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P08183 (MDR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 172. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Multidrug resistance protein 1

EC=3.6.3.44
Alternative name(s):
ATP-binding cassette sub-family B member 1
P-glycoprotein 1
CD_antigen=CD243
Gene names
Name:ABCB1
Synonyms:MDR1, PGY1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1280 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

Catalytic activity

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Subunit structure

Interacts with PSMB5. Ref.10

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Expressed in liver, kidney, small intestine and brain.

Polymorphism

Genetic variation in ABCB1 may play a role in patients who do not respond to drug treatment.

Involvement in disease

Inflammatory bowel disease 13 (IBD13) [MIM:612244]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.21

Sequence similarities

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification]

Contains 2 ABC transmembrane type-1 domains.

Contains 2 ABC transporter domains.

Sequence caution

The sequence AAM49149.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainRepeat
Transmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG2/M transition of mitotic cell cycle

Inferred from direct assay PubMed 19384922. Source: DFLAT

drug transmembrane transport

Traceable author statement. Source: Reactome

response to drug

Traceable author statement PubMed 3022150. Source: ProtInc

small molecule metabolic process

Traceable author statement. Source: Reactome

stem cell proliferation

Inferred from mutant phenotype PubMed 19384922. Source: DFLAT

transmembrane transport

Inferred from Biological aspect of Ancestor. Source: RefGenome

transport

Traceable author statement PubMed 3022150. Source: ProtInc

   Cellular_componentGolgi membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

apical plasma membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

cell surface

Inferred from direct assay PubMed 19384922. Source: DFLAT

extracellular vesicular exosome

Inferred from direct assay PubMed 19056867PubMed 23376485. Source: UniProt

integral component of membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

intercellular canaliculus

Inferred from Biological aspect of Ancestor. Source: RefGenome

membrane

Traceable author statement PubMed 3022150. Source: ProtInc

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionATP binding

Traceable author statement PubMed 3768958. Source: ProtInc

ATPase activity, coupled to transmembrane movement of substances

Inferred from Biological aspect of Ancestor. Source: RefGenome

protein binding

Inferred from physical interaction PubMed 17088979PubMed 20711237. Source: IntAct

transporter activity

Traceable author statement PubMed 3022150. Source: ProtInc

xenobiotic-transporting ATPase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

LAPTM4BQ86VI42EBI-1057359,EBI-3267258
RNF2Q994962EBI-1057359,EBI-722416

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12801280Multidrug resistance protein 1
PRO_0000093332

Regions

Topological domain1 – 4444Cytoplasmic By similarity
Transmembrane45 – 6723Helical; Potential
Topological domain68 – 11649Extracellular By similarity
Transmembrane117 – 13721Helical; Potential
Topological domain138 – 18649Cytoplasmic By similarity
Transmembrane187 – 20822Helical; Potential
Topological domain209 – 2157Extracellular By similarity
Transmembrane216 – 23621Helical; Potential
Topological domain237 – 29256Cytoplasmic By similarity
Transmembrane293 – 31624Helical; Potential
Topological domain317 – 33014Extracellular By similarity
Transmembrane331 – 35222Helical; Potential
Topological domain353 – 711359Cytoplasmic By similarity
Transmembrane712 – 73221Helical; Potential
Topological domain733 – 75624Extracellular By similarity
Transmembrane757 – 77721Helical; Potential
Topological domain778 – 83255Cytoplasmic By similarity
Transmembrane833 – 85321Helical; Potential
Topological domain8541Extracellular By similarity
Transmembrane855 – 87420Helical; Potential
Topological domain875 – 93460Cytoplasmic By similarity
Transmembrane935 – 95723Helical; Potential
Topological domain958 – 97316Extracellular By similarity
Transmembrane974 – 99522Helical; Potential
Topological domain996 – 1280285Cytoplasmic By similarity
Domain51 – 357307ABC transmembrane type-1 1
Domain392 – 628237ABC transporter 1
Domain711 – 1000290ABC transmembrane type-1 2
Domain1035 – 1273239ABC transporter 2
Nucleotide binding427 – 4348ATP 1 By similarity
Nucleotide binding1070 – 10778ATP 2 By similarity

Amino acid modifications

Modified residue6601Phosphoserine By similarity
Glycosylation911N-linked (GlcNAc...) Potential
Glycosylation941N-linked (GlcNAc...) Potential
Glycosylation991N-linked (GlcNAc...) Potential

Natural variations

Natural variant171F → L. Ref.4
Corresponds to variant rs28381804 [ dbSNP | Ensembl ].
VAR_022276
Natural variant211N → D. Ref.4 Ref.5 Ref.15 Ref.16 Ref.17
Corresponds to variant rs9282564 [ dbSNP | Ensembl ].
VAR_014704
Natural variant441N → S.
Corresponds to variant rs1202183 [ dbSNP | Ensembl ].
VAR_055423
Natural variant801A → E.
Corresponds to variant rs9282565 [ dbSNP | Ensembl ].
VAR_055424
Natural variant1031F → L Rare polymorphism. Ref.16
VAR_015001
Natural variant1081E → K. Ref.18
VAR_018351
Natural variant1851G → V in a colchicine-selected multidrug-resistant cell line; confers increased resistance to colchicine. Ref.1 Ref.3 Ref.13
Corresponds to variant rs1128501 [ dbSNP | Ensembl ].
VAR_015002
Natural variant2611I → V.
Corresponds to variant rs36008564 [ dbSNP | Ensembl ].
VAR_055425
Natural variant4001S → N. Ref.4 Ref.16 Ref.17
Corresponds to variant rs2229109 [ dbSNP | Ensembl ].
VAR_015003
Natural variant5661E → K. Ref.4
Corresponds to variant rs28381902 [ dbSNP | Ensembl ].
VAR_022277
Natural variant5931R → C. Ref.4
Corresponds to variant rs28381914 [ dbSNP | Ensembl ].
VAR_022278
Natural variant5991A → T.
Corresponds to variant rs2235036 [ dbSNP | Ensembl ].
VAR_055426
Natural variant6691R → C.
Corresponds to variant rs35023033 [ dbSNP | Ensembl ].
VAR_055427
Natural variant8011V → M.
Corresponds to variant rs2235039 [ dbSNP | Ensembl ].
VAR_055428
Natural variant8291I → V.
Corresponds to variant rs2032581 [ dbSNP | Ensembl ].
VAR_055429
Natural variant8361I → V. Ref.4
Corresponds to variant rs28381967 [ dbSNP | Ensembl ].
VAR_022279
Natural variant8871K → N in a colorectal cancer sample; somatic mutation. Ref.23
VAR_035737
Natural variant8931S → A Common allele; associated with susceptibility to IBD13; has decreased enzyme activity. Ref.1 Ref.2 Ref.3 Ref.4 Ref.14 Ref.17 Ref.20 Ref.21
Corresponds to variant rs2032582 [ dbSNP | Ensembl ].
VAR_013361
Natural variant8931S → T Rare allele. Ref.17 Ref.20 Ref.21
Corresponds to variant rs2032582 [ dbSNP | Ensembl ].
VAR_013362
Natural variant9861M → V.
VAR_018352
Natural variant9991A → T. Ref.14
VAR_015004
Natural variant10511P → A. Ref.4
Corresponds to variant rs28401798 [ dbSNP | Ensembl ].
VAR_022280
Natural variant11071Q → P. Ref.17
Corresponds to variant rs55852620 [ dbSNP | Ensembl ].
VAR_015005
Natural variant11411S → T. Ref.4
Corresponds to variant rs2229107 [ dbSNP | Ensembl ].
VAR_022281
Natural variant12511V → I. Ref.4 Ref.19
Corresponds to variant rs28364274 [ dbSNP | Ensembl ].
VAR_018353

Experimental info

Sequence conflict231S → R in CAA41558. Ref.8
Sequence conflict3361Missing in AAB69423. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P08183 [UniParc].

Last modified May 26, 2009. Version 3.
Checksum: F0230744AB288C73

FASTA1,280141,479
        10         20         30         40         50         60 
MDLEGDRNGG AKKKNFFKLN NKSEKDKKEK KPTVSVFSMF RYSNWLDKLY MVVGTLAAII 

        70         80         90        100        110        120 
HGAGLPLMML VFGEMTDIFA NAGNLEDLMS NITNRSDIND TGFFMNLEED MTRYAYYYSG 

       130        140        150        160        170        180 
IGAGVLVAAY IQVSFWCLAA GRQIHKIRKQ FFHAIMRQEI GWFDVHDVGE LNTRLTDDVS 

       190        200        210        220        230        240 
KINEGIGDKI GMFFQSMATF FTGFIVGFTR GWKLTLVILA ISPVLGLSAA VWAKILSSFT 

       250        260        270        280        290        300 
DKELLAYAKA GAVAEEVLAA IRTVIAFGGQ KKELERYNKN LEEAKRIGIK KAITANISIG 

       310        320        330        340        350        360 
AAFLLIYASY ALAFWYGTTL VLSGEYSIGQ VLTVFFSVLI GAFSVGQASP SIEAFANARG 

       370        380        390        400        410        420 
AAYEIFKIID NKPSIDSYSK SGHKPDNIKG NLEFRNVHFS YPSRKEVKIL KGLNLKVQSG 

       430        440        450        460        470        480 
QTVALVGNSG CGKSTTVQLM QRLYDPTEGM VSVDGQDIRT INVRFLREII GVVSQEPVLF 

       490        500        510        520        530        540 
ATTIAENIRY GRENVTMDEI EKAVKEANAY DFIMKLPHKF DTLVGERGAQ LSGGQKQRIA 

       550        560        570        580        590        600 
IARALVRNPK ILLLDEATSA LDTESEAVVQ VALDKARKGR TTIVIAHRLS TVRNADVIAG 

       610        620        630        640        650        660 
FDDGVIVEKG NHDELMKEKG IYFKLVTMQT AGNEVELENA ADESKSEIDA LEMSSNDSRS 

       670        680        690        700        710        720 
SLIRKRSTRR SVRGSQAQDR KLSTKEALDE SIPPVSFWRI MKLNLTEWPY FVVGVFCAII 

       730        740        750        760        770        780 
NGGLQPAFAI IFSKIIGVFT RIDDPETKRQ NSNLFSLLFL ALGIISFITF FLQGFTFGKA 

       790        800        810        820        830        840 
GEILTKRLRY MVFRSMLRQD VSWFDDPKNT TGALTTRLAN DAAQVKGAIG SRLAVITQNI 

       850        860        870        880        890        900 
ANLGTGIIIS FIYGWQLTLL LLAIVPIIAI AGVVEMKMLS GQALKDKKEL EGSGKIATEA 

       910        920        930        940        950        960 
IENFRTVVSL TQEQKFEHMY AQSLQVPYRN SLRKAHIFGI TFSFTQAMMY FSYAGCFRFG 

       970        980        990       1000       1010       1020 
AYLVAHKLMS FEDVLLVFSA VVFGAMAVGQ VSSFAPDYAK AKISAAHIIM IIEKTPLIDS 

      1030       1040       1050       1060       1070       1080 
YSTEGLMPNT LEGNVTFGEV VFNYPTRPDI PVLQGLSLEV KKGQTLALVG SSGCGKSTVV 

      1090       1100       1110       1120       1130       1140 
QLLERFYDPL AGKVLLDGKE IKRLNVQWLR AHLGIVSQEP ILFDCSIAEN IAYGDNSRVV 

      1150       1160       1170       1180       1190       1200 
SQEEIVRAAK EANIHAFIES LPNKYSTKVG DKGTQLSGGQ KQRIAIARAL VRQPHILLLD 

      1210       1220       1230       1240       1250       1260 
EATSALDTES EKVVQEALDK AREGRTCIVI AHRLSTIQNA DLIVVFQNGR VKEHGTHQQL 

      1270       1280 
LAQKGIYFSM VSVQAGTKRQ 

« Hide

References

« Hide 'large scale' references
[1]"Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells."
Chen C.-J., Chin J.E., Ueda K., Clark D.P., Pastan I., Gottesman M.M., Roninson I.B.
Cell 47:381-389(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-185 AND ALA-893.
[2]"Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins."
Chen C.-J., Clark D.P., Ueda K., Pastan I., Gottesman M.M., Roninson I.B.
J. Biol. Chem. 265:506-514(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-893.
[3]"Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins."
Chen G., Duran G.E., Steger K.A., Lacayo N.J., Jaffrezou J.P., Dumontet C., Sikic B.I.
J. Biol. Chem. 272:5974-5982(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-185 AND ALA-893.
[4]NIEHS SNPs program
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-17; ASP-21; ASN-400; LYS-566; CYS-593; VAL-836; ALA-893; ALA-1051; THR-1141 AND ILE-1251.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-21.
Tissue: Thalamus.
[6]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"mdr1/P-glycoprotein gene segments analyzed from various human leukemic cell lines exhibiting different multidrug resistance profiles."
Gekeler V., Weger S., Probst H.
Biochem. Biophys. Res. Commun. 169:796-802(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 178-215 AND 800-856.
[8]"P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance."
Kioka N., Tsubota J., Kakehi Y., Komano T., Gottesman M.M., Pastan I., Ueda K.
Biochem. Biophys. Res. Commun. 162:224-231(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-23.
[9]"ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2."
Kerb R., Hoffmeyer S., Brinkmann U.
Pharmacogenomics 2:51-64(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[10]"Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome."
Begley G.S., Horvath A.R., Taylor J.C., Higgins C.F.
Mol. Immunol. 42:137-141(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PSMB5.
[11]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene."
Choi K.H., Chen C.-J., Kriegler M., Roninson I.B.
Cell 53:519-529(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT VAL-185.
[14]"Genetic polymorphism in MDR-1: a tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors."
Mickley L.A., Lee J.-S., Weng Z., Zhan Z., Alvarez M., Wilson W., Bates S.E., Fojo T.
Blood 91:1749-1756(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ALA-893 AND THR-999.
[15]"A new polymorphism (N21D) in the exon 2 of the human MDR1 gene encoding the P-glycoprotein."
Decleves X., Chevillard S., Charpentier C., Vielh P., Laplanche J.-L.
Hum. Mutat. 15:486-486(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT ASP-21.
[16]"Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo."
Hoffmeyer S., Burk O., von Richter O., Arnold H.P., Brockmoeller J., Johne A., Cascorbi I., Gerloff T., Roots I., Eichelbaum M., Brinkmann U.
Proc. Natl. Acad. Sci. U.S.A. 97:3473-3478(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ASP-21; LEU-103 AND ASN-400.
[17]"Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects."
Cascorbi I., Gerloff T., Johne A., Meisel C., Hoffmeyer S., Schwab M., Schaeffeler E., Eichelbaum M., Brinkmann U., Roots I.
Clin. Pharmacol. Ther. 69:169-174(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ASP-21; ASN-400; ALA-893; THR-893 AND PRO-1107.
[18]"Polymorphism of MDR1 gene in healthy Japanese subjects: a novel SNP with an amino acid substitution (Glu108Lys)."
Honda T., Dan Y., Koyabu N., Ieiri I., Otsubo K., Higuchi S., Ohtani H., Sawada J.
Drug Metab. Pharmacokinet. 17:479-481(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT LYS-108.
[19]"Twelve novel single nucleotide polymorphisms in ABCB1/MDR1 among Japanese patients with ventricular tachycardia who were administered amiodarone."
Itoda M., Saito Y., Komamura K., Ueno K., Kamakura S., Ozawa S., Sawada J.
Drug Metab. Pharmacokinet. 17:566-571(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT ILE-1251.
[20]"Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population."
Saito S., Iida A., Sekine A., Miura Y., Ogawa C., Kawauchi S., Higuchi S., Nakamura Y.
J. Hum. Genet. 47:38-50(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ALA-893 AND THR-893.
[21]"MDR1 Ala893 polymorphism is associated with inflammatory bowel disease."
Brant S.R., Panhuysen C.I.M., Nicolae D., Reddy D.M., Bonen D.K., Karaliukas R., Zhang L., Swanson E., Datta L.W., Moran T., Ravenhill G., Duerr R.H., Achkar J.-P., Karban A.S., Cho J.H.
Am. J. Hum. Genet. 73:1282-1292(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ALA-893 AND THR-893, ASSOCIATION WITH SUSCEPTIBILITY TO IBD13.
[22]Erratum
Brant S.R., Panhuysen C.I.M., Nicolae D., Reddy D.M., Bonen D.K., Karaliukas R., Zhang L., Swanson E., Datta L.W., Moran T., Ravenhill G., Duerr R.H., Achkar J.-P., Karban A.S., Cho J.H.
Am. J. Hum. Genet. 74:1080-1080(2004)
[23]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-887.
+Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs
SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

P-glycoprotein entry

ABCMdb

Database for mutations in ABC proteins

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M14758 mRNA. Translation: AAA59575.1.
M29447 expand/collapse EMBL AC list , M29424, M29425, M29426, M29427, M29428, M29429, M29430, M29431, M29432, M29433, M29434, M29435, M29436, M29437, M29438, M29439, M29440, M29441, M29442, M29443, M29444, M29445, M29446 Genomic DNA. Translation: AAA59576.1.
AF016535 mRNA. Translation: AAB69423.1.
AY910577 Genomic DNA. Translation: AAW82430.1.
AK290159 mRNA. Translation: BAF82848.1.
AC002457 Genomic DNA. Translation: AAM49149.1. Sequence problems.
AC005068 Genomic DNA. No translation available.
M37724 Genomic DNA. Translation: AAA88047.1.
M37725 Genomic DNA. Translation: AAA88048.1.
X58723 Genomic DNA. Translation: CAA41558.1.
CCDSCCDS5608.1.
PIRDVHU1. A34914.
RefSeqNP_000918.2. NM_000927.4.
UniGeneHs.489033.
Hs.737655.

3D structure databases

ProteinModelPortalP08183.
SMRP08183. Positions 32-630.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111262. 10 interactions.
IntActP08183. 6 interactions.
MINTMINT-5000901.
STRING9606.ENSP00000265724.

Chemistry

BindingDBP08183.
ChEMBLCHEMBL4302.
DrugBankDB00171. Adenosine triphosphate.
DB00802. Alfentanil.
DB01169. Arsenic trioxide.
DB01072. Atazanavir.
DB01136. Carvedilol.
DB01394. Colchicine.
DB00091. Cyclosporine.
DB00694. Daunorubicin.
DB00975. Dipyridamole.
DB01196. Estramustine.
DB00875. Flupenthixol.
DB00619. Imatinib.
DB01167. Itraconazole.
DB00622. Nicardipine.
DB01182. Propafenone.
DB01103. Quinacrine.
DB00908. Quinidine.
DB00243. Ranolazine.
DB01045. Rifampin.
DB00778. Roxithromycin.
DB01232. Saquinavir.
DB00675. Tamoxifen.
DB00570. Vinblastine.

Protein family/group databases

TCDB3.A.1.201.1. the atp-binding cassette (abc) superfamily.

PTM databases

PhosphoSiteP08183.

Polymorphism databases

DMDM238054374.

Proteomic databases

MaxQBP08183.
PaxDbP08183.
PRIDEP08183.

Protocols and materials databases

DNASU5243.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000265724; ENSP00000265724; ENSG00000085563.
GeneID5243.
KEGGhsa:5243.
UCSCuc003uiz.2. human.

Organism-specific databases

CTD5243.
GeneCardsGC07M087132.
H-InvDBHIX0033521.
HGNCHGNC:40. ABCB1.
HPACAB001716.
HPA002199.
MIM171050. gene.
612244. phenotype.
neXtProtNX_P08183.
Orphanet771. Ulcerative colitis.
PharmGKBPA267.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1132.
HOVERGENHBG080809.
InParanoidP08183.
KOK05658.
OMAITQNVAN.
OrthoDBEOG7Z3F4H.
PhylomeDBP08183.
TreeFamTF105193.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressP08183.
BgeeP08183.
CleanExHS_ABCB1.
GenevestigatorP08183.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiP-glycoprotein.
GenomeRNAi5243.
NextBio20254.
PROP08183.
SOURCESearch...

Entry information

Entry nameMDR1_HUMAN
AccessionPrimary (citable) accession number: P08183
Secondary accession number(s): A8K294, Q12755, Q14812
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: May 26, 2009
Last modified: July 9, 2014
This is version 172 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries