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P08172

- ACM2_HUMAN

UniProt

P08172 - ACM2_HUMAN

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Protein

Muscarinic acetylcholine receptor M2

Gene

CHRM2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.2 Publications

GO - Molecular functioni

  1. G-protein coupled acetylcholine receptor activity Source: UniProtKB

GO - Biological processi

  1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: ProtInc
  2. G-protein coupled acetylcholine receptor signaling pathway Source: UniProtKB
  3. G-protein coupled receptor signaling pathway Source: ProtInc
  4. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  5. nervous system development Source: ProtInc
  6. phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway Source: ProtInc
  7. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: UniProtKB
  8. regulation of heart contraction Source: ProtInc
  9. response to virus Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_16943. Muscarinic acetylcholine receptors.
REACT_19231. G alpha (i) signalling events.
SignaLinkiP08172.

Names & Taxonomyi

Protein namesi
Recommended name:
Muscarinic acetylcholine receptor M2
Gene namesi
Name:CHRM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:1951. CHRM2.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Cell junctionsynapsepostsynaptic cell membrane; Multi-pass membrane protein
Note: Phosphorylation in response to agonist binding promotes receptor internalization.By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. integral component of plasma membrane Source: UniProtKB
  3. plasma membrane Source: LIFEdb
  4. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

Major depressive disorder (MDD) [MIM:608516]: A common psychiatric disorder. It is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning.1 Publication
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi58 – 581N → A: Nearly abolishes signaling via downstream effectors. 1 Publication
Mutagenesisi103 – 1031D → E: Reduced affinity for acetylcholine. Abolishes signaling via downstream effectors. 1 Publication
Mutagenesisi206 – 2061Y → F: Abolishes signaling via downstream effectors. 1 Publication
Mutagenesisi404 – 4041N → Q: Reduced affinity for acetylcholine. Reduces signaling via downstream effectors. 1 Publication

Organism-specific databases

MIMi103780. phenotype.
608516. phenotype.
PharmGKBiPA111.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466Muscarinic acetylcholine receptor M2PRO_0000069021Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi96 ↔ 176
Disulfide bondi413 ↔ 416
Modified residuei446 – 4461PhosphothreonineSequence Analysis
Modified residuei450 – 4501PhosphothreonineSequence Analysis
Modified residuei465 – 4651PhosphothreonineSequence Analysis

Post-translational modificationi

Phosphorylated in response to agonist treatment.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP08172.
PRIDEiP08172.

PTM databases

PhosphoSiteiP08172.

Expressioni

Inductioni

Up-regulated in response to enterovirus 71 (EV71) infection.1 Publication

Gene expression databases

BgeeiP08172.
CleanExiHS_CHRM2.
ExpressionAtlasiP08172. baseline and differential.
GenevestigatoriP08172.

Organism-specific databases

HPAiCAB022338.
HPA029795.

Interactioni

Subunit structurei

Interacts with ARRB1 and ARRB2. Interacts with GNB2L1/RACK1; the interaction regulates CHRM2 internalization.3 Publications

Protein-protein interaction databases

BioGridi107551. 4 interactions.
IntActiP08172. 4 interactions.
STRINGi9606.ENSP00000319984.

Structurei

Secondary structure

1
466
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi23 – 5028
Helixi52 – 543
Helixi57 – 7418
Helixi76 – 8510
Beta strandi86 – 883
Helixi93 – 12634
Turni128 – 1303
Helixi132 – 1343
Helixi137 – 16630
Helixi179 – 1824
Helixi184 – 19411
Helixi196 – 21318
Helixi384 – 41229
Helixi414 – 4163
Helixi419 – 43113
Turni432 – 4343
Helixi435 – 4439
Helixi445 – 45410

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LUBmodel-A1-50[»]
3UONX-ray3.00A1-217[»]
A377-466[»]
4MQSX-ray3.50A1-466[»]
4MQTX-ray3.70A1-466[»]
ProteinModelPortaliP08172.
SMRiP08172. Positions 20-217, 377-456.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222ExtracellularAdd
BLAST
Topological domaini46 – 5914CytoplasmicAdd
BLAST
Topological domaini81 – 9717ExtracellularAdd
BLAST
Topological domaini120 – 13920CytoplasmicAdd
BLAST
Topological domaini163 – 18422ExtracellularAdd
BLAST
Topological domaini210 – 387178CytoplasmicAdd
BLAST
Topological domaini411 – 4188Extracellular
Topological domaini443 – 46624CytoplasmicAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4523Helical; Name=1Add
BLAST
Transmembranei60 – 8021Helical; Name=2Add
BLAST
Transmembranei98 – 11922Helical; Name=3Add
BLAST
Transmembranei140 – 16223Helical; Name=4Add
BLAST
Transmembranei185 – 20925Helical; Name=5Add
BLAST
Transmembranei388 – 41023Helical; Name=6Add
BLAST
Transmembranei419 – 44224Helical; Name=7Add
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni103 – 1075Agonist bindingCurated
Regioni403 – 4042Agonist bindingCurated
Regioni426 – 4305Agonist bindingCurated

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi120 – 1223Important for signaling
Motifi436 – 4405Important for signaling

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG250863.
GeneTreeiENSGT00760000119165.
HOGENOMiHOG000231484.
HOVERGENiHBG105720.
InParanoidiP08172.
KOiK04130.
OMAiNNNMPGS.
OrthoDBiEOG7V49Z7.
PhylomeDBiP08172.
TreeFamiTF320495.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001065. Musac_Ach_M2_rcpt.
IPR000995. Musac_Ach_rcpt.
[Graphical view]
PANTHERiPTHR24249:SF57. PTHR24249:SF57. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00243. MUSCARINICR.
PR00539. MUSCRINICM2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08172-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNSTNSSNN SLALTSPYKT FEVVFIVLVA GSLSLVTIIG NILVMVSIKV
60 70 80 90 100
NRHLQTVNNY FLFSLACADL IIGVFSMNLY TLYTVIGYWP LGPVVCDLWL
110 120 130 140 150
ALDYVVSNAS VMNLLIISFD RYFCVTKPLT YPVKRTTKMA GMMIAAAWVL
160 170 180 190 200
SFILWAPAIL FWQFIVGVRT VEDGECYIQF FSNAAVTFGT AIAAFYLPVI
210 220 230 240 250
IMTVLYWHIS RASKSRIKKD KKEPVANQDP VSPSLVQGRI VKPNNNNMPS
260 270 280 290 300
SDDGLEHNKI QNGKAPRDPV TENCVQGEEK ESSNDSTSVS AVASNMRDDE
310 320 330 340 350
ITQDENTVST SLGHSKDENS KQTCIRIGTK TPKSDSCTPT NTTVEVVGSS
360 370 380 390 400
GQNGDEKQNI VARKIVKMTK QPAKKKPPPS REKKVTRTIL AILLAFIITW
410 420 430 440 450
APYNVMVLIN TFCAPCIPNT VWTIGYWLCY INSTINPACY ALCNATFKKT
460
FKHLLMCHYK NIGATR
Length:466
Mass (Da):51,715
Last modified:August 1, 1988 - v1
Checksum:i2FC2FD7748C22BEC
GO

Polymorphismi

Genetic variations in CHRM2 can influence susceptibility to alcoholism [MIMi:103780].

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16404 Genomic DNA. Translation: AAA51570.1.
X15264 Genomic DNA. Translation: CAA33335.1.
AF498916 mRNA. Translation: AAM18939.1.
BC095547 mRNA. Translation: AAH95547.1.
BC106741 mRNA. Translation: AAI06742.1.
BC106742 mRNA. Translation: AAI06743.1.
AB041391 Genomic DNA. Translation: BAA94476.1.
CCDSiCCDS5843.1.
PIRiS10126.
RefSeqiNP_000730.1. NM_000739.2.
NP_001006627.1. NM_001006626.1.
NP_001006628.1. NM_001006627.1.
NP_001006629.1. NM_001006628.1.
NP_001006630.1. NM_001006629.1.
NP_001006631.1. NM_001006630.1.
NP_001006632.1. NM_001006631.1.
NP_001006633.1. NM_001006632.1.
UniGeneiHs.535891.

Genome annotation databases

EnsembliENST00000320658; ENSP00000319984; ENSG00000181072.
ENST00000401861; ENSP00000384401; ENSG00000181072.
ENST00000445907; ENSP00000399745; ENSG00000181072.
ENST00000453373; ENSP00000415386; ENSG00000181072.
GeneIDi1129.
KEGGihsa:1129.
UCSCiuc003vtf.1. human.

Polymorphism databases

DMDMi113122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16404 Genomic DNA. Translation: AAA51570.1 .
X15264 Genomic DNA. Translation: CAA33335.1 .
AF498916 mRNA. Translation: AAM18939.1 .
BC095547 mRNA. Translation: AAH95547.1 .
BC106741 mRNA. Translation: AAI06742.1 .
BC106742 mRNA. Translation: AAI06743.1 .
AB041391 Genomic DNA. Translation: BAA94476.1 .
CCDSi CCDS5843.1.
PIRi S10126.
RefSeqi NP_000730.1. NM_000739.2.
NP_001006627.1. NM_001006626.1.
NP_001006628.1. NM_001006627.1.
NP_001006629.1. NM_001006628.1.
NP_001006630.1. NM_001006629.1.
NP_001006631.1. NM_001006630.1.
NP_001006632.1. NM_001006631.1.
NP_001006633.1. NM_001006632.1.
UniGenei Hs.535891.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1LUB model - A 1-50 [» ]
3UON X-ray 3.00 A 1-217 [» ]
A 377-466 [» ]
4MQS X-ray 3.50 A 1-466 [» ]
4MQT X-ray 3.70 A 1-466 [» ]
ProteinModelPortali P08172.
SMRi P08172. Positions 20-217, 377-456.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107551. 4 interactions.
IntActi P08172. 4 interactions.
STRINGi 9606.ENSP00000319984.

Chemistry

BindingDBi P08172.
ChEMBLi CHEMBL2094109.
DrugBanki DB08897. Aclidinium.
DB00321. Amitriptyline.
DB00543. Amoxapine.
DB00517. Anisotropine Methylbromide.
DB01238. Aripiprazole.
DB00572. Atropine.
DB01019. Bethanechol.
DB00835. Brompheniramine.
DB00411. Carbachol.
DB01239. Chlorprothixene.
DB00568. Cinnarizine.
DB00363. Clozapine.
DB00907. Cocaine.
DB00785. Cryptenamine.
DB00434. Cyproheptadine.
DB00496. Darifenacin.
DB01151. Desipramine.
DB00804. Dicyclomine.
DB08801. Dimetindene.
DB01231. Diphenidol.
DB00280. Disopyramide.
DB01135. Doxacurium chloride.
DB01142. Doxepin.
DB00392. Ethopropazine.
DB06702. Fesoterodine.
DB01148. Flavoxate.
DB00483. Gallamine Triethiodide.
DB00986. Glycopyrrolate.
DB00725. Homatropine Methylbromide.
DB00424. Hyoscyamine.
DB00458. Imipramine.
DB00332. Ipratropium bromide.
DB01221. Ketamine.
DB00408. Loxapine.
DB00934. Maprotiline.
DB01403. Methotrimeprazine.
DB00462. Methylscopolamine bromide.
DB00340. Metixene.
DB01336. Metocurine.
DB01226. Mivacurium.
DB00622. Nicardipine.
DB00540. Nortriptyline.
DB00334. Olanzapine.
DB01062. Oxybutynin.
DB00383. Oxyphencyclimine.
DB01337. Pancuronium.
DB00715. Paroxetine.
DB00454. Pethidine.
DB01085. Pilocarpine.
DB01338. Pipecuronium.
DB00387. Procyclidine.
DB00420. Promazine.
DB01069. Promethazine.
DB00777. Propiomazine.
DB01224. Quetiapine.
DB00728. Rocuronium.
DB00747. Scopolamine.
DB01591. Solifenacin.
DB00202. Succinylcholine.
DB01409. Tiotropium.
DB01036. Tolterodine.
DB00508. Triflupromazine.
DB00376. Trihexyphenidyl.
DB00726. Trimipramine.
DB00809. Tropicamide.
DB00246. Ziprasidone.
GuidetoPHARMACOLOGYi 14.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P08172.

Polymorphism databases

DMDMi 113122.

Proteomic databases

PaxDbi P08172.
PRIDEi P08172.

Protocols and materials databases

DNASUi 1129.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000320658 ; ENSP00000319984 ; ENSG00000181072 .
ENST00000401861 ; ENSP00000384401 ; ENSG00000181072 .
ENST00000445907 ; ENSP00000399745 ; ENSG00000181072 .
ENST00000453373 ; ENSP00000415386 ; ENSG00000181072 .
GeneIDi 1129.
KEGGi hsa:1129.
UCSCi uc003vtf.1. human.

Organism-specific databases

CTDi 1129.
GeneCardsi GC07P136553.
HGNCi HGNC:1951. CHRM2.
HPAi CAB022338.
HPA029795.
MIMi 103780. phenotype.
118493. gene.
608516. phenotype.
neXtProti NX_P08172.
PharmGKBi PA111.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG250863.
GeneTreei ENSGT00760000119165.
HOGENOMi HOG000231484.
HOVERGENi HBG105720.
InParanoidi P08172.
KOi K04130.
OMAi NNNMPGS.
OrthoDBi EOG7V49Z7.
PhylomeDBi P08172.
TreeFami TF320495.

Enzyme and pathway databases

Reactomei REACT_16943. Muscarinic acetylcholine receptors.
REACT_19231. G alpha (i) signalling events.
SignaLinki P08172.

Miscellaneous databases

GeneWikii Muscarinic_acetylcholine_receptor_M2.
GenomeRNAii 1129.
NextBioi 4680.
PROi P08172.
SOURCEi Search...

Gene expression databases

Bgeei P08172.
CleanExi HS_CHRM2.
ExpressionAtlasi P08172. baseline and differential.
Genevestigatori P08172.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001065. Musac_Ach_M2_rcpt.
IPR000995. Musac_Ach_rcpt.
[Graphical view ]
PANTHERi PTHR24249:SF57. PTHR24249:SF57. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00243. MUSCARINICR.
PR00539. MUSCRINICM2R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a family of muscarinic acetylcholine receptor genes."
    Bonner T.I., Buckley N.J., Young A.C., Brann M.R.
    Science 237:527-532(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors."
    Peralta E.G., Ashkenazi A., Winslow J.W., Smith D.H., Ramachandran J., Capon D.J.
    EMBO J. 6:3923-3929(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Human-specific amino acid changes found in 103 protein-coding genes."
    Kitano T., Liu Y.-H., Ueda S., Saitou N.
    Mol. Biol. Evol. 21:936-944(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-466.
  6. "Arrestin interactions with G protein-coupled receptors. Direct binding studies of wild type and mutant arrestins with rhodopsin, beta 2-adrenergic, and m2 muscarinic cholinergic receptors."
    Gurevich V.V., Dion S.B., Onorato J.J., Ptasienski J., Kim C.M., Sterne-Marr R., Hosey M.M., Benovic J.L.
    J. Biol. Chem. 270:720-731(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARRB1 AND ARRB2.
  7. "Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection."
    Leong W.F., Chow V.T.
    Cell. Microbiol. 8:565-580(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, IDENTIFICATION BY MASS SPECTROMETRY.
  8. "Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome."
    Wang J.C., Hinrichs A.L., Stock H., Budde J., Allen R., Bertelsen S., Kwon J.M., Wu W., Dick D.M., Rice J., Jones K., Nurnberger J.I. Jr., Tischfield J., Porjesz B., Edenberg H.J., Hesselbrock V., Crowe R., Schuckit M.
    , Begleiter H., Reich T., Goate A.M., Bierut L.J.
    Hum. Mol. Genet. 13:1903-1911(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ALCOHOLISM AND MAJOR DEPRESSIVE DISORDER.
  9. "RACK1 associates with muscarinic receptors and regulates M(2) receptor trafficking."
    Reiner C.L., McCullar J.S., Kow R.L., Le J.H., Goodlett D.R., Nathanson N.M.
    PLoS ONE 5:E13517-E13517(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GNB2L1.
  10. "Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist."
    Haga K., Kruse A.C., Asada H., Yurugi-Kobayashi T., Shiroishi M., Zhang C., Weis W.I., Okada T., Kobilka B.K., Haga T., Kobayashi T.
    Nature 482:547-551(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) IN COMPLEX WITH THE ANTAGONIST 3-QUINUCLIDINYLBENZILATE, SUBCELLULAR LOCATION, TOPOLOGY, DISULFIDE BOND.
  11. Cited for: X-RAY CRYSTALLOGRAPHY (3.50 ANGSTROMS) IN COMPLEXES WITH THE AGONIST IPEROXO AND THE ALLOSTERIC EFFECTOR LY2119620, FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, DISULFIDE BOND, MOTIF, MUTAGENESIS OF ASN-58; ASP-103; TYR-206 AND ASN-404.

Entry informationi

Entry nameiACM2_HUMAN
AccessioniPrimary (citable) accession number: P08172
Secondary accession number(s): Q4VBK6, Q9P1X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: October 29, 2014
This is version 155 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3