Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Early 35 kDa protein

Gene

P35

Organism
Autographa californica nuclear polyhedrosis virus (AcMNPV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Blocks the insect or worm host cells apoptotic response initiated by the viral infection. Confers protection from cell death in mammalian cells. Acts by blocking the activity of members of the caspase family of proteases. Required for late and very late gene expression.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Keywords - Biological processi

Apoptosis, Host-virus interaction, Inhibition of host caspases by virus, Modulation of host cell apoptosis by virus

Protein family/group databases

MEROPSiI50.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Early 35 kDa protein
Alternative name(s):
Apoptosis-preventing protein
p35
Gene namesi
Name:P35
OrganismiAutographa californica nuclear polyhedrosis virus (AcMNPV)
Taxonomic identifieri46015 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageBaculoviridaeAlphabaculovirus
Virus hostiLepidoptera (butterflies and moths) [TaxID: 7088]
Proteomesi
  • UP000008292 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Early 35 kDa proteinPRO_0000132898Add
BLAST

Miscellaneous databases

PMAP-CutDBP08160.

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Protein-protein interaction databases

IntActiP08160. 1 interaction.
MINTiMINT-192519.

Structurei

Secondary structure

1
299
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 86Combined sources
Beta strandi11 – 2212Combined sources
Beta strandi25 – 3410Combined sources
Beta strandi40 – 423Combined sources
Beta strandi43 – 519Combined sources
Beta strandi53 – 564Combined sources
Helixi63 – 7513Combined sources
Helixi76 – 783Combined sources
Beta strandi94 – 974Combined sources
Beta strandi102 – 1076Combined sources
Helixi108 – 1103Combined sources
Helixi111 – 12111Combined sources
Helixi127 – 13610Combined sources
Helixi138 – 1414Combined sources
Beta strandi144 – 1463Combined sources
Beta strandi148 – 1558Combined sources
Turni157 – 1604Combined sources
Beta strandi161 – 1633Combined sources
Beta strandi165 – 1717Combined sources
Beta strandi177 – 1804Combined sources
Beta strandi188 – 1903Combined sources
Beta strandi192 – 2009Combined sources
Helixi207 – 21610Combined sources
Beta strandi228 – 2358Combined sources
Beta strandi237 – 25014Combined sources
Beta strandi253 – 2575Combined sources
Beta strandi260 – 27213Combined sources
Turni273 – 2764Combined sources
Beta strandi277 – 28812Combined sources
Beta strandi293 – 2975Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I3PX-ray3.10A2-299[»]
1I3SX-ray2.70A/B/C2-299[»]
1I4EX-ray3.00A2-299[»]
1P35X-ray2.20A/B/C2-299[»]
2FUNX-ray3.00A/C2-299[»]
ProteinModelPortaliP08160.
SMRiP08160. Positions 2-299.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08160.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.60.250.10. 1 hit.
InterProiIPR003429. Baculovirus_p35.
[Graphical view]
PfamiPF02331. P35. 1 hit.
[Graphical view]
SUPFAMiSSF49894. SSF49894. 1 hit.

Sequencei

Sequence statusi: Complete.

P08160-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCVIFPVEID VSQTIIRDCQ VDKQTRELVY INKIMNTQLT KPVLMMFNIS
60 70 80 90 100
GPIRSVTRKN NNLRDRIKSK VDEQFDQLER DYSDQMDGFH DSIKYFKDEH
110 120 130 140 150
YSVSCQNGSV LKSKFAKILK SHDYTDKKSI EAYEKYCLPK LVDERNDYYV
160 170 180 190 200
AVCVLKPGFE NGSNQVLSFE YNPIGNKVIV PFAHEINDTG LYEYDVVAYV
210 220 230 240 250
DSVQFDGEQF EEFVQSLILP SSFKNSEKVL YYNEASKNKS MIYKALEFTT
260 270 280 290
ESSWGKSEKY NWKIFCNGFI YDKKSKVLYV KLHNVTSALN KNVILNTIK
Length:299
Mass (Da):34,829
Last modified:August 1, 1988 - v1
Checksum:iF8BC3BEB9E64382E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16821 Genomic DNA. Translation: AAA46703.1.
L22858 Genomic DNA. Translation: AAA66765.1.
PIRiA27840. WMNV35.
RefSeqiNP_054165.1. NC_001623.1.

Genome annotation databases

GeneIDi1403968.
KEGGivg:1403968.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16821 Genomic DNA. Translation: AAA46703.1.
L22858 Genomic DNA. Translation: AAA66765.1.
PIRiA27840. WMNV35.
RefSeqiNP_054165.1. NC_001623.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I3PX-ray3.10A2-299[»]
1I3SX-ray2.70A/B/C2-299[»]
1I4EX-ray3.00A2-299[»]
1P35X-ray2.20A/B/C2-299[»]
2FUNX-ray3.00A/C2-299[»]
ProteinModelPortaliP08160.
SMRiP08160. Positions 2-299.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP08160. 1 interaction.
MINTiMINT-192519.

Protein family/group databases

MEROPSiI50.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1403968.
KEGGivg:1403968.

Miscellaneous databases

EvolutionaryTraceiP08160.
PMAP-CutDBP08160.

Family and domain databases

Gene3Di2.60.250.10. 1 hit.
InterProiIPR003429. Baculovirus_p35.
[Graphical view]
PfamiPF02331. P35. 1 hit.
[Graphical view]
SUPFAMiSSF49894. SSF49894. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVP35_NPVAC
AccessioniPrimary (citable) accession number: P08160
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.