P08151 (GLI1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein GLI1

Alternative name(s):
Glioma-associated oncogene
Oncogene GLI

Gene names

Name:	GLI1
Synonyms:	GLI

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1106 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation. Ref.6 Ref.7
Subunit structure	Interacts with KIF7 By similarity. Interacts with ZIC1; the interaction enhances transcription activation. Ref.6 Ref.7
Subcellular location	Cytoplasm. Nucleus. Note: Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36. Phosphorylation by ULK3 may promote nuclear localization. Translocation to the nucleus is promoted by interaction with ZIC1. Ref.6 Ref.7 Ref.8
Tissue specificity	Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract. Ref.8
Induction	Amplified in glioblastoma cells.
Post-translational modification	Phosphorylated in vitro by ULK3. Ref.8 Acetylation at Lys-518 down-regulates transcriptional activity. Deacetylated by HDAC1.
Sequence similarities	Belongs to the GLI C2H2-type zinc-finger protein family. Contains 5 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Differentiation Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Proto-oncogene
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator Developmental protein
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cerebellar cortex morphogenesis Inferred from electronic annotation. Source: Compara digestive tract morphogenesis Traceable author statement PubMed 11001584. Source: BHF-UCL dorsal/ventral pattern formation Inferred from electronic annotation. Source: Compara epidermal cell differentiation Inferred from direct assay PubMed 12165851. Source: UniProtKB lung development Inferred from electronic annotation. Source: Compara negative regulation of canonical Wnt receptor signaling pathway Inferred from mutant phenotype PubMed 17035233. Source: UniProtKB notochord regression Inferred from electronic annotation. Source: Compara osteoblast differentiation Inferred from direct assay PubMed 12165851. Source: UniProtKB pituitary gland development Inferred from electronic annotation. Source: Compara positive regulation of DNA replication Inferred from direct assay PubMed 12165851. Source: UniProtKB positive regulation of cell proliferation Inferred from mutant phenotype PubMed 12165851. Source: UniProtKB positive regulation of smoothened signaling pathway Inferred from direct assay PubMed 17035233. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 12165851. Source: UniProtKB proximal/distal pattern formation Inferred from electronic annotation. Source: Compara smoothened signaling pathway Inferred from direct assay Ref.8. Source: UniProtKB smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Inferred from electronic annotation. Source: Compara spermatogenesis Inferred from electronic annotation. Source: Compara ventral midline development Inferred from electronic annotation. Source: Compara
Cellular_component	cilium Inferred from electronic annotation. Source: Compara cytosol Inferred from direct assay PubMed 18559511. Source: UniProtKB nucleus Inferred from direct assay Ref.6Ref.7Ref.8. Source: UniProtKB
Molecular_function	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara chromatin binding Inferred from electronic annotation. Source: Compara transcription regulatory region DNA binding Inferred from direct assay PubMed 17035233. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ITCH	Q96J02	4	EBI-308084,EBI-1564678
Numb	Q9QZS3-2	4	EBI-308084,EBI-3896014	From a different organism.
RPS6KB1	P23443	4	EBI-308084,EBI-1775921
RPS6KB1	P23443-2	2	EBI-308084,EBI-6093204
SUFU	Q9UMX1	5	EBI-308084,EBI-740595
SUFU	Q9UMX1-1	2	EBI-308084,EBI-740615
SUFU	Q9UMX1-2	4	EBI-308084,EBI-740621
Zic1	P46684	2	EBI-308084,EBI-308006	From a different organism.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P08151-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P08151-2)

The sequence of this isoform differs from the canonical sequence as follows:
     34-74: Missing.

Note: Undetectable in normal cells but highly expressed in cancer cells.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1106

1106

Zinc finger protein GLI1

PRO_0000047197

Regions

Zinc finger

235 – 260

26

C2H2-type 1

Zinc finger

268 – 295

28

C2H2-type 2

Zinc finger

301 – 325

25

C2H2-type 3

Zinc finger

331 – 356

26

C2H2-type 4

Zinc finger

362 – 387

26

C2H2-type 5

Region

1 – 20

20

SNAG domain By similarity

Compositional bias

1038 – 1055

18

Asp/Glu-rich (acidic)

Amino acid modifications

Modified residue

518

1

N6-acetyllysine Ref.9

Natural variations

Alternative sequence

34 – 74

41

Missing in isoform 2.

VSP_042215

Natural variant

210

1

P → A in a breast cancer sample; somatic mutation. Ref.12

VAR_035557

Natural variant

514

1

T → I in a breast cancer sample; somatic mutation. Ref.12

VAR_035558

Natural variant

817

1

E → Q in a breast cancer sample; somatic mutation. Ref.12

VAR_035559

Natural variant

884

1

D → A. Ref.11

VAR_015114

Natural variant

933

1

G → D. Ref.2 Ref.11
Corresponds to variant rs2228224 [ dbSNP | Ensembl ].

VAR_015115

Natural variant

1012

1

G → V.
Corresponds to variant rs2229300 [ dbSNP | Ensembl ].

VAR_052723

Natural variant

1100

1

E → Q. Ref.2 Ref.11
Corresponds to variant rs2228226 [ dbSNP | Ensembl ].

VAR_015116

Experimental info

Sequence conflict

1106

1

A → AS in ACX35434. Ref.3

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1106

Helix Strand Turn

Details...

Helix

249 – 259

11

Beta strand

261 – 263

3

Turn

276 – 279

4

Helix

285 – 291

7

Helix

293 – 296

4

Helix

315 – 324

10

Beta strand

341 – 346

6

Helix

349 – 354

6

Turn

367 – 369

3

Beta strand

372 – 375

4

Helix

376 – 381

6

Turn

382 – 384

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 1, 1988. Version 1. Checksum: E29B11D1A6CD3D91	FASTA	1,106	117,904
	10 20 30 40 50 60 MFNSMTPPPI SSYGEPCCLR PLPSQGAPSV GTEGLSGPPF CHQANLMSGP HSYGPARETN 70 80 90 100 110 120 SCTEGPLFSS PRSAVKLTKK RALSISPLSD ASLDLQTVIR TSPSSLVAFI NSRCTSPGGS 130 140 150 160 170 180 YGHLSIGTMS PSLGFPAQMN HQKGPSPSFG VQPCGPHDSA RGGMIPHPQS RGPFPTCQLK 190 200 210 220 230 240 SELDMLVGKC REEPLEGDMS SPNSTGIQDP LLGMLDGRED LEREEKREPE SVYETDCRWD 250 260 270 280 290 300 GCSQEFDSQE QLVHHINSEH IHGERKEFVC HWGGCSRELR PFKAQYMLVV HMRRHTGEKP 310 320 330 340 350 360 HKCTFEGCRK SYSRLENLKT HLRSHTGEKP YMCEHEGCSK AFSNASDRAK HQNRTHSNEK 370 380 390 400 410 420 PYVCKLPGCT KRYTDPSSLR KHVKTVHGPD AHVTKRHRGD GPLPRAPSIS TVEPKREREG 430 440 450 460 470 480 GPIREESRLT VPEGAMKPQP SPGAQSSCSS DHSPAGSAAN TDSGVEMTGN AGGSTEDLSS 490 500 510 520 530 540 LDEGPCIAGT GLSTLRRLEN LRLDQLHQLR PIGTRGLKLP SLSHTGTTVS RRVGPPVSLE 550 560 570 580 590 600 RRSSSSSSIS SAYTVSRRSS LASPFPPGSP PENGASSLPG LMPAQHYLLR ARYASARGGG 610 620 630 640 650 660 TSPTAASSLD RIGGLPMPPW RSRAEYPGYN PNAGVTRRAS DPAQAADRPA PARVQRFKSL 670 680 690 700 710 720 GCVHTPPTVA GGGQNFDPYL PTSVYSPQPP SITENAAMDA RGLQEEPEVG TSMVGSGLNP 730 740 750 760 770 780 YMDFPPTDTL GYGGPEGAAA EPYGARGPGS LPLGPGPPTN YGPNPCPQQA SYPDPTQETW 790 800 810 820 830 840 GEFPSHSGLY PGPKALGGTY SQCPRLEHYG QVQVKPEQGC PVGSDSTGLA PCLNAHPSEG 850 860 870 880 890 900 PPHPQPLFSH YPQPSPPQYL QSGPYTQPPP DYLPSEPRPC LDFDSPTHST GQLKAQLVCN 910 920 930 940 950 960 YVQSQQELLW EGGGREDAPA QEPSYQSPKF LGGSQVSPSR AKAPVNTYGP GFGPNLPNHK 970 980 990 1000 1010 1020 SGSYPTPSPC HENFVVGANR ASHRAAAPPR LLPPLPTCYG PLKVGGTNPS CGHPEVGRLG 1030 1040 1050 1060 1070 1080 GGPALYPPPE GQVCNPLDSL DLDNTQLDFV AILDEPQGLS PPPSHDQRGS SGHTPPPSGP 1090 1100 PNMAVGNMSV LLRSLPGETE FLNSSA
	Isoform 2 [UniParc]. Checksum: BEDBBC5D160A6A1C	FASTA	1,065	113,676
	10 20 30 40 50 60 MFNSMTPPPI SSYGEPCCLR PLPSQGAPSV GTEVKLTKKR ALSISPLSDA SLDLQTVIRT 70 80 90 100 110 120 SPSSLVAFIN SRCTSPGGSY GHLSIGTMSP SLGFPAQMNH QKGPSPSFGV QPCGPHDSAR 130 140 150 160 170 180 GGMIPHPQSR GPFPTCQLKS ELDMLVGKCR EEPLEGDMSS PNSTGIQDPL LGMLDGREDL 190 200 210 220 230 240 EREEKREPES VYETDCRWDG CSQEFDSQEQ LVHHINSEHI HGERKEFVCH WGGCSRELRP 250 260 270 280 290 300 FKAQYMLVVH MRRHTGEKPH KCTFEGCRKS YSRLENLKTH LRSHTGEKPY MCEHEGCSKA 310 320 330 340 350 360 FSNASDRAKH QNRTHSNEKP YVCKLPGCTK RYTDPSSLRK HVKTVHGPDA HVTKRHRGDG 370 380 390 400 410 420 PLPRAPSIST VEPKREREGG PIREESRLTV PEGAMKPQPS PGAQSSCSSD HSPAGSAANT 430 440 450 460 470 480 DSGVEMTGNA GGSTEDLSSL DEGPCIAGTG LSTLRRLENL RLDQLHQLRP IGTRGLKLPS 490 500 510 520 530 540 LSHTGTTVSR RVGPPVSLER RSSSSSSISS AYTVSRRSSL ASPFPPGSPP ENGASSLPGL 550 560 570 580 590 600 MPAQHYLLRA RYASARGGGT SPTAASSLDR IGGLPMPPWR SRAEYPGYNP NAGVTRRASD 610 620 630 640 650 660 PAQAADRPAP ARVQRFKSLG CVHTPPTVAG GGQNFDPYLP TSVYSPQPPS ITENAAMDAR 670 680 690 700 710 720 GLQEEPEVGT SMVGSGLNPY MDFPPTDTLG YGGPEGAAAE PYGARGPGSL PLGPGPPTNY 730 740 750 760 770 780 GPNPCPQQAS YPDPTQETWG EFPSHSGLYP GPKALGGTYS QCPRLEHYGQ VQVKPEQGCP 790 800 810 820 830 840 VGSDSTGLAP CLNAHPSEGP PHPQPLFSHY PQPSPPQYLQ SGPYTQPPPD YLPSEPRPCL 850 860 870 880 890 900 DFDSPTHSTG QLKAQLVCNY VQSQQELLWE GGGREDAPAQ EPSYQSPKFL GGSQVSPSRA 910 920 930 940 950 960 KAPVNTYGPG FGPNLPNHKS GSYPTPSPCH ENFVVGANRA SHRAAAPPRL LPPLPTCYGP 970 980 990 1000 1010 1020 LKVGGTNPSC GHPEVGRLGG GPALYPPPEG QVCNPLDSLD LDNTQLDFVA ILDEPQGLSP 1030 1040 1050 1060 PPSHDQRGSS GHTPPPSGPP NMAVGNMSVL LRSLPGETEF LNSSA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The GLI gene is a member of the Kruppel family of zinc finger proteins." Kinzler K.W., Ruppert J.M., Bigner S.H., Vogelstein B. Nature 332:371-374(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Polymorphic variants of the human oncogene GLI1 function similarly." Yoon J.W., Kent P., Clark A., Patterson J., Villavicencio E., Iannaccone P., Walterhouse D. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASP-933 AND GLN-1100.
[3]	"A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion." Lo H.W., Zhu H., Cao X., Aldrich A., Ali-Osman F. Cancer Res. 69:6790-6798(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
[4]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Muscle.
[6]	"Gli regulation by the opposing activities of fused and suppressor of fused." Murone M., Luoh S.-L., Stone D., Li W., Gurney A., Armanini M., Grey C., Rosenthal A., de Sauvage F.J. Nat. Cell Biol. 2:310-312(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH STK36 AND SUFU.
[7]	"Physical and functional interactions between Zic and Gli proteins." Koyabu Y., Nakata K., Mizugishi K., Aruga J., Mikoshiba K. J. Biol. Chem. 276:6889-6892(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH ZIC1, SUBCELLULAR LOCATION.
[8]	"Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway." Maloverjan A., Piirsoo M., Michelson P., Kogerman P., Osterlund T. Exp. Cell Res. 316:627-637(2010) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PHOSPHORYLATION.
[9]	"Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation." Canettieri G., Di Marcotullio L., Greco A., Coni S., Antonucci L., Infante P., Pietrosanti L., De Smaele E., Ferretti E., Miele E., Pelloni M., De Simone G., Pedone E.M., Gallinari P., Giorgi A., Steinkuhler C., Vitagliano L., Pedone C. , Schinin M.E., Screpanti I., Gulino A. Nat. Cell Biol. 12:132-142(2010) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION AT LYS-518.
[10]	"Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers." Pavletich N.P., Pabo C.O. Science 261:1701-1707(1993) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 234-388.
[11]	"Identification of polymorphic variants of the GLI1 oncogene." Wang X.Q., Chan N., Rothnagel J.A. J. Invest. Dermatol. 115:328-329(2000) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS ALA-884; ASP-933 AND GLN-1100.
[12]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-210; ILE-514 AND GLN-817.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X07384 mRNA. Translation: CAA30297.1.
AF316573 Genomic DNA. Translation: AAM13391.1.
GQ890670 mRNA. Translation: ACX35434.1.
AC022506 Genomic DNA. No translation available.
BC013000 mRNA. Translation: AAH13000.1.

IPI

IPI00027451.

PIR

TVHUGL. S00672.

RefSeq

NP_001153517.1. NM_001160045.1.
NP_001161081.1. NM_001167609.1.
NP_005260.1. NM_005269.2.

UniGene

Hs.632702.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2GLI	X-ray	2.60	A	234-388	[»]

ProteinModelPortal

P08151.

ModBase

Search...

Protein-protein interaction databases

IntAct

P08151. 12 interactions.

MINT

MINT-189932.

STRING

9606.ENSP00000228682.

PTM databases

PhosphoSite

P08151.

Polymorphism databases

DMDM

121323.

Proteomic databases

PaxDb

P08151.

PRIDE

P08151.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000228682; ENSP00000228682; ENSG00000111087.
ENST00000528467; ENSP00000434408; ENSG00000111087.
ENST00000546141; ENSP00000441006; ENSG00000111087.

GeneID

2735.

KEGG

hsa:2735.

UCSC

uc001snx.3. human.

Organism-specific databases

CTD

2735.

GeneCards

GC12P057853.

H-InvDB

HIX0010767.

HGNC

HGNC:4317. GLI1.

HPA

CAB009460.

MIM

165220. gene.

neXtProt

NX_P08151.

PharmGKB

PA28720.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5048.

HOGENOM

HOG000290688.

HOVERGEN

HBG080668.

InParanoid

P08151.

KO

K16797.

OMA

CPRLEHY.

OrthoDB

EOG4T1HKP.

PhylomeDB

P08151.

Enzyme and pathway databases

Pathway_Interaction_DB

hedgehog_glipathway. Hedgehog signaling events mediated by Gli proteins.

Gene expression databases

ArrayExpress

P08151.

Bgee

P08151.

CleanEx

HS_GLI1.

Genevestigator

P08151.

GermOnline

ENSG00000111087. Homo sapiens.

Family and domain databases

Gene3D

3.30.160.60. 5 hits.

InterPro

IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]

Pfam

PF00096. zf-C2H2. 1 hit.
[Graphical view]

SMART

SM00355. ZnF_C2H2. 5 hits.
[Graphical view]

PROSITE

PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

P08151.

ChEMBL

CHEMBL5461.

EvolutionaryTrace

P08151.

GenomeRNAi

2735.

NextBio

10780.

SOURCE

Search...

Entry information

Entry name

GLI1_HUMAN

Accession

Primary (citable) accession number: P08151
Secondary accession number(s): D0EUY3, E9PQQ9, Q8TDN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	August 1, 1988
Last modified:	May 1, 2013
This is version 152 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.