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Protein

Early 35 kDa protein

Gene

P35

Organism
Autographa californica nuclear polyhedrosis virus (AcMNPV)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as an inhibitor of the host RNA interference antiviral response. Inhibits the insect host cell apoptotic response initiated by the viral infection. Blocks as well the activity of members of the caspase family of proteases. Required for late and very late gene expression.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Suppressor of RNA silencing, Thiol protease inhibitor
Biological processApoptosis, Host-virus interaction, Inhibition of host caspases by virus, Modulation of host cell apoptosis by virus

Protein family/group databases

MEROPSiI50.001

Names & Taxonomyi

Protein namesi
Recommended name:
Early 35 kDa protein
Alternative name(s):
Apoptosis-preventing protein
p35
Gene namesi
Name:P35
OrganismiAutographa californica nuclear polyhedrosis virus (AcMNPV)
Taxonomic identifieri46015 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageBaculoviridaeAlphabaculovirus
Virus hostiLepidoptera (butterflies and moths) [TaxID: 7088]
Proteomesi
  • UP000008292 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001328981 – 299Early 35 kDa proteinAdd BLAST299

Miscellaneous databases

PMAP-CutDBiP08160

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Protein-protein interaction databases

IntActiP08160, 1 interactor
MINTiP08160

Structurei

Secondary structure

1299
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 8Combined sources6
Beta strandi11 – 22Combined sources12
Beta strandi25 – 34Combined sources10
Beta strandi40 – 42Combined sources3
Beta strandi43 – 51Combined sources9
Beta strandi53 – 56Combined sources4
Helixi63 – 75Combined sources13
Helixi76 – 78Combined sources3
Beta strandi94 – 97Combined sources4
Beta strandi102 – 107Combined sources6
Helixi108 – 110Combined sources3
Helixi111 – 121Combined sources11
Helixi127 – 136Combined sources10
Helixi138 – 141Combined sources4
Beta strandi144 – 146Combined sources3
Beta strandi148 – 155Combined sources8
Turni157 – 160Combined sources4
Beta strandi161 – 163Combined sources3
Beta strandi165 – 171Combined sources7
Beta strandi177 – 180Combined sources4
Beta strandi188 – 190Combined sources3
Beta strandi192 – 200Combined sources9
Helixi207 – 216Combined sources10
Beta strandi228 – 235Combined sources8
Beta strandi237 – 250Combined sources14
Beta strandi253 – 257Combined sources5
Beta strandi260 – 272Combined sources13
Turni273 – 276Combined sources4
Beta strandi277 – 288Combined sources12
Beta strandi293 – 297Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I3PX-ray3.10A2-299[»]
1I3SX-ray2.70A/B/C2-299[»]
1I4EX-ray3.00A2-299[»]
1P35X-ray2.20A/B/C2-299[»]
2FUNX-ray3.00A/C2-299[»]
ProteinModelPortaliP08160
SMRiP08160
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08160

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG090000HC

Family and domain databases

Gene3Di2.60.250.10, 1 hit
InterProiView protein in InterPro
IPR003429 Baculovirus_p35
IPR036562 Baculovirus_p35_sf
PfamiView protein in Pfam
PF02331 P35, 1 hit
SUPFAMiSSF49894 SSF49894, 1 hit

Sequencei

Sequence statusi: Complete.

P08160-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCVIFPVEID VSQTIIRDCQ VDKQTRELVY INKIMNTQLT KPVLMMFNIS
60 70 80 90 100
GPIRSVTRKN NNLRDRIKSK VDEQFDQLER DYSDQMDGFH DSIKYFKDEH
110 120 130 140 150
YSVSCQNGSV LKSKFAKILK SHDYTDKKSI EAYEKYCLPK LVDERNDYYV
160 170 180 190 200
AVCVLKPGFE NGSNQVLSFE YNPIGNKVIV PFAHEINDTG LYEYDVVAYV
210 220 230 240 250
DSVQFDGEQF EEFVQSLILP SSFKNSEKVL YYNEASKNKS MIYKALEFTT
260 270 280 290
ESSWGKSEKY NWKIFCNGFI YDKKSKVLYV KLHNVTSALN KNVILNTIK
Length:299
Mass (Da):34,829
Last modified:August 1, 1988 - v1
Checksum:iF8BC3BEB9E64382E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16821 Genomic DNA Translation: AAA46703.1
L22858 Genomic DNA Translation: AAA66765.1
PIRiA27840 WMNV35
RefSeqiNP_054165.1, NC_001623.1

Genome annotation databases

GeneIDi1403968
KEGGivg:1403968

Similar proteinsi

Entry informationi

Entry nameiP35_NPVAC
AccessioniPrimary (citable) accession number: P08160
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: April 25, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health