_013361893S → A Common allele; associated with susceptibility to IBD13; has decreased enzyme activity. 8 PublicationsCorresponds to variant dbSNP:rs2032582Ensembl.1
Natural variantiVAR_013362893S → T Rare allele. 3 PublicationsCorresponds to variant dbSNP:rs2032582Ensembl.1
Natural variantiVAR_018352986M → V. 1
Natural variantiVAR_015004999A → T1 PublicationCorresponds to variant dbSNP:rs72552784Ensembl.1
Natural variantiVAR_0222801051P → A1 PublicationCorresponds to variant dbSNP:rs28401798Ensembl.1
Natural variantiVAR_0150051107Q → P1 PublicationCorresponds to variant dbSNP:rs55852620Ensembl.1
Natural variantiVAR_0222811141S → T1 PublicationCorresponds to variant dbSNP:rs2229107Ensembl.1
Natural variantiVAR_0183531251V → I2 PublicationsCorresponds to variant dbSNP:rs28364274Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055769113 – 177RYAYY…TRLTD → S in isoform 2. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14758 mRNA. Translation: AAA59575.1.
M29447
, M29424, M29425, M29426, M29427, M29428, M29429, M29430, M29431, M29432, M29433, M29434, M29435, M29436, M29437, M29438, M29439, M29440, M29441, M29442, M29443, M29444, M29445, M29446 Genomic DNA. Translation: AAA59576.1.
AF016535 mRNA. Translation: AAB69423.1.
EU854148 mRNA. Translation: ACF94688.1.
AY910577 Genomic DNA. Translation: AAW82430.1.
AK290159 mRNA. Translation: BAF82848.1.
AC002457 Genomic DNA. Translation: AAM49149.1. Sequence problems.
AC005068 Genomic DNA. No translation available.
M37724 Genomic DNA. Translation: AAA88047.1.
M37725 Genomic DNA. Translation: AAA88048.1.
X58723 Genomic DNA. Translation: CAA41558.1.
CCDSiCCDS5608.1. [P08183-1]
PIRiA34914. DVHU1.
RefSeqiNP_000918.2. NM_000927.4. [P08183-1]
UniGeneiHs.489033.
Hs.689936.
Hs.737655.

Genome annotation databases

EnsembliENST00000265724; ENSP00000265724; ENSG00000085563. [P08183-1]
ENST00000543898; ENSP00000444095; ENSG00000085563. [P08183-2]
ENST00000622132; ENSP00000478255; ENSG00000085563. [P08183-1]
GeneIDi5243.
KEGGihsa:5243.
UCSCiuc003uiz.3. human. [P08183-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMDR1_HUMAN
AccessioniPrimary (citable) accession number: P08183
Secondary accession number(s): A8K294
, B5AK60, Q12755, Q14812
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: May 26, 2009
Last modified: June 7, 2017
This is version 204 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families