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Protein

Muscarinic acetylcholine receptor M2

Gene

CHRM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.2 Publications

GO - Molecular functioni

  • drug binding Source: Ensembl
  • G-protein coupled acetylcholine receptor activity Source: UniProtKB

GO - Biological processi

  • adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway Source: GO_Central
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: ProtInc
  • G-protein coupled acetylcholine receptor signaling pathway Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  • nervous system development Source: ProtInc
  • phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway Source: ProtInc
  • regulation of heart contraction Source: ProtInc
  • regulation of smooth muscle contraction Source: GO_Central
  • response to virus Source: UniProtKB
  • synaptic transmission, cholinergic Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181072-MONOMER.
ReactomeiR-HSA-390648. Muscarinic acetylcholine receptors.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.
SignaLinkiP08172.
SIGNORiP08172.

Names & Taxonomyi

Protein namesi
Recommended name:
Muscarinic acetylcholine receptor M2
Gene namesi
Name:CHRM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:1951. CHRM2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22ExtracellularAdd BLAST22
Transmembranei23 – 45Helical; Name=1Add BLAST23
Topological domaini46 – 59CytoplasmicAdd BLAST14
Transmembranei60 – 80Helical; Name=2Add BLAST21
Topological domaini81 – 97ExtracellularAdd BLAST17
Transmembranei98 – 119Helical; Name=3Add BLAST22
Topological domaini120 – 139CytoplasmicAdd BLAST20
Transmembranei140 – 162Helical; Name=4Add BLAST23
Topological domaini163 – 184ExtracellularAdd BLAST22
Transmembranei185 – 209Helical; Name=5Add BLAST25
Topological domaini210 – 387CytoplasmicAdd BLAST178
Transmembranei388 – 410Helical; Name=6Add BLAST23
Topological domaini411 – 418Extracellular8
Transmembranei419 – 442Helical; Name=7Add BLAST24
Topological domaini443 – 466CytoplasmicAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

Major depressive disorder (MDD)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA common psychiatric disorder. It is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning.
See also OMIM:608516

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi58N → A: Nearly abolishes signaling via downstream effectors. 1 Publication1
Mutagenesisi103D → E: Reduced affinity for acetylcholine. Abolishes signaling via downstream effectors. 1 Publication1
Mutagenesisi206Y → F: Abolishes signaling via downstream effectors. 1 Publication1
Mutagenesisi404N → Q: Reduced affinity for acetylcholine. Reduces signaling via downstream effectors. 1 Publication1

Organism-specific databases

DisGeNETi1129.
MIMi103780. phenotype.
608516. phenotype.
OpenTargetsiENSG00000181072.
PharmGKBiPA111.

Chemistry databases

ChEMBLiCHEMBL211.
DrugBankiDB08897. Aclidinium.
DB00321. Amitriptyline.
DB00543. Amoxapine.
DB00517. Anisotropine Methylbromide.
DB01238. Aripiprazole.
DB00572. Atropine.
DB01019. Bethanechol.
DB00835. Brompheniramine.
DB00411. Carbachol.
DB01239. Chlorprothixene.
DB00568. Cinnarizine.
DB00363. Clozapine.
DB00907. Cocaine.
DB00785. Cryptenamine.
DB00434. Cyproheptadine.
DB00496. Darifenacin.
DB01151. Desipramine.
DB00804. Dicyclomine.
DB08801. Dimetindene.
DB01231. Diphenidol.
DB00280. Disopyramide.
DB01135. Doxacurium chloride.
DB01142. Doxepin.
DB00392. Ethopropazine.
DB06702. Fesoterodine.
DB01148. Flavoxate.
DB00483. Gallamine Triethiodide.
DB00986. Glycopyrrolate.
DB00725. Homatropine Methylbromide.
DB00424. Hyoscyamine.
DB00458. Imipramine.
DB00332. Ipratropium bromide.
DB01221. Ketamine.
DB00408. Loxapine.
DB00934. Maprotiline.
DB01403. Methotrimeprazine.
DB00462. Methylscopolamine bromide.
DB00340. Metixene.
DB01336. Metocurine.
DB01226. Mivacurium.
DB00622. Nicardipine.
DB00540. Nortriptyline.
DB00334. Olanzapine.
DB01062. Oxybutynin.
DB00383. Oxyphencyclimine.
DB01337. Pancuronium.
DB00715. Paroxetine.
DB00454. Pethidine.
DB01085. Pilocarpine.
DB01338. Pipecuronium.
DB00387. Procyclidine.
DB00420. Promazine.
DB01069. Promethazine.
DB00777. Propiomazine.
DB01224. Quetiapine.
DB00728. Rocuronium.
DB00747. Scopolamine.
DB01591. Solifenacin.
DB00202. Succinylcholine.
DB01409. Tiotropium.
DB01036. Tolterodine.
DB00508. Triflupromazine.
DB00376. Trihexyphenidyl.
DB00726. Trimipramine.
DB00809. Tropicamide.
DB09076. Umeclidinium.
DB00246. Ziprasidone.
GuidetoPHARMACOLOGYi14.

Polymorphism and mutation databases

BioMutaiCHRM2.
DMDMi113122.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690211 – 466Muscarinic acetylcholine receptor M2Add BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1
Glycosylationi9N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi96 ↔ 176
Modified residuei232PhosphoserineBy similarity1
Disulfide bondi413 ↔ 416
Modified residuei446PhosphothreonineSequence analysis1
Modified residuei450PhosphothreonineSequence analysis1
Modified residuei465PhosphothreonineSequence analysis1

Post-translational modificationi

Phosphorylated in response to agonist treatment.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP08172.
PaxDbiP08172.
PeptideAtlasiP08172.
PRIDEiP08172.

PTM databases

iPTMnetiP08172.
PhosphoSitePlusiP08172.
SwissPalmiP08172.

Expressioni

Inductioni

Up-regulated in response to enterovirus 71 (EV71) infection.1 Publication

Gene expression databases

BgeeiENSG00000181072.
CleanExiHS_CHRM2.
ExpressionAtlasiP08172. baseline and differential.
GenevisibleiP08172. HS.

Organism-specific databases

HPAiCAB022338.
HPA029795.

Interactioni

Subunit structurei

Interacts with ARRB1 and ARRB2. Interacts with RACK1; the interaction regulates CHRM2 internalization.3 Publications

Protein-protein interaction databases

BioGridi107551. 4 interactors.
DIPiDIP-56282N.
IntActiP08172. 12 interactors.
STRINGi9606.ENSP00000319984.

Chemistry databases

BindingDBiP08172.

Structurei

Secondary structure

1466
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi23 – 50Combined sources28
Helixi52 – 54Combined sources3
Helixi57 – 74Combined sources18
Helixi76 – 85Combined sources10
Beta strandi86 – 88Combined sources3
Helixi93 – 126Combined sources34
Turni128 – 130Combined sources3
Helixi132 – 134Combined sources3
Helixi137 – 166Combined sources30
Helixi179 – 182Combined sources4
Helixi184 – 194Combined sources11
Helixi196 – 213Combined sources18
Helixi384 – 412Combined sources29
Helixi414 – 416Combined sources3
Helixi419 – 431Combined sources13
Turni432 – 434Combined sources3
Helixi435 – 443Combined sources9
Helixi445 – 454Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LUBmodel-A1-50[»]
3UONX-ray3.00A1-217[»]
A377-466[»]
4MQSX-ray3.50A1-466[»]
4MQTX-ray3.70A1-466[»]
ProteinModelPortaliP08172.
SMRiP08172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni103 – 107Agonist bindingCurated5
Regioni403 – 404Agonist bindingCurated2
Regioni426 – 430Agonist bindingCurated5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi120 – 122Important for signaling3
Motifi436 – 440Important for signaling5

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4220. Eukaryota.
ENOG410YCQR. LUCA.
GeneTreeiENSGT00780000121874.
HOGENOMiHOG000231484.
HOVERGENiHBG105720.
InParanoidiP08172.
KOiK04130.
OMAiNNNMPGS.
OrthoDBiEOG091G06VI.
PhylomeDBiP08172.
TreeFamiTF320495.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001065. Musac_Ach_M2_rcpt.
IPR000995. Musac_Ach_rcpt.
[Graphical view]
PANTHERiPTHR24249:SF57. PTHR24249:SF57. 4 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00243. MUSCARINICR.
PR00539. MUSCRINICM2R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08172-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNSTNSSNN SLALTSPYKT FEVVFIVLVA GSLSLVTIIG NILVMVSIKV
60 70 80 90 100
NRHLQTVNNY FLFSLACADL IIGVFSMNLY TLYTVIGYWP LGPVVCDLWL
110 120 130 140 150
ALDYVVSNAS VMNLLIISFD RYFCVTKPLT YPVKRTTKMA GMMIAAAWVL
160 170 180 190 200
SFILWAPAIL FWQFIVGVRT VEDGECYIQF FSNAAVTFGT AIAAFYLPVI
210 220 230 240 250
IMTVLYWHIS RASKSRIKKD KKEPVANQDP VSPSLVQGRI VKPNNNNMPS
260 270 280 290 300
SDDGLEHNKI QNGKAPRDPV TENCVQGEEK ESSNDSTSVS AVASNMRDDE
310 320 330 340 350
ITQDENTVST SLGHSKDENS KQTCIRIGTK TPKSDSCTPT NTTVEVVGSS
360 370 380 390 400
GQNGDEKQNI VARKIVKMTK QPAKKKPPPS REKKVTRTIL AILLAFIITW
410 420 430 440 450
APYNVMVLIN TFCAPCIPNT VWTIGYWLCY INSTINPACY ALCNATFKKT
460
FKHLLMCHYK NIGATR
Length:466
Mass (Da):51,715
Last modified:August 1, 1988 - v1
Checksum:i2FC2FD7748C22BEC
GO

Polymorphismi

Genetic variations in CHRM2 can influence susceptibility to alcoholism [MIMi:103780].1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16404 Genomic DNA. Translation: AAA51570.1.
X15264 Genomic DNA. Translation: CAA33335.1.
AF498916 mRNA. Translation: AAM18939.1.
BC095547 mRNA. Translation: AAH95547.1.
BC106741 mRNA. Translation: AAI06742.1.
BC106742 mRNA. Translation: AAI06743.1.
AB041391 Genomic DNA. Translation: BAA94476.1.
CCDSiCCDS5843.1.
PIRiS10126.
RefSeqiNP_000730.1. NM_000739.2.
NP_001006627.1. NM_001006626.1.
NP_001006628.1. NM_001006627.1.
NP_001006629.1. NM_001006628.1.
NP_001006630.1. NM_001006629.1.
NP_001006631.1. NM_001006630.1.
NP_001006632.1. NM_001006631.1.
NP_001006633.1. NM_001006632.1.
XP_011514071.1. XM_011515769.2.
UniGeneiHs.535891.

Genome annotation databases

EnsembliENST00000320658; ENSP00000319984; ENSG00000181072.
ENST00000401861; ENSP00000384401; ENSG00000181072.
ENST00000445907; ENSP00000399745; ENSG00000181072.
ENST00000453373; ENSP00000415386; ENSG00000181072.
GeneIDi1129.
KEGGihsa:1129.
UCSCiuc003vtg.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16404 Genomic DNA. Translation: AAA51570.1.
X15264 Genomic DNA. Translation: CAA33335.1.
AF498916 mRNA. Translation: AAM18939.1.
BC095547 mRNA. Translation: AAH95547.1.
BC106741 mRNA. Translation: AAI06742.1.
BC106742 mRNA. Translation: AAI06743.1.
AB041391 Genomic DNA. Translation: BAA94476.1.
CCDSiCCDS5843.1.
PIRiS10126.
RefSeqiNP_000730.1. NM_000739.2.
NP_001006627.1. NM_001006626.1.
NP_001006628.1. NM_001006627.1.
NP_001006629.1. NM_001006628.1.
NP_001006630.1. NM_001006629.1.
NP_001006631.1. NM_001006630.1.
NP_001006632.1. NM_001006631.1.
NP_001006633.1. NM_001006632.1.
XP_011514071.1. XM_011515769.2.
UniGeneiHs.535891.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LUBmodel-A1-50[»]
3UONX-ray3.00A1-217[»]
A377-466[»]
4MQSX-ray3.50A1-466[»]
4MQTX-ray3.70A1-466[»]
ProteinModelPortaliP08172.
SMRiP08172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107551. 4 interactors.
DIPiDIP-56282N.
IntActiP08172. 12 interactors.
STRINGi9606.ENSP00000319984.

Chemistry databases

BindingDBiP08172.
ChEMBLiCHEMBL211.
DrugBankiDB08897. Aclidinium.
DB00321. Amitriptyline.
DB00543. Amoxapine.
DB00517. Anisotropine Methylbromide.
DB01238. Aripiprazole.
DB00572. Atropine.
DB01019. Bethanechol.
DB00835. Brompheniramine.
DB00411. Carbachol.
DB01239. Chlorprothixene.
DB00568. Cinnarizine.
DB00363. Clozapine.
DB00907. Cocaine.
DB00785. Cryptenamine.
DB00434. Cyproheptadine.
DB00496. Darifenacin.
DB01151. Desipramine.
DB00804. Dicyclomine.
DB08801. Dimetindene.
DB01231. Diphenidol.
DB00280. Disopyramide.
DB01135. Doxacurium chloride.
DB01142. Doxepin.
DB00392. Ethopropazine.
DB06702. Fesoterodine.
DB01148. Flavoxate.
DB00483. Gallamine Triethiodide.
DB00986. Glycopyrrolate.
DB00725. Homatropine Methylbromide.
DB00424. Hyoscyamine.
DB00458. Imipramine.
DB00332. Ipratropium bromide.
DB01221. Ketamine.
DB00408. Loxapine.
DB00934. Maprotiline.
DB01403. Methotrimeprazine.
DB00462. Methylscopolamine bromide.
DB00340. Metixene.
DB01336. Metocurine.
DB01226. Mivacurium.
DB00622. Nicardipine.
DB00540. Nortriptyline.
DB00334. Olanzapine.
DB01062. Oxybutynin.
DB00383. Oxyphencyclimine.
DB01337. Pancuronium.
DB00715. Paroxetine.
DB00454. Pethidine.
DB01085. Pilocarpine.
DB01338. Pipecuronium.
DB00387. Procyclidine.
DB00420. Promazine.
DB01069. Promethazine.
DB00777. Propiomazine.
DB01224. Quetiapine.
DB00728. Rocuronium.
DB00747. Scopolamine.
DB01591. Solifenacin.
DB00202. Succinylcholine.
DB01409. Tiotropium.
DB01036. Tolterodine.
DB00508. Triflupromazine.
DB00376. Trihexyphenidyl.
DB00726. Trimipramine.
DB00809. Tropicamide.
DB09076. Umeclidinium.
DB00246. Ziprasidone.
GuidetoPHARMACOLOGYi14.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP08172.
PhosphoSitePlusiP08172.
SwissPalmiP08172.

Polymorphism and mutation databases

BioMutaiCHRM2.
DMDMi113122.

Proteomic databases

EPDiP08172.
PaxDbiP08172.
PeptideAtlasiP08172.
PRIDEiP08172.

Protocols and materials databases

DNASUi1129.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320658; ENSP00000319984; ENSG00000181072.
ENST00000401861; ENSP00000384401; ENSG00000181072.
ENST00000445907; ENSP00000399745; ENSG00000181072.
ENST00000453373; ENSP00000415386; ENSG00000181072.
GeneIDi1129.
KEGGihsa:1129.
UCSCiuc003vtg.2. human.

Organism-specific databases

CTDi1129.
DisGeNETi1129.
GeneCardsiCHRM2.
HGNCiHGNC:1951. CHRM2.
HPAiCAB022338.
HPA029795.
MIMi103780. phenotype.
118493. gene.
608516. phenotype.
neXtProtiNX_P08172.
OpenTargetsiENSG00000181072.
PharmGKBiPA111.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4220. Eukaryota.
ENOG410YCQR. LUCA.
GeneTreeiENSGT00780000121874.
HOGENOMiHOG000231484.
HOVERGENiHBG105720.
InParanoidiP08172.
KOiK04130.
OMAiNNNMPGS.
OrthoDBiEOG091G06VI.
PhylomeDBiP08172.
TreeFamiTF320495.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181072-MONOMER.
ReactomeiR-HSA-390648. Muscarinic acetylcholine receptors.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.
SignaLinkiP08172.
SIGNORiP08172.

Miscellaneous databases

ChiTaRSiCHRM2. human.
GeneWikiiMuscarinic_acetylcholine_receptor_M2.
GenomeRNAii1129.
PROiP08172.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000181072.
CleanExiHS_CHRM2.
ExpressionAtlasiP08172. baseline and differential.
GenevisibleiP08172. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001065. Musac_Ach_M2_rcpt.
IPR000995. Musac_Ach_rcpt.
[Graphical view]
PANTHERiPTHR24249:SF57. PTHR24249:SF57. 4 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00243. MUSCARINICR.
PR00539. MUSCRINICM2R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACM2_HUMAN
AccessioniPrimary (citable) accession number: P08172
Secondary accession number(s): Q4VBK6, Q9P1X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 2, 2016
This is version 174 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.