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P08133

- ANXA6_HUMAN

UniProt

P08133 - ANXA6_HUMAN

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Protein

Annexin A6

Gene

ANXA6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May associate with CD21. May regulate the release of Ca2+ from intracellular stores.

GO - Molecular functioni

  1. calcium-dependent phospholipid binding Source: UniProtKB
  2. calcium-dependent protein binding Source: AgBase
  3. calcium ion binding Source: InterPro
  4. cholesterol binding Source: UniProt
  5. GTP binding Source: UniProt
  6. ligand-gated ion channel activity Source: UniProt
  7. lipid binding Source: UniProt
  8. protein homodimerization activity Source: UniProt

GO - Biological processi

  1. calcium ion transport Source: Ensembl
  2. ion transmembrane transport Source: UniProt
  3. protein homooligomerization Source: UniProt
  4. regulation of muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Protein family/group databases

TCDBi1.A.31.1.2. the annexin (annexin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A6
Alternative name(s):
67 kDa calelectrin
Annexin VI
Annexin-6
Calphobindin-II
Short name:
CPB-II
Chromobindin-20
Lipocortin VI
Protein III
p68
p70
Gene namesi
Name:ANXA6
Synonyms:ANX6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:544. ANXA6.

Subcellular locationi

Cytoplasm By similarity. Melanosome 1 Publication
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. focal adhesion Source: UniProtKB
  3. late endosome membrane Source: UniProt
  4. lysosomal membrane Source: UniProt
  5. membrane Source: UniProtKB
  6. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24834.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 673672Annexin A6PRO_0000067494Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications
Modified residuei30 – 301Phosphotyrosine1 Publication
Modified residuei63 – 631N6-acetyllysine1 Publication
Modified residuei68 – 681N6-acetyllysine1 Publication
Modified residuei75 – 751N6-acetyllysine1 Publication
Modified residuei81 – 811N6-acetyllysine1 Publication
Modified residuei201 – 2011PhosphotyrosineBy similarity
Modified residuei306 – 3061N6-acetyllysine1 Publication
Modified residuei370 – 3701N6-acetyllysine1 Publication
Modified residuei418 – 4181N6-acetyllysine1 Publication
Modified residuei483 – 4831N6-acetyllysine1 Publication
Modified residuei620 – 6201N6-acetyllysine1 Publication

Post-translational modificationi

Phosphorylated in response to growth factor stimulation.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP08133.
PaxDbiP08133.
PRIDEiP08133.

2D gel databases

REPRODUCTION-2DPAGEIPI00221226.
UCD-2DPAGEP08133.

PTM databases

PhosphoSiteiP08133.

Expressioni

Inductioni

By Epstein-Barr virus (EBV).

Gene expression databases

BgeeiP08133.
CleanExiHS_ANXA6.
ExpressionAtlasiP08133. baseline and differential.
GenevestigatoriP08133.

Organism-specific databases

HPAiCAB005077.
HPA002462.
HPA009650.

Interactioni

Protein-protein interaction databases

BioGridi106806. 28 interactions.
IntActiP08133. 10 interactions.
MINTiMINT-4999263.
STRINGi9606.ENSP00000346550.

Structurei

Secondary structure

1
673
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi22 – 3211Combined sources
Beta strandi34 – 374Combined sources
Helixi40 – 478Combined sources
Helixi52 – 6615Combined sources
Helixi70 – 778Combined sources
Helixi80 – 9011Combined sources
Helixi93 – 10513Combined sources
Beta strandi106 – 1094Combined sources
Helixi112 – 12110Combined sources
Helixi124 – 13714Combined sources
Helixi142 – 1498Combined sources
Helixi152 – 16312Combined sources
Helixi174 – 18714Combined sources
Turni188 – 1903Combined sources
Beta strandi191 – 1933Combined sources
Helixi196 – 20510Combined sources
Helixi208 – 22114Combined sources
Beta strandi222 – 2243Combined sources
Helixi226 – 2305Combined sources
Turni231 – 2333Combined sources
Helixi236 – 26227Combined sources
Beta strandi264 – 2685Combined sources
Helixi271 – 28010Combined sources
Turni281 – 2855Combined sources
Helixi286 – 29611Combined sources
Beta strandi297 – 2993Combined sources
Helixi301 – 3066Combined sources
Helixi311 – 32111Combined sources
Helixi333 – 34816Combined sources
Helixi365 – 37612Combined sources
Beta strandi377 – 3804Combined sources
Helixi383 – 3919Combined sources
Helixi395 – 40915Combined sources
Helixi413 – 4208Combined sources
Helixi424 – 43310Combined sources
Helixi436 – 44813Combined sources
Beta strandi449 – 4524Combined sources
Helixi455 – 46410Combined sources
Helixi467 – 48115Combined sources
Helixi485 – 4928Combined sources
Helixi495 – 50410Combined sources
Helixi516 – 53015Combined sources
Helixi535 – 5373Combined sources
Helixi546 – 5538Combined sources
Helixi556 – 56813Combined sources
Beta strandi569 – 5724Combined sources
Helixi574 – 5818Combined sources
Helixi584 – 61128Combined sources
Beta strandi613 – 6164Combined sources
Helixi619 – 62810Combined sources
Turni630 – 6334Combined sources
Helixi634 – 64512Combined sources
Helixi649 – 6568Combined sources
Helixi659 – 66810Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1M9IX-ray2.65A2-673[»]
ProteinModelPortaliP08133.
SMRiP08133. Positions 10-673.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08133.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati29 – 8961Annexin 1Add
BLAST
Repeati101 – 16161Annexin 2Add
BLAST
Repeati185 – 24561Annexin 3Add
BLAST
Repeati260 – 32061Annexin 4Add
BLAST
Repeati372 – 43261Annexin 5Add
BLAST
Repeati444 – 50461Annexin 6Add
BLAST
Repeati533 – 59361Annexin 7Add
BLAST
Repeati608 – 66861Annexin 8Add
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 8 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiNOG267770.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP08133.
KOiK17094.
OMAiEKSLYSM.
OrthoDBiEOG74XS72.
PhylomeDBiP08133.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 8 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002393. AnnexinVI.
[Graphical view]
PfamiPF00191. Annexin. 8 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00202. ANNEXINVI.
SMARTiSM00335. ANX. 8 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 8 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P08133-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKPAQGAKY RGSIHDFPGF DPNQDAEALY TAMKGFGSDK EAILDIITSR
60 70 80 90 100
SNRQRQEVCQ SYKSLYGKDL IADLKYELTG KFERLIVGLM RPPAYCDAKE
110 120 130 140 150
IKDAISGIGT DEKCLIEILA SRTNEQMHQL VAAYKDAYER DLEADIIGDT
160 170 180 190 200
SGHFQKMLVV LLQGTREEDD VVSEDLVQQD VQDLYEAGEL KWGTDEAQFI
210 220 230 240 250
YILGNRSKQH LRLVFDEYLK TTGKPIEASI RGELSGDFEK LMLAVVKCIR
260 270 280 290 300
STPEYFAERL FKAMKGLGTR DNTLIRIMVS RSELDMLDIR EIFRTKYEKS
310 320 330 340 350
LYSMIKNDTS GEYKKTLLKL SGGDDDAAGQ FFPEAAQVAY QMWELSAVAR
360 370 380 390 400
VELKGTVRPA NDFNPDADAK ALRKAMKGLG TDEDTIIDII THRSNVQRQQ
410 420 430 440 450
IRQTFKSHFG RDLMTDLKSE ISGDLARLIL GLMMPPAHYD AKQLKKAMEG
460 470 480 490 500
AGTDEKALIE ILATRTNAEI RAINEAYKED YHKSLEDALS SDTSGHFRRI
510 520 530 540 550
LISLATGHRE EGGENLDQAR EDAQVAAEIL EIADTPSGDK TSLETRFMTI
560 570 580 590 600
LCTRSYPHLR RVFQEFIKMT NYDVEHTIKK EMSGDVRDAF VAIVQSVKNK
610 620 630 640 650
PLFFADKLYK SMKGAGTDEK TLTRIMVSRS EIDLLNIRRE FIEKYDKSLH
660 670
QAIEGDTSGD FLKALLALCG GED
Length:673
Mass (Da):75,873
Last modified:January 23, 2007 - v3
Checksum:i90F47474F7F6D7B6
GO
Isoform 2 (identifier: P08133-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Note: No experimental confirmation available.

Show »
Length:641
Mass (Da):72,423
Checksum:i61E3E5CAF66A51E3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti221 – 2211T → A in BAH13893. (PubMed:14702039)Curated
Sequence conflicti226 – 2272IE → MK in AAA35656. (PubMed:2963335)Curated
Sequence conflicti248 – 2481C → R in BAC86715. (PubMed:14702039)Curated
Sequence conflicti555 – 5551S → T in AAA35656. (PubMed:2963335)Curated
Sequence conflicti619 – 6191E → D in CAA68286. (PubMed:3258820)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3232Missing in isoform 2. 1 PublicationVSP_045480Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00097 mRNA. Translation: CAA68286.1.
J03578 mRNA. Translation: AAA35656.1.
D00510 mRNA. Translation: BAA00400.1.
AK126836 mRNA. Translation: BAC86715.1. Sequence problems.
AK303078 mRNA. Translation: BAH13893.1.
AC008641 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61684.1.
CH471062 Genomic DNA. Translation: EAW61686.1.
BC017046 mRNA. Translation: AAH17046.1.
CCDSiCCDS47315.1. [P08133-1]
CCDS54941.1. [P08133-2]
PIRiJU0032. AQHU68.
RefSeqiNP_001146.2. NM_001155.4. [P08133-1]
NP_001180473.1. NM_001193544.1. [P08133-2]
UniGeneiHs.412117.

Genome annotation databases

EnsembliENST00000354546; ENSP00000346550; ENSG00000197043. [P08133-1]
ENST00000523714; ENSP00000430517; ENSG00000197043. [P08133-2]
GeneIDi309.
KEGGihsa:309.
UCSCiuc003ltl.2. human. [P08133-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00097 mRNA. Translation: CAA68286.1 .
J03578 mRNA. Translation: AAA35656.1 .
D00510 mRNA. Translation: BAA00400.1 .
AK126836 mRNA. Translation: BAC86715.1 . Sequence problems.
AK303078 mRNA. Translation: BAH13893.1 .
AC008641 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61684.1 .
CH471062 Genomic DNA. Translation: EAW61686.1 .
BC017046 mRNA. Translation: AAH17046.1 .
CCDSi CCDS47315.1. [P08133-1 ]
CCDS54941.1. [P08133-2 ]
PIRi JU0032. AQHU68.
RefSeqi NP_001146.2. NM_001155.4. [P08133-1 ]
NP_001180473.1. NM_001193544.1. [P08133-2 ]
UniGenei Hs.412117.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1M9I X-ray 2.65 A 2-673 [» ]
ProteinModelPortali P08133.
SMRi P08133. Positions 10-673.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106806. 28 interactions.
IntActi P08133. 10 interactions.
MINTi MINT-4999263.
STRINGi 9606.ENSP00000346550.

Protein family/group databases

TCDBi 1.A.31.1.2. the annexin (annexin) family.

PTM databases

PhosphoSitei P08133.

2D gel databases

REPRODUCTION-2DPAGE IPI00221226.
UCD-2DPAGE P08133.

Proteomic databases

MaxQBi P08133.
PaxDbi P08133.
PRIDEi P08133.

Protocols and materials databases

DNASUi 309.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000354546 ; ENSP00000346550 ; ENSG00000197043 . [P08133-1 ]
ENST00000523714 ; ENSP00000430517 ; ENSG00000197043 . [P08133-2 ]
GeneIDi 309.
KEGGi hsa:309.
UCSCi uc003ltl.2. human. [P08133-1 ]

Organism-specific databases

CTDi 309.
GeneCardsi GC05M150460.
HGNCi HGNC:544. ANXA6.
HPAi CAB005077.
HPA002462.
HPA009650.
MIMi 114070. gene.
neXtProti NX_P08133.
PharmGKBi PA24834.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG267770.
GeneTreei ENSGT00760000118972.
HOGENOMi HOG000158803.
HOVERGENi HBG061815.
InParanoidi P08133.
KOi K17094.
OMAi EKSLYSM.
OrthoDBi EOG74XS72.
PhylomeDBi P08133.
TreeFami TF105452.

Miscellaneous databases

ChiTaRSi ANXA6. human.
EvolutionaryTracei P08133.
GeneWikii ANXA6.
GenomeRNAii 309.
NextBioi 1247.
PROi P08133.
SOURCEi Search...

Gene expression databases

Bgeei P08133.
CleanExi HS_ANXA6.
ExpressionAtlasi P08133. baseline and differential.
Genevestigatori P08133.

Family and domain databases

Gene3Di 1.10.220.10. 8 hits.
InterProi IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002393. AnnexinVI.
[Graphical view ]
Pfami PF00191. Annexin. 8 hits.
[Graphical view ]
PRINTSi PR00196. ANNEXIN.
PR00202. ANNEXINVI.
SMARTi SM00335. ANX. 8 hits.
[Graphical view ]
PROSITEi PS00223. ANNEXIN. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of the human, membrane-associated Ca2+-binding protein p68 a novel member of a protein family."
    Crompton M.R., Owens R.J., Totty N.F., Moss S.E., Waterfield M.D., Crumpton M.J.
    EMBO J. 7:21-27(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Human 67-kDa calelectrin contains a duplication of four repeats found in 35-kDa lipocortins."
    Suedhof T.C., Slaughter C.A., Leznicki I., Barjon P., Reynolds G.A.
    Proc. Natl. Acad. Sci. U.S.A. 85:664-668(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE.
  3. "Structure and expression of cDNA for calphobindin II, a human placental coagulation inhibitor."
    Iwasaki A., Suda M., Watanabe M., Nakao H., Hattori Y., Nagoya T., Saino Y., Shidara Y., Maki M.
    J. Biochem. 106:43-49(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Amygdala and Thymus.
  5. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.
  8. "Structure and properties of calphobindin II, an anticoagulant protein from human placenta."
    Yoshizaki H., Mizoguchi T., Arai K., Shiratsuchi M., Shidara Y., Maki M.
    J. Biochem. 107:43-50(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-673.
  9. "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."
    Aboulaich N., Vainonen J.P., Stralfors P., Vener A.V.
    Biochem. J. 383:237-248(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 485-499.
    Tissue: Adipocyte.
  10. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Melanoma.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-30, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-63; LYS-68; LYS-75; LYS-81; LYS-306; LYS-370; LYS-418; LYS-483 AND LYS-620, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  15. "The structure of recombinant human annexin VI in crystals and membrane-bound."
    Benz J., Bergner A., Hofmann A., Demange P., Goettig P., Liemann S., Huber R., Voges D.
    J. Mol. Biol. 260:638-643(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS).

Entry informationi

Entry nameiANXA6_HUMAN
AccessioniPrimary (citable) accession number: P08133
Secondary accession number(s): B7Z8A7
, D3DQH4, E9PGK1, Q6ZT79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 167 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Seems to bind one calcium ion with high affinity.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3