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Protein

Beta-microseminoprotein

Gene

MSMB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-microseminoprotein
Alternative name(s):
Immunoglobulin-binding factor
Short name:
IGBF
PN44
Prostate secreted seminal plasma protein
Prostate secretory protein of 94 amino acids
Short name:
PSP-94
Short name:
PSP94
Seminal plasma beta-inhibin
Gene namesi
Name:MSMB
Synonyms:PRSP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:7372. MSMB.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: ProtInc
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Prostate cancer, hereditary, 13 (HPC13)
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
See also OMIM:611928

Organism-specific databases

MalaCardsiMSMB.
MIMi611928. phenotype.
Orphaneti1331. Familial prostate cancer.
PharmGKBiPA31177.

Polymorphism and mutation databases

BioMutaiMSMB.
DMDMi131436.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20205 PublicationsAdd
BLAST
Chaini21 – 11494Beta-microseminoproteinPRO_0000019268Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi22 ↔ 70
Disulfide bondi38 ↔ 62
Disulfide bondi57 ↔ 93
Disulfide bondi60 ↔ 69
Disulfide bondi84 ↔ 107

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP08118.
PeptideAtlasiP08118.
PRIDEiP08118.

PTM databases

iPTMnetiP08118.
PhosphoSiteiP08118.

Expressioni

Tissue specificityi

Strongly expressed in prostate, liver, kidney, breast and penis. Also expressed in pancreas, esophagus, stomach, deodenum, colon, trachea, lung, salivary glands and fallopian tube. PSP94 is expressed in lung and breast, whereas PSP57 is found in kidney and bladder.2 Publications

Gene expression databases

BgeeiENSG00000138294.
CleanExiHS_MSMB.
GenevisibleiP08118. HS.

Organism-specific databases

HPAiCAB026357.
HPA051257.

Interactioni

Subunit structurei

Homodimer; Interacts with PI16.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SGTAO437653EBI-10195681,EBI-347996

Protein-protein interaction databases

BioGridi110583. 2 interactions.
IntActiP08118. 1 interaction.

Structurei

Secondary structure

1
114
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi22 – 265Combined sources
Beta strandi33 – 353Combined sources
Beta strandi51 – 533Combined sources
Beta strandi57 – 626Combined sources
Beta strandi64 – 718Combined sources
Beta strandi75 – 795Combined sources
Turni81 – 833Combined sources
Beta strandi84 – 896Combined sources
Helixi90 – 923Combined sources
Beta strandi94 – 1018Combined sources
Beta strandi110 – 1134Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IZ3NMR-A21-114[»]
3IX0X-ray2.30A/B/C/D21-114[»]
ProteinModelPortaliP08118.
SMRiP08118. Positions 21-114.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08118.

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-microseminoprotein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3M2. Eukaryota.
ENOG410Y4MW. LUCA.
GeneTreeiENSGT00390000010587.
HOGENOMiHOG000113668.
HOVERGENiHBG031716.
InParanoidiP08118.
OMAiCKYIVVE.
OrthoDBiEOG091G0YU5.
PhylomeDBiP08118.
TreeFamiTF338336.

Family and domain databases

InterProiIPR008735. PSP94.
[Graphical view]
PANTHERiPTHR10500. PTHR10500. 1 hit.
PfamiPF05825. PSP94. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform PSP94 (identifier: P08118-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNVLLGSVVI FATFVTLCNA SCYFIPNEGV PGDSTRKCMD LKGNKHPINS
60 70 80 90 100
EWQTDNCETC TCYETEISCC TLVSTPVGYD KDNCQRIFKK EDCKYIVVEK
110
KDPKKTCSVS EWII
Length:114
Mass (Da):12,865
Last modified:August 1, 1988 - v1
Checksum:iD0B13E436D70BB1D
GO
Isoform PSP57 (identifier: P08118-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-77: KCMDLKGNKH...SCCTLVSTPV → MFLHLWVMTK...QKRPVLSVNG
     78-114: Missing.

Show »
Length:77
Mass (Da):8,778
Checksum:iADF30AB8D7A63C9A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti113 – 1131I → G AA sequence (PubMed:6434350).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171L → S.
Corresponds to variant rs1804776 [ dbSNP | Ensembl ].
VAR_011935
Natural varianti25 – 251I → M.
Corresponds to variant rs1804778 [ dbSNP | Ensembl ].
VAR_011936
Natural varianti52 – 521W → R.
Corresponds to variant rs1804780 [ dbSNP | Ensembl ].
VAR_011937
Natural varianti53 – 531Q → R.
Corresponds to variant rs1804468 [ dbSNP | Ensembl ].
VAR_011938
Natural varianti80 – 801D → A.
Corresponds to variant rs1802774 [ dbSNP | Ensembl ].
VAR_011939
Natural varianti87 – 871I → T.
Corresponds to variant rs1802771 [ dbSNP | Ensembl ].
VAR_011940
Natural varianti91 – 911E → G.
Corresponds to variant rs1804469 [ dbSNP | Ensembl ].
VAR_011941
Natural varianti92 – 921D → G.
Corresponds to variant rs1804461 [ dbSNP | Ensembl ].
VAR_011942
Natural varianti98 – 981V → L.
Corresponds to variant rs1804464 [ dbSNP | Ensembl ].
VAR_011943

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei37 – 7741KCMDL…VSTPV → MFLHLWVMTKTTAKESSRRR TASISWWRRRTQKRPVLSVN G in isoform PSP57. 1 PublicationVSP_003275Add
BLAST
Alternative sequencei78 – 11437Missing in isoform PSP57. 1 PublicationVSP_003276Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15885 mRNA. Translation: AAA36635.1.
M34376
, M34373, M34374, M34375 Genomic DNA. Translation: AAA59871.1.
X57928
, X57929, X57930, X57931 Genomic DNA. Translation: CAA41002.1.
S67815 mRNA. Translation: AAB29732.1.
U22178 mRNA. Translation: AAA83556.1.
U78976 mRNA. Translation: AAB37355.1.
BT006816 mRNA. Translation: AAP35462.1.
CR457015 mRNA. Translation: CAG33296.1.
AL450342 Genomic DNA. Translation: CAI14475.1.
AL450342 Genomic DNA. Translation: CAI14476.1.
BC005257 mRNA. Translation: AAH05257.1.
AJ133356 Genomic DNA. Translation: CAB39325.1.
CCDSiCCDS73095.1. [P08118-2]
CCDS73096.1. [P08118-1]
PIRiA34567.
G01730.
RefSeqiNP_002434.1. NM_002443.3. [P08118-1]
NP_619540.1. NM_138634.2. [P08118-2]
UniGeneiHs.255462.

Genome annotation databases

EnsembliENST00000581478; ENSP00000462641; ENSG00000263639. [P08118-2]
ENST00000582163; ENSP00000463092; ENSG00000263639. [P08118-1]
GeneIDi4477.
KEGGihsa:4477.
UCSCiuc001jiq.5. human. [P08118-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15885 mRNA. Translation: AAA36635.1.
M34376
, M34373, M34374, M34375 Genomic DNA. Translation: AAA59871.1.
X57928
, X57929, X57930, X57931 Genomic DNA. Translation: CAA41002.1.
S67815 mRNA. Translation: AAB29732.1.
U22178 mRNA. Translation: AAA83556.1.
U78976 mRNA. Translation: AAB37355.1.
BT006816 mRNA. Translation: AAP35462.1.
CR457015 mRNA. Translation: CAG33296.1.
AL450342 Genomic DNA. Translation: CAI14475.1.
AL450342 Genomic DNA. Translation: CAI14476.1.
BC005257 mRNA. Translation: AAH05257.1.
AJ133356 Genomic DNA. Translation: CAB39325.1.
CCDSiCCDS73095.1. [P08118-2]
CCDS73096.1. [P08118-1]
PIRiA34567.
G01730.
RefSeqiNP_002434.1. NM_002443.3. [P08118-1]
NP_619540.1. NM_138634.2. [P08118-2]
UniGeneiHs.255462.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IZ3NMR-A21-114[»]
3IX0X-ray2.30A/B/C/D21-114[»]
ProteinModelPortaliP08118.
SMRiP08118. Positions 21-114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110583. 2 interactions.
IntActiP08118. 1 interaction.

PTM databases

iPTMnetiP08118.
PhosphoSiteiP08118.

Polymorphism and mutation databases

BioMutaiMSMB.
DMDMi131436.

Proteomic databases

PaxDbiP08118.
PeptideAtlasiP08118.
PRIDEiP08118.

Protocols and materials databases

DNASUi4477.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000581478; ENSP00000462641; ENSG00000263639. [P08118-2]
ENST00000582163; ENSP00000463092; ENSG00000263639. [P08118-1]
GeneIDi4477.
KEGGihsa:4477.
UCSCiuc001jiq.5. human. [P08118-1]

Organism-specific databases

CTDi4477.
GeneCardsiMSMB.
HGNCiHGNC:7372. MSMB.
HPAiCAB026357.
HPA051257.
MalaCardsiMSMB.
MIMi157145. gene.
611928. phenotype.
neXtProtiNX_P08118.
Orphaneti1331. Familial prostate cancer.
PharmGKBiPA31177.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3M2. Eukaryota.
ENOG410Y4MW. LUCA.
GeneTreeiENSGT00390000010587.
HOGENOMiHOG000113668.
HOVERGENiHBG031716.
InParanoidiP08118.
OMAiCKYIVVE.
OrthoDBiEOG091G0YU5.
PhylomeDBiP08118.
TreeFamiTF338336.

Miscellaneous databases

EvolutionaryTraceiP08118.
GeneWikiiMSMB.
GenomeRNAii4477.
PROiP08118.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138294.
CleanExiHS_MSMB.
GenevisibleiP08118. HS.

Family and domain databases

InterProiIPR008735. PSP94.
[Graphical view]
PANTHERiPTHR10500. PTHR10500. 1 hit.
PfamiPF05825. PSP94. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSMB_HUMAN
AccessioniPrimary (citable) accession number: P08118
Secondary accession number(s): B1API6
, P11999, Q13125, Q6IAY9, Q9UC59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: September 7, 2016
This is version 159 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Specific receptors for this protein are found on spermatozoa and in the prostate.

Caution

Was originally thought to inhibit the secretion of FSH by pituitary cells.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.