Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Aldehyde dehydrogenase

Gene

aldA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi: ethanol degradation

This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Aldehyde dehydrogenase (aldA)
This subpathway is part of the pathway ethanol degradation, which is itself part of Alcohol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei165Transition state stabilizerBy similarity1
Active sitei264Proton acceptorPROSITE-ProRule annotation1
Active sitei298NucleophilePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi241 – 246NADBy similarity6

GO - Molecular functioni

  • aldehyde dehydrogenase (NAD) activity Source: ASPGD
  • aldehyde dehydrogenase [NAD(P)+] activity Source: ASPGD

GO - Biological processi

  • acetaldehyde catabolic process Source: ASPGD
  • acetate biosynthetic process Source: ASPGD
  • carbon catabolite activation of transcription Source: ASPGD
  • cellular response to osmotic stress Source: ASPGD
  • ethanol catabolic process Source: UniProtKB-UniPathway
  • ethanol metabolic process Source: ASPGD
  • threonine catabolic process Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase (EC:1.2.1.3)
Short name:
ALDDH
Short name:
ALDH
Gene namesi
Name:aldA
Synonyms:aspA
ORF Names:AN0554
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VIII
  • UP000005890 Componenti: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EnsemblFungi
  • extracellular region Source: ASPGD
  • Golgi apparatus Source: EnsemblFungi
  • intracellular Source: ASPGD
  • nucleus Source: EnsemblFungi
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000564381 – 497Aldehyde dehydrogenaseAdd BLAST497

Proteomic databases

PRIDEiP08157.

Interactioni

Protein-protein interaction databases

BioGridi1957104. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliP08157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

HOGENOMiHOG000271505.
InParanoidiP08157.
KOiK00128.
OMAiHDAAKTW.
OrthoDBiEOG092C1LLH.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08157-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLFTTIET PVIKYEQPLG LFINNEFVKG VEGKTFQVIN PSNEKVITSV
60 70 80 90 100
HEATEKDVDV AVAAARAAFE GPWRQVTPSE RGILINKLAD LMERDIDTLA
110 120 130 140 150
AIESLDNGKA FTMAKVDLAN SIGCLRYYAG WADKIHGQTI DTNPETLTYT
160 170 180 190 200
RHEPVGVCGQ IIPWNFPLLM WSWKIGPAVA AGNTVVLKTA EQTPLSALYA
210 220 230 240 250
AKLIKEAGFP AGVINVISGF GRTAGAAISS HMDIDKVAFT GSTLVGRTIL
260 270 280 290 300
QAAAKSNLKK VTLELGGKSP NIVFDDADID NAISWANFGI FFNHGQCCCA
310 320 330 340 350
GSRILVQEGI YDKFVARFKE RAQKNKVGNP FEQDTFQGPQ VSQLQFDRIM
360 370 380 390 400
EYINHGKKAG ATVATGGDRH GNEGYFIQPT VFTDVTSDMK IAQEEIFGPV
410 420 430 440 450
VTIQKFKDEA EAIKIGNSTD YGLAAAVHTK NVNTAIRVSN ALKAGTVWIN
460 470 480 490
NYNMISYQAP FGGFKQSGLG RELGSYALEN YTQIKTVHYR LGDALFA
Length:497
Mass (Da):54,139
Last modified:May 1, 2007 - v2
Checksum:i9C6CFC62731A25BD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191E → Q in AAA33293 (PubMed:3036652).Curated1
Sequence conflicti208G → P in AAA33293 (PubMed:3036652).Curated1
Sequence conflicti247R → P in AAA33293 (PubMed:3036652).Curated1
Sequence conflicti409E → V in AAA33293 (PubMed:3036652).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16197 Genomic DNA. Translation: AAA33293.1.
AF260123 Genomic DNA. Translation: AAK18072.1.
AACD01000007 Genomic DNA. Translation: EAA66653.1.
BN001308 Genomic DNA. Translation: CBF89245.1.
PIRiA29055.
RefSeqiXP_658158.1. XM_653066.1.

Genome annotation databases

EnsemblFungiiCADANIAT00002125; CADANIAP00002125; CADANIAG00002125.
EAA66653; EAA66653; AN0554.2.
GeneIDi2876330.
KEGGiani:AN0554.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16197 Genomic DNA. Translation: AAA33293.1.
AF260123 Genomic DNA. Translation: AAK18072.1.
AACD01000007 Genomic DNA. Translation: EAA66653.1.
BN001308 Genomic DNA. Translation: CBF89245.1.
PIRiA29055.
RefSeqiXP_658158.1. XM_653066.1.

3D structure databases

ProteinModelPortaliP08157.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1957104. 1 interactor.

Proteomic databases

PRIDEiP08157.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00002125; CADANIAP00002125; CADANIAG00002125.
EAA66653; EAA66653; AN0554.2.
GeneIDi2876330.
KEGGiani:AN0554.2.

Phylogenomic databases

HOGENOMiHOG000271505.
InParanoidiP08157.
KOiK00128.
OMAiHDAAKTW.
OrthoDBiEOG092C1LLH.

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALDH_EMENI
AccessioniPrimary (citable) accession number: P08157
Secondary accession number(s): C8VSL3, Q5BFX6, Q9C1Q6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: May 1, 2007
Last modified: November 30, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.