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P08172

- ACM2_HUMAN

UniProt

P08172 - ACM2_HUMAN

Protein

Muscarinic acetylcholine receptor M2

Gene

CHRM2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 154 (01 Oct 2014)
      Sequence version 1 (01 Aug 1988)
      Previous versions | rss
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    Functioni

    The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.2 Publications

    GO - Molecular functioni

    1. G-protein coupled acetylcholine receptor activity Source: UniProtKB

    GO - Biological processi

    1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: ProtInc
    2. G-protein coupled acetylcholine receptor signaling pathway Source: UniProtKB
    3. G-protein coupled receptor signaling pathway Source: ProtInc
    4. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
    5. nervous system development Source: ProtInc
    6. phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway Source: ProtInc
    7. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: UniProtKB
    8. regulation of heart contraction Source: ProtInc
    9. response to virus Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_16943. Muscarinic acetylcholine receptors.
    REACT_19231. G alpha (i) signalling events.
    SignaLinkiP08172.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Muscarinic acetylcholine receptor M2
    Gene namesi
    Name:CHRM2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:1951. CHRM2.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein. Cell junctionsynapsepostsynaptic cell membrane; Multi-pass membrane protein
    Note: Phosphorylation in response to agonist binding promotes receptor internalization.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. integral component of plasma membrane Source: UniProtKB
    3. plasma membrane Source: LIFEdb
    4. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Involvement in diseasei

    Major depressive disorder (MDD) [MIM:608516]: A common psychiatric disorder. It is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning.1 Publication
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi58 – 581N → A: Nearly abolishes signaling via downstream effectors. 1 Publication
    Mutagenesisi103 – 1031D → E: Reduced affinity for acetylcholine. Abolishes signaling via downstream effectors. 1 Publication
    Mutagenesisi206 – 2061Y → F: Abolishes signaling via downstream effectors. 1 Publication
    Mutagenesisi404 – 4041N → Q: Reduced affinity for acetylcholine. Reduces signaling via downstream effectors. 1 Publication

    Organism-specific databases

    MIMi103780. phenotype.
    608516. phenotype.
    PharmGKBiPA111.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 466466Muscarinic acetylcholine receptor M2PRO_0000069021Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi96 ↔ 176
    Disulfide bondi413 ↔ 416
    Modified residuei446 – 4461PhosphothreonineSequence Analysis
    Modified residuei450 – 4501PhosphothreonineSequence Analysis
    Modified residuei465 – 4651PhosphothreonineSequence Analysis

    Post-translational modificationi

    Phosphorylated in response to agonist treatment.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP08172.
    PRIDEiP08172.

    PTM databases

    PhosphoSiteiP08172.

    Expressioni

    Inductioni

    Up-regulated in response to enterovirus 71 (EV71) infection.1 Publication

    Gene expression databases

    ArrayExpressiP08172.
    BgeeiP08172.
    CleanExiHS_CHRM2.
    GenevestigatoriP08172.

    Organism-specific databases

    HPAiCAB022338.
    HPA029795.

    Interactioni

    Subunit structurei

    Interacts with ARRB1 and ARRB2. Interacts with GNB2L1/RACK1; the interaction regulates CHRM2 internalization.3 Publications

    Protein-protein interaction databases

    BioGridi107551. 4 interactions.
    IntActiP08172. 4 interactions.
    STRINGi9606.ENSP00000319984.

    Structurei

    Secondary structure

    1
    466
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi23 – 5028
    Helixi52 – 543
    Helixi57 – 7418
    Helixi76 – 8510
    Beta strandi86 – 883
    Helixi93 – 12634
    Turni128 – 1303
    Helixi132 – 1343
    Helixi137 – 16630
    Helixi179 – 1824
    Helixi184 – 19411
    Helixi196 – 21318
    Helixi384 – 41229
    Helixi414 – 4163
    Helixi419 – 43113
    Turni432 – 4343
    Helixi435 – 4439
    Helixi445 – 45410

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1LUBmodel-A1-50[»]
    3UONX-ray3.00A1-217[»]
    A377-466[»]
    4MQSX-ray3.50A1-466[»]
    4MQTX-ray3.70A1-466[»]
    ProteinModelPortaliP08172.
    SMRiP08172. Positions 20-217, 377-456.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2222ExtracellularAdd
    BLAST
    Topological domaini46 – 5914CytoplasmicAdd
    BLAST
    Topological domaini81 – 9717ExtracellularAdd
    BLAST
    Topological domaini120 – 13920CytoplasmicAdd
    BLAST
    Topological domaini163 – 18422ExtracellularAdd
    BLAST
    Topological domaini210 – 387178CytoplasmicAdd
    BLAST
    Topological domaini411 – 4188Extracellular
    Topological domaini443 – 46624CytoplasmicAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4523Helical; Name=1Add
    BLAST
    Transmembranei60 – 8021Helical; Name=2Add
    BLAST
    Transmembranei98 – 11922Helical; Name=3Add
    BLAST
    Transmembranei140 – 16223Helical; Name=4Add
    BLAST
    Transmembranei185 – 20925Helical; Name=5Add
    BLAST
    Transmembranei388 – 41023Helical; Name=6Add
    BLAST
    Transmembranei419 – 44224Helical; Name=7Add
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni103 – 1075Agonist bindingCurated
    Regioni403 – 4042Agonist bindingCurated
    Regioni426 – 4305Agonist bindingCurated

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi120 – 1223Important for signaling
    Motifi436 – 4405Important for signaling

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG250863.
    HOGENOMiHOG000231484.
    HOVERGENiHBG105720.
    InParanoidiP08172.
    KOiK04130.
    OMAiNNNMPGS.
    OrthoDBiEOG7V49Z7.
    PhylomeDBiP08172.
    TreeFamiTF320495.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001065. Musac_Ach_M2_rcpt.
    IPR000995. Musac_Ach_rcpt.
    [Graphical view]
    PANTHERiPTHR24249:SF57. PTHR24249:SF57. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00243. MUSCARINICR.
    PR00539. MUSCRINICM2R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P08172-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNSTNSSNN SLALTSPYKT FEVVFIVLVA GSLSLVTIIG NILVMVSIKV    50
    NRHLQTVNNY FLFSLACADL IIGVFSMNLY TLYTVIGYWP LGPVVCDLWL 100
    ALDYVVSNAS VMNLLIISFD RYFCVTKPLT YPVKRTTKMA GMMIAAAWVL 150
    SFILWAPAIL FWQFIVGVRT VEDGECYIQF FSNAAVTFGT AIAAFYLPVI 200
    IMTVLYWHIS RASKSRIKKD KKEPVANQDP VSPSLVQGRI VKPNNNNMPS 250
    SDDGLEHNKI QNGKAPRDPV TENCVQGEEK ESSNDSTSVS AVASNMRDDE 300
    ITQDENTVST SLGHSKDENS KQTCIRIGTK TPKSDSCTPT NTTVEVVGSS 350
    GQNGDEKQNI VARKIVKMTK QPAKKKPPPS REKKVTRTIL AILLAFIITW 400
    APYNVMVLIN TFCAPCIPNT VWTIGYWLCY INSTINPACY ALCNATFKKT 450
    FKHLLMCHYK NIGATR 466
    Length:466
    Mass (Da):51,715
    Last modified:August 1, 1988 - v1
    Checksum:i2FC2FD7748C22BEC
    GO

    Polymorphismi

    Genetic variations in CHRM2 can influence susceptibility to alcoholism [MIMi:103780].

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16404 Genomic DNA. Translation: AAA51570.1.
    X15264 Genomic DNA. Translation: CAA33335.1.
    AF498916 mRNA. Translation: AAM18939.1.
    BC095547 mRNA. Translation: AAH95547.1.
    BC106741 mRNA. Translation: AAI06742.1.
    BC106742 mRNA. Translation: AAI06743.1.
    AB041391 Genomic DNA. Translation: BAA94476.1.
    CCDSiCCDS5843.1.
    PIRiS10126.
    RefSeqiNP_000730.1. NM_000739.2.
    NP_001006627.1. NM_001006626.1.
    NP_001006628.1. NM_001006627.1.
    NP_001006629.1. NM_001006628.1.
    NP_001006630.1. NM_001006629.1.
    NP_001006631.1. NM_001006630.1.
    NP_001006632.1. NM_001006631.1.
    NP_001006633.1. NM_001006632.1.
    UniGeneiHs.535891.

    Genome annotation databases

    EnsembliENST00000320658; ENSP00000319984; ENSG00000181072.
    ENST00000401861; ENSP00000384401; ENSG00000181072.
    ENST00000445907; ENSP00000399745; ENSG00000181072.
    ENST00000453373; ENSP00000415386; ENSG00000181072.
    GeneIDi1129.
    KEGGihsa:1129.
    UCSCiuc003vtf.1. human.

    Polymorphism databases

    DMDMi113122.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16404 Genomic DNA. Translation: AAA51570.1 .
    X15264 Genomic DNA. Translation: CAA33335.1 .
    AF498916 mRNA. Translation: AAM18939.1 .
    BC095547 mRNA. Translation: AAH95547.1 .
    BC106741 mRNA. Translation: AAI06742.1 .
    BC106742 mRNA. Translation: AAI06743.1 .
    AB041391 Genomic DNA. Translation: BAA94476.1 .
    CCDSi CCDS5843.1.
    PIRi S10126.
    RefSeqi NP_000730.1. NM_000739.2.
    NP_001006627.1. NM_001006626.1.
    NP_001006628.1. NM_001006627.1.
    NP_001006629.1. NM_001006628.1.
    NP_001006630.1. NM_001006629.1.
    NP_001006631.1. NM_001006630.1.
    NP_001006632.1. NM_001006631.1.
    NP_001006633.1. NM_001006632.1.
    UniGenei Hs.535891.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1LUB model - A 1-50 [» ]
    3UON X-ray 3.00 A 1-217 [» ]
    A 377-466 [» ]
    4MQS X-ray 3.50 A 1-466 [» ]
    4MQT X-ray 3.70 A 1-466 [» ]
    ProteinModelPortali P08172.
    SMRi P08172. Positions 20-217, 377-456.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107551. 4 interactions.
    IntActi P08172. 4 interactions.
    STRINGi 9606.ENSP00000319984.

    Chemistry

    BindingDBi P08172.
    ChEMBLi CHEMBL2095187.
    DrugBanki DB00517. Anisotropine Methylbromide.
    DB00572. Atropine.
    DB00767. Benzquinamide.
    DB00411. Carbachol.
    DB00785. Cryptenamine.
    DB01176. Cyclizine.
    DB01151. Desipramine.
    DB01231. Diphenidol.
    DB01334. Doxacurium.
    DB01135. Doxacurium chloride.
    DB01148. Flavoxate.
    DB00483. Gallamine Triethiodide.
    DB00725. Homatropine Methylbromide.
    DB00424. Hyoscyamine.
    DB00332. Ipratropium.
    DB01403. Methotrimeprazine.
    DB00340. Metixene.
    DB01336. Metocurine.
    DB01226. Mivacurium.
    DB00334. Olanzapine.
    DB01062. Oxybutynin.
    DB00383. Oxyphencyclimine.
    DB01085. Pilocarpine.
    DB00387. Procyclidine.
    DB00420. Promazine.
    DB01069. Promethazine.
    DB00777. Propiomazine.
    DB00728. Rocuronium.
    DB00372. Thiethylperazine.
    DB01036. Tolterodine.
    DB00505. Tridihexethyl.
    DB00508. Triflupromazine.
    GuidetoPHARMACOLOGYi 14.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P08172.

    Polymorphism databases

    DMDMi 113122.

    Proteomic databases

    PaxDbi P08172.
    PRIDEi P08172.

    Protocols and materials databases

    DNASUi 1129.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320658 ; ENSP00000319984 ; ENSG00000181072 .
    ENST00000401861 ; ENSP00000384401 ; ENSG00000181072 .
    ENST00000445907 ; ENSP00000399745 ; ENSG00000181072 .
    ENST00000453373 ; ENSP00000415386 ; ENSG00000181072 .
    GeneIDi 1129.
    KEGGi hsa:1129.
    UCSCi uc003vtf.1. human.

    Organism-specific databases

    CTDi 1129.
    GeneCardsi GC07P136553.
    HGNCi HGNC:1951. CHRM2.
    HPAi CAB022338.
    HPA029795.
    MIMi 103780. phenotype.
    118493. gene.
    608516. phenotype.
    neXtProti NX_P08172.
    PharmGKBi PA111.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG250863.
    HOGENOMi HOG000231484.
    HOVERGENi HBG105720.
    InParanoidi P08172.
    KOi K04130.
    OMAi NNNMPGS.
    OrthoDBi EOG7V49Z7.
    PhylomeDBi P08172.
    TreeFami TF320495.

    Enzyme and pathway databases

    Reactomei REACT_16943. Muscarinic acetylcholine receptors.
    REACT_19231. G alpha (i) signalling events.
    SignaLinki P08172.

    Miscellaneous databases

    GeneWikii Muscarinic_acetylcholine_receptor_M2.
    GenomeRNAii 1129.
    NextBioi 4680.
    PROi P08172.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P08172.
    Bgeei P08172.
    CleanExi HS_CHRM2.
    Genevestigatori P08172.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001065. Musac_Ach_M2_rcpt.
    IPR000995. Musac_Ach_rcpt.
    [Graphical view ]
    PANTHERi PTHR24249:SF57. PTHR24249:SF57. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00243. MUSCARINICR.
    PR00539. MUSCRINICM2R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a family of muscarinic acetylcholine receptor genes."
      Bonner T.I., Buckley N.J., Young A.C., Brann M.R.
      Science 237:527-532(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors."
      Peralta E.G., Ashkenazi A., Winslow J.W., Smith D.H., Ramachandran J., Capon D.J.
      EMBO J. 6:3923-3929(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Human-specific amino acid changes found in 103 protein-coding genes."
      Kitano T., Liu Y.-H., Ueda S., Saitou N.
      Mol. Biol. Evol. 21:936-944(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-466.
    6. "Arrestin interactions with G protein-coupled receptors. Direct binding studies of wild type and mutant arrestins with rhodopsin, beta 2-adrenergic, and m2 muscarinic cholinergic receptors."
      Gurevich V.V., Dion S.B., Onorato J.J., Ptasienski J., Kim C.M., Sterne-Marr R., Hosey M.M., Benovic J.L.
      J. Biol. Chem. 270:720-731(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARRB1 AND ARRB2.
    7. "Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection."
      Leong W.F., Chow V.T.
      Cell. Microbiol. 8:565-580(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, IDENTIFICATION BY MASS SPECTROMETRY.
    8. "Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome."
      Wang J.C., Hinrichs A.L., Stock H., Budde J., Allen R., Bertelsen S., Kwon J.M., Wu W., Dick D.M., Rice J., Jones K., Nurnberger J.I. Jr., Tischfield J., Porjesz B., Edenberg H.J., Hesselbrock V., Crowe R., Schuckit M.
      , Begleiter H., Reich T., Goate A.M., Bierut L.J.
      Hum. Mol. Genet. 13:1903-1911(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ALCOHOLISM AND MAJOR DEPRESSIVE DISORDER.
    9. "RACK1 associates with muscarinic receptors and regulates M(2) receptor trafficking."
      Reiner C.L., McCullar J.S., Kow R.L., Le J.H., Goodlett D.R., Nathanson N.M.
      PLoS ONE 5:E13517-E13517(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GNB2L1.
    10. "Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist."
      Haga K., Kruse A.C., Asada H., Yurugi-Kobayashi T., Shiroishi M., Zhang C., Weis W.I., Okada T., Kobilka B.K., Haga T., Kobayashi T.
      Nature 482:547-551(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) IN COMPLEX WITH THE ANTAGONIST 3-QUINUCLIDINYLBENZILATE, SUBCELLULAR LOCATION, TOPOLOGY, DISULFIDE BOND.
    11. Cited for: X-RAY CRYSTALLOGRAPHY (3.50 ANGSTROMS) IN COMPLEXES WITH THE AGONIST IPEROXO AND THE ALLOSTERIC EFFECTOR LY2119620, FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, DISULFIDE BOND, MOTIF, MUTAGENESIS OF ASN-58; ASP-103; TYR-206 AND ASN-404.

    Entry informationi

    Entry nameiACM2_HUMAN
    AccessioniPrimary (citable) accession number: P08172
    Secondary accession number(s): Q4VBK6, Q9P1X9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: August 1, 1988
    Last modified: October 1, 2014
    This is version 154 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3