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P08110

- ENPL_CHICK

UniProt

P08110 - ENPL_CHICK

Protein

Endoplasmin

Gene

HSP90B1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Aug 1988)
      Previous versions | rss
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    Functioni

    Molecular chaperone that functions in the processing and transport of secreted proteins. Has ATPase activity By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei106 – 1061ATPBy similarity
    Binding sitei148 – 1481ATPBy similarity
    Binding sitei161 – 1611ATPBy similarity
    Binding sitei167 – 1671ATPBy similarity
    Binding sitei198 – 1981ATP; via amide nitrogenBy similarity
    Binding sitei447 – 4471ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein folding Source: InterPro
    2. response to stress Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Calcium, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endoplasmin
    Alternative name(s):
    Heat shock 108 kDa protein
    Short name:
    HSP 108
    Short name:
    HSP108
    Heat shock protein 90 kDa beta member 1
    Transferrin-binding protein
    Gene namesi
    Name:HSP90B1
    Synonyms:TRA1
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: AgBase
    2. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 795774EndoplasminPRO_0000013601Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi137 – 137InterchainBy similarity
    Glycosylationi216 – 2161N-linked (GlcNAc...)1 Publication
    Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi501 – 5011N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP08110.
    PRIDEiP08110.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.

    Protein-protein interaction databases

    BioGridi675192. 1 interaction.
    IntActiP08110. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP08110.
    SMRiP08110. Positions 68-754.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi792 – 7954Prevents secretion from ER

    Sequence similaritiesi

    Belongs to the heat shock protein 90 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0326.
    HOGENOMiHOG000031988.
    HOVERGENiHBG007374.
    InParanoidiP08110.
    KOiK09487.
    PhylomeDBiP08110.

    Family and domain databases

    Gene3Di3.30.565.10. 2 hits.
    HAMAPiMF_00505. HSP90.
    InterProiIPR003594. HATPase_ATP-bd.
    IPR019805. Heat_shock_protein_90_CS.
    IPR001404. Hsp90_fam.
    IPR020575. Hsp90_N.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    [Graphical view]
    PANTHERiPTHR11528. PTHR11528. 1 hit.
    PfamiPF02518. HATPase_c. 1 hit.
    PF00183. HSP90. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002583. Hsp90. 1 hit.
    PRINTSiPR00775. HEATSHOCK90.
    SMARTiSM00387. HATPase_c. 1 hit.
    [Graphical view]
    SUPFAMiSSF54211. SSF54211. 1 hit.
    SSF55874. SSF55874. 2 hits.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00298. HSP90. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P08110-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSAWALALA CTLLLAASVT AEEVDVDATV EEDLGKSREG SRTDDEVVQR    50
    EEEAIQLDGL NASQIKEIRE KSEKFAFQAE VNRMMKLIIN SLYKNKEIFL 100
    RELISNASDA LDKIRLISLT DENALAGNEE LTVKIKCDKE KNMLHVTDTG 150
    IGMTKEELIK NLGTIAKSGT SEFLNKMTEM QDDSQSTSEL IGQFGVGFYS 200
    AFLVADRVIV TSKHNNDTQH IWESDSNEFS VIDDPRGNTL GRGTTITLVL 250
    KEEASDYLEL DTVKNLVKKY SQFINFPIYV WSSKTETVEE PVEEEEAKEE 300
    KEETDDNEAA VEEEEEEKKP KTKKVEKTVW DWELMNDIKP IWQRPSKEVE 350
    EDEYKAFYKT FSKEHDDPMA YIHFTAEGEV TFKSILFVPN SAPRGLFDEY 400
    GSKKSDFIKL YVRRVFITDD FHDMMPKYLN FVKGVVDSDD LPLNVSRETL 450
    QQHKLLKVIR KKLVRKTLDM IKKIAEEKYN DTFWKEFGTN VKLGVIEDHS 500
    NRTRLAKLLR FQSSHHESNL TSLDQYVERM KEKQDKIYFM AGASRKEAES 550
    SPFVERLLKK GYEVIYLTEP VDEYCIQALP EFDGKRFQNV AKEGVKFEES 600
    EKSKESREAL EKEFEPLLNW MKDKALKDKI EKAVLSQRLT QSPCALVASQ 650
    YGWSGNMERI MKAQAYQTGK DISTNYYASQ KKTFEINPRH PLIKDMLRRV 700
    KENEDDKTVS DLAVVLFETA TLRSGYMLPD TKEYGDRIER MLRLSLNIDL 750
    DAKVEEEPEE PEDAAEEAEQ DEEEVDADAE DSETQKESTD VKDEL 795
    Length:795
    Mass (Da):91,555
    Last modified:August 1, 1988 - v1
    Checksum:iBE1B29E1DBEC5A9A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti206 – 2061D → E in AAA48827. (PubMed:3027654)Curated
    Sequence conflicti206 – 2061D → E in CAA28629. 1 PublicationCurated
    Sequence conflicti267 – 2671V → L in AAA48827. (PubMed:3027654)Curated
    Sequence conflicti303 – 3031E → Q in AAA48827. (PubMed:3027654)Curated
    Sequence conflicti307 – 3071N → D in AAA48827. (PubMed:3027654)Curated
    Sequence conflicti307 – 3071N → D in CAA28629. 1 PublicationCurated
    Sequence conflicti317 – 3171E → H in AAA48827. (PubMed:3027654)Curated
    Sequence conflicti378 – 3781G → A in AAA48827. (PubMed:3027654)Curated
    Sequence conflicti593 – 5942EG → DR in AAA48827. (PubMed:3027654)Curated
    Sequence conflicti653 – 6531W → C in AAA48827. (PubMed:3027654)Curated
    Sequence conflicti669 – 6757GKDISTN → VFSS in CAA28629. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M14772 mRNA. Translation: AAA48826.1.
    M31321 Genomic DNA. Translation: AAA48827.1.
    X04961 Genomic DNA. Translation: CAA28629.1.
    PIRiA24461. HHCH08.
    I50255.
    RefSeqiNP_989620.1. NM_204289.1.
    UniGeneiGga.4724.

    Genome annotation databases

    GeneIDi374163.
    KEGGigga:374163.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M14772 mRNA. Translation: AAA48826.1 .
    M31321 Genomic DNA. Translation: AAA48827.1 .
    X04961 Genomic DNA. Translation: CAA28629.1 .
    PIRi A24461. HHCH08.
    I50255.
    RefSeqi NP_989620.1. NM_204289.1.
    UniGenei Gga.4724.

    3D structure databases

    ProteinModelPortali P08110.
    SMRi P08110. Positions 68-754.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 675192. 1 interaction.
    IntActi P08110. 1 interaction.

    Proteomic databases

    PaxDbi P08110.
    PRIDEi P08110.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 374163.
    KEGGi gga:374163.

    Organism-specific databases

    CTDi 7184.

    Phylogenomic databases

    eggNOGi COG0326.
    HOGENOMi HOG000031988.
    HOVERGENi HBG007374.
    InParanoidi P08110.
    KOi K09487.
    PhylomeDBi P08110.

    Miscellaneous databases

    NextBioi 20813673.
    PROi P08110.

    Family and domain databases

    Gene3Di 3.30.565.10. 2 hits.
    HAMAPi MF_00505. HSP90.
    InterProi IPR003594. HATPase_ATP-bd.
    IPR019805. Heat_shock_protein_90_CS.
    IPR001404. Hsp90_fam.
    IPR020575. Hsp90_N.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    [Graphical view ]
    PANTHERi PTHR11528. PTHR11528. 1 hit.
    Pfami PF02518. HATPase_c. 1 hit.
    PF00183. HSP90. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002583. Hsp90. 1 hit.
    PRINTSi PR00775. HEATSHOCK90.
    SMARTi SM00387. HATPase_c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54211. SSF54211. 1 hit.
    SSF55874. SSF55874. 2 hits.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00298. HSP90. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Amino acid sequence of a chicken heat shock protein derived from the complementary DNA nucleotide sequence."
      Kulomaa M.S., Weigel N.L., Kleinsek D.A., Beattie W.G., Conneely O.M., March C., Zarucki-Schulz T., Schrader W.T., O'Malley B.W.
      Biochemistry 25:6244-6251(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning of a steroid-regulated 108K heat shock protein gene from hen oviduct."
      Kleinsek D.A., Beattie W.G., Tsai M.J., O'Malley B.W.
      Nucleic Acids Res. 14:10053-10069(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Oviduct.
    3. Forsgren M.
      Submitted (SEP-1987) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Oviduct.
    4. "A chicken transferrin binding protein is heat shock protein 108."
      Hayes G.R., Himpler B.S., Weiner K.X.B., Lucas J.J.
      Biochem. Biophys. Res. Commun. 200:65-70(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, GLYCOSYLATION AT ASN-216.

    Entry informationi

    Entry nameiENPL_CHICK
    AccessioniPrimary (citable) accession number: P08110
    Secondary accession number(s): Q90869, Q90870
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: August 1, 1988
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3