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P08133

- ANXA6_HUMAN

UniProt

P08133 - ANXA6_HUMAN

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Protein
Annexin A6
Gene
ANXA6, ANX6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May associate with CD21. May regulate the release of Ca2+ from intracellular stores.

GO - Molecular functioni

  1. GTP binding Source: UniProt
  2. calcium ion binding Source: InterPro
  3. calcium-dependent phospholipid binding Source: UniProtKB
  4. calcium-dependent protein binding Source: AgBase
  5. cholesterol binding Source: UniProt
  6. ligand-gated ion channel activity Source: UniProt
  7. lipid binding Source: UniProt
  8. protein binding Source: UniProtKB
  9. protein homodimerization activity Source: UniProt

GO - Biological processi

  1. calcium ion transport Source: Ensembl
  2. ion transmembrane transport Source: UniProt
  3. protein homooligomerization Source: UniProt
  4. regulation of muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Protein family/group databases

TCDBi1.A.31.1.2. the annexin (annexin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A6
Alternative name(s):
67 kDa calelectrin
Annexin VI
Annexin-6
Calphobindin-II
Short name:
CPB-II
Chromobindin-20
Lipocortin VI
Protein III
p68
p70
Gene namesi
Name:ANXA6
Synonyms:ANX6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:544. ANXA6.

Subcellular locationi

Cytoplasm By similarity. Melanosome
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.1 Publication

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. late endosome membrane Source: UniProt
  3. lysosomal membrane Source: UniProt
  4. melanosome Source: UniProtKB-SubCell
  5. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24834.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 673672Annexin A6
PRO_0000067494Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications
Modified residuei30 – 301Phosphotyrosine1 Publication
Modified residuei63 – 631N6-acetyllysine1 Publication
Modified residuei68 – 681N6-acetyllysine1 Publication
Modified residuei75 – 751N6-acetyllysine1 Publication
Modified residuei81 – 811N6-acetyllysine1 Publication
Modified residuei201 – 2011Phosphotyrosine By similarity
Modified residuei306 – 3061N6-acetyllysine1 Publication
Modified residuei370 – 3701N6-acetyllysine1 Publication
Modified residuei418 – 4181N6-acetyllysine1 Publication
Modified residuei483 – 4831N6-acetyllysine1 Publication
Modified residuei620 – 6201N6-acetyllysine1 Publication

Post-translational modificationi

Phosphorylated in response to growth factor stimulation.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP08133.
PaxDbiP08133.
PRIDEiP08133.

2D gel databases

REPRODUCTION-2DPAGEIPI00221226.
UCD-2DPAGEP08133.

PTM databases

PhosphoSiteiP08133.

Expressioni

Inductioni

By Epstein-Barr virus (EBV).

Gene expression databases

ArrayExpressiP08133.
BgeeiP08133.
CleanExiHS_ANXA6.
GenevestigatoriP08133.

Organism-specific databases

HPAiCAB005077.
HPA002462.
HPA009650.

Interactioni

Protein-protein interaction databases

BioGridi106806. 28 interactions.
IntActiP08133. 10 interactions.
MINTiMINT-4999263.
STRINGi9606.ENSP00000346550.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi22 – 3211
Beta strandi34 – 374
Helixi40 – 478
Helixi52 – 6615
Helixi70 – 778
Helixi80 – 9011
Helixi93 – 10513
Beta strandi106 – 1094
Helixi112 – 12110
Helixi124 – 13714
Helixi142 – 1498
Helixi152 – 16312
Helixi174 – 18714
Turni188 – 1903
Beta strandi191 – 1933
Helixi196 – 20510
Helixi208 – 22114
Beta strandi222 – 2243
Helixi226 – 2305
Turni231 – 2333
Helixi236 – 26227
Beta strandi264 – 2685
Helixi271 – 28010
Turni281 – 2855
Helixi286 – 29611
Beta strandi297 – 2993
Helixi301 – 3066
Helixi311 – 32111
Helixi333 – 34816
Helixi365 – 37612
Beta strandi377 – 3804
Helixi383 – 3919
Helixi395 – 40915
Helixi413 – 4208
Helixi424 – 43310
Helixi436 – 44813
Beta strandi449 – 4524
Helixi455 – 46410
Helixi467 – 48115
Helixi485 – 4928
Helixi495 – 50410
Helixi516 – 53015
Helixi535 – 5373
Helixi546 – 5538
Helixi556 – 56813
Beta strandi569 – 5724
Helixi574 – 5818
Helixi584 – 61128
Beta strandi613 – 6164
Helixi619 – 62810
Turni630 – 6334
Helixi634 – 64512
Helixi649 – 6568
Helixi659 – 66810

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1M9IX-ray2.65A2-673[»]
ProteinModelPortaliP08133.
SMRiP08133. Positions 10-673.

Miscellaneous databases

EvolutionaryTraceiP08133.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati29 – 8961Annexin 1
Add
BLAST
Repeati101 – 16161Annexin 2
Add
BLAST
Repeati185 – 24561Annexin 3
Add
BLAST
Repeati260 – 32061Annexin 4
Add
BLAST
Repeati372 – 43261Annexin 5
Add
BLAST
Repeati444 – 50461Annexin 6
Add
BLAST
Repeati533 – 59361Annexin 7
Add
BLAST
Repeati608 – 66861Annexin 8
Add
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.
Contains 8 annexin repeats.

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiNOG267770.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP08133.
KOiK17094.
OMAiEKSLYSM.
OrthoDBiEOG74XS72.
PhylomeDBiP08133.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 8 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002393. AnnexinVI.
[Graphical view]
PfamiPF00191. Annexin. 8 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00202. ANNEXINVI.
SMARTiSM00335. ANX. 8 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 8 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P08133-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAKPAQGAKY RGSIHDFPGF DPNQDAEALY TAMKGFGSDK EAILDIITSR    50
SNRQRQEVCQ SYKSLYGKDL IADLKYELTG KFERLIVGLM RPPAYCDAKE 100
IKDAISGIGT DEKCLIEILA SRTNEQMHQL VAAYKDAYER DLEADIIGDT 150
SGHFQKMLVV LLQGTREEDD VVSEDLVQQD VQDLYEAGEL KWGTDEAQFI 200
YILGNRSKQH LRLVFDEYLK TTGKPIEASI RGELSGDFEK LMLAVVKCIR 250
STPEYFAERL FKAMKGLGTR DNTLIRIMVS RSELDMLDIR EIFRTKYEKS 300
LYSMIKNDTS GEYKKTLLKL SGGDDDAAGQ FFPEAAQVAY QMWELSAVAR 350
VELKGTVRPA NDFNPDADAK ALRKAMKGLG TDEDTIIDII THRSNVQRQQ 400
IRQTFKSHFG RDLMTDLKSE ISGDLARLIL GLMMPPAHYD AKQLKKAMEG 450
AGTDEKALIE ILATRTNAEI RAINEAYKED YHKSLEDALS SDTSGHFRRI 500
LISLATGHRE EGGENLDQAR EDAQVAAEIL EIADTPSGDK TSLETRFMTI 550
LCTRSYPHLR RVFQEFIKMT NYDVEHTIKK EMSGDVRDAF VAIVQSVKNK 600
PLFFADKLYK SMKGAGTDEK TLTRIMVSRS EIDLLNIRRE FIEKYDKSLH 650
QAIEGDTSGD FLKALLALCG GED 673
Length:673
Mass (Da):75,873
Last modified:January 23, 2007 - v3
Checksum:i90F47474F7F6D7B6
GO
Isoform 2 (identifier: P08133-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Note: No experimental confirmation available.

Show »
Length:641
Mass (Da):72,423
Checksum:i61E3E5CAF66A51E3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3232Missing in isoform 2.
VSP_045480Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti221 – 2211T → A in BAH13893. 1 Publication
Sequence conflicti226 – 2272IE → MK in AAA35656. 1 Publication
Sequence conflicti248 – 2481C → R in BAC86715. 1 Publication
Sequence conflicti555 – 5551S → T in AAA35656. 1 Publication
Sequence conflicti619 – 6191E → D in CAA68286. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00097 mRNA. Translation: CAA68286.1.
J03578 mRNA. Translation: AAA35656.1.
D00510 mRNA. Translation: BAA00400.1.
AK126836 mRNA. Translation: BAC86715.1. Sequence problems.
AK303078 mRNA. Translation: BAH13893.1.
AC008641 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61684.1.
CH471062 Genomic DNA. Translation: EAW61686.1.
BC017046 mRNA. Translation: AAH17046.1.
CCDSiCCDS47315.1. [P08133-1]
CCDS54941.1. [P08133-2]
PIRiJU0032. AQHU68.
RefSeqiNP_001146.2. NM_001155.4. [P08133-1]
NP_001180473.1. NM_001193544.1. [P08133-2]
UniGeneiHs.412117.

Genome annotation databases

EnsembliENST00000354546; ENSP00000346550; ENSG00000197043. [P08133-1]
ENST00000523714; ENSP00000430517; ENSG00000197043. [P08133-2]
GeneIDi309.
KEGGihsa:309.
UCSCiuc003ltl.2. human. [P08133-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00097 mRNA. Translation: CAA68286.1 .
J03578 mRNA. Translation: AAA35656.1 .
D00510 mRNA. Translation: BAA00400.1 .
AK126836 mRNA. Translation: BAC86715.1 . Sequence problems.
AK303078 mRNA. Translation: BAH13893.1 .
AC008641 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61684.1 .
CH471062 Genomic DNA. Translation: EAW61686.1 .
BC017046 mRNA. Translation: AAH17046.1 .
CCDSi CCDS47315.1. [P08133-1 ]
CCDS54941.1. [P08133-2 ]
PIRi JU0032. AQHU68.
RefSeqi NP_001146.2. NM_001155.4. [P08133-1 ]
NP_001180473.1. NM_001193544.1. [P08133-2 ]
UniGenei Hs.412117.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1M9I X-ray 2.65 A 2-673 [» ]
ProteinModelPortali P08133.
SMRi P08133. Positions 10-673.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106806. 28 interactions.
IntActi P08133. 10 interactions.
MINTi MINT-4999263.
STRINGi 9606.ENSP00000346550.

Protein family/group databases

TCDBi 1.A.31.1.2. the annexin (annexin) family.

PTM databases

PhosphoSitei P08133.

2D gel databases

REPRODUCTION-2DPAGE IPI00221226.
UCD-2DPAGE P08133.

Proteomic databases

MaxQBi P08133.
PaxDbi P08133.
PRIDEi P08133.

Protocols and materials databases

DNASUi 309.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000354546 ; ENSP00000346550 ; ENSG00000197043 . [P08133-1 ]
ENST00000523714 ; ENSP00000430517 ; ENSG00000197043 . [P08133-2 ]
GeneIDi 309.
KEGGi hsa:309.
UCSCi uc003ltl.2. human. [P08133-1 ]

Organism-specific databases

CTDi 309.
GeneCardsi GC05M150460.
HGNCi HGNC:544. ANXA6.
HPAi CAB005077.
HPA002462.
HPA009650.
MIMi 114070. gene.
neXtProti NX_P08133.
PharmGKBi PA24834.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG267770.
HOGENOMi HOG000158803.
HOVERGENi HBG061815.
InParanoidi P08133.
KOi K17094.
OMAi EKSLYSM.
OrthoDBi EOG74XS72.
PhylomeDBi P08133.
TreeFami TF105452.

Miscellaneous databases

ChiTaRSi ANXA6. human.
EvolutionaryTracei P08133.
GeneWikii ANXA6.
GenomeRNAii 309.
NextBioi 1247.
PROi P08133.
SOURCEi Search...

Gene expression databases

ArrayExpressi P08133.
Bgeei P08133.
CleanExi HS_ANXA6.
Genevestigatori P08133.

Family and domain databases

Gene3Di 1.10.220.10. 8 hits.
InterProi IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002393. AnnexinVI.
[Graphical view ]
Pfami PF00191. Annexin. 8 hits.
[Graphical view ]
PRINTSi PR00196. ANNEXIN.
PR00202. ANNEXINVI.
SMARTi SM00335. ANX. 8 hits.
[Graphical view ]
PROSITEi PS00223. ANNEXIN. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of the human, membrane-associated Ca2+-binding protein p68 a novel member of a protein family."
    Crompton M.R., Owens R.J., Totty N.F., Moss S.E., Waterfield M.D., Crumpton M.J.
    EMBO J. 7:21-27(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Human 67-kDa calelectrin contains a duplication of four repeats found in 35-kDa lipocortins."
    Suedhof T.C., Slaughter C.A., Leznicki I., Barjon P., Reynolds G.A.
    Proc. Natl. Acad. Sci. U.S.A. 85:664-668(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE.
  3. "Structure and expression of cDNA for calphobindin II, a human placental coagulation inhibitor."
    Iwasaki A., Suda M., Watanabe M., Nakao H., Hattori Y., Nagoya T., Saino Y., Shidara Y., Maki M.
    J. Biochem. 106:43-49(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Amygdala and Thymus.
  5. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.
  8. "Structure and properties of calphobindin II, an anticoagulant protein from human placenta."
    Yoshizaki H., Mizoguchi T., Arai K., Shiratsuchi M., Shidara Y., Maki M.
    J. Biochem. 107:43-50(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-673.
  9. "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."
    Aboulaich N., Vainonen J.P., Stralfors P., Vener A.V.
    Biochem. J. 383:237-248(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 485-499.
    Tissue: Adipocyte.
  10. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Melanoma.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-30, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-63; LYS-68; LYS-75; LYS-81; LYS-306; LYS-370; LYS-418; LYS-483 AND LYS-620, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  15. "The structure of recombinant human annexin VI in crystals and membrane-bound."
    Benz J., Bergner A., Hofmann A., Demange P., Goettig P., Liemann S., Huber R., Voges D.
    J. Mol. Biol. 260:638-643(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS).

Entry informationi

Entry nameiANXA6_HUMAN
AccessioniPrimary (citable) accession number: P08133
Secondary accession number(s): B7Z8A7
, D3DQH4, E9PGK1, Q6ZT79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 164 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Seems to bind one calcium ion with high affinity.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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