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Protein

Endoplasmin

Gene

HSP90B1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone that functions in the processing and transport of secreted proteins. Has ATPase activity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106ATPBy similarity1
Binding sitei148ATPBy similarity1
Binding sitei161ATPBy similarity1
Binding sitei167ATPBy similarity1
Binding sitei198ATP; via amide nitrogenBy similarity1
Binding sitei447ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

  • intracellular sequestering of iron ion Source: AgBase
  • protein folding Source: InterPro
  • response to stress Source: InterPro

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmin
Alternative name(s):
Heat shock 108 kDa protein
Short name:
HSP 108
Short name:
HSP108
Heat shock protein 90 kDa beta member 1
Transferrin-binding protein
Gene namesi
Name:HSP90B1
Synonyms:TRA1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001360122 – 795EndoplasminAdd BLAST774

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi137InterchainBy similarity
Glycosylationi216N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi444N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi480N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi501N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP08110
PRIDEiP08110

PTM databases

iPTMnetiP08110

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi675192, 1 interactor
IntActiP08110, 1 interactor
STRINGi9031.ENSGALP00000020744

Structurei

3D structure databases

ProteinModelPortaliP08110
SMRiP08110
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi792 – 795Prevents secretion from ER4

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0020 Eukaryota
COG0326 LUCA
HOGENOMiHOG000031988
HOVERGENiHBG007374
InParanoidiP08110
KOiK09487
PhylomeDBiP08110

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505 HSP90, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR019805 Heat_shock_protein_90_CS
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528 PTHR11528, 1 hit
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00183 HSP90, 1 hit
PIRSFiPIRSF002583 Hsp90, 1 hit
PRINTSiPR00775 HEATSHOCK90
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 2 hits
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS00298 HSP90, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08110-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSAWALALA CTLLLAASVT AEEVDVDATV EEDLGKSREG SRTDDEVVQR
60 70 80 90 100
EEEAIQLDGL NASQIKEIRE KSEKFAFQAE VNRMMKLIIN SLYKNKEIFL
110 120 130 140 150
RELISNASDA LDKIRLISLT DENALAGNEE LTVKIKCDKE KNMLHVTDTG
160 170 180 190 200
IGMTKEELIK NLGTIAKSGT SEFLNKMTEM QDDSQSTSEL IGQFGVGFYS
210 220 230 240 250
AFLVADRVIV TSKHNNDTQH IWESDSNEFS VIDDPRGNTL GRGTTITLVL
260 270 280 290 300
KEEASDYLEL DTVKNLVKKY SQFINFPIYV WSSKTETVEE PVEEEEAKEE
310 320 330 340 350
KEETDDNEAA VEEEEEEKKP KTKKVEKTVW DWELMNDIKP IWQRPSKEVE
360 370 380 390 400
EDEYKAFYKT FSKEHDDPMA YIHFTAEGEV TFKSILFVPN SAPRGLFDEY
410 420 430 440 450
GSKKSDFIKL YVRRVFITDD FHDMMPKYLN FVKGVVDSDD LPLNVSRETL
460 470 480 490 500
QQHKLLKVIR KKLVRKTLDM IKKIAEEKYN DTFWKEFGTN VKLGVIEDHS
510 520 530 540 550
NRTRLAKLLR FQSSHHESNL TSLDQYVERM KEKQDKIYFM AGASRKEAES
560 570 580 590 600
SPFVERLLKK GYEVIYLTEP VDEYCIQALP EFDGKRFQNV AKEGVKFEES
610 620 630 640 650
EKSKESREAL EKEFEPLLNW MKDKALKDKI EKAVLSQRLT QSPCALVASQ
660 670 680 690 700
YGWSGNMERI MKAQAYQTGK DISTNYYASQ KKTFEINPRH PLIKDMLRRV
710 720 730 740 750
KENEDDKTVS DLAVVLFETA TLRSGYMLPD TKEYGDRIER MLRLSLNIDL
760 770 780 790
DAKVEEEPEE PEDAAEEAEQ DEEEVDADAE DSETQKESTD VKDEL
Length:795
Mass (Da):91,555
Last modified:August 1, 1988 - v1
Checksum:iBE1B29E1DBEC5A9A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti206D → E in AAA48827 (PubMed:3027654).Curated1
Sequence conflicti206D → E in CAA28629 (Ref. 3) Curated1
Sequence conflicti267V → L in AAA48827 (PubMed:3027654).Curated1
Sequence conflicti303E → Q in AAA48827 (PubMed:3027654).Curated1
Sequence conflicti307N → D in AAA48827 (PubMed:3027654).Curated1
Sequence conflicti307N → D in CAA28629 (Ref. 3) Curated1
Sequence conflicti317E → H in AAA48827 (PubMed:3027654).Curated1
Sequence conflicti378G → A in AAA48827 (PubMed:3027654).Curated1
Sequence conflicti593 – 594EG → DR in AAA48827 (PubMed:3027654).Curated2
Sequence conflicti653W → C in AAA48827 (PubMed:3027654).Curated1
Sequence conflicti669 – 675GKDISTN → VFSS in CAA28629 (Ref. 3) Curated7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14772 mRNA Translation: AAA48826.1
M31321 Genomic DNA Translation: AAA48827.1
X04961 Genomic DNA Translation: CAA28629.1
PIRiA24461 HHCH08
I50255
RefSeqiNP_989620.1, NM_204289.1
UniGeneiGga.4724

Genome annotation databases

GeneIDi374163
KEGGigga:374163

Similar proteinsi

Entry informationi

Entry nameiENPL_CHICK
AccessioniPrimary (citable) accession number: P08110
Secondary accession number(s): Q90869, Q90870
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: March 28, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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