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Protein

Early 35 kDa protein

Gene

P35

Organism
Autographa californica nuclear polyhedrosis virus (AcMNPV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions as an inhibitor of the host RNA interference antiviral response. Inhibits the insect host cell apoptotic response initiated by the viral infection. Blocks as well the activity of members of the caspase family of proteases. Required for late and very late gene expression.3 Publications

GO - Molecular functioni

GO - Biological processi

  • negative regulation of apoptotic process Source: CACAO
  • negative regulation of RNA interference Source: UniProtKB
  • suppression by virus of host apoptotic process Source: UniProtKB
  • suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Suppressor of RNA silencing, Thiol protease inhibitor

Keywords - Biological processi

Apoptosis, Host-virus interaction, Inhibition of host caspases by virus, Modulation of host cell apoptosis by virus

Protein family/group databases

MEROPSiI50.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Early 35 kDa protein
Alternative name(s):
Apoptosis-preventing protein
p35
Gene namesi
Name:P35
OrganismiAutographa californica nuclear polyhedrosis virus (AcMNPV)
Taxonomic identifieri46015 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageBaculoviridaeAlphabaculovirus
Virus hostiLepidoptera (butterflies and moths) [TaxID: 7088]
Proteomesi
  • UP000008292 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001328981 – 299Early 35 kDa proteinAdd BLAST299

Miscellaneous databases

PMAP-CutDBP08160.

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Protein-protein interaction databases

IntActiP08160. 1 interactor.
MINTiMINT-192519.

Structurei

Secondary structure

1299
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 8Combined sources6
Beta strandi11 – 22Combined sources12
Beta strandi25 – 34Combined sources10
Beta strandi40 – 42Combined sources3
Beta strandi43 – 51Combined sources9
Beta strandi53 – 56Combined sources4
Helixi63 – 75Combined sources13
Helixi76 – 78Combined sources3
Beta strandi94 – 97Combined sources4
Beta strandi102 – 107Combined sources6
Helixi108 – 110Combined sources3
Helixi111 – 121Combined sources11
Helixi127 – 136Combined sources10
Helixi138 – 141Combined sources4
Beta strandi144 – 146Combined sources3
Beta strandi148 – 155Combined sources8
Turni157 – 160Combined sources4
Beta strandi161 – 163Combined sources3
Beta strandi165 – 171Combined sources7
Beta strandi177 – 180Combined sources4
Beta strandi188 – 190Combined sources3
Beta strandi192 – 200Combined sources9
Helixi207 – 216Combined sources10
Beta strandi228 – 235Combined sources8
Beta strandi237 – 250Combined sources14
Beta strandi253 – 257Combined sources5
Beta strandi260 – 272Combined sources13
Turni273 – 276Combined sources4
Beta strandi277 – 288Combined sources12
Beta strandi293 – 297Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I3PX-ray3.10A2-299[»]
1I3SX-ray2.70A/B/C2-299[»]
1I4EX-ray3.00A2-299[»]
1P35X-ray2.20A/B/C2-299[»]
2FUNX-ray3.00A/C2-299[»]
ProteinModelPortaliP08160.
SMRiP08160.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08160.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.60.250.10. 1 hit.
InterProiIPR003429. Baculovirus_p35.
[Graphical view]
PfamiPF02331. P35. 1 hit.
[Graphical view]
SUPFAMiSSF49894. SSF49894. 1 hit.

Sequencei

Sequence statusi: Complete.

P08160-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCVIFPVEID VSQTIIRDCQ VDKQTRELVY INKIMNTQLT KPVLMMFNIS
60 70 80 90 100
GPIRSVTRKN NNLRDRIKSK VDEQFDQLER DYSDQMDGFH DSIKYFKDEH
110 120 130 140 150
YSVSCQNGSV LKSKFAKILK SHDYTDKKSI EAYEKYCLPK LVDERNDYYV
160 170 180 190 200
AVCVLKPGFE NGSNQVLSFE YNPIGNKVIV PFAHEINDTG LYEYDVVAYV
210 220 230 240 250
DSVQFDGEQF EEFVQSLILP SSFKNSEKVL YYNEASKNKS MIYKALEFTT
260 270 280 290
ESSWGKSEKY NWKIFCNGFI YDKKSKVLYV KLHNVTSALN KNVILNTIK
Length:299
Mass (Da):34,829
Last modified:August 1, 1988 - v1
Checksum:iF8BC3BEB9E64382E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16821 Genomic DNA. Translation: AAA46703.1.
L22858 Genomic DNA. Translation: AAA66765.1.
PIRiA27840. WMNV35.
RefSeqiNP_054165.1. NC_001623.1.

Genome annotation databases

GeneIDi1403968.
KEGGivg:1403968.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16821 Genomic DNA. Translation: AAA46703.1.
L22858 Genomic DNA. Translation: AAA66765.1.
PIRiA27840. WMNV35.
RefSeqiNP_054165.1. NC_001623.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I3PX-ray3.10A2-299[»]
1I3SX-ray2.70A/B/C2-299[»]
1I4EX-ray3.00A2-299[»]
1P35X-ray2.20A/B/C2-299[»]
2FUNX-ray3.00A/C2-299[»]
ProteinModelPortaliP08160.
SMRiP08160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP08160. 1 interactor.
MINTiMINT-192519.

Protein family/group databases

MEROPSiI50.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1403968.
KEGGivg:1403968.

Miscellaneous databases

EvolutionaryTraceiP08160.
PMAP-CutDBP08160.

Family and domain databases

Gene3Di2.60.250.10. 1 hit.
InterProiIPR003429. Baculovirus_p35.
[Graphical view]
PfamiPF02331. P35. 1 hit.
[Graphical view]
SUPFAMiSSF49894. SSF49894. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiP35_NPVAC
AccessioniPrimary (citable) accession number: P08160
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 30, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.