UniProtKB - P08183 (MDR1_HUMAN)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Multidrug resistance protein 1
Gene
ABCB1
Organism
Homo sapiens (Human)
Status
Functioni
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Catalytic activityi
ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 427 – 434 | ATP 1PROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1070 – 1077 | ATP 2PROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity, coupled to transmembrane movement of substances Source: ProtInc
- ATP binding Source: ProtInc
- ceramide-translocating ATPase activity Source: BHF-UCL
- phosphatidylcholine-translocating ATPase activity Source: BHF-UCL
- phosphatidylethanolamine-translocating ATPase activity Source: BHF-UCL
- transporter activity Source: ProtInc
- xenobiotic transmembrane transporting ATPase activity Source: Reactome
GO - Biological processi
- ceramide translocation Source: BHF-UCL
- G2/M transition of mitotic cell cycle Source: DFLAT
- phospholipid translocation Source: BHF-UCL
- positive regulation of anion channel activity Source: CAFA
- regulation of chloride transport Source: CAFA
- regulation of response to osmotic stress Source: CAFA
- response to drug Source: ProtInc
- stem cell proliferation Source: DFLAT
- transmembrane transport Source: Reactome
Keywordsi
Molecular function | Hydrolase |
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 3.6.3.44. 2681. |
Reactomei | R-HSA-2161517. Abacavir transmembrane transport. R-HSA-382556. ABC-family proteins mediated transport. |
SIGNORi | P08183. |
Protein family/group databases
MoonProti | P08183. |
TCDBi | 3.A.1.201.1. the atp-binding cassette (abc) superfamily. |
Chemistry databases
SwissLipidsi | SLP:000000385. |
Names & Taxonomyi
Protein namesi | Recommended name: Multidrug resistance protein 1 (EC:3.6.3.44)Alternative name(s): ATP-binding cassette sub-family B member 1 P-glycoprotein 1 CD_antigen: CD243 |
Gene namesi | Name:ABCB1 Synonyms:MDR1, PGY1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000085563.14. |
HGNCi | HGNC:40. ABCB1. |
MIMi | 171050. gene. |
neXtProti | NX_P08183. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 44 | CytoplasmicBy similarityAdd BLAST | 44 | |
Transmembranei | 45 – 67 | HelicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Topological domaini | 68 – 116 | ExtracellularBy similarityAdd BLAST | 49 | |
Transmembranei | 117 – 137 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 138 – 186 | CytoplasmicBy similarityAdd BLAST | 49 | |
Transmembranei | 187 – 208 | HelicalPROSITE-ProRule annotationAdd BLAST | 22 | |
Topological domaini | 209 – 215 | ExtracellularBy similarity | 7 | |
Transmembranei | 216 – 236 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 237 – 292 | CytoplasmicBy similarityAdd BLAST | 56 | |
Transmembranei | 293 – 316 | HelicalPROSITE-ProRule annotationAdd BLAST | 24 | |
Topological domaini | 317 – 330 | ExtracellularBy similarityAdd BLAST | 14 | |
Transmembranei | 331 – 352 | HelicalPROSITE-ProRule annotationAdd BLAST | 22 | |
Topological domaini | 353 – 711 | CytoplasmicBy similarityAdd BLAST | 359 | |
Transmembranei | 712 – 732 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 733 – 756 | ExtracellularBy similarityAdd BLAST | 24 | |
Transmembranei | 757 – 777 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 778 – 832 | CytoplasmicBy similarityAdd BLAST | 55 | |
Transmembranei | 833 – 853 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 854 | ExtracellularBy similarity | 1 | |
Transmembranei | 855 – 874 | HelicalPROSITE-ProRule annotationAdd BLAST | 20 | |
Topological domaini | 875 – 934 | CytoplasmicBy similarityAdd BLAST | 60 | |
Transmembranei | 935 – 957 | HelicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Topological domaini | 958 – 973 | ExtracellularBy similarityAdd BLAST | 16 | |
Transmembranei | 974 – 995 | HelicalPROSITE-ProRule annotationAdd BLAST | 22 | |
Topological domaini | 996 – 1280 | CytoplasmicBy similarityAdd BLAST | 285 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Inflammatory bowel disease 13 (IBD13)
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
See also OMIM:612244Organism-specific databases
DisGeNETi | 5243. |
MalaCardsi | ABCB1. |
MIMi | 612244. phenotype. |
OpenTargetsi | ENSG00000085563. |
Orphaneti | 771. Ulcerative colitis. |
PharmGKBi | PA267. |
Chemistry databases
ChEMBLi | CHEMBL4302. |
DrugBanki | DB01193. Acebutolol. DB00316. Acetaminophen. DB00945. Acetylsalicylic acid. DB00171. Adenosine triphosphate. DB08916. Afatinib. DB00518. Albendazole. DB04630. Aldosterone. DB11363. Alectinib. DB00802. Alfentanil. DB00523. Alitretinoin. DB00915. Amantadine. DB06403. Ambrisentan. DB00345. Aminohippuric acid. DB01118. Amiodarone. DB00321. Amitriptyline. DB00381. Amlodipine. DB00701. Amprenavir. DB00276. Amsacrine. DB06605. Apixaban. DB01169. Arsenic trioxide. DB00637. Astemizole. DB01072. Atazanavir. DB00335. Atenolol. DB01076. Atorvastatin. DB06626. Axitinib. DB00972. Azelastine. DB00207. Azithromycin. DB01086. Benzocaine. DB01244. Bepridil. DB00443. Betamethasone. DB00810. Biperiden. DB08873. Boceprevir. DB06616. Bosutinib. DB08870. Brentuximab vedotin. DB01200. Bromocriptine. DB00921. Buprenorphine. DB00490. Buspirone. DB06772. Cabazitaxel. DB00201. Caffeine. DB04690. Camptothecin. DB08907. Canagliflozin. DB00796. Candesartan. DB01197. Captopril. DB00564. Carbamazepine. DB08889. Carfilzomib. DB01136. Carvedilol. DB00520. Caspofungin. DB09063. Ceritinib. DB00439. Cerivastatin. DB00608. Chloroquine. DB00477. Chlorpromazine. DB00672. Chlorpropamide. DB01239. Chlorprothixene. DB04540. Cholesterol. DB02659. Cholic Acid. DB01340. Cilazapril. DB00501. Cimetidine. DB00537. Ciprofloxacin. DB00515. Cisplatin. DB00215. Citalopram. DB01211. Clarithromycin. DB00349. Clobazam. DB00845. Clofazimine. DB00882. Clomifene. DB01242. Clomipramine. DB00575. Clonidine. DB00758. Clopidogrel. DB00257. Clotrimazole. DB00363. Clozapine. DB09065. Cobicistat. DB05239. Cobimetinib. DB01394. Colchicine. DB02587. Colforsin. DB00286. Conjugated Equine Estrogens. DB08865. Crizotinib. DB00531. Cyclophosphamide. DB00091. Cyclosporine. DB06695. Dabigatran etexilate. DB08912. Dabrafenib. DB09102. Daclatasvir. DB00970. Dactinomycin. DB06292. Dapagliflozin. DB01254. Dasatinib. DB00694. Daunorubicin. DB04840. Debrisoquin. DB01151. Desipramine. DB00967. Desloratadine. DB01234. Dexamethasone. DB00514. Dextromethorphan. DB00829. Diazepam. DB00586. Diclofenac. DB00255. Diethylstilbestrol. DB01396. Digitoxin. DB00390. Digoxin. DB00320. Dihydroergotamine. DB02901. Dihydrotestosterone. DB00343. Diltiazem. DB00975. Dipyridamole. DB01248. Docetaxel. DB01184. Domperidone. DB00590. Doxazosin. DB01142. Doxepin. DB00997. Doxorubicin. DB00470. Dronabinol. DB04855. Dronedarone. DB09075. Edoxaban. DB04881. Elacridar. DB11574. Elbasvir. DB00216. Eletriptan. DB00584. Enalapril. DB08899. Enzalutamide. DB00751. Epinastine. DB01253. Ergonovine. DB00696. Ergotamine. DB00530. Erlotinib. DB00199. Erythromycin. DB00783. Estradiol. DB01196. Estramustine. DB04573. Estriol. DB00655. Estrone. DB00977. Ethinyl Estradiol. DB00773. Etoposide. DB06414. Etravirine. DB00973. Ezetimibe. DB01023. Felodipine. DB00813. Fentanyl. DB06702. Fesoterodine. DB00950. Fexofenadine. DB08874. Fidaxomicin. DB00196. Fluconazole. DB00472. Fluoxetine. DB00875. Flupentixol. DB00623. Fluphenazine. DB00690. Flurazepam. DB08906. Fluticasone furoate. DB00176. Fluvoxamine. DB05449. FM-VP4. DB00317. Gefitinib. DB00441. Gemcitabine. DB01645. Genistein. DB01016. Glyburide. DB09462. Glycerin. DB04077. Glycerol. DB00027. Gramicidin D. DB11575. Grazoprevir. DB00365. Grepafloxacin. DB00502. Haloperidol. DB00741. Hydrocortisone. DB01050. Ibuprofen. DB09054. Idelalisib. DB00619. Imatinib. DB00458. Imipramine. DB05039. Indacaterol. DB00224. Indinavir. DB00328. Indomethacin. DB00762. Irinotecan. DB06636. Isavuconazonium. DB01167. Itraconazole. DB08820. Ivacaftor. DB00602. Ivermectin. DB01221. Ketamine. DB01587. Ketazolam. DB01026. Ketoconazole. DB00709. Lamivudine. DB00555. Lamotrigine. DB00448. Lansoprazole. DB01259. Lapatinib. DB00480. Lenalidomide. DB09078. Lenvatinib. DB01202. Levetiracetam. DB01137. Levofloxacin. DB08918. Levomilnacipran. DB00451. Levothyroxine. DB00281. Lidocaine. DB08882. Linagliptin. DB00279. Liothyronine. DB01583. Liotrix. DB00722. Lisinopril. DB08827. Lomitapide. DB00836. Loperamide. DB01601. Lopinavir. DB00455. Loratadine. DB00678. Losartan. DB00227. Lovastatin. DB00742. Mannitol. DB00934. Maprotiline. DB00643. Mebendazole. DB00358. Mefloquine. DB00351. Megestrol acetate. DB00371. Meprobamate. DB00333. Methadone. DB00563. Methotrexate. DB00959. Methylprednisolone. DB00264. Metoprolol. DB01388. Mibefradil. DB01110. Miconazole. DB00683. Midazolam. DB00834. Mifepristone. DB08893. Mirabegron. DB00305. Mitomycin. DB01204. Mitoxantrone. DB00295. Morphine. DB00688. Mycophenolate mofetil. DB01203. Nadolol. DB01183. Naloxone. DB00704. Naltrexone. DB03467. Naringenin. DB01149. Nefazodone. DB00220. Nelfinavir. DB01400. Neostigmine. DB00622. Nicardipine. DB01115. Nifedipine. DB04868. Nilotinib. DB09079. Nintedanib. DB00401. Nisoldipine. DB01595. Nitrazepam. DB01054. Nitrendipine. DB00585. Nizatidine. DB00717. Norethisterone. DB00334. Olanzapine. DB09296. Ombitasvir. DB00338. Omeprazole. DB09330. Osimertinib. DB04417. P-Nitrophenol. DB01229. Paclitaxel. DB03796. Palmitic Acid. DB06603. Panobinostat. DB00213. Pantoprazole. DB00715. Paroxetine. DB06589. Pazopanib. DB00790. Perindopril. DB01174. Phenobarbital. DB00252. Phenytoin. DB01100. Pimozide. DB08860. Pitavastatin. DB02261. Platelet Activating Factor. DB08910. Pomalidomide. DB08901. Ponatinib. DB01263. Posaconazole. DB00175. Pravastatin. DB00457. Prazosin. DB00860. Prednisolone. DB00635. Prednisone. DB01032. Probenecid. DB00396. Progesterone. DB01069. Promethazine. DB01182. Propafenone. DB00571. Propranolol. DB00344. Protriptyline. DB04216. Quercetin. DB01224. Quetiapine. DB01103. Quinacrine. DB00908. Quinidine. DB00468. Quinine. DB00863. Ranitidine. DB00234. Reboxetine. DB08896. Regorafenib. DB00206. Reserpine. DB01045. Rifampicin. DB08864. Rilpivirine. DB00734. Risperidone. DB00503. Ritonavir. DB06228. Rivaroxaban. DB09291. Rolapitant. DB06176. Romidepsin. DB00778. Roxithromycin. DB00936. Salicylic acid. DB01232. Saquinavir. DB00747. Scopolamine. DB01037. Selegiline. DB11362. Selexipag. DB01104. Sertraline. DB06207. Silodosin. DB06290. Simeprevir. DB00641. Simvastatin. DB00877. Sirolimus. DB01261. Sitagliptin. DB08934. Sofosbuvir. DB00398. Sorafenib. DB01208. Sparfloxacin. DB03203. Sphingosine. DB00421. Spironolactone. DB01323. St. John's Wort. DB02010. Staurosporine. DB00428. Streptozocin. DB01138. Sulfinpyrazone. DB00669. Sumatriptan. DB01268. Sunitinib. DB00382. Tacrine. DB00864. Tacrolimus. DB00675. Tamoxifen. DB04348. Taurocholic Acid. DB09161. Technetium Tc-99m sestamibi. DB05521. Telaprevir. DB00966. Telmisartan. DB06287. Temsirolimus. DB01162. Terazosin. DB00342. Terfenadine. DB04905. Tesmilifene. DB00624. Testosterone. DB08816. Ticagrelor. DB00373. Timolol. DB06212. Tolvaptan. DB01030. Topotecan. DB00539. Toremifene. DB05773. Trastuzumab emtansine. DB00656. Trazodone. DB00831. Trifluoperazine. DB00508. Triflupromazine. DB00440. Trimethoprim. DB00726. Trimipramine. DB01361. Troleandomycin. DB08867. Ulipristal. DB09076. Umeclidinium. DB01339. Vecuronium. DB11581. Venetoclax. DB00285. Venlafaxine. DB00661. Verapamil. DB00570. Vinblastine. DB00541. Vincristine. DB00361. Vinorelbine. DB08828. Vismodegib. DB04877. Voacamine. DB00495. Zidovudine. DB04832. Zimelidine. |
Polymorphism and mutation databases
BioMutai | ABCB1. |
DMDMi | 238054374. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093332 | 1 – 1280 | Multidrug resistance protein 1Add BLAST | 1280 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 91 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 94 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 99 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 660 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | P08183. |
MaxQBi | P08183. |
PaxDbi | P08183. |
PeptideAtlasi | P08183. |
PRIDEi | P08183. |
PTM databases
iPTMneti | P08183. |
PhosphoSitePlusi | P08183. |
Expressioni
Tissue specificityi
Expressed in liver, kidney, small intestine and brain.
Gene expression databases
Bgeei | ENSG00000085563. |
CleanExi | HS_ABCB1. |
ExpressionAtlasi | P08183. baseline and differential. |
Genevisiblei | P08183. HS. |
Organism-specific databases
HPAi | CAB001716. HPA002199. |
Interactioni
Subunit structurei
Interacts with PSMB5. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.2 Publications
Binary interactionsi
Protein-protein interaction databases
BioGridi | 111262. 16 interactors. |
IntActi | P08183. 8 interactors. |
MINTi | P08183. |
STRINGi | 9606.ENSP00000265724. |
Chemistry databases
BindingDBi | P08183. |
Structurei
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6C0V | electron microscopy | 3.40 | A | 1-1280 | [»] | |
ProteinModelPortali | P08183. | |||||
SMRi | P08183. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 51 – 357 | ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST | 307 | |
Domaini | 392 – 628 | ABC transporter 1PROSITE-ProRule annotationAdd BLAST | 237 | |
Domaini | 711 – 1000 | ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST | 290 | |
Domaini | 1035 – 1273 | ABC transporter 2PROSITE-ProRule annotationAdd BLAST | 239 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification]Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0055. Eukaryota. COG1132. LUCA. |
GeneTreei | ENSGT00530000062896. |
HOVERGENi | HBG080809. |
InParanoidi | P08183. |
KOi | K05658. |
OMAi | MQTRGNE. |
OrthoDBi | EOG091G0HVA. |
PhylomeDBi | P08183. |
TreeFami | TF105193. |
Family and domain databases
Gene3Di | 1.20.1560.10. 2 hits. |
InterProi | View protein in InterPro IPR003593. AAA+_ATPase. IPR011527. ABC1_TM_dom. IPR036640. ABC1_TM_sf. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR030258. MDR1. IPR027417. P-loop_NTPase. |
PANTHERi | PTHR24221:SF251. PTHR24221:SF251. 2 hits. |
Pfami | View protein in Pfam PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. |
SMARTi | View protein in SMART SM00382. AAA. 2 hits. |
SUPFAMi | SSF52540. SSF52540. 2 hits. SSF90123. SSF90123. 2 hits. |
PROSITEi | View protein in PROSITE PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: P08183-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MDLEGDRNGG AKKKNFFKLN NKSEKDKKEK KPTVSVFSMF RYSNWLDKLY
60 70 80 90 100
MVVGTLAAII HGAGLPLMML VFGEMTDIFA NAGNLEDLMS NITNRSDIND
110 120 130 140 150
TGFFMNLEED MTRYAYYYSG IGAGVLVAAY IQVSFWCLAA GRQIHKIRKQ
160 170 180 190 200
FFHAIMRQEI GWFDVHDVGE LNTRLTDDVS KINEGIGDKI GMFFQSMATF
210 220 230 240 250
FTGFIVGFTR GWKLTLVILA ISPVLGLSAA VWAKILSSFT DKELLAYAKA
260 270 280 290 300
GAVAEEVLAA IRTVIAFGGQ KKELERYNKN LEEAKRIGIK KAITANISIG
310 320 330 340 350
AAFLLIYASY ALAFWYGTTL VLSGEYSIGQ VLTVFFSVLI GAFSVGQASP
360 370 380 390 400
SIEAFANARG AAYEIFKIID NKPSIDSYSK SGHKPDNIKG NLEFRNVHFS
410 420 430 440 450
YPSRKEVKIL KGLNLKVQSG QTVALVGNSG CGKSTTVQLM QRLYDPTEGM
460 470 480 490 500
VSVDGQDIRT INVRFLREII GVVSQEPVLF ATTIAENIRY GRENVTMDEI
510 520 530 540 550
EKAVKEANAY DFIMKLPHKF DTLVGERGAQ LSGGQKQRIA IARALVRNPK
560 570 580 590 600
ILLLDEATSA LDTESEAVVQ VALDKARKGR TTIVIAHRLS TVRNADVIAG
610 620 630 640 650
FDDGVIVEKG NHDELMKEKG IYFKLVTMQT AGNEVELENA ADESKSEIDA
660 670 680 690 700
LEMSSNDSRS SLIRKRSTRR SVRGSQAQDR KLSTKEALDE SIPPVSFWRI
710 720 730 740 750
MKLNLTEWPY FVVGVFCAII NGGLQPAFAI IFSKIIGVFT RIDDPETKRQ
760 770 780 790 800
NSNLFSLLFL ALGIISFITF FLQGFTFGKA GEILTKRLRY MVFRSMLRQD
810 820 830 840 850
VSWFDDPKNT TGALTTRLAN DAAQVKGAIG SRLAVITQNI ANLGTGIIIS
860 870 880 890 900
FIYGWQLTLL LLAIVPIIAI AGVVEMKMLS GQALKDKKEL EGSGKIATEA
910 920 930 940 950
IENFRTVVSL TQEQKFEHMY AQSLQVPYRN SLRKAHIFGI TFSFTQAMMY
960 970 980 990 1000
FSYAGCFRFG AYLVAHKLMS FEDVLLVFSA VVFGAMAVGQ VSSFAPDYAK
1010 1020 1030 1040 1050
AKISAAHIIM IIEKTPLIDS YSTEGLMPNT LEGNVTFGEV VFNYPTRPDI
1060 1070 1080 1090 1100
PVLQGLSLEV KKGQTLALVG SSGCGKSTVV QLLERFYDPL AGKVLLDGKE
1110 1120 1130 1140 1150
IKRLNVQWLR AHLGIVSQEP ILFDCSIAEN IAYGDNSRVV SQEEIVRAAK
1160 1170 1180 1190 1200
EANIHAFIES LPNKYSTKVG DKGTQLSGGQ KQRIAIARAL VRQPHILLLD
1210 1220 1230 1240 1250
EATSALDTES EKVVQEALDK AREGRTCIVI AHRLSTIQNA DLIVVFQNGR
1260 1270 1280
VKEHGTHQQL LAQKGIYFSM VSVQAGTKRQ
Sequence cautioni
The sequence AAM49149 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 23 | S → R in CAA41558 (PubMed:2568832).Curated | 1 | |
Sequence conflicti | 336 | Missing in AAB69423 (PubMed:9038218).Curated | 1 |
Polymorphismi
Genetic variation in ABCB1 may play a role in patients who do not respond to drug treatment.3 Publications
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022276 | 17 | F → L1 PublicationCorresponds to variant dbSNP:rs28381804Ensembl. | 1 | |
Natural variantiVAR_014704 | 21 | N → D5 PublicationsCorresponds to variant dbSNP:rs9282564Ensembl. | 1 | |
Natural variantiVAR_055423 | 44 | N → S. Corresponds to variant dbSNP:rs1202183Ensembl. | 1 | |
Natural variantiVAR_055424 | 80 | A → E. Corresponds to variant dbSNP:rs9282565Ensembl. | 1 | |
Natural variantiVAR_015001 | 103 | F → L Rare polymorphism. 1 Publication | 1 | |
Natural variantiVAR_018351 | 108 | E → K1 Publication | 1 | |
Natural variantiVAR_015002 | 185 | G → V in a colchicine-selected multidrug-resistant cell line; confers increased resistance to colchicine. 3 PublicationsCorresponds to variant dbSNP:rs1128501Ensembl. | 1 | |
Natural variantiVAR_055425 | 261 | I → V. Corresponds to variant dbSNP:rs36008564Ensembl. | 1 | |
Natural variantiVAR_015003 | 400 | S → N3 PublicationsCorresponds to variant dbSNP:rs2229109Ensembl. | 1 | |
Natural variantiVAR_022277 | 566 | E → K1 PublicationCorresponds to variant dbSNP:rs28381902Ensembl. | 1 | |
Natural variantiVAR_022278 | 593 | R → C1 PublicationCorresponds to variant dbSNP:rs28381914Ensembl. | 1 | |
Natural variantiVAR_055426 | 599 | A → T. Corresponds to variant dbSNP:rs2235036Ensembl. | 1 | |
Natural variantiVAR_055427 | 669 | R → C. Corresponds to variant dbSNP:rs35023033Ensembl. | 1 | |
Natural variantiVAR_055428 | 801 | V → M. Corresponds to variant dbSNP:rs2235039Ensembl. | 1 | |
Natural variantiVAR_055429 | 829 | I → V. Corresponds to variant dbSNP:rs2032581Ensembl. | 1 | |
Natural variantiVAR_022279 | 836 | I → V1 PublicationCorresponds to variant dbSNP:rs28381967Ensembl. | 1 | |
Natural variantiVAR_035737 | 887 | K → N in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_013361 | 893 | S → A Common allele; associated with susceptibility to IBD13; has decreased enzyme activity. 8 PublicationsCorresponds to variant dbSNP:rs2032582Ensembl. | 1 | |
Natural variantiVAR_013362 | 893 | S → T Rare allele. 3 PublicationsCorresponds to variant dbSNP:rs2032582Ensembl. | 1 | |
Natural variantiVAR_018352 | 986 | M → V. Corresponds to variant dbSNP:rs926081975Ensembl. | 1 | |
Natural variantiVAR_015004 | 999 | A → T1 PublicationCorresponds to variant dbSNP:rs72552784Ensembl. | 1 | |
Natural variantiVAR_022280 | 1051 | P → A1 PublicationCorresponds to variant dbSNP:rs28401798Ensembl. | 1 | |
Natural variantiVAR_015005 | 1107 | Q → P1 PublicationCorresponds to variant dbSNP:rs55852620Ensembl. | 1 | |
Natural variantiVAR_022281 | 1141 | S → T1 PublicationCorresponds to variant dbSNP:rs2229107Ensembl. | 1 | |
Natural variantiVAR_018353 | 1251 | V → I2 PublicationsCorresponds to variant dbSNP:rs28364274Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055769 | 113 – 177 | RYAYY…TRLTD → S in isoform 2. 1 PublicationAdd BLAST | 65 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14758 mRNA. Translation: AAA59575.1. M29447 M29446 Genomic DNA. Translation: AAA59576.1. AF016535 mRNA. Translation: AAB69423.1. EU854148 mRNA. Translation: ACF94688.1. AY910577 Genomic DNA. Translation: AAW82430.1. AK290159 mRNA. Translation: BAF82848.1. AC002457 Genomic DNA. Translation: AAM49149.1. Sequence problems. AC005068 Genomic DNA. No translation available. M37724 Genomic DNA. Translation: AAA88047.1. M37725 Genomic DNA. Translation: AAA88048.1. X58723 Genomic DNA. Translation: CAA41558.1. |
CCDSi | CCDS5608.1. [P08183-1] |
PIRi | A34914. DVHU1. |
RefSeqi | NP_000918.2. NM_000927.4. [P08183-1] |
UniGenei | Hs.489033. Hs.689936. Hs.737655. |
Genome annotation databases
Ensembli | ENST00000265724; ENSP00000265724; ENSG00000085563. [P08183-1] ENST00000543898; ENSP00000444095; ENSG00000085563. [P08183-2] ENST00000622132; ENSP00000478255; ENSG00000085563. [P08183-1] |
GeneIDi | 5243. |
KEGGi | hsa:5243. |
UCSCi | uc003uiz.3. human. [P08183-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | MDR1_HUMAN | |
Accessioni | P08183Primary (citable) accession number: P08183 Secondary accession number(s): A8K294 Q14812 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | May 26, 2009 | |
Last modified: | March 28, 2018 | |
This is version 210 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |