P08157 (ALDH_EMENI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aldehyde dehydrogenase
Short name=ALDDH
Short name=ALDH
EC=1.2.1.3

Gene names

Name:	aldA
Synonyms:	aspA
ORF Names:	AN0554

Organism

Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) [Reference proteome]

Taxonomic identifier

227321 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Emericella › Emericella nidulans › mitosporic Emericella nidulans

Protein attributes

Sequence length	497 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	An aldehyde + NAD+ + H2O = a carboxylate + NADH.
Pathway	Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ethanol catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 497	497	Aldehyde dehydrogenase		PRO_0000056438
Regions
	Nucleotide binding	241 – 246	6	NAD By similarity
Sites
	Active site	264	1	Proton acceptor By similarity
	Active site	298	1	Nucleophile By similarity
	Site	165	1	Transition state stabilizer By similarity
Experimental info
	Sequence conflict	191	1	E → Q in AAA33293. Ref.1
	Sequence conflict	208	1	G → P in AAA33293. Ref.1
	Sequence conflict	247	1	R → P in AAA33293. Ref.1
	Sequence conflict	409	1	E → V in AAA33293. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P08157 [UniParc]. Last modified May 1, 2007. Version 2. Checksum: 9C6CFC62731A25BD	FASTA	497	54,139
	10 20 30 40 50 60 MSDLFTTIET PVIKYEQPLG LFINNEFVKG VEGKTFQVIN PSNEKVITSV HEATEKDVDV 70 80 90 100 110 120 AVAAARAAFE GPWRQVTPSE RGILINKLAD LMERDIDTLA AIESLDNGKA FTMAKVDLAN 130 140 150 160 170 180 SIGCLRYYAG WADKIHGQTI DTNPETLTYT RHEPVGVCGQ IIPWNFPLLM WSWKIGPAVA 190 200 210 220 230 240 AGNTVVLKTA EQTPLSALYA AKLIKEAGFP AGVINVISGF GRTAGAAISS HMDIDKVAFT 250 260 270 280 290 300 GSTLVGRTIL QAAAKSNLKK VTLELGGKSP NIVFDDADID NAISWANFGI FFNHGQCCCA 310 320 330 340 350 360 GSRILVQEGI YDKFVARFKE RAQKNKVGNP FEQDTFQGPQ VSQLQFDRIM EYINHGKKAG 370 380 390 400 410 420 ATVATGGDRH GNEGYFIQPT VFTDVTSDMK IAQEEIFGPV VTIQKFKDEA EAIKIGNSTD 430 440 450 460 470 480 YGLAAAVHTK NVNTAIRVSN ALKAGTVWIN NYNMISYQAP FGGFKQSGLG RELGSYALEN 490 YTQIKTVHYR LGDALFA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of the aldA gene of Aspergillus nidulans." Pickett M., Gwynne D.I., Buxton F.P., Elliott R., Davies R.W., Lockington R.A., Scazzocchio C., Sealy-Lewis H.M. Gene 51:217-226(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Regulation of the aldehyde dehydrogenase gene (aldA) and its role in the control of the coinducer level necessary for induction of the ethanol utilization pathway in Aspergillus nidulans." Flipphi M., Mathieu M., Cirpus I., Panozzo C., Felenbok B. J. Biol. Chem. 276:6950-6958(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae." Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W. Nature 438:1105-1115(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[4]	"The 2008 update of the Aspergillus nidulans genome annotation: a community effort." Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G. , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G. Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M16197 Genomic DNA. Translation: AAA33293.1. AF260123 Genomic DNA. Translation: AAK18072.1. AACD01000007 Genomic DNA. Translation: EAA66653.1. BN001308 Genomic DNA. Translation: CBF89245.1.
PIR	A29055.
RefSeq	XP_658158.1. XM_653066.1.
3D structure databases
ProteinModelPortal	P08157.
SMR	P08157. Positions 21-487.
ModBase	Search...
Proteomic databases
PRIDE	P08157.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADANIAT00002125; CADANIAP00002125; CADANIAG00002125.
GeneID	2876330.
KEGG	ani:AN0554.2.
Phylogenomic databases
eggNOG	COG1012.
HOGENOM	HOG000271505.
KO	K00128.
OMA	IERDRAY.
OrthoDB	EOG4Q885T.
Enzyme and pathway databases
UniPathway	UPA00780; UER00768.
Family and domain databases
Gene3D	3.40.309.10. 1 hit. 3.40.605.10. 1 hit.
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. [Graphical view]
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDH_EMENI

Accession

Primary (citable) accession number: P08157
Secondary accession number(s): C8VSL3, Q5BFX6, Q9C1Q6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	May 1, 2007
Last modified:	April 3, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program