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Protein

Annexin A6

Gene

ANXA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May associate with CD21. May regulate the release of Ca2+ from intracellular stores.

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: UniProtKB
  • calcium-dependent protein binding Source: AgBase
  • calcium ion binding Source: InterPro
  • cholesterol binding Source: UniProtKB
  • GTP binding Source: UniProtKB
  • ligand-gated ion channel activity Source: UniProtKB
  • lipid binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • apoptotic signaling pathway Source: Ensembl
  • calcium ion transport Source: Ensembl
  • ion transmembrane transport Source: UniProtKB
  • mitochondrial calcium ion homeostasis Source: Ensembl
  • protein homooligomerization Source: UniProtKB
  • regulation of muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-445355. Smooth Muscle Contraction.

Protein family/group databases

TCDBi1.A.31.1.2. the annexin (annexin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A6
Alternative name(s):
67 kDa calelectrin
Annexin VI
Annexin-6
Calphobindin-II
Short name:
CPB-II
Chromobindin-20
Lipocortin VI
Protein III
p68
p70
Gene namesi
Name:ANXA6
Synonyms:ANX6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:544. ANXA6.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • late endosome membrane Source: UniProtKB
  • lysosomal membrane Source: UniProtKB
  • melanosome Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
  • mitochondrion Source: GOC
  • perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi309.
OpenTargetsiENSG00000197043.
PharmGKBiPA24834.

Polymorphism and mutation databases

BioMutaiANXA6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000674942 – 673Annexin A6Add BLAST672

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei13PhosphoserineCombined sources1
Modified residuei30PhosphotyrosineCombined sources1
Modified residuei63N6-acetyllysineCombined sources1
Modified residuei68N6-acetyllysineCombined sources1
Modified residuei75N6-acetyllysineCombined sources1
Modified residuei81N6-acetyllysineCombined sources1
Modified residuei201PhosphotyrosineBy similarity1
Modified residuei306N6-acetyllysineCombined sources1
Modified residuei370N6-acetyllysineCombined sources1
Modified residuei418N6-acetyllysineCombined sources1
Modified residuei422PhosphoserineBy similarity1
Modified residuei483N6-acetyllysineCombined sources1
Modified residuei537PhosphoserineCombined sources1
Modified residuei620N6-acetyllysineCombined sources1

Post-translational modificationi

Phosphorylated in response to growth factor stimulation.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP08133.
MaxQBiP08133.
PaxDbiP08133.
PeptideAtlasiP08133.
PRIDEiP08133.

2D gel databases

REPRODUCTION-2DPAGEIPI00221226.
UCD-2DPAGEP08133.

PTM databases

iPTMnetiP08133.
PhosphoSitePlusiP08133.
SwissPalmiP08133.

Expressioni

Inductioni

By Epstein-Barr virus (EBV).

Gene expression databases

BgeeiENSG00000197043.
CleanExiHS_ANXA6.
ExpressionAtlasiP08133. baseline and differential.
GenevisibleiP08133. HS.

Organism-specific databases

HPAiCAB005077.
HPA002462.
HPA009650.

Interactioni

GO - Molecular functioni

  • calcium-dependent protein binding Source: AgBase
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi106806. 36 interactors.
IntActiP08133. 14 interactors.
MINTiMINT-4999263.
STRINGi9606.ENSP00000346550.

Structurei

Secondary structure

1673
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi22 – 32Combined sources11
Beta strandi34 – 37Combined sources4
Helixi40 – 47Combined sources8
Helixi52 – 66Combined sources15
Helixi70 – 77Combined sources8
Helixi80 – 90Combined sources11
Helixi93 – 105Combined sources13
Beta strandi106 – 109Combined sources4
Helixi112 – 121Combined sources10
Helixi124 – 137Combined sources14
Helixi142 – 149Combined sources8
Helixi152 – 163Combined sources12
Helixi174 – 187Combined sources14
Turni188 – 190Combined sources3
Beta strandi191 – 193Combined sources3
Helixi196 – 205Combined sources10
Helixi208 – 221Combined sources14
Beta strandi222 – 224Combined sources3
Helixi226 – 230Combined sources5
Turni231 – 233Combined sources3
Helixi236 – 262Combined sources27
Beta strandi264 – 268Combined sources5
Helixi271 – 280Combined sources10
Turni281 – 285Combined sources5
Helixi286 – 296Combined sources11
Beta strandi297 – 299Combined sources3
Helixi301 – 306Combined sources6
Helixi311 – 321Combined sources11
Helixi333 – 348Combined sources16
Helixi365 – 376Combined sources12
Beta strandi377 – 380Combined sources4
Helixi383 – 391Combined sources9
Helixi395 – 409Combined sources15
Helixi413 – 420Combined sources8
Helixi424 – 433Combined sources10
Helixi436 – 448Combined sources13
Beta strandi449 – 452Combined sources4
Helixi455 – 464Combined sources10
Helixi467 – 481Combined sources15
Helixi485 – 492Combined sources8
Helixi495 – 504Combined sources10
Helixi516 – 530Combined sources15
Helixi535 – 537Combined sources3
Helixi546 – 553Combined sources8
Helixi556 – 568Combined sources13
Beta strandi569 – 572Combined sources4
Helixi574 – 581Combined sources8
Helixi584 – 611Combined sources28
Beta strandi613 – 616Combined sources4
Helixi619 – 628Combined sources10
Turni630 – 633Combined sources4
Helixi634 – 645Combined sources12
Helixi649 – 656Combined sources8
Helixi659 – 668Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M9IX-ray2.65A2-673[»]
ProteinModelPortaliP08133.
SMRiP08133.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08133.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati29 – 89Annexin 1Add BLAST61
Repeati101 – 161Annexin 2Add BLAST61
Repeati185 – 245Annexin 3Add BLAST61
Repeati260 – 320Annexin 4Add BLAST61
Repeati372 – 432Annexin 5Add BLAST61
Repeati444 – 504Annexin 6Add BLAST61
Repeati533 – 593Annexin 7Add BLAST61
Repeati608 – 668Annexin 8Add BLAST61

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 8 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP08133.
KOiK17094.
OMAiQRQEICQ.
OrthoDBiEOG091G0H6H.
PhylomeDBiP08133.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 8 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002393. AnnexinVI.
[Graphical view]
PANTHERiPTHR10502:SF19. PTHR10502:SF19. 1 hit.
PfamiPF00191. Annexin. 8 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00202. ANNEXINVI.
SMARTiSM00335. ANX. 8 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 8 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P08133-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKPAQGAKY RGSIHDFPGF DPNQDAEALY TAMKGFGSDK EAILDIITSR
60 70 80 90 100
SNRQRQEVCQ SYKSLYGKDL IADLKYELTG KFERLIVGLM RPPAYCDAKE
110 120 130 140 150
IKDAISGIGT DEKCLIEILA SRTNEQMHQL VAAYKDAYER DLEADIIGDT
160 170 180 190 200
SGHFQKMLVV LLQGTREEDD VVSEDLVQQD VQDLYEAGEL KWGTDEAQFI
210 220 230 240 250
YILGNRSKQH LRLVFDEYLK TTGKPIEASI RGELSGDFEK LMLAVVKCIR
260 270 280 290 300
STPEYFAERL FKAMKGLGTR DNTLIRIMVS RSELDMLDIR EIFRTKYEKS
310 320 330 340 350
LYSMIKNDTS GEYKKTLLKL SGGDDDAAGQ FFPEAAQVAY QMWELSAVAR
360 370 380 390 400
VELKGTVRPA NDFNPDADAK ALRKAMKGLG TDEDTIIDII THRSNVQRQQ
410 420 430 440 450
IRQTFKSHFG RDLMTDLKSE ISGDLARLIL GLMMPPAHYD AKQLKKAMEG
460 470 480 490 500
AGTDEKALIE ILATRTNAEI RAINEAYKED YHKSLEDALS SDTSGHFRRI
510 520 530 540 550
LISLATGHRE EGGENLDQAR EDAQVAAEIL EIADTPSGDK TSLETRFMTI
560 570 580 590 600
LCTRSYPHLR RVFQEFIKMT NYDVEHTIKK EMSGDVRDAF VAIVQSVKNK
610 620 630 640 650
PLFFADKLYK SMKGAGTDEK TLTRIMVSRS EIDLLNIRRE FIEKYDKSLH
660 670
QAIEGDTSGD FLKALLALCG GED
Length:673
Mass (Da):75,873
Last modified:January 23, 2007 - v3
Checksum:i90F47474F7F6D7B6
GO
Isoform 2 (identifier: P08133-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Note: No experimental confirmation available.
Show »
Length:641
Mass (Da):72,423
Checksum:i61E3E5CAF66A51E3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti221T → A in BAH13893 (PubMed:14702039).Curated1
Sequence conflicti226 – 227IE → MK in AAA35656 (PubMed:2963335).Curated2
Sequence conflicti248C → R in BAC86715 (PubMed:14702039).Curated1
Sequence conflicti555S → T in AAA35656 (PubMed:2963335).Curated1
Sequence conflicti619E → D in CAA68286 (PubMed:3258820).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0454801 – 32Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00097 mRNA. Translation: CAA68286.1.
J03578 mRNA. Translation: AAA35656.1.
D00510 mRNA. Translation: BAA00400.1.
AK126836 mRNA. Translation: BAC86715.1. Sequence problems.
AK303078 mRNA. Translation: BAH13893.1.
AC008641 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61684.1.
CH471062 Genomic DNA. Translation: EAW61686.1.
BC017046 mRNA. Translation: AAH17046.1.
CCDSiCCDS47315.1. [P08133-1]
CCDS54941.1. [P08133-2]
PIRiJU0032. AQHU68.
RefSeqiNP_001146.2. NM_001155.4. [P08133-1]
NP_001180473.1. NM_001193544.1. [P08133-2]
UniGeneiHs.412117.

Genome annotation databases

EnsembliENST00000354546; ENSP00000346550; ENSG00000197043. [P08133-1]
ENST00000523714; ENSP00000430517; ENSG00000197043. [P08133-2]
GeneIDi309.
KEGGihsa:309.
UCSCiuc003ltl.3. human. [P08133-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00097 mRNA. Translation: CAA68286.1.
J03578 mRNA. Translation: AAA35656.1.
D00510 mRNA. Translation: BAA00400.1.
AK126836 mRNA. Translation: BAC86715.1. Sequence problems.
AK303078 mRNA. Translation: BAH13893.1.
AC008641 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61684.1.
CH471062 Genomic DNA. Translation: EAW61686.1.
BC017046 mRNA. Translation: AAH17046.1.
CCDSiCCDS47315.1. [P08133-1]
CCDS54941.1. [P08133-2]
PIRiJU0032. AQHU68.
RefSeqiNP_001146.2. NM_001155.4. [P08133-1]
NP_001180473.1. NM_001193544.1. [P08133-2]
UniGeneiHs.412117.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M9IX-ray2.65A2-673[»]
ProteinModelPortaliP08133.
SMRiP08133.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106806. 36 interactors.
IntActiP08133. 14 interactors.
MINTiMINT-4999263.
STRINGi9606.ENSP00000346550.

Protein family/group databases

TCDBi1.A.31.1.2. the annexin (annexin) family.

PTM databases

iPTMnetiP08133.
PhosphoSitePlusiP08133.
SwissPalmiP08133.

Polymorphism and mutation databases

BioMutaiANXA6.

2D gel databases

REPRODUCTION-2DPAGEIPI00221226.
UCD-2DPAGEP08133.

Proteomic databases

EPDiP08133.
MaxQBiP08133.
PaxDbiP08133.
PeptideAtlasiP08133.
PRIDEiP08133.

Protocols and materials databases

DNASUi309.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354546; ENSP00000346550; ENSG00000197043. [P08133-1]
ENST00000523714; ENSP00000430517; ENSG00000197043. [P08133-2]
GeneIDi309.
KEGGihsa:309.
UCSCiuc003ltl.3. human. [P08133-1]

Organism-specific databases

CTDi309.
DisGeNETi309.
GeneCardsiANXA6.
HGNCiHGNC:544. ANXA6.
HPAiCAB005077.
HPA002462.
HPA009650.
MIMi114070. gene.
neXtProtiNX_P08133.
OpenTargetsiENSG00000197043.
PharmGKBiPA24834.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP08133.
KOiK17094.
OMAiQRQEICQ.
OrthoDBiEOG091G0H6H.
PhylomeDBiP08133.
TreeFamiTF105452.

Enzyme and pathway databases

ReactomeiR-HSA-445355. Smooth Muscle Contraction.

Miscellaneous databases

ChiTaRSiANXA6. human.
EvolutionaryTraceiP08133.
GeneWikiiANXA6.
GenomeRNAii309.
PROiP08133.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197043.
CleanExiHS_ANXA6.
ExpressionAtlasiP08133. baseline and differential.
GenevisibleiP08133. HS.

Family and domain databases

Gene3Di1.10.220.10. 8 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002393. AnnexinVI.
[Graphical view]
PANTHERiPTHR10502:SF19. PTHR10502:SF19. 1 hit.
PfamiPF00191. Annexin. 8 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00202. ANNEXINVI.
SMARTiSM00335. ANX. 8 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANXA6_HUMAN
AccessioniPrimary (citable) accession number: P08133
Secondary accession number(s): B7Z8A7
, D3DQH4, E9PGK1, Q6ZT79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 185 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Seems to bind one calcium ion with high affinity.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.