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Protein

Casein kinase II subunit beta

Gene

CkIIbeta

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.By similarity1 Publication

GO - Molecular functioni

  • protein kinase activity Source: FlyBase
  • protein kinase regulator activity Source: FlyBase
  • protein serine/threonine kinase activity Source: FlyBase

GO - Biological processi

  • cellular response to starvation Source: FlyBase
  • circadian rhythm Source: FlyBase
  • eclosion rhythm Source: FlyBase
  • intracellular mRNA localization involved in pattern specification process Source: FlyBase
  • locomotor rhythm Source: FlyBase
  • mushroom body development Source: FlyBase
  • neurogenesis Source: FlyBase
  • oocyte dorsal/ventral axis specification Source: FlyBase
  • protein phosphorylation Source: FlyBase
  • rhythmic behavior Source: FlyBase
  • Wnt signaling pathway Source: UniProtKB-KW

Keywordsi

Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-DME-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase II subunit beta
Short name:
CK II beta
Gene namesi
Name:CkIIbeta
Synonyms:Cask-II-b
ORF Names:CG15224
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0000259. CkIIbeta.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • cytosol Source: FlyBase
  • nucleus Source: FlyBase
  • protein kinase CK2 complex Source: FlyBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000682451 – 235Casein kinase II subunit betaAdd BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2Phosphoserine; by autocatalysisCurated1

Post-translational modificationi

Phosphorylated by alpha subunit.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP08182.
PRIDEiP08182.

PTM databases

iPTMnetiP08182.

Expressioni

Gene expression databases

BgeeiFBgn0000259.
ExpressionAtlasiP08182. differential.
GenevisibleiP08182. DM.

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.

Protein-protein interaction databases

BioGridi58538. 51 interactors.
DIPiDIP-17048N.
IntActiP08182. 10 interactors.
MINTiMINT-252263.
STRINGi7227.FBpp0089135.

Structurei

3D structure databases

ProteinModelPortaliP08182.
SMRiP08182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 64Asp/Glu-rich (acidic)10

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3092. Eukaryota.
COG5041. LUCA.
GeneTreeiENSGT00390000003781.
InParanoidiP08182.
KOiK03115.
OMAiDTIPKRI.
OrthoDBiEOG091G0L2H.
PhylomeDBiP08182.

Family and domain databases

Gene3Di1.10.1820.10. 1 hit.
2.20.25.20. 1 hit.
InterProiView protein in InterPro
IPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
PANTHERiPTHR11740. PTHR11740. 1 hit.
PfamiView protein in Pfam
PF01214. CK_II_beta. 1 hit.
PRINTSiPR00472. CASNKINASEII.
SMARTiView protein in SMART
SM01085. CK_II_beta. 1 hit.
SUPFAMiSSF57798. SSF57798. 1 hit.
PROSITEiView protein in PROSITE
PS01101. CK2_BETA. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform E (identifier: P08182-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSSEEVSWV TWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPNYRQAL
60 70 80 90 100
DMILDLEPED ELEDNPLQSD MTEQAAEMLY GLIHARYILT NRGIAQMIEK
110 120 130 140 150
YQTGDFGHCP RVYCESQPML PLGLSDIPGE AMVKTYCPKC IDVYTPKSSR
160 170 180 190 200
HHHTDGAYFG TGFPHMLFMV HPEYRPKRPT NQFVPRLYGF KIHSLAYQIQ
210 220 230
LQAAANFKMP LRAQRGQPPK DEEPENNADT VPKRL
Note: No experimental confirmation available.
Length:235
Mass (Da):27,088
Last modified:September 27, 2004 - v2
Checksum:i8109CBF2A2B543B1
GO
Isoform B (identifier: P08182-3) [UniParc]FASTAAdd to basket
Also known as: G

The sequence of this isoform differs from the canonical sequence as follows:
     214-235: QRGQPPKDEEPENNADTVPKRL → KN

Show »
Length:215
Mass (Da):24,829
Checksum:i51D375BCEC4AC06F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011641214 – 235QRGQP…VPKRL → KN in isoform B. 2 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16535 mRNA. Translation: AAA28430.1.
U52952 Genomic DNA. Translation: AAC13880.1.
AE014298 Genomic DNA. Translation: AAF48092.3.
AE014298 Genomic DNA. Translation: AAF48093.1.
AE014298 Genomic DNA. Translation: AAS65321.1.
AY113447 mRNA. Translation: AAM29452.1.
RefSeqiNP_001014731.1. NM_001014731.2. [P08182-3]
NP_001245628.1. NM_001258699.1. [P08182-3]
NP_511131.3. NM_078576.5. [P08182-3]
NP_542940.1. NM_080762.4. [P08182-3]
NP_727561.1. NM_167304.3. [P08182-3]
NP_727562.1. NM_167305.3. [P08182-3]
NP_996415.1. NM_206692.3. [P08182-1]
UniGeneiDm.142.

Genome annotation databases

EnsemblMetazoaiFBtr0073562; FBpp0089135; FBgn0000259. [P08182-1]
GeneIDi32132.
KEGGidme:Dmel_CG15224.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16535 mRNA. Translation: AAA28430.1.
U52952 Genomic DNA. Translation: AAC13880.1.
AE014298 Genomic DNA. Translation: AAF48092.3.
AE014298 Genomic DNA. Translation: AAF48093.1.
AE014298 Genomic DNA. Translation: AAS65321.1.
AY113447 mRNA. Translation: AAM29452.1.
RefSeqiNP_001014731.1. NM_001014731.2. [P08182-3]
NP_001245628.1. NM_001258699.1. [P08182-3]
NP_511131.3. NM_078576.5. [P08182-3]
NP_542940.1. NM_080762.4. [P08182-3]
NP_727561.1. NM_167304.3. [P08182-3]
NP_727562.1. NM_167305.3. [P08182-3]
NP_996415.1. NM_206692.3. [P08182-1]
UniGeneiDm.142.

3D structure databases

ProteinModelPortaliP08182.
SMRiP08182.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi58538. 51 interactors.
DIPiDIP-17048N.
IntActiP08182. 10 interactors.
MINTiMINT-252263.
STRINGi7227.FBpp0089135.

PTM databases

iPTMnetiP08182.

Proteomic databases

PaxDbiP08182.
PRIDEiP08182.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0073562; FBpp0089135; FBgn0000259. [P08182-1]
GeneIDi32132.
KEGGidme:Dmel_CG15224.

Organism-specific databases

CTDi32132.
FlyBaseiFBgn0000259. CkIIbeta.

Phylogenomic databases

eggNOGiKOG3092. Eukaryota.
COG5041. LUCA.
GeneTreeiENSGT00390000003781.
InParanoidiP08182.
KOiK03115.
OMAiDTIPKRI.
OrthoDBiEOG091G0L2H.
PhylomeDBiP08182.

Enzyme and pathway databases

ReactomeiR-DME-6798695. Neutrophil degranulation.

Miscellaneous databases

GenomeRNAii32132.
PROiPR:P08182.

Gene expression databases

BgeeiFBgn0000259.
ExpressionAtlasiP08182. differential.
GenevisibleiP08182. DM.

Family and domain databases

Gene3Di1.10.1820.10. 1 hit.
2.20.25.20. 1 hit.
InterProiView protein in InterPro
IPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
PANTHERiPTHR11740. PTHR11740. 1 hit.
PfamiView protein in Pfam
PF01214. CK_II_beta. 1 hit.
PRINTSiPR00472. CASNKINASEII.
SMARTiView protein in SMART
SM01085. CK_II_beta. 1 hit.
SUPFAMiSSF57798. SSF57798. 1 hit.
PROSITEiView protein in PROSITE
PS01101. CK2_BETA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCSK2B_DROME
AccessioniPrimary (citable) accession number: P08182
Secondary accession number(s): Q76NS4, Q9VYU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: September 27, 2004
Last modified: April 12, 2017
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.