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Protein

Casein kinase II subunit beta

Gene

CkIIbeta

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.By similarity1 Publication

GO - Molecular functioni

  • protein kinase activity Source: FlyBase
  • protein kinase regulator activity Source: FlyBase
  • protein serine/threonine kinase activity Source: FlyBase

GO - Biological processi

  • circadian rhythm Source: FlyBase
  • eclosion rhythm Source: FlyBase
  • intracellular mRNA localization involved in pattern specification process Source: FlyBase
  • locomotor rhythm Source: FlyBase
  • mushroom body development Source: FlyBase
  • oocyte dorsal/ventral axis specification Source: FlyBase
  • protein phosphorylation Source: FlyBase
  • rhythmic behavior Source: FlyBase
  • Wnt signaling pathway Source: UniProtKB-KW

Keywordsi

Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-DME-209190 Phosphorylation of CI
R-DME-209214 Phosphorylation of SMO
R-DME-432553 Phosphorylation of PER and TIM
R-DME-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase II subunit beta
Short name:
CK II beta
Gene namesi
Name:CkIIbeta
Synonyms:Cask-II-b
ORF Names:CG15224
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0000259 CkIIbeta

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000682451 – 235Casein kinase II subunit betaAdd BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2Phosphoserine; by autocatalysisCurated1

Post-translational modificationi

Phosphorylated by alpha subunit.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP08182
PRIDEiP08182

PTM databases

iPTMnetiP08182

Expressioni

Gene expression databases

BgeeiFBgn0000259
ExpressionAtlasiP08182 differential
GenevisibleiP08182 DM

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.

Binary interactionsi

WithEntry#Exp.IntActNotes
CkIIalphaP081814EBI-128120,EBI-93115

Protein-protein interaction databases

BioGridi58538, 62 interactors
DIPiDIP-17048N
IntActiP08182, 51 interactors
MINTiP08182
STRINGi7227.FBpp0089135

Structurei

3D structure databases

ProteinModelPortaliP08182
SMRiP08182
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 64Asp/Glu-rich (acidic)10

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3092 Eukaryota
COG5041 LUCA
GeneTreeiENSGT00390000003781
InParanoidiP08182
KOiK03115
OMAiCPRVLCQ
OrthoDBiEOG091G0L2H
PhylomeDBiP08182

Family and domain databases

Gene3Di1.10.1820.10, 1 hit
InterProiView protein in InterPro
IPR016149 Casein_kin_II_reg-sub_N
IPR035991 Casein_kinase_II_beta_like
IPR000704 Casein_kinase_II_reg-sub
PANTHERiPTHR11740 PTHR11740, 1 hit
PfamiView protein in Pfam
PF01214 CK_II_beta, 1 hit
PRINTSiPR00472 CASNKINASEII
SMARTiView protein in SMART
SM01085 CK_II_beta, 1 hit
SUPFAMiSSF57798 SSF57798, 1 hit
PROSITEiView protein in PROSITE
PS01101 CK2_BETA, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform E (identifier: P08182-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSSEEVSWV TWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPNYRQAL
60 70 80 90 100
DMILDLEPED ELEDNPLQSD MTEQAAEMLY GLIHARYILT NRGIAQMIEK
110 120 130 140 150
YQTGDFGHCP RVYCESQPML PLGLSDIPGE AMVKTYCPKC IDVYTPKSSR
160 170 180 190 200
HHHTDGAYFG TGFPHMLFMV HPEYRPKRPT NQFVPRLYGF KIHSLAYQIQ
210 220 230
LQAAANFKMP LRAQRGQPPK DEEPENNADT VPKRL
Note: No experimental confirmation available.
Length:235
Mass (Da):27,088
Last modified:September 27, 2004 - v2
Checksum:i8109CBF2A2B543B1
GO
Isoform B (identifier: P08182-3) [UniParc]FASTAAdd to basket
Also known as: G

The sequence of this isoform differs from the canonical sequence as follows:
     214-235: QRGQPPKDEEPENNADTVPKRL → KN

Show »
Length:215
Mass (Da):24,829
Checksum:i51D375BCEC4AC06F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011641214 – 235QRGQP…VPKRL → KN in isoform B. 2 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16535 mRNA Translation: AAA28430.1
U52952 Genomic DNA Translation: AAC13880.1
AE014298 Genomic DNA Translation: AAF48092.3
AE014298 Genomic DNA Translation: AAF48093.1
AE014298 Genomic DNA Translation: AAS65321.1
AY113447 mRNA Translation: AAM29452.1
RefSeqiNP_001014731.1, NM_001014731.2 [P08182-3]
NP_001245628.1, NM_001258699.1 [P08182-3]
NP_511131.3, NM_078576.5 [P08182-3]
NP_542940.1, NM_080762.4 [P08182-3]
NP_727561.1, NM_167304.3 [P08182-3]
NP_727562.1, NM_167305.3 [P08182-3]
NP_996415.1, NM_206692.3 [P08182-1]
UniGeneiDm.142

Genome annotation databases

EnsemblMetazoaiFBtr0073558; FBpp0073403; FBgn0000259 [P08182-3]
FBtr0073560; FBpp0073405; FBgn0000259 [P08182-3]
FBtr0073561; FBpp0073406; FBgn0000259 [P08182-3]
FBtr0073562; FBpp0089135; FBgn0000259 [P08182-1]
FBtr0100540; FBpp0099985; FBgn0000259 [P08182-3]
FBtr0299569; FBpp0288844; FBgn0000259 [P08182-3]
FBtr0307896; FBpp0300330; FBgn0000259 [P08182-3]
GeneIDi32132
KEGGidme:Dmel_CG15224

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCSK2B_DROME
AccessioniPrimary (citable) accession number: P08182
Secondary accession number(s): Q76NS4, Q9VYU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: September 27, 2004
Last modified: March 28, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health