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Protein

Rho-related GTP-binding protein RhoC

Gene

RHOC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 19GTPBy similarity8
Nucleotide bindingi59 – 63GTPBy similarity5
Nucleotide bindingi117 – 120GTPBy similarity4

GO - Molecular functioni

  • GTP binding Source: UniProtKB-KW
  • signal transducer activity Source: UniProtKB

GO - Biological processi

  • apical junction assembly Source: UniProtKB
  • cytokinesis Source: UniProtKB
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • positive regulation of lipase activity Source: AgBase
  • regulation of small GTPase mediated signal transduction Source: Reactome
  • skeletal muscle satellite cell migration Source: AgBase
  • small GTPase mediated signal transduction Source: InterPro
  • wound healing, spreading of cells Source: AgBase
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000155366-MONOMER.
ReactomeiR-HSA-194840. Rho GTPase cycle.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-416572. Sema4D induced cell migration and growth-cone collapse.
R-HSA-5625740. RHO GTPases activate PKNs.
R-HSA-5625900. RHO GTPases activate CIT.
R-HSA-5627117. RHO GTPases Activate ROCKs.
R-HSA-5663220. RHO GTPases Activate Formins.
R-HSA-5666185. RHO GTPases Activate Rhotekin and Rhophilins.
SignaLinkiP08134.
SIGNORiP08134.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoC
Alternative name(s):
Rho cDNA clone 9
Short name:
h9
Gene namesi
Name:RHOC
Synonyms:ARH9, ARHC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:669. RHOC.

Subcellular locationi

GO - Cellular componenti

  • cleavage furrow Source: UniProtKB
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • nucleus Source: Ensembl
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi389.
OpenTargetsiENSG00000155366.
PharmGKBiPA24951.

Polymorphism and mutation databases

BioMutaiRHOC.
DMDMi132543.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000420221 – 190Rho-related GTP-binding protein RhoCAdd BLAST190
PropeptideiPRO_0000042023191 – 193Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34O-linked (GlcNAc); by Photorhabdus PAU_022301 Publication1
Modified residuei41ADP-ribosylasparagine; by botulinum toxinBy similarity1
Modified residuei190Cysteine methyl esterBy similarity1
Lipidationi190S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

(Microbial infection) Glycosylated at Tyr-34 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rho and leads to actin disassembly.1 Publication

Keywords - PTMi

ADP-ribosylation, Glycoprotein, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP08134.
MaxQBiP08134.
PaxDbiP08134.
PeptideAtlasiP08134.
PRIDEiP08134.
TopDownProteomicsiP08134.

PTM databases

iPTMnetiP08134.
PhosphoSitePlusiP08134.
SwissPalmiP08134.

Expressioni

Gene expression databases

BgeeiENSG00000155366.
CleanExiHS_RHOC.
ExpressionAtlasiP08134. baseline and differential.
GenevisibleiP08134. HS.

Organism-specific databases

HPAiHPA062346.

Interactioni

Subunit structurei

Interacts with RTKN (By similarity). Interacts with AKAP13, DIAPH1, PKN2, ROCK1 and ROCK2. Interacts with ARHGDIA.By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM65BQ9Y4F95EBI-747589,EBI-2798942

Protein-protein interaction databases

BioGridi106882. 30 interactors.
IntActiP08134. 10 interactors.
MINTiMINT-1216716.
STRINGi9606.ENSP00000285735.

Structurei

Secondary structure

1193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 13Combined sources10
Helixi18 – 27Combined sources10
Beta strandi43 – 48Combined sources6
Beta strandi51 – 58Combined sources8
Helixi64 – 66Combined sources3
Turni67 – 69Combined sources3
Helixi70 – 73Combined sources4
Beta strandi78 – 85Combined sources8
Helixi89 – 97Combined sources9
Helixi99 – 106Combined sources8
Beta strandi112 – 117Combined sources6
Helixi119 – 121Combined sources3
Helixi125 – 132Combined sources8
Turni133 – 135Combined sources3
Helixi141 – 150Combined sources10
Beta strandi154 – 158Combined sources5
Turni161 – 163Combined sources3
Helixi167 – 179Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z2CX-ray3.00A/C1-193[»]
2GCNX-ray1.85A1-181[»]
2GCOX-ray1.40A/B1-181[»]
2GCPX-ray2.15A1-181[»]
ProteinModelPortaliP08134.
SMRiP08134.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08134.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi34 – 42Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000119020.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiP08134.
KOiK07857.
OMAiKRRGACQ.
PhylomeDBiP08134.
TreeFamiTF300837.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08134-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYIADIEVDG
60 70 80 90 100
KQVELALWDT AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT
110 120 130 140 150
PEVKHFCPNV PIILVGNKKD LRQDEHTRRE LAKMKQEPVR SEEGRDMANR
160 170 180 190
ISAFGYLECS AKTKEGVREV FEMATRAGLQ VRKNKRRRGC PIL
Length:193
Mass (Da):22,006
Last modified:August 1, 1988 - v1
Checksum:iA193DA581560F131
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051974120D → H.Corresponds to variant rs11538959dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06821 mRNA. Translation: CAA29969.1.
L25081 mRNA. Translation: AAC33179.1.
AF498972 mRNA. Translation: AAM21119.1.
CR450360 mRNA. Translation: CAG29356.1.
BT019448 mRNA. Translation: AAV38255.1.
AK094474 mRNA. Translation: BAG52873.1.
AL603832 Genomic DNA. Translation: CAI14058.1.
CH471122 Genomic DNA. Translation: EAW56534.1.
BC007245 mRNA. Translation: AAH07245.1.
BC009177 mRNA. Translation: AAH09177.1.
BC052808 mRNA. Translation: AAH52808.1.
CCDSiCCDS854.1.
PIRiS01029. TVHURC.
RefSeqiNP_001036143.1. NM_001042678.1.
NP_001036144.1. NM_001042679.1.
NP_786886.1. NM_175744.4.
UniGeneiHs.502659.
Hs.658289.

Genome annotation databases

EnsembliENST00000285735; ENSP00000285735; ENSG00000155366.
ENST00000339083; ENSP00000345236; ENSG00000155366.
ENST00000369632; ENSP00000358646; ENSG00000155366.
ENST00000369633; ENSP00000358647; ENSG00000155366.
ENST00000369637; ENSP00000358651; ENSG00000155366.
ENST00000369638; ENSP00000358652; ENSG00000155366.
ENST00000369642; ENSP00000358656; ENSG00000155366.
GeneIDi389.
KEGGihsa:389.
UCSCiuc001ecp.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06821 mRNA. Translation: CAA29969.1.
L25081 mRNA. Translation: AAC33179.1.
AF498972 mRNA. Translation: AAM21119.1.
CR450360 mRNA. Translation: CAG29356.1.
BT019448 mRNA. Translation: AAV38255.1.
AK094474 mRNA. Translation: BAG52873.1.
AL603832 Genomic DNA. Translation: CAI14058.1.
CH471122 Genomic DNA. Translation: EAW56534.1.
BC007245 mRNA. Translation: AAH07245.1.
BC009177 mRNA. Translation: AAH09177.1.
BC052808 mRNA. Translation: AAH52808.1.
CCDSiCCDS854.1.
PIRiS01029. TVHURC.
RefSeqiNP_001036143.1. NM_001042678.1.
NP_001036144.1. NM_001042679.1.
NP_786886.1. NM_175744.4.
UniGeneiHs.502659.
Hs.658289.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z2CX-ray3.00A/C1-193[»]
2GCNX-ray1.85A1-181[»]
2GCOX-ray1.40A/B1-181[»]
2GCPX-ray2.15A1-181[»]
ProteinModelPortaliP08134.
SMRiP08134.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106882. 30 interactors.
IntActiP08134. 10 interactors.
MINTiMINT-1216716.
STRINGi9606.ENSP00000285735.

PTM databases

iPTMnetiP08134.
PhosphoSitePlusiP08134.
SwissPalmiP08134.

Polymorphism and mutation databases

BioMutaiRHOC.
DMDMi132543.

Proteomic databases

EPDiP08134.
MaxQBiP08134.
PaxDbiP08134.
PeptideAtlasiP08134.
PRIDEiP08134.
TopDownProteomicsiP08134.

Protocols and materials databases

DNASUi389.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285735; ENSP00000285735; ENSG00000155366.
ENST00000339083; ENSP00000345236; ENSG00000155366.
ENST00000369632; ENSP00000358646; ENSG00000155366.
ENST00000369633; ENSP00000358647; ENSG00000155366.
ENST00000369637; ENSP00000358651; ENSG00000155366.
ENST00000369638; ENSP00000358652; ENSG00000155366.
ENST00000369642; ENSP00000358656; ENSG00000155366.
GeneIDi389.
KEGGihsa:389.
UCSCiuc001ecp.1. human.

Organism-specific databases

CTDi389.
DisGeNETi389.
GeneCardsiRHOC.
HGNCiHGNC:669. RHOC.
HPAiHPA062346.
MIMi165380. gene.
neXtProtiNX_P08134.
OpenTargetsiENSG00000155366.
PharmGKBiPA24951.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000119020.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiP08134.
KOiK07857.
OMAiKRRGACQ.
PhylomeDBiP08134.
TreeFamiTF300837.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000155366-MONOMER.
ReactomeiR-HSA-194840. Rho GTPase cycle.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-416572. Sema4D induced cell migration and growth-cone collapse.
R-HSA-5625740. RHO GTPases activate PKNs.
R-HSA-5625900. RHO GTPases activate CIT.
R-HSA-5627117. RHO GTPases Activate ROCKs.
R-HSA-5663220. RHO GTPases Activate Formins.
R-HSA-5666185. RHO GTPases Activate Rhotekin and Rhophilins.
SignaLinkiP08134.
SIGNORiP08134.

Miscellaneous databases

ChiTaRSiRHOC. human.
EvolutionaryTraceiP08134.
GeneWikiiRhoC.
GenomeRNAii389.
PROiP08134.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155366.
CleanExiHS_RHOC.
ExpressionAtlasiP08134. baseline and differential.
GenevisibleiP08134. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHOC_HUMAN
AccessioniPrimary (citable) accession number: P08134
Secondary accession number(s): B3KSW1, Q6ICN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 30, 2016
This is version 192 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.