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P08151

- GLI1_HUMAN

UniProt

P08151 - GLI1_HUMAN

Protein

Zinc finger protein GLI1

Gene

GLI1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 167 (01 Oct 2014)
      Sequence version 1 (01 Aug 1988)
      Previous versions | rss
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    Functioni

    Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri235 – 26026C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 29528C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri301 – 32525C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri331 – 35626C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri362 – 38726C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. DNA binding Source: MGI
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: UniProtKB
    5. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
    6. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. cerebellar cortex morphogenesis Source: Ensembl
    2. digestive tract morphogenesis Source: BHF-UCL
    3. dorsal/ventral pattern formation Source: Ensembl
    4. epidermal cell differentiation Source: UniProtKB
    5. lung development Source: Ensembl
    6. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
    7. notochord regression Source: Ensembl
    8. osteoblast differentiation Source: UniProtKB
    9. pituitary gland development Source: Ensembl
    10. positive regulation of cell proliferation Source: UniProtKB
    11. positive regulation of DNA replication Source: UniProtKB
    12. positive regulation of smoothened signaling pathway Source: UniProtKB
    13. positive regulation of transcription, DNA-templated Source: UniProtKB
    14. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    15. proximal/distal pattern formation Source: Ensembl
    16. regulation of smoothened signaling pathway Source: UniProtKB
    17. smoothened signaling pathway Source: UniProtKB
    18. smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: Ensembl
    19. spermatogenesis Source: Ensembl
    20. ventral midline development Source: Ensembl

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    SignaLinkiP08151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein GLI1
    Alternative name(s):
    Glioma-associated oncogene
    Oncogene GLI
    Gene namesi
    Name:GLI1
    Synonyms:GLI
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:4317. GLI1.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36. Phosphorylation by ULK3 may promote nuclear localization. Translocation to the nucleus is promoted by interaction with ZIC1.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: UniProtKB
    3. intracellular membrane-bounded organelle Source: HPA
    4. nucleus Source: UniProtKB
    5. primary cilium Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    PharmGKBiPA28720.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11061106Zinc finger protein GLI1PRO_0000047197Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei518 – 5181N6-acetyllysine1 Publication

    Post-translational modificationi

    Phosphorylated in vitro by ULK3.1 Publication
    Acetylation at Lys-518 down-regulates transcriptional activity. Deacetylated by HDAC1.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiP08151.
    PRIDEiP08151.

    PTM databases

    PhosphoSiteiP08151.

    Expressioni

    Tissue specificityi

    Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract.1 Publication

    Inductioni

    Amplified in glioblastoma cells.

    Gene expression databases

    ArrayExpressiP08151.
    BgeeiP08151.
    CleanExiHS_GLI1.
    GenevestigatoriP08151.

    Organism-specific databases

    HPAiCAB009460.
    HPA034585.

    Interactioni

    Subunit structurei

    Interacts with KIF7 By similarity. Interacts with ZIC1; the interaction enhances transcription activation.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ITCHQ96J024EBI-308084,EBI-1564678
    NumbQ9QZS3-24EBI-308084,EBI-3896014From a different organism.
    RPS6KB1P234434EBI-308084,EBI-1775921
    RPS6KB1P23443-22EBI-308084,EBI-6093204
    STK36Q9NRP72EBI-308084,EBI-863797
    SUFUQ9UMX19EBI-308084,EBI-740595
    SUFUQ9UMX1-12EBI-308084,EBI-740615
    SUFUQ9UMX1-24EBI-308084,EBI-740621
    VHLP40337-12EBI-308084,EBI-3504450
    VHLP40337-32EBI-308084,EBI-301270
    Zic1P466842EBI-308084,EBI-308006From a different organism.

    Protein-protein interaction databases

    BioGridi108997. 20 interactions.
    DIPiDIP-32536N.
    IntActiP08151. 14 interactions.
    MINTiMINT-189932.
    STRINGi9606.ENSP00000228682.

    Structurei

    Secondary structure

    1
    1106
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi120 – 1234
    Helixi249 – 25911
    Beta strandi261 – 2633
    Turni276 – 2794
    Helixi285 – 2917
    Helixi293 – 2964
    Helixi315 – 32410
    Beta strandi341 – 3466
    Helixi349 – 3546
    Turni367 – 3693
    Beta strandi372 – 3754
    Helixi376 – 3816
    Turni382 – 3843

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2GLIX-ray2.60A234-388[»]
    4BLBX-ray2.80E/F/G/H115-131[»]
    4KMDX-ray1.70B112-128[»]
    ProteinModelPortaliP08151.
    SMRiP08151. Positions 143-181, 234-388.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP08151.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2020SNAG domainBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1038 – 105518Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri235 – 26026C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 29528C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri301 – 32525C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri331 – 35626C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri362 – 38726C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000290688.
    HOVERGENiHBG080668.
    InParanoidiP08151.
    KOiK16797.
    OMAiCPRLEHY.
    OrthoDBiEOG7X6KZ8.
    PhylomeDBiP08151.
    TreeFamiTF350216.

    Family and domain databases

    Gene3Di3.30.160.60. 5 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P08151-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFNSMTPPPI SSYGEPCCLR PLPSQGAPSV GTEGLSGPPF CHQANLMSGP     50
    HSYGPARETN SCTEGPLFSS PRSAVKLTKK RALSISPLSD ASLDLQTVIR 100
    TSPSSLVAFI NSRCTSPGGS YGHLSIGTMS PSLGFPAQMN HQKGPSPSFG 150
    VQPCGPHDSA RGGMIPHPQS RGPFPTCQLK SELDMLVGKC REEPLEGDMS 200
    SPNSTGIQDP LLGMLDGRED LEREEKREPE SVYETDCRWD GCSQEFDSQE 250
    QLVHHINSEH IHGERKEFVC HWGGCSRELR PFKAQYMLVV HMRRHTGEKP 300
    HKCTFEGCRK SYSRLENLKT HLRSHTGEKP YMCEHEGCSK AFSNASDRAK 350
    HQNRTHSNEK PYVCKLPGCT KRYTDPSSLR KHVKTVHGPD AHVTKRHRGD 400
    GPLPRAPSIS TVEPKREREG GPIREESRLT VPEGAMKPQP SPGAQSSCSS 450
    DHSPAGSAAN TDSGVEMTGN AGGSTEDLSS LDEGPCIAGT GLSTLRRLEN 500
    LRLDQLHQLR PIGTRGLKLP SLSHTGTTVS RRVGPPVSLE RRSSSSSSIS 550
    SAYTVSRRSS LASPFPPGSP PENGASSLPG LMPAQHYLLR ARYASARGGG 600
    TSPTAASSLD RIGGLPMPPW RSRAEYPGYN PNAGVTRRAS DPAQAADRPA 650
    PARVQRFKSL GCVHTPPTVA GGGQNFDPYL PTSVYSPQPP SITENAAMDA 700
    RGLQEEPEVG TSMVGSGLNP YMDFPPTDTL GYGGPEGAAA EPYGARGPGS 750
    LPLGPGPPTN YGPNPCPQQA SYPDPTQETW GEFPSHSGLY PGPKALGGTY 800
    SQCPRLEHYG QVQVKPEQGC PVGSDSTGLA PCLNAHPSEG PPHPQPLFSH 850
    YPQPSPPQYL QSGPYTQPPP DYLPSEPRPC LDFDSPTHST GQLKAQLVCN 900
    YVQSQQELLW EGGGREDAPA QEPSYQSPKF LGGSQVSPSR AKAPVNTYGP 950
    GFGPNLPNHK SGSYPTPSPC HENFVVGANR ASHRAAAPPR LLPPLPTCYG 1000
    PLKVGGTNPS CGHPEVGRLG GGPALYPPPE GQVCNPLDSL DLDNTQLDFV 1050
    AILDEPQGLS PPPSHDQRGS SGHTPPPSGP PNMAVGNMSV LLRSLPGETE 1100
    FLNSSA 1106
    Length:1,106
    Mass (Da):117,904
    Last modified:August 1, 1988 - v1
    Checksum:iE29B11D1A6CD3D91
    GO
    Isoform 2 (identifier: P08151-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         34-74: Missing.

    Note: Undetectable in normal cells but highly expressed in cancer cells.

    Show »
    Length:1,065
    Mass (Da):113,676
    Checksum:iBEDBBC5D160A6A1C
    GO
    Isoform 3 (identifier: P08151-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-128: Missing.

    Note: No experimental confirmation available. Gene prediction based on partial mRNA and EST data.

    Show »
    Length:978
    Mass (Da):104,627
    Checksum:i947FFF4234D96403
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1106 – 11061A → AS in ACX35434. (PubMed:19706761)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti210 – 2101P → A in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035557
    Natural varianti514 – 5141T → I in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035558
    Natural varianti817 – 8171E → Q in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035559
    Natural varianti884 – 8841D → A.1 Publication
    VAR_015114
    Natural varianti933 – 9331G → D.2 Publications
    Corresponds to variant rs2228224 [ dbSNP | Ensembl ].
    VAR_015115
    Natural varianti1012 – 10121G → V.
    Corresponds to variant rs2229300 [ dbSNP | Ensembl ].
    VAR_052723
    Natural varianti1100 – 11001E → Q.2 Publications
    Corresponds to variant rs2228226 [ dbSNP | Ensembl ].
    VAR_015116

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 128128Missing in isoform 3. CuratedVSP_054829Add
    BLAST
    Alternative sequencei34 – 7441Missing in isoform 2. 1 PublicationVSP_042215Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07384 mRNA. Translation: CAA30297.1.
    AF316573 Genomic DNA. Translation: AAM13391.1.
    GQ890670 mRNA. Translation: ACX35434.1.
    AC022506 Genomic DNA. No translation available.
    BC013000 mRNA. Translation: AAH13000.1.
    CCDSiCCDS53806.1. [P08151-2]
    CCDS53807.1. [P08151-3]
    CCDS8940.1. [P08151-1]
    PIRiS00672. TVHUGL.
    RefSeqiNP_001153517.1. NM_001160045.1. [P08151-3]
    NP_001161081.1. NM_001167609.1. [P08151-2]
    NP_005260.1. NM_005269.2. [P08151-1]
    XP_005268856.1. XM_005268799.1. [P08151-3]
    UniGeneiHs.632702.

    Genome annotation databases

    EnsembliENST00000228682; ENSP00000228682; ENSG00000111087. [P08151-1]
    ENST00000528467; ENSP00000434408; ENSG00000111087. [P08151-2]
    ENST00000543426; ENSP00000437607; ENSG00000111087. [P08151-3]
    ENST00000546141; ENSP00000441006; ENSG00000111087. [P08151-2]
    GeneIDi2735.
    KEGGihsa:2735.
    UCSCiuc001snx.3. human. [P08151-1]
    uc021qzi.1. human. [P08151-2]

    Polymorphism databases

    DMDMi121323.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07384 mRNA. Translation: CAA30297.1 .
    AF316573 Genomic DNA. Translation: AAM13391.1 .
    GQ890670 mRNA. Translation: ACX35434.1 .
    AC022506 Genomic DNA. No translation available.
    BC013000 mRNA. Translation: AAH13000.1 .
    CCDSi CCDS53806.1. [P08151-2 ]
    CCDS53807.1. [P08151-3 ]
    CCDS8940.1. [P08151-1 ]
    PIRi S00672. TVHUGL.
    RefSeqi NP_001153517.1. NM_001160045.1. [P08151-3 ]
    NP_001161081.1. NM_001167609.1. [P08151-2 ]
    NP_005260.1. NM_005269.2. [P08151-1 ]
    XP_005268856.1. XM_005268799.1. [P08151-3 ]
    UniGenei Hs.632702.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2GLI X-ray 2.60 A 234-388 [» ]
    4BLB X-ray 2.80 E/F/G/H 115-131 [» ]
    4KMD X-ray 1.70 B 112-128 [» ]
    ProteinModelPortali P08151.
    SMRi P08151. Positions 143-181, 234-388.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108997. 20 interactions.
    DIPi DIP-32536N.
    IntActi P08151. 14 interactions.
    MINTi MINT-189932.
    STRINGi 9606.ENSP00000228682.

    Chemistry

    BindingDBi P08151.
    ChEMBLi CHEMBL5461.

    PTM databases

    PhosphoSitei P08151.

    Polymorphism databases

    DMDMi 121323.

    Proteomic databases

    PaxDbi P08151.
    PRIDEi P08151.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000228682 ; ENSP00000228682 ; ENSG00000111087 . [P08151-1 ]
    ENST00000528467 ; ENSP00000434408 ; ENSG00000111087 . [P08151-2 ]
    ENST00000543426 ; ENSP00000437607 ; ENSG00000111087 . [P08151-3 ]
    ENST00000546141 ; ENSP00000441006 ; ENSG00000111087 . [P08151-2 ]
    GeneIDi 2735.
    KEGGi hsa:2735.
    UCSCi uc001snx.3. human. [P08151-1 ]
    uc021qzi.1. human. [P08151-2 ]

    Organism-specific databases

    CTDi 2735.
    GeneCardsi GC12P057853.
    H-InvDB HIX0010767.
    HGNCi HGNC:4317. GLI1.
    HPAi CAB009460.
    HPA034585.
    MIMi 165220. gene.
    neXtProti NX_P08151.
    PharmGKBi PA28720.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000290688.
    HOVERGENi HBG080668.
    InParanoidi P08151.
    KOi K16797.
    OMAi CPRLEHY.
    OrthoDBi EOG7X6KZ8.
    PhylomeDBi P08151.
    TreeFami TF350216.

    Enzyme and pathway databases

    SignaLinki P08151.

    Miscellaneous databases

    EvolutionaryTracei P08151.
    GeneWikii GLI1.
    GenomeRNAii 2735.
    NextBioi 10780.
    PROi P08151.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P08151.
    Bgeei P08151.
    CleanExi HS_GLI1.
    Genevestigatori P08151.

    Family and domain databases

    Gene3Di 3.30.160.60. 5 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The GLI gene is a member of the Kruppel family of zinc finger proteins."
      Kinzler K.W., Ruppert J.M., Bigner S.H., Vogelstein B.
      Nature 332:371-374(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Polymorphic variants of the human oncogene GLI1 function similarly."
      Yoon J.W., Kent P., Clark A., Patterson J., Villavicencio E., Iannaccone P., Walterhouse D.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASP-933 AND GLN-1100.
    3. "A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion."
      Lo H.W., Zhu H., Cao X., Aldrich A., Ali-Osman F.
      Cancer Res. 69:6790-6798(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
    4. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Muscle.
    6. "Gli regulation by the opposing activities of fused and suppressor of fused."
      Murone M., Luoh S.-L., Stone D., Li W., Gurney A., Armanini M., Grey C., Rosenthal A., de Sauvage F.J.
      Nat. Cell Biol. 2:310-312(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH STK36 AND SUFU.
    7. "Physical and functional interactions between Zic and Gli proteins."
      Koyabu Y., Nakata K., Mizugishi K., Aruga J., Mikoshiba K.
      J. Biol. Chem. 276:6889-6892(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ZIC1, SUBCELLULAR LOCATION.
    8. "Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway."
      Maloverjan A., Piirsoo M., Michelson P., Kogerman P., Osterlund T.
      Exp. Cell Res. 316:627-637(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PHOSPHORYLATION.
    9. Cited for: ACETYLATION AT LYS-518.
    10. "Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers."
      Pavletich N.P., Pabo C.O.
      Science 261:1701-1707(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 234-388.
    11. "Identification of polymorphic variants of the GLI1 oncogene."
      Wang X.Q., Chan N., Rothnagel J.A.
      J. Invest. Dermatol. 115:328-329(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ALA-884; ASP-933 AND GLN-1100.
    12. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-210; ILE-514 AND GLN-817.

    Entry informationi

    Entry nameiGLI1_HUMAN
    AccessioniPrimary (citable) accession number: P08151
    Secondary accession number(s): D0EUY3
    , E9PQQ9, F5H6H8, Q8TDN9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: August 1, 1988
    Last modified: October 1, 2014
    This is version 167 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3