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P08157

- ALDH_EMENI

UniProt

P08157 - ALDH_EMENI

Protein

Aldehyde dehydrogenase

Gene

aldA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (01 May 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei165 – 1651Transition state stabilizerBy similarity
    Active sitei264 – 2641Proton acceptorPROSITE-ProRule annotation
    Active sitei298 – 2981NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi241 – 2466NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: ASPGD
    2. aldehyde dehydrogenase [NAD(P)+] activity Source: ASPGD

    GO - Biological processi

    1. acetaldehyde catabolic process Source: ASPGD
    2. acetate biosynthetic process Source: ASPGD
    3. carbon catabolite activation of transcription Source: ASPGD
    4. cellular response to osmotic stress Source: ASPGD
    5. ethanol catabolic process Source: UniProtKB-UniPathway
    6. ethanol metabolic process Source: ASPGD
    7. threonine catabolic process Source: ASPGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00780; UER00768.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase (EC:1.2.1.3)
    Short name:
    ALDDH
    Short name:
    ALDH
    Gene namesi
    Name:aldA
    Synonyms:aspA
    ORF Names:AN0554
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome VIII

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: ASPGD
    2. intracellular Source: ASPGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497Aldehyde dehydrogenasePRO_0000056438Add
    BLAST

    Proteomic databases

    PRIDEiP08157.

    Interactioni

    Protein-protein interaction databases

    BioGridi1957104. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP08157.
    SMRiP08157. Positions 21-487.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    KOiK00128.
    OMAiYINTGKQ.
    OrthoDBiEOG7S226Z.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR015657. Aminobutyraldehyde_DH.
    [Graphical view]
    PANTHERiPTHR11699:SF46. PTHR11699:SF46. 1 hit.
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P08157-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDLFTTIET PVIKYEQPLG LFINNEFVKG VEGKTFQVIN PSNEKVITSV    50
    HEATEKDVDV AVAAARAAFE GPWRQVTPSE RGILINKLAD LMERDIDTLA 100
    AIESLDNGKA FTMAKVDLAN SIGCLRYYAG WADKIHGQTI DTNPETLTYT 150
    RHEPVGVCGQ IIPWNFPLLM WSWKIGPAVA AGNTVVLKTA EQTPLSALYA 200
    AKLIKEAGFP AGVINVISGF GRTAGAAISS HMDIDKVAFT GSTLVGRTIL 250
    QAAAKSNLKK VTLELGGKSP NIVFDDADID NAISWANFGI FFNHGQCCCA 300
    GSRILVQEGI YDKFVARFKE RAQKNKVGNP FEQDTFQGPQ VSQLQFDRIM 350
    EYINHGKKAG ATVATGGDRH GNEGYFIQPT VFTDVTSDMK IAQEEIFGPV 400
    VTIQKFKDEA EAIKIGNSTD YGLAAAVHTK NVNTAIRVSN ALKAGTVWIN 450
    NYNMISYQAP FGGFKQSGLG RELGSYALEN YTQIKTVHYR LGDALFA 497
    Length:497
    Mass (Da):54,139
    Last modified:May 1, 2007 - v2
    Checksum:i9C6CFC62731A25BD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti191 – 1911E → Q in AAA33293. (PubMed:3036652)Curated
    Sequence conflicti208 – 2081G → P in AAA33293. (PubMed:3036652)Curated
    Sequence conflicti247 – 2471R → P in AAA33293. (PubMed:3036652)Curated
    Sequence conflicti409 – 4091E → V in AAA33293. (PubMed:3036652)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16197 Genomic DNA. Translation: AAA33293.1.
    AF260123 Genomic DNA. Translation: AAK18072.1.
    AACD01000007 Genomic DNA. Translation: EAA66653.1.
    BN001308 Genomic DNA. Translation: CBF89245.1.
    PIRiA29055.
    RefSeqiXP_658158.1. XM_653066.1.

    Genome annotation databases

    EnsemblFungiiCADANIAT00002125; CADANIAP00002125; CADANIAG00002125.
    GeneIDi2876330.
    KEGGiani:AN0554.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16197 Genomic DNA. Translation: AAA33293.1 .
    AF260123 Genomic DNA. Translation: AAK18072.1 .
    AACD01000007 Genomic DNA. Translation: EAA66653.1 .
    BN001308 Genomic DNA. Translation: CBF89245.1 .
    PIRi A29055.
    RefSeqi XP_658158.1. XM_653066.1.

    3D structure databases

    ProteinModelPortali P08157.
    SMRi P08157. Positions 21-487.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 1957104. 1 interaction.

    Proteomic databases

    PRIDEi P08157.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANIAT00002125 ; CADANIAP00002125 ; CADANIAG00002125 .
    GeneIDi 2876330.
    KEGGi ani:AN0554.2.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    KOi K00128.
    OMAi YINTGKQ.
    OrthoDBi EOG7S226Z.

    Enzyme and pathway databases

    UniPathwayi UPA00780 ; UER00768 .

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR015657. Aminobutyraldehyde_DH.
    [Graphical view ]
    PANTHERi PTHR11699:SF46. PTHR11699:SF46. 1 hit.
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Regulation of the aldehyde dehydrogenase gene (aldA) and its role in the control of the coinducer level necessary for induction of the ethanol utilization pathway in Aspergillus nidulans."
      Flipphi M., Mathieu M., Cirpus I., Panozzo C., Felenbok B.
      J. Biol. Chem. 276:6950-6958(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    4. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

    Entry informationi

    Entry nameiALDH_EMENI
    AccessioniPrimary (citable) accession number: P08157
    Secondary accession number(s): C8VSL3, Q5BFX6, Q9C1Q6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3