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P08183 - MDR1_HUMAN

UniProt

P08183 - MDR1_HUMAN

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Protein

Multidrug resistance protein 1

Gene

ABCB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

Catalytic activityi

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi427 – 4348ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1070 – 10778ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: GO_Central
  2. ATP binding Source: ProtInc
  3. transporter activity Source: ProtInc
  4. xenobiotic-transporting ATPase activity Source: UniProtKB-EC

GO - Biological processi

  1. drug transmembrane transport Source: Reactome
  2. G2/M transition of mitotic cell cycle Source: DFLAT
  3. response to drug Source: ProtInc
  4. small molecule metabolic process Source: Reactome
  5. stem cell proliferation Source: DFLAT
  6. transmembrane transport Source: GO_Central
  7. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_120801. Abacavir transmembrane transport.
REACT_15480. ABC-family proteins mediated transport.

Protein family/group databases

MoonProtiP08183.
TCDBi3.A.1.201.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein 1 (EC:3.6.3.44)
Alternative name(s):
ATP-binding cassette sub-family B member 1
P-glycoprotein 1
CD_antigen: CD243
Gene namesi
Name:ABCB1
Synonyms:MDR1, PGY1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:40. ABCB1.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444CytoplasmicBy similarityAdd
BLAST
Transmembranei45 – 6723HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini68 – 11649ExtracellularBy similarityAdd
BLAST
Transmembranei117 – 13721HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini138 – 18649CytoplasmicBy similarityAdd
BLAST
Transmembranei187 – 20822HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini209 – 2157ExtracellularBy similarity
Transmembranei216 – 23621HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini237 – 29256CytoplasmicBy similarityAdd
BLAST
Transmembranei293 – 31624HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini317 – 33014ExtracellularBy similarityAdd
BLAST
Transmembranei331 – 35222HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini353 – 711359CytoplasmicBy similarityAdd
BLAST
Transmembranei712 – 73221HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini733 – 75624ExtracellularBy similarityAdd
BLAST
Transmembranei757 – 77721HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini778 – 83255CytoplasmicBy similarityAdd
BLAST
Transmembranei833 – 85321HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini854 – 8541ExtracellularBy similarity
Transmembranei855 – 87420HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini875 – 93460CytoplasmicBy similarityAdd
BLAST
Transmembranei935 – 95723HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini958 – 97316ExtracellularBy similarityAdd
BLAST
Transmembranei974 – 99522HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini996 – 1280285CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: DFLAT
  2. extracellular vesicular exosome Source: UniProtKB
  3. integral component of membrane Source: GO_Central
  4. membrane Source: ProtInc
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Inflammatory bowel disease 13

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.

See also OMIM:612244
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti893 – 8931S → A Common allele; associated with susceptibility to IBD13; has decreased enzyme activity. 8 Publications
Corresponds to variant rs2032582 [ dbSNP | Ensembl ].		VAR_013361

Organism-specific databases

MIMi612244. phenotype.
Orphaneti771. Ulcerative colitis.
PharmGKBiPA267.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12801280Multidrug resistance protein 1PRO_0000093332Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
Modified residuei660 – 6601PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP08183.
PaxDbiP08183.
PRIDEiP08183.

PTM databases

PhosphoSiteiP08183.

Expressioni

Tissue specificityi

Expressed in liver, kidney, small intestine and brain.

Gene expression databases

BgeeiP08183.
CleanExiHS_ABCB1.
ExpressionAtlasiP08183. baseline and differential.
GenevestigatoriP08183.

Organism-specific databases

HPAiCAB001716.
HPA002199.

Interactioni

Subunit structurei

Interacts with PSMB5. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LAPTM4BQ86VI42EBI-1057359,EBI-3267258
RNF2Q994962EBI-1057359,EBI-722416

Protein-protein interaction databases

BioGridi111262. 11 interactions.
IntActiP08183. 6 interactions.
MINTiMINT-5000901.
STRINGi9606.ENSP00000265724.

Structurei

3D structure databases

ProteinModelPortaliP08183.
SMRiP08183. Positions 32-630.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 357307ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini392 – 628237ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini711 – 1000290ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1035 – 1273239ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification]Curated
Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
GeneTreeiENSGT00530000062896.
HOVERGENiHBG080809.
InParanoidiP08183.
KOiK05658.
OMAiRTINVRH.
OrthoDBiEOG7Z3F4H.
PhylomeDBiP08183.
TreeFamiTF105193.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030258. MDR1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24221:SF155. PTHR24221:SF155. 1 hit.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P08183-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLEGDRNGG AKKKNFFKLN NKSEKDKKEK KPTVSVFSMF RYSNWLDKLY 
        60         70         80         90        100
MVVGTLAAII HGAGLPLMML VFGEMTDIFA NAGNLEDLMS NITNRSDIND 
       110        120        130        140        150
TGFFMNLEED MTRYAYYYSG IGAGVLVAAY IQVSFWCLAA GRQIHKIRKQ 
       160        170        180        190        200
FFHAIMRQEI GWFDVHDVGE LNTRLTDDVS KINEGIGDKI GMFFQSMATF 
       210        220        230        240        250
FTGFIVGFTR GWKLTLVILA ISPVLGLSAA VWAKILSSFT DKELLAYAKA 
       260        270        280        290        300
GAVAEEVLAA IRTVIAFGGQ KKELERYNKN LEEAKRIGIK KAITANISIG 
       310        320        330        340        350
AAFLLIYASY ALAFWYGTTL VLSGEYSIGQ VLTVFFSVLI GAFSVGQASP 
       360        370        380        390        400
SIEAFANARG AAYEIFKIID NKPSIDSYSK SGHKPDNIKG NLEFRNVHFS 
       410        420        430        440        450
YPSRKEVKIL KGLNLKVQSG QTVALVGNSG CGKSTTVQLM QRLYDPTEGM 
       460        470        480        490        500
VSVDGQDIRT INVRFLREII GVVSQEPVLF ATTIAENIRY GRENVTMDEI 
       510        520        530        540        550
EKAVKEANAY DFIMKLPHKF DTLVGERGAQ LSGGQKQRIA IARALVRNPK 
       560        570        580        590        600
ILLLDEATSA LDTESEAVVQ VALDKARKGR TTIVIAHRLS TVRNADVIAG 
       610        620        630        640        650
FDDGVIVEKG NHDELMKEKG IYFKLVTMQT AGNEVELENA ADESKSEIDA 
       660        670        680        690        700
LEMSSNDSRS SLIRKRSTRR SVRGSQAQDR KLSTKEALDE SIPPVSFWRI 
       710        720        730        740        750
MKLNLTEWPY FVVGVFCAII NGGLQPAFAI IFSKIIGVFT RIDDPETKRQ 
       760        770        780        790        800
NSNLFSLLFL ALGIISFITF FLQGFTFGKA GEILTKRLRY MVFRSMLRQD 
       810        820        830        840        850
VSWFDDPKNT TGALTTRLAN DAAQVKGAIG SRLAVITQNI ANLGTGIIIS 
       860        870        880        890        900
FIYGWQLTLL LLAIVPIIAI AGVVEMKMLS GQALKDKKEL EGSGKIATEA 
       910        920        930        940        950
IENFRTVVSL TQEQKFEHMY AQSLQVPYRN SLRKAHIFGI TFSFTQAMMY 
       960        970        980        990       1000
FSYAGCFRFG AYLVAHKLMS FEDVLLVFSA VVFGAMAVGQ VSSFAPDYAK 
      1010       1020       1030       1040       1050
AKISAAHIIM IIEKTPLIDS YSTEGLMPNT LEGNVTFGEV VFNYPTRPDI 
      1060       1070       1080       1090       1100
PVLQGLSLEV KKGQTLALVG SSGCGKSTVV QLLERFYDPL AGKVLLDGKE 
      1110       1120       1130       1140       1150
IKRLNVQWLR AHLGIVSQEP ILFDCSIAEN IAYGDNSRVV SQEEIVRAAK 
      1160       1170       1180       1190       1200
EANIHAFIES LPNKYSTKVG DKGTQLSGGQ KQRIAIARAL VRQPHILLLD 
      1210       1220       1230       1240       1250
EATSALDTES EKVVQEALDK AREGRTCIVI AHRLSTIQNA DLIVVFQNGR 
      1260       1270       1280
VKEHGTHQQL LAQKGIYFSM VSVQAGTKRQ
Length:1,280
Mass (Da):141,479
Last modified:May 26, 2009 - v3
Checksum:iF0230744AB288C73
GO
Isoform 2 (identifier: P08183-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-177: RYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTD → S

Show »
Length:1,216
Mass (Da):134,032
Checksum:i227233F5F2259A8C
GO

Sequence cautioni

The sequence AAM49149.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231S → R in CAA41558. (PubMed:2568832)Curated
Sequence conflicti336 – 3361Missing in AAB69423. (PubMed:9038218)Curated

Polymorphismi

Genetic variation in ABCB1 may play a role in patients who do not respond to drug treatment.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171F → L.1 Publication
Corresponds to variant rs28381804 [ dbSNP | Ensembl ].		VAR_022276
Natural varianti21 – 211N → D.5 Publications
Corresponds to variant rs9282564 [ dbSNP | Ensembl ].		VAR_014704
Natural varianti44 – 441N → S.
Corresponds to variant rs1202183 [ dbSNP | Ensembl ].		VAR_055423
Natural varianti80 – 801A → E.
Corresponds to variant rs9282565 [ dbSNP | Ensembl ].		VAR_055424
Natural varianti103 – 1031F → L Rare polymorphism. 1 Publication
VAR_015001
Natural varianti108 – 1081E → K.1 Publication
VAR_018351
Natural varianti185 – 1851G → V in a colchicine-selected multidrug-resistant cell line; confers increased resistance to colchicine. 3 Publications
Corresponds to variant rs1128501 [ dbSNP | Ensembl ].		VAR_015002
Natural varianti261 – 2611I → V.
Corresponds to variant rs36008564 [ dbSNP | Ensembl ].		VAR_055425
Natural varianti400 – 4001S → N.3 Publications
Corresponds to variant rs2229109 [ dbSNP | Ensembl ].		VAR_015003
Natural varianti566 – 5661E → K.1 Publication
Corresponds to variant rs28381902 [ dbSNP | Ensembl ].		VAR_022277
Natural varianti593 – 5931R → C.1 Publication
Corresponds to variant rs28381914 [ dbSNP | Ensembl ].		VAR_022278
Natural varianti599 – 5991A → T.
Corresponds to variant rs2235036 [ dbSNP | Ensembl ].		VAR_055426
Natural varianti669 – 6691R → C.
Corresponds to variant rs35023033 [ dbSNP | Ensembl ].		VAR_055427
Natural varianti801 – 8011V → M.
Corresponds to variant rs2235039 [ dbSNP | Ensembl ].		VAR_055428
Natural varianti829 – 8291I → V.
Corresponds to variant rs2032581 [ dbSNP | Ensembl ].		VAR_055429
Natural varianti836 – 8361I → V.1 Publication
Corresponds to variant rs28381967 [ dbSNP | Ensembl ].		VAR_022279
Natural varianti887 – 8871K → N in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035737
Natural varianti893 – 8931S → A Common allele; associated with susceptibility to IBD13; has decreased enzyme activity. 8 Publications
Corresponds to variant rs2032582 [ dbSNP | Ensembl ].		VAR_013361
Natural varianti893 – 8931S → T Rare allele. 3 Publications
Corresponds to variant rs2032582 [ dbSNP | Ensembl ].		VAR_013362
Natural varianti986 – 9861M → V.
VAR_018352
Natural varianti999 – 9991A → T.1 Publication
VAR_015004
Natural varianti1051 – 10511P → A.1 Publication
Corresponds to variant rs28401798 [ dbSNP | Ensembl ].		VAR_022280
Natural varianti1107 – 11071Q → P.1 Publication
Corresponds to variant rs55852620 [ dbSNP | Ensembl ].		VAR_015005
Natural varianti1141 – 11411S → T.1 Publication
Corresponds to variant rs2229107 [ dbSNP | Ensembl ].		VAR_022281
Natural varianti1251 – 12511V → I.2 Publications
Corresponds to variant rs28364274 [ dbSNP | Ensembl ].		VAR_018353

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei113 – 17765RYAYY…TRLTD → S in isoform 2. 1 PublicationVSP_055769Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14758 mRNA. Translation: AAA59575.1.
M29447
, M29424, M29425, M29426, M29427, M29428, M29429, M29430, M29431, M29432, M29433, M29434, M29435, M29436, M29437, M29438, M29439, M29440, M29441, M29442, M29443, M29444, M29445, M29446 Genomic DNA. Translation: AAA59576.1.
AF016535 mRNA. Translation: AAB69423.1.
EU854148 mRNA. Translation: ACF94688.1.
AY910577 Genomic DNA. Translation: AAW82430.1.
AK290159 mRNA. Translation: BAF82848.1.
AC002457 Genomic DNA. Translation: AAM49149.1. Sequence problems.
AC005068 Genomic DNA. No translation available.
M37724 Genomic DNA. Translation: AAA88047.1.
M37725 Genomic DNA. Translation: AAA88048.1.
X58723 Genomic DNA. Translation: CAA41558.1.
CCDSiCCDS5608.1. [P08183-1]
PIRiA34914. DVHU1.
RefSeqiNP_000918.2. NM_000927.4. [P08183-1]
UniGeneiHs.489033.
Hs.737655.

Genome annotation databases

EnsembliENST00000265724; ENSP00000265724; ENSG00000085563. [P08183-1]
ENST00000543898; ENSP00000444095; ENSG00000085563. [P08183-2]
ENST00000622132; ENSP00000478255; ENSG00000085563. [P08183-1]
GeneIDi5243.
KEGGihsa:5243.
UCSCiuc003uiz.2. human. [P08183-1]
uc011khc.2. human.

Polymorphism databases

DMDMi238054374.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs
SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

P-glycoprotein entry

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14758 mRNA. Translation: AAA59575.1.
M29447
, M29424, M29425, M29426, M29427, M29428, M29429, M29430, M29431, M29432, M29433, M29434, M29435, M29436, M29437, M29438, M29439, M29440, M29441, M29442, M29443, M29444, M29445, M29446 Genomic DNA. Translation: AAA59576.1.
AF016535 mRNA. Translation: AAB69423.1.
EU854148 mRNA. Translation: ACF94688.1.
AY910577 Genomic DNA. Translation: AAW82430.1.
AK290159 mRNA. Translation: BAF82848.1.
AC002457 Genomic DNA. Translation: AAM49149.1. Sequence problems.
AC005068 Genomic DNA. No translation available.
M37724 Genomic DNA. Translation: AAA88047.1.
M37725 Genomic DNA. Translation: AAA88048.1.
X58723 Genomic DNA. Translation: CAA41558.1.
CCDSiCCDS5608.1. [P08183-1]
PIRiA34914. DVHU1.
RefSeqiNP_000918.2. NM_000927.4. [P08183-1]
UniGeneiHs.489033.
Hs.737655.

3D structure databases

ProteinModelPortaliP08183.
SMRiP08183. Positions 32-630.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111262. 11 interactions.
IntActiP08183. 6 interactions.
MINTiMINT-5000901.
STRINGi9606.ENSP00000265724.

Chemistry

BindingDBiP08183.
ChEMBLiCHEMBL4302.
DrugBankiDB01193. Acebutolol.
DB00316. Acetaminophen.
DB00945. Acetylsalicylic acid.
DB00171. Adenosine triphosphate.
DB05773. ado-trastuzumab emtansine.
DB08916. Afatinib.
DB00518. Albendazole.
DB00802. Alfentanil.
DB00523. Alitretinoin.
DB00915. Amantadine.
DB00345. Aminohippurate.
DB01118. Amiodarone.
DB00321. Amitriptyline.
DB00381. Amlodipine.
DB00701. Amprenavir.
DB00276. Amsacrine.
DB06605. Apixaban.
DB01169. Arsenic trioxide.
DB00637. Astemizole.
DB01072. Atazanavir.
DB00335. Atenolol.
DB01076. Atorvastatin.
DB06626. Axitinib.
DB00972. Azelastine.
DB00207. Azithromycin.
DB01086. Benzocaine.
DB01244. Bepridil.
DB00443. Betamethasone.
DB00810. Biperiden.
DB08873. Boceprevir.
DB06616. Bosutinib.
DB08870. Brentuximab vedotin.
DB01200. Bromocriptine.
DB00921. Buprenorphine.
DB00490. Buspirone.
DB06772. Cabazitaxel.
DB00201. Caffeine.
DB08907. Canagliflozin.
DB00796. Candesartan.
DB01197. Captopril.
DB00564. Carbamazepine.
DB08889. Carfilzomib.
DB01136. Carvedilol.
DB00520. Caspofungin.
DB00608. Chloroquine.
DB00477. Chlorpromazine.
DB00672. Chlorpropamide.
DB01239. Chlorprothixene.
DB01340. Cilazapril.
DB00501. Cimetidine.
DB00537. Ciprofloxacin.
DB00515. Cisplatin.
DB00215. Citalopram.
DB01211. Clarithromycin.
DB00349. Clobazam.
DB00845. Clofazimine.
DB00882. Clomifene.
DB01242. Clomipramine.
DB00575. Clonidine.
DB00758. Clopidogrel.
DB00257. Clotrimazole.
DB00363. Clozapine.
DB01394. Colchicine.
DB00286. Conjugated Estrogens.
DB08865. Crizotinib.
DB00531. Cyclophosphamide.
DB00091. Cyclosporine.
DB06695. Dabigatran etexilate.
DB08912. Dabrafenib.
DB00970. Dactinomycin.
DB06292. Dapagliflozin.
DB01254. Dasatinib.
DB00694. Daunorubicin.
DB04840. Debrisoquin.
DB01151. Desipramine.
DB00967. Desloratadine.
DB01234. Dexamethasone.
DB00514. Dextromethorphan.
DB00829. Diazepam.
DB00586. Diclofenac.
DB00255. Diethylstilbestrol.
DB01396. Digitoxin.
DB00390. Digoxin.
DB00320. Dihydroergotamine.
DB00343. Diltiazem.
DB00975. Dipyridamole.
DB01248. Docetaxel.
DB01184. Domperidone.
DB00590. Doxazosin.
DB01142. Doxepin.
DB00997. Doxorubicin.
DB00470. Dronabinol.
DB04855. Dronedarone.
DB00216. Eletriptan.
DB00584. Enalapril.
DB08899. Enzalutamide.
DB00751. Epinastine.
DB01253. Ergonovine.
DB00696. Ergotamine.
DB00530. Erlotinib.
DB00199. Erythromycin.
DB00783. Estradiol.
DB01196. Estramustine.
DB04573. Estriol.
DB00655. Estrone.
DB00977. Ethinyl Estradiol.
DB00773. Etoposide.
DB06414. Etravirine.
DB00973. Ezetimibe.
DB01023. Felodipine.
DB00813. Fentanyl.
DB06702. Fesoterodine.
DB00950. Fexofenadine.
DB08874. Fidaxomicin.
DB00196. Fluconazole.
DB00472. Fluoxetine.
DB00875. Flupentixol.
DB00623. Fluphenazine.
DB00690. Flurazepam.
DB08906. Fluticasone furoate.
DB00176. Fluvoxamine.
DB00317. Gefitinib.
DB00441. Gemcitabine.
DB01016. Glyburide.
DB00027. Gramicidin D.
DB00502. Haloperidol.
DB00741. Hydrocortisone.
DB01050. Ibuprofen.
DB00619. Imatinib.
DB00458. Imipramine.
DB05039. Indacaterol.
DB00224. Indinavir.
DB00328. Indomethacin.
DB00762. Irinotecan.
DB01167. Itraconazole.
DB08820. Ivacaftor.
DB00602. Ivermectin.
DB01221. Ketamine.
DB01587. Ketazolam.
DB01026. Ketoconazole.
DB00709. Lamivudine.
DB00555. Lamotrigine.
DB00448. Lansoprazole.
DB01259. Lapatinib.
DB00480. Lenalidomide.
DB01202. Levetiracetam.
DB01137. Levofloxacin.
DB08918. Levomilnacipran.
DB00451. Levothyroxine.
DB00281. Lidocaine.
DB08882. Linagliptin.
DB00279. Liothyronine.
DB01583. Liotrix.
DB00722. Lisinopril.
DB08827. Lomitapide.
DB00836. Loperamide.
DB01601. Lopinavir.
DB00455. Loratadine.
DB00678. Losartan.
DB00227. Lovastatin.
DB00742. Mannitol.
DB00934. Maprotiline.
DB00643. Mebendazole.
DB00358. Mefloquine.
DB00351. Megestrol acetate.
DB00371. Meprobamate.
DB00333. Methadone.
DB00563. Methotrexate.
DB00959. Methylprednisolone.
DB00264. Metoprolol.
DB01110. Miconazole.
DB00683. Midazolam.
DB00834. Mifepristone.
DB08893. Mirabegron.
DB00305. Mitomycin.
DB01204. Mitoxantrone.
DB00295. Morphine.
DB00688. Mycophenolate mofetil.
DB01203. Nadolol.
DB01183. Naloxone.
DB00704. Naltrexone.
DB01149. Nefazodone.
DB00220. Nelfinavir.
DB01400. Neostigmine.
DB00622. Nicardipine.
DB01115. Nifedipine.
DB04868. Nilotinib.
DB00401. Nisoldipine.
DB01595. Nitrazepam.
DB01054. Nitrendipine.
DB00585. Nizatidine.
DB00717. Norethindrone.
DB00334. Olanzapine.
DB00338. Omeprazole.
DB01229. Paclitaxel.
DB00213. Pantoprazole.
DB00715. Paroxetine.
DB06589. Pazopanib.
DB00790. Perindopril.
DB01174. Phenobarbital.
DB00252. Phenytoin.
DB01100. Pimozide.
DB08860. Pitavastatin.
DB08910. Pomalidomide.
DB08901. Ponatinib.
DB01263. Posaconazole.
DB00175. Pravastatin.
DB00457. Prazosin.
DB00860. Prednisolone.
DB00635. Prednisone.
DB01032. Probenecid.
DB00396. Progesterone.
DB01069. Promethazine.
DB01182. Propafenone.
DB00571. Propranolol.
DB00344. Protriptyline.
DB01224. Quetiapine.
DB01103. Quinacrine.
DB00908. Quinidine.
DB00468. Quinine.
DB00863. Ranitidine.
DB00234. Reboxetine.
DB08896. Regorafenib.
DB00206. Reserpine.
DB01045. Rifampicin.
DB08864. Rilpivirine.
DB00734. Risperidone.
DB00503. Ritonavir.
DB06228. Rivaroxaban.
DB00778. Roxithromycin.
DB00936. Salicylic acid.
DB01232. Saquinavir.
DB00747. Scopolamine.
DB01037. Selegiline.
DB01104. Sertraline.
DB06207. Silodosin.
DB06290. SIMEPREVIR.
DB00641. Simvastatin.
DB00877. Sirolimus.
DB01261. Sitagliptin.
DB08934. SOFOSBUVIR.
DB00398. Sorafenib.
DB01208. Sparfloxacin.
DB00421. Spironolactone.
DB00428. Streptozocin.
DB01138. Sulfinpyrazone.
DB00669. Sumatriptan.
DB01268. Sunitinib.
DB00864. Tacrolimus.
DB00675. Tamoxifen.
DB05521. Telaprevir.
DB00966. Telmisartan.
DB06287. Temsirolimus.
DB01162. Terazosin.
DB00624. Testosterone.
DB08816. Ticagrelor.
DB00373. Timolol.
DB06212. Tolvaptan.
DB01030. Topotecan.
DB00539. Toremifene.
DB00656. Trazodone.
DB00831. Trifluoperazine.
DB00508. Triflupromazine.
DB00440. Trimethoprim.
DB00726. Trimipramine.
DB01361. Troleandomycin.
DB01339. Vecuronium.
DB00285. Venlafaxine.
DB00661. Verapamil.
DB00570. Vinblastine.
DB00541. Vincristine.
DB00361. Vinorelbine.
DB08828. Vismodegib.
DB04877. Voacamine.
DB00495. Zidovudine.

Protein family/group databases

MoonProtiP08183.
TCDBi3.A.1.201.1. the atp-binding cassette (abc) superfamily.

PTM databases

PhosphoSiteiP08183.

Polymorphism databases

DMDMi238054374.

Proteomic databases

MaxQBiP08183.
PaxDbiP08183.
PRIDEiP08183.

Protocols and materials databases

DNASUi5243.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265724; ENSP00000265724; ENSG00000085563. [P08183-1]
ENST00000543898; ENSP00000444095; ENSG00000085563. [P08183-2]
ENST00000622132; ENSP00000478255; ENSG00000085563. [P08183-1]
GeneIDi5243.
KEGGihsa:5243.
UCSCiuc003uiz.2. human. [P08183-1]
uc011khc.2. human.

Organism-specific databases

CTDi5243.
GeneCardsiGC07M087132.
H-InvDBHIX0033521.
HGNCiHGNC:40. ABCB1.
HPAiCAB001716.
HPA002199.
MIMi171050. gene.
612244. phenotype.
neXtProtiNX_P08183.
Orphaneti771. Ulcerative colitis.
PharmGKBiPA267.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1132.
GeneTreeiENSGT00530000062896.
HOVERGENiHBG080809.
InParanoidiP08183.
KOiK05658.
OMAiRTINVRH.
OrthoDBiEOG7Z3F4H.
PhylomeDBiP08183.
TreeFamiTF105193.

Enzyme and pathway databases

ReactomeiREACT_120801. Abacavir transmembrane transport.
REACT_15480. ABC-family proteins mediated transport.

Miscellaneous databases

ChiTaRSiABCB1. human.
GeneWikiiP-glycoprotein.
GenomeRNAii5243.
NextBioi20254.
PROiP08183.
SOURCEiSearch...

Gene expression databases

BgeeiP08183.
CleanExiHS_ABCB1.
ExpressionAtlasiP08183. baseline and differential.
GenevestigatoriP08183.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030258. MDR1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24221:SF155. PTHR24221:SF155. 1 hit.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells."
    Chen C.-J., Chin J.E., Ueda K., Clark D.P., Pastan I., Gottesman M.M., Roninson I.B.
    Cell 47:381-389(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS VAL-185 AND ALA-893.
  2. "Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins."
    Chen C.-J., Clark D.P., Ueda K., Pastan I., Gottesman M.M., Roninson I.B.
    J. Biol. Chem. 265:506-514(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-893.
  3. "Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins."
    Chen G., Duran G.E., Steger K.A., Lacayo N.J., Jaffrezou J.P., Dumontet C., Sikic B.I.
    J. Biol. Chem. 272:5974-5982(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS VAL-185 AND ALA-893.
  4. "Cloning of P-glycoprotein cDNA sequence from breast cancer MCF7 cell line."
    Jiang Y., Sun Q., Xie Z., Liu F., Xu W., Wang Y.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  5. NIEHS SNPs program
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-17; ASP-21; ASN-400; LYS-566; CYS-593; VAL-836; ALA-893; ALA-1051; THR-1141 AND ILE-1251.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-21.
    Tissue: Thalamus.
  7. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "mdr1/P-glycoprotein gene segments analyzed from various human leukemic cell lines exhibiting different multidrug resistance profiles."
    Gekeler V., Weger S., Probst H.
    Biochem. Biophys. Res. Commun. 169:796-802(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 178-215 AND 800-856.
  9. "P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance."
    Kioka N., Tsubota J., Kakehi Y., Komano T., Gottesman M.M., Pastan I., Ueda K.
    Biochem. Biophys. Res. Commun. 162:224-231(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-23 (ISOFORM 1/2).
  10. "ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2."
    Kerb R., Hoffmeyer S., Brinkmann U.
    Pharmacogenomics 2:51-64(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  11. "Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome."
    Begley G.S., Horvath A.R., Taylor J.C., Higgins C.F.
    Mol. Immunol. 42:137-141(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PSMB5.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function."
    Katayama K., Yamaguchi M., Noguchi K., Sugimoto Y.
    Cancer Lett. 345:124-131(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PPP2R3C.
  15. "An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene."
    Choi K.H., Chen C.-J., Kriegler M., Roninson I.B.
    Cell 53:519-529(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT VAL-185.
  16. "Genetic polymorphism in MDR-1: a tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors."
    Mickley L.A., Lee J.-S., Weng Z., Zhan Z., Alvarez M., Wilson W., Bates S.E., Fojo T.
    Blood 91:1749-1756(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ALA-893 AND THR-999.
  17. "A new polymorphism (N21D) in the exon 2 of the human MDR1 gene encoding the P-glycoprotein."
    Decleves X., Chevillard S., Charpentier C., Vielh P., Laplanche J.-L.
    Hum. Mutat. 15:486-486(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ASP-21.
  18. "Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo."
    Hoffmeyer S., Burk O., von Richter O., Arnold H.P., Brockmoeller J., Johne A., Cascorbi I., Gerloff T., Roots I., Eichelbaum M., Brinkmann U.
    Proc. Natl. Acad. Sci. U.S.A. 97:3473-3478(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ASP-21; LEU-103 AND ASN-400.
  19. "Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects."
    Cascorbi I., Gerloff T., Johne A., Meisel C., Hoffmeyer S., Schwab M., Schaeffeler E., Eichelbaum M., Brinkmann U., Roots I.
    Clin. Pharmacol. Ther. 69:169-174(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ASP-21; ASN-400; ALA-893; THR-893 AND PRO-1107.
  20. "Polymorphism of MDR1 gene in healthy Japanese subjects: a novel SNP with an amino acid substitution (Glu108Lys)."
    Honda T., Dan Y., Koyabu N., Ieiri I., Otsubo K., Higuchi S., Ohtani H., Sawada J.
    Drug Metab. Pharmacokinet. 17:479-481(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT LYS-108.
  21. "Twelve novel single nucleotide polymorphisms in ABCB1/MDR1 among Japanese patients with ventricular tachycardia who were administered amiodarone."
    Itoda M., Saito Y., Komamura K., Ueno K., Kamakura S., Ozawa S., Sawada J.
    Drug Metab. Pharmacokinet. 17:566-571(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ILE-1251.
  22. "Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population."
    Saito S., Iida A., Sekine A., Miura Y., Ogawa C., Kawauchi S., Higuchi S., Nakamura Y.
    J. Hum. Genet. 47:38-50(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ALA-893 AND THR-893.
  23. Cited for: VARIANTS ALA-893 AND THR-893, ASSOCIATION WITH SUSCEPTIBILITY TO IBD13.
  24. Erratum
    Brant S.R., Panhuysen C.I.M., Nicolae D., Reddy D.M., Bonen D.K., Karaliukas R., Zhang L., Swanson E., Datta L.W., Moran T., Ravenhill G., Duerr R.H., Achkar J.-P., Karban A.S., Cho J.H.
    Am. J. Hum. Genet. 74:1080-1080(2004)
  25. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-887.
+Additional computationally mapped references.

Entry informationi

Entry nameiMDR1_HUMAN
AccessioniPrimary (citable) accession number: P08183
Secondary accession number(s): A8K294
, B5AK60, Q12755, Q14812
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: May 26, 2009
Last modified: February 4, 2015
This is version 178 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.