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P08157 (ALDH_EMENI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldehyde dehydrogenase

Short name=ALDDH
Short name=ALDH
EC=1.2.1.3
Gene names
Name:aldA
Synonyms:aspA
ORF Names:AN0554
OrganismEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) [Reference proteome]
Taxonomic identifier227321 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathway

Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Aldehyde dehydrogenase
PRO_0000056438

Regions

Nucleotide binding241 – 2466NAD By similarity

Sites

Active site2641Proton acceptor By similarity
Active site2981Nucleophile By similarity
Site1651Transition state stabilizer By similarity

Experimental info

Sequence conflict1911E → Q in AAA33293. Ref.1
Sequence conflict2081G → P in AAA33293. Ref.1
Sequence conflict2471R → P in AAA33293. Ref.1
Sequence conflict4091E → V in AAA33293. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P08157 [UniParc].

Last modified May 1, 2007. Version 2.
Checksum: 9C6CFC62731A25BD

FASTA49754,139
        10         20         30         40         50         60 
MSDLFTTIET PVIKYEQPLG LFINNEFVKG VEGKTFQVIN PSNEKVITSV HEATEKDVDV 

        70         80         90        100        110        120 
AVAAARAAFE GPWRQVTPSE RGILINKLAD LMERDIDTLA AIESLDNGKA FTMAKVDLAN 

       130        140        150        160        170        180 
SIGCLRYYAG WADKIHGQTI DTNPETLTYT RHEPVGVCGQ IIPWNFPLLM WSWKIGPAVA 

       190        200        210        220        230        240 
AGNTVVLKTA EQTPLSALYA AKLIKEAGFP AGVINVISGF GRTAGAAISS HMDIDKVAFT 

       250        260        270        280        290        300 
GSTLVGRTIL QAAAKSNLKK VTLELGGKSP NIVFDDADID NAISWANFGI FFNHGQCCCA 

       310        320        330        340        350        360 
GSRILVQEGI YDKFVARFKE RAQKNKVGNP FEQDTFQGPQ VSQLQFDRIM EYINHGKKAG 

       370        380        390        400        410        420 
ATVATGGDRH GNEGYFIQPT VFTDVTSDMK IAQEEIFGPV VTIQKFKDEA EAIKIGNSTD 

       430        440        450        460        470        480 
YGLAAAVHTK NVNTAIRVSN ALKAGTVWIN NYNMISYQAP FGGFKQSGLG RELGSYALEN 

       490 
YTQIKTVHYR LGDALFA 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of the aldA gene of Aspergillus nidulans."
Pickett M., Gwynne D.I., Buxton F.P., Elliott R., Davies R.W., Lockington R.A., Scazzocchio C., Sealy-Lewis H.M.
Gene 51:217-226(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Regulation of the aldehyde dehydrogenase gene (aldA) and its role in the control of the coinducer level necessary for induction of the ethanol utilization pathway in Aspergillus nidulans."
Flipphi M., Mathieu M., Cirpus I., Panozzo C., Felenbok B.
J. Biol. Chem. 276:6950-6958(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae."
Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. expand/collapse author list , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.
Nature 438:1105-1115(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[4]"The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G. expand/collapse author list , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M16197 Genomic DNA. Translation: AAA33293.1.
AF260123 Genomic DNA. Translation: AAK18072.1.
AACD01000007 Genomic DNA. Translation: EAA66653.1.
BN001308 Genomic DNA. Translation: CBF89245.1.
PIRA29055.
RefSeqXP_658158.1. XM_653066.1.

3D structure databases

ProteinModelPortalP08157.
SMRP08157. Positions 21-487.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP08157.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADANIAT00002125; CADANIAP00002125; CADANIAG00002125.
GeneID2876330.
KEGGani:AN0554.2.

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
KOK00128.
OMADNGRDKG.
OrthoDBEOG7S226Z.

Enzyme and pathway databases

UniPathwayUPA00780; UER00768.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALDH_EMENI
AccessionPrimary (citable) accession number: P08157
Secondary accession number(s): C8VSL3, Q5BFX6, Q9C1Q6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: May 1, 2007
Last modified: January 22, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways