Reviewed, UniProtKB/Swiss-Prot P08157 (ALDH_EMENI)

Names and origin

Protein names

Recommended name:
    Aldehyde dehydrogenase
      Short name=ALDDH
      Short name=ALDH
    EC=1.2.1.3

Gene names

Name:	aldA
Synonyms:	aspA
ORF Names:	AN0554

Organism

Emericella nidulans (Aspergillus nidulans) [Complete proteome]

Taxonomic identifier

162425 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Emericella

Protein attributes

Sequence length	497 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An aldehyde + NAD+ + H2O = an acid + NADH.
Pathway	Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 497	497	Aldehyde dehydrogenase		PRO_0000056438
Regions
	Nucleotide binding	241 – 246	6	NAD By similarity
Sites
	Active site	264	1	Proton acceptor By similarity
	Active site	298	1	Nucleophile By similarity
	Site	165	1	Transition state stabilizer By similarity
Experimental info
	Sequence conflict	191	1	E → Q in AAA33293. Ref.1
	Sequence conflict	208	1	G → P in AAA33293. Ref.1
	Sequence conflict	247	1	R → P in AAA33293. Ref.1
	Sequence conflict	409	1	E → V in AAA33293. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P08157-1 [UniParc]. Last modified May 1, 2007. Version 2. Checksum: 9C6CFC62731A25BD	FASTA	497	54,139
	10 20 30 40 50 60 MSDLFTTIET PVIKYEQPLG LFINNEFVKG VEGKTFQVIN PSNEKVITSV HEATEKDVDV 70 80 90 100 110 120 AVAAARAAFE GPWRQVTPSE RGILINKLAD LMERDIDTLA AIESLDNGKA FTMAKVDLAN 130 140 150 160 170 180 SIGCLRYYAG WADKIHGQTI DTNPETLTYT RHEPVGVCGQ IIPWNFPLLM WSWKIGPAVA 190 200 210 220 230 240 AGNTVVLKTA EQTPLSALYA AKLIKEAGFP AGVINVISGF GRTAGAAISS HMDIDKVAFT 250 260 270 280 290 300 GSTLVGRTIL QAAAKSNLKK VTLELGGKSP NIVFDDADID NAISWANFGI FFNHGQCCCA 310 320 330 340 350 360 GSRILVQEGI YDKFVARFKE RAQKNKVGNP FEQDTFQGPQ VSQLQFDRIM EYINHGKKAG 370 380 390 400 410 420 ATVATGGDRH GNEGYFIQPT VFTDVTSDMK IAQEEIFGPV VTIQKFKDEA EAIKIGNSTD 430 440 450 460 470 480 YGLAAAVHTK NVNTAIRVSN ALKAGTVWIN NYNMISYQAP FGGFKQSGLG RELGSYALEN 490 YTQIKTVHYR LGDALFA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of the aldA gene of Aspergillus nidulans." Pickett M., Gwynne D.I., Buxton F.P., Elliott R., Davies R.W., Lockington R.A., Scazzocchio C., Sealy-Lewis H.M. Gene 51:217-226(1987) [PubMed: 3036652] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Regulation of the aldehyde dehydrogenase gene (aldA) and its role in the control of the coinducer level necessary for induction of the ethanol utilization pathway in Aspergillus nidulans." Flipphi M., Mathieu M., Cirpus I., Panozzo C., Felenbok B. J. Biol. Chem. 276:6950-6958(2001) [PubMed: 11102439] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae." Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W. Nature 438:1105-1115(2005) [PubMed: 16372000] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FGSC 4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M16197 Genomic DNA. Translation: AAA33293.1. AF260123 Genomic DNA. Translation: AAK18072.1. AACD01000007 Genomic DNA. Translation: EAA66653.1.
PIR	A29055.
RefSeq	XP_658158.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2876330.
KEGG	ani:AN0554.2.
Enzyme and pathway databases
BRENDA	1.2.1.3. 3859.
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDH_EMENI

Accession

Primary (citable) accession number: P08157
Secondary accession number(s): Q5BFX6, Q9C1Q6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	May 1, 2007
Last modified:	November 24, 2009
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)