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Protein

Endoplasmin

Gene

HSP90B1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone that functions in the processing and transport of secreted proteins. Has ATPase activity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106ATPBy similarity1
Binding sitei148ATPBy similarity1
Binding sitei161ATPBy similarity1
Binding sitei167ATPBy similarity1
Binding sitei198ATP; via amide nitrogenBy similarity1
Binding sitei447ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

  • intracellular sequestering of iron ion Source: AgBase
  • protein folding Source: InterPro
  • response to stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmin
Alternative name(s):
Heat shock 108 kDa protein
Short name:
HSP 108
Short name:
HSP108
Heat shock protein 90 kDa beta member 1
Transferrin-binding protein
Gene namesi
Name:HSP90B1
Synonyms:TRA1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001360122 – 795EndoplasminAdd BLAST774

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...)Sequence analysis1
Glycosylationi106N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi137InterchainBy similarity
Glycosylationi216N-linked (GlcNAc...)1 Publication1
Glycosylationi444N-linked (GlcNAc...)Sequence analysis1
Glycosylationi480N-linked (GlcNAc...)Sequence analysis1
Glycosylationi501N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP08110.
PRIDEiP08110.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

Protein-protein interaction databases

BioGridi675192. 1 interactor.
IntActiP08110. 1 interactor.
STRINGi9031.ENSGALP00000020744.

Structurei

3D structure databases

ProteinModelPortaliP08110.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi792 – 795Prevents secretion from ER4

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0020. Eukaryota.
COG0326. LUCA.
HOGENOMiHOG000031988.
HOVERGENiHBG007374.
InParanoidiP08110.
KOiK09487.
PhylomeDBiP08110.

Family and domain databases

Gene3Di3.30.565.10. 2 hits.
HAMAPiMF_00505. HSP90. 1 hit.
InterProiIPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 2 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00298. HSP90. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08110-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSAWALALA CTLLLAASVT AEEVDVDATV EEDLGKSREG SRTDDEVVQR
60 70 80 90 100
EEEAIQLDGL NASQIKEIRE KSEKFAFQAE VNRMMKLIIN SLYKNKEIFL
110 120 130 140 150
RELISNASDA LDKIRLISLT DENALAGNEE LTVKIKCDKE KNMLHVTDTG
160 170 180 190 200
IGMTKEELIK NLGTIAKSGT SEFLNKMTEM QDDSQSTSEL IGQFGVGFYS
210 220 230 240 250
AFLVADRVIV TSKHNNDTQH IWESDSNEFS VIDDPRGNTL GRGTTITLVL
260 270 280 290 300
KEEASDYLEL DTVKNLVKKY SQFINFPIYV WSSKTETVEE PVEEEEAKEE
310 320 330 340 350
KEETDDNEAA VEEEEEEKKP KTKKVEKTVW DWELMNDIKP IWQRPSKEVE
360 370 380 390 400
EDEYKAFYKT FSKEHDDPMA YIHFTAEGEV TFKSILFVPN SAPRGLFDEY
410 420 430 440 450
GSKKSDFIKL YVRRVFITDD FHDMMPKYLN FVKGVVDSDD LPLNVSRETL
460 470 480 490 500
QQHKLLKVIR KKLVRKTLDM IKKIAEEKYN DTFWKEFGTN VKLGVIEDHS
510 520 530 540 550
NRTRLAKLLR FQSSHHESNL TSLDQYVERM KEKQDKIYFM AGASRKEAES
560 570 580 590 600
SPFVERLLKK GYEVIYLTEP VDEYCIQALP EFDGKRFQNV AKEGVKFEES
610 620 630 640 650
EKSKESREAL EKEFEPLLNW MKDKALKDKI EKAVLSQRLT QSPCALVASQ
660 670 680 690 700
YGWSGNMERI MKAQAYQTGK DISTNYYASQ KKTFEINPRH PLIKDMLRRV
710 720 730 740 750
KENEDDKTVS DLAVVLFETA TLRSGYMLPD TKEYGDRIER MLRLSLNIDL
760 770 780 790
DAKVEEEPEE PEDAAEEAEQ DEEEVDADAE DSETQKESTD VKDEL
Length:795
Mass (Da):91,555
Last modified:August 1, 1988 - v1
Checksum:iBE1B29E1DBEC5A9A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti206D → E in AAA48827 (PubMed:3027654).Curated1
Sequence conflicti206D → E in CAA28629 (Ref. 3) Curated1
Sequence conflicti267V → L in AAA48827 (PubMed:3027654).Curated1
Sequence conflicti303E → Q in AAA48827 (PubMed:3027654).Curated1
Sequence conflicti307N → D in AAA48827 (PubMed:3027654).Curated1
Sequence conflicti307N → D in CAA28629 (Ref. 3) Curated1
Sequence conflicti317E → H in AAA48827 (PubMed:3027654).Curated1
Sequence conflicti378G → A in AAA48827 (PubMed:3027654).Curated1
Sequence conflicti593 – 594EG → DR in AAA48827 (PubMed:3027654).Curated2
Sequence conflicti653W → C in AAA48827 (PubMed:3027654).Curated1
Sequence conflicti669 – 675GKDISTN → VFSS in CAA28629 (Ref. 3) Curated7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14772 mRNA. Translation: AAA48826.1.
M31321 Genomic DNA. Translation: AAA48827.1.
X04961 Genomic DNA. Translation: CAA28629.1.
PIRiA24461. HHCH08.
I50255.
RefSeqiNP_989620.1. NM_204289.1.
UniGeneiGga.4724.

Genome annotation databases

GeneIDi374163.
KEGGigga:374163.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14772 mRNA. Translation: AAA48826.1.
M31321 Genomic DNA. Translation: AAA48827.1.
X04961 Genomic DNA. Translation: CAA28629.1.
PIRiA24461. HHCH08.
I50255.
RefSeqiNP_989620.1. NM_204289.1.
UniGeneiGga.4724.

3D structure databases

ProteinModelPortaliP08110.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi675192. 1 interactor.
IntActiP08110. 1 interactor.
STRINGi9031.ENSGALP00000020744.

Proteomic databases

PaxDbiP08110.
PRIDEiP08110.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi374163.
KEGGigga:374163.

Organism-specific databases

CTDi7184.

Phylogenomic databases

eggNOGiKOG0020. Eukaryota.
COG0326. LUCA.
HOGENOMiHOG000031988.
HOVERGENiHBG007374.
InParanoidiP08110.
KOiK09487.
PhylomeDBiP08110.

Miscellaneous databases

PROiP08110.

Family and domain databases

Gene3Di3.30.565.10. 2 hits.
HAMAPiMF_00505. HSP90. 1 hit.
InterProiIPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 2 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00298. HSP90. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiENPL_CHICK
AccessioniPrimary (citable) accession number: P08110
Secondary accession number(s): Q90869, Q90870
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: October 5, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.