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P08104

- SCN3A_RAT

UniProt

P08104 - SCN3A_RAT

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Protein

Sodium channel protein type 3 subunit alpha

Gene

Scn3a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.

GO - Molecular functioni

  1. calmodulin binding Source: RGD
  2. sodium ion binding Source: RGD
  3. voltage-gated sodium channel activity Source: RGD

GO - Biological processi

  1. cellular response to antibiotic Source: RGD
  2. membrane depolarization during action potential Source: RefGenome
  3. nervous system development Source: RGD
  4. neuronal action potential Source: RGD
  5. response to pyrethroid Source: RGD
  6. response to wounding Source: RGD
  7. sensory perception of pain Source: RGD
  8. sodium ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BRENDAi2.4.1.19. 2814.

Protein family/group databases

TCDBi1.A.1.10.1. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel protein type 3 subunit alpha
Alternative name(s):
Sodium channel protein brain III subunit alpha
Sodium channel protein type III subunit alpha
Voltage-gated sodium channel subtype III
Voltage-gated sodium channel subunit alpha Nav1.3
Gene namesi
Name:Scn3a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3635. Scn3a.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: RGD
  2. neuronal cell body Source: RGD
  3. voltage-gated sodium channel complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19511951Sodium channel protein type 3 subunit alphaPRO_0000048494Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi307 – 3071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi339 – 3391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1317 – 13171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1331 – 13311N-linked (GlcNAc...)Sequence Analysis
Modified residuei1452 – 14521Phosphoserine; by PKCBy similarity

Post-translational modificationi

May be ubiquitinated by NEDD4L; which would promote its endocytosis.By similarity
Phosphorylation at Ser-1452 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP08104.
PRIDEiP08104.

Expressioni

Gene expression databases

GenevestigatoriP08104.

Interactioni

Subunit structurei

The sodium channel consists of a large polypeptide and 2-3 smaller ones. This sequence represents a large polypeptide. Interacts with NEDD4L (By similarity).By similarity

Protein-protein interaction databases

BioGridi269080. 2 interactions.
STRINGi10116.ENSRNOP00000006646.

Structurei

Secondary structure

1
1951
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi161 – 17414

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QG9NMR-A156-176[»]
ProteinModelPortaliP08104.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08104.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 123123CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini148 – 1558ExtracellularSequence Analysis
Topological domaini176 – 18813CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini208 – 2136ExtracellularSequence Analysis
Topological domaini234 – 24815CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini274 – 400127ExtracellularSequence AnalysisAdd
BLAST
Topological domaini427 – 705279CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini731 – 74111ExtracellularSequence AnalysisAdd
BLAST
Topological domaini766 – 7738CytoplasmicSequence Analysis
Topological domaini794 – 7996ExtracellularSequence Analysis
Topological domaini821 – 83515CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini857 – 90953ExtracellularSequence AnalysisAdd
BLAST
Topological domaini936 – 1152217CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini1177 – 118913ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1216 – 12216CytoplasmicSequence Analysis
Topological domaini1244 – 12474ExtracellularSequence Analysis
Topological domaini1270 – 128819CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini1311 – 139282ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1420 – 147253CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini1497 – 150711ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1532 – 15376CytoplasmicSequence Analysis
Topological domaini1562 – 157110ExtracellularSequence Analysis
Topological domaini1594 – 160815CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini1632 – 169766ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1723 – 1951229CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei124 – 14724Helical; Name=S1 of repeat ISequence AnalysisAdd
BLAST
Transmembranei156 – 17520Helical; Name=S2 of repeat ISequence AnalysisAdd
BLAST
Transmembranei189 – 20719Helical; Name=S3 of repeat ISequence AnalysisAdd
BLAST
Transmembranei214 – 23320Helical; Voltage-sensor; Name=S4 of repeat ISequence AnalysisAdd
BLAST
Transmembranei249 – 27325Helical; Name=S5 of repeat ISequence AnalysisAdd
BLAST
Transmembranei401 – 42626Helical; Name=S6 of repeat ISequence AnalysisAdd
BLAST
Transmembranei706 – 73025Helical; Name=S1 of repeat IISequence AnalysisAdd
BLAST
Transmembranei742 – 76524Helical; Name=S2 of repeat IISequence AnalysisAdd
BLAST
Transmembranei774 – 79320Helical; Name=S3 of repeat IISequence AnalysisAdd
BLAST
Transmembranei800 – 82021Helical; Voltage-sensor; Name=S4 of repeat IISequence AnalysisAdd
BLAST
Transmembranei836 – 85621Helical; Name=S5 of repeat IISequence AnalysisAdd
BLAST
Transmembranei910 – 93526Helical; Name=S6 of repeat IISequence AnalysisAdd
BLAST
Transmembranei1153 – 117624Helical; Name=S1 of repeat IIISequence AnalysisAdd
BLAST
Transmembranei1190 – 121526Helical; Name=S2 of repeat IIISequence AnalysisAdd
BLAST
Transmembranei1222 – 124322Helical; Name=S3 of repeat IIISequence AnalysisAdd
BLAST
Transmembranei1248 – 126922Helical; Voltage-sensor; Name=S4 of repeat IIISequence AnalysisAdd
BLAST
Transmembranei1289 – 131022Helical; Name=S5 of repeat IIISequence AnalysisAdd
BLAST
Transmembranei1393 – 141927Helical; Name=S6 of repeat IIISequence AnalysisAdd
BLAST
Transmembranei1473 – 149624Helical; Name=S1 of repeat IVSequence AnalysisAdd
BLAST
Transmembranei1508 – 153124Helical; Name=S2 of repeat IVSequence AnalysisAdd
BLAST
Transmembranei1538 – 156124Helical; Name=S3 of repeat IVSequence AnalysisAdd
BLAST
Transmembranei1572 – 159322Helical; Voltage-sensor; Name=S4 of repeat IVSequence AnalysisAdd
BLAST
Transmembranei1609 – 163123Helical; Name=S5 of repeat IVSequence AnalysisAdd
BLAST
Transmembranei1698 – 172225Helical; Name=S6 of repeat IVSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati110 – 455346IAdd
BLAST
Repeati693 – 965273IIAdd
BLAST
Repeati1139 – 1450312IIIAdd
BLAST
Repeati1459 – 1757299IVAdd
BLAST
Domaini1851 – 188030IQAdd
BLAST

Domaini

The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Contains 1 IQ domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
HOVERGENiHBG053100.
InParanoidiP08104.
KOiK04836.
PhylomeDBiP08104.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR028808. Na_channel_a3su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PANTHERiPTHR10037:SF200. PTHR10037:SF200. 1 hit.
PfamiPF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08104-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKKE QDIDDENKPK
60 70 80 90 100
PNSDLEAGKN LPFIYGDIPP EMVSEPLEDL DPYYVSKKTF VVLNKGKAIF
110 120 130 140 150
RFSATSALYI LTPLNPVRKI AIKILVHSLF SMLIMCTILT NCVFMTLSNP
160 170 180 190 200
PDWTKNVEYT FTGIYTFESL IKILARGFCL EDFTFLRDPW NWLDFSVIVM
210 220 230 240 250
AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL IQSVKKLSDV
260 270 280 290 300
MILTVFCLSV FALIGLQLFM GNLRNKCSQW PPSDSAFETN TTSYFNGTMD
310 320 330 340 350
SNGTFVNVTM STFNWKDYIA DDSHFYVLDG QKDPLLCGNG SDAGQCPEGY
360 370 380 390 400
ICVKAGRNPN YGYTSFDTFS WAFLSLFRLM TQDYWENLYQ LTLRAAGKTY
410 420 430 440 450
MIFFVLVIFL GSFYLVNLIL AVVAMAYEEQ NQATLEEAEQ KEAEFQQMLE
460 470 480 490 500
QLKKQQEEAQ AVAAASAASR DFSGIGGLGE LLESSSEASK LSSKSAKEWR
510 520 530 540 550
NRRKKRRQRE HLEGNHRADG DRFPKSESED SVKRRSFLLS LDGNPLTGDK
560 570 580 590 600
KLCSPHQSLL SIRGSLFSPR RNSKTSIFSF RGRAKDVGSE NDFADDEHST
610 620 630 640 650
FEDSESRRDS LFVPHRPGER RNSNGTTTET EVRKRRLSSY QISMEMLEDS
660 670 680 690 700
SGRQRSMSIA SILTNTMEEL EESRQKCPPC WYRFANVFLI WDCCDAWLKV
710 720 730 740 750
KHLVNLIVMD PFVDLAITIC IVLNTLFMAM EHYPMTQQFS SVLTVGNLVF
760 770 780 790 800
TGIFTAEMVL KIIAMDPYYY FQEGWNIFDG IIVSLSLMEL GLANVEGLSV
810 820 830 840 850
LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV
860 870 880 890 900
GMQLFGKSYK ECVCKINVDC KLPRWHMNDF FHSFLIVFRV LCGEWIETMW
910 920 930 940 950
DCMEVAGQTM CLIVFMLVMV IGNLVVLNLF LALLLSSFSS DNLAATDDDN
960 970 980 990 1000
EMNNLQIAVG RMQKGIDFVK NKIRECFRKA FFRKPKVIEI QEGNKIDSCM
1010 1020 1030 1040 1050
SNNTGIEISK ELNYLKDGNG TTSGVGTGSS VEKYVIDEND YMSFINNPSL
1060 1070 1080 1090 1100
TVTVPIAVGE SDFENLNTEE FSSESELEES KEKLNATSSS EGSTVDVAPP
1110 1120 1130 1140 1150
REGEQAEIEP EEDLKPEACF TEGCIKKFPF CQVSTEEGKG KIWWNLRKTC
1160 1170 1180 1190 1200
YSIVEHNWFE TFIVFMILLS SGALAFEDIY IEQRKTIKTM LEYADKVFTY
1210 1220 1230 1240 1250
IFILEMLLKW VAYGFQTYFT NAWCWLDFLI VDVSLVSLVA NALGYSELGA
1260 1270 1280 1290 1300
IKSLRTLRAL RPLRALSRFE GMRVVVNALV GAIPSIMNVL LVCLIFWLIF
1310 1320 1330 1340 1350
SIMGVNLFAG KFYHCVNTTT GNMFEIKEVN NFSDCQALGK QARWKNVKVN
1360 1370 1380 1390 1400
FDNVGAGYLA LLQVATFKGW MDIMYAAVDS RDVKLQPIYE ENLYMYLYFV
1410 1420 1430 1440 1450
IFIIFGSFFT LNLFIGVIID NFNQQKKKFG GQDIFMTEEQ KKYYNAMKKL
1460 1470 1480 1490 1500
GSKKPQKPIP RPANKFQGMV FDFVTRQVFD ISIMILICLN MVTMMVETDD
1510 1520 1530 1540 1550
QSKYMTLVLS RINLVFIVLF TGEFLLKLIS LRYYYFTIGW NIFDFVVVIL
1560 1570 1580 1590 1600
SIVGMFLAEL IEKYFVSPTL FRVIRLARIG RILRLIKGAK GIRTLLFALM
1610 1620 1630 1640 1650
MSLPALFNIG LLLFLVMFIY AIFGMSNFAY VKKEAGIDDM FNFETFGNSM
1660 1670 1680 1690 1700
ICLFQITTSA GWDGLLAPIL NSAPPDCDPD AIHPGSSVKG DCGNPSVGIF
1710 1720 1730 1740 1750
FFVSYIIISF LVVVNMYIAV ILENFSVATE ESAEPLSEDD FEMFYEVWEK
1760 1770 1780 1790 1800
FDPDATQFIE FCKLSDFAAA LDPPLLIAKP NKVQLIAMDL PMVSGDRIHC
1810 1820 1830 1840 1850
LDILFAFTKR VLGESGEMDA LRIQMEDRFM ASNPSKVSYE PITTTLKRKQ
1860 1870 1880 1890 1900
EEVSAAIIQR NYRCYLLKQR LKNISSKYDK ETIKGRIDLP IKGDMVIDKL
1910 1920 1930 1940 1950
NGNSTPEKTD GSSSTTSPPS YDSVTKPDKE KFEKDKPEKE IKGKEVRENQ

K
Length:1,951
Mass (Da):221,387
Last modified:August 1, 1988 - v1
Checksum:i74E5E851524BD10E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00766 mRNA. Translation: CAA68735.1.
PIRiS00320.
RefSeqiNP_037251.1. NM_013119.1.
UniGeneiRn.87394.

Genome annotation databases

GeneIDi497770.
KEGGirno:497770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00766 mRNA. Translation: CAA68735.1 .
PIRi S00320.
RefSeqi NP_037251.1. NM_013119.1.
UniGenei Rn.87394.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1QG9 NMR - A 156-176 [» ]
ProteinModelPortali P08104.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 269080. 2 interactions.
STRINGi 10116.ENSRNOP00000006646.

Chemistry

BindingDBi P08104.
ChEMBLi CHEMBL4966.
GuidetoPHARMACOLOGYi 580.

Protein family/group databases

TCDBi 1.A.1.10.1. the voltage-gated ion channel (vic) superfamily.

Proteomic databases

PaxDbi P08104.
PRIDEi P08104.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 497770.
KEGGi rno:497770.

Organism-specific databases

CTDi 6328.
RGDi 3635. Scn3a.

Phylogenomic databases

eggNOGi COG1226.
HOVERGENi HBG053100.
InParanoidi P08104.
KOi K04836.
PhylomeDBi P08104.

Enzyme and pathway databases

BRENDAi 2.4.1.19. 2814.

Miscellaneous databases

EvolutionaryTracei P08104.
NextBioi 697756.
PROi P08104.

Gene expression databases

Genevestigatori P08104.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR028808. Na_channel_a3su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view ]
PANTHERi PTHR10037:SF200. PTHR10037:SF200. 1 hit.
Pfami PF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view ]
PRINTSi PR00170. NACHANNEL.
SMARTi SM00015. IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary structure of rat brain sodium channel III deduced from the cDNA sequence."
    Kayano T., Noda M., Flockerzi V., Takahashi H., Numa S.
    FEBS Lett. 228:187-194(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.

Entry informationi

Entry nameiSCN3A_RAT
AccessioniPrimary (citable) accession number: P08104
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: October 29, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3