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P08104

- SCN3A_RAT

UniProt

P08104 - SCN3A_RAT

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Protein
Sodium channel protein type 3 subunit alpha
Gene
Scn3a
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.

GO - Molecular functioni

  1. calmodulin binding Source: RGD
  2. protein binding Source: RGD
  3. sodium ion binding Source: RGD
  4. voltage-gated sodium channel activity Source: RGD
Complete GO annotation...

GO - Biological processi

  1. cellular response to antibiotic Source: RGD
  2. membrane depolarization during action potential Source: RefGenome
  3. nervous system development Source: RGD
  4. neuronal action potential Source: RGD
  5. response to pyrethroid Source: RGD
  6. response to wounding Source: RGD
  7. sensory perception of pain Source: RGD
  8. sodium ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BRENDAi2.4.1.19. 2814.

Protein family/group databases

TCDBi1.A.1.10.1. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel protein type 3 subunit alpha
Alternative name(s):
Sodium channel protein brain III subunit alpha
Sodium channel protein type III subunit alpha
Voltage-gated sodium channel subtype III
Voltage-gated sodium channel subunit alpha Nav1.3
Gene namesi
Name:Scn3a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3635. Scn3a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 123123Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei124 – 14724Helical; Name=S1 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini148 – 1558Extracellular Reviewed prediction
Transmembranei156 – 17520Helical; Name=S2 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini176 – 18813Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei189 – 20719Helical; Name=S3 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini208 – 2136Extracellular Reviewed prediction
Transmembranei214 – 23320Helical; Voltage-sensor; Name=S4 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini234 – 24815Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei249 – 27325Helical; Name=S5 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini274 – 400127Extracellular Reviewed prediction
Add
BLAST
Transmembranei401 – 42626Helical; Name=S6 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini427 – 705279Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei706 – 73025Helical; Name=S1 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini731 – 74111Extracellular Reviewed prediction
Add
BLAST
Transmembranei742 – 76524Helical; Name=S2 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini766 – 7738Cytoplasmic Reviewed prediction
Transmembranei774 – 79320Helical; Name=S3 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini794 – 7996Extracellular Reviewed prediction
Transmembranei800 – 82021Helical; Voltage-sensor; Name=S4 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini821 – 83515Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei836 – 85621Helical; Name=S5 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini857 – 90953Extracellular Reviewed prediction
Add
BLAST
Transmembranei910 – 93526Helical; Name=S6 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini936 – 1152217Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1153 – 117624Helical; Name=S1 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1177 – 118913Extracellular Reviewed prediction
Add
BLAST
Transmembranei1190 – 121526Helical; Name=S2 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1216 – 12216Cytoplasmic Reviewed prediction
Transmembranei1222 – 124322Helical; Name=S3 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1244 – 12474Extracellular Reviewed prediction
Transmembranei1248 – 126922Helical; Voltage-sensor; Name=S4 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1270 – 128819Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1289 – 131022Helical; Name=S5 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1311 – 139282Extracellular Reviewed prediction
Add
BLAST
Transmembranei1393 – 141927Helical; Name=S6 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1420 – 147253Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1473 – 149624Helical; Name=S1 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1497 – 150711Extracellular Reviewed prediction
Add
BLAST
Transmembranei1508 – 153124Helical; Name=S2 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1532 – 15376Cytoplasmic Reviewed prediction
Transmembranei1538 – 156124Helical; Name=S3 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1562 – 157110Extracellular Reviewed prediction
Transmembranei1572 – 159322Helical; Voltage-sensor; Name=S4 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1594 – 160815Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1609 – 163123Helical; Name=S5 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1632 – 169766Extracellular Reviewed prediction
Add
BLAST
Transmembranei1698 – 172225Helical; Name=S6 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1723 – 1951229Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. axon Source: RGD
  2. neuronal cell body Source: RGD
  3. voltage-gated sodium channel complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19511951Sodium channel protein type 3 subunit alpha
PRO_0000048494Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi211 – 2111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi290 – 2901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi296 – 2961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi302 – 3021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi307 – 3071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi339 – 3391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1317 – 13171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1331 – 13311N-linked (GlcNAc...) Reviewed prediction
Modified residuei1452 – 14521Phosphoserine; by PKC By similarity

Post-translational modificationi

May be ubiquitinated by NEDD4L; which would promote its endocytosis By similarity.
Phosphorylation at Ser-1452 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents By similarity.

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP08104.
PRIDEiP08104.

Expressioni

Gene expression databases

GenevestigatoriP08104.

Interactioni

Subunit structurei

The sodium channel consists of a large polypeptide and 2-3 smaller ones. This sequence represents a large polypeptide. Interacts with NEDD4L By similarity.

Protein-protein interaction databases

BioGridi269080. 2 interactions.
STRINGi10116.ENSRNOP00000006646.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi161 – 17414

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QG9NMR-A156-176[»]
ProteinModelPortaliP08104.

Miscellaneous databases

EvolutionaryTraceiP08104.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati110 – 455346I
Add
BLAST
Repeati693 – 965273II
Add
BLAST
Repeati1139 – 1450312III
Add
BLAST
Repeati1459 – 1757299IV
Add
BLAST
Domaini1851 – 188030IQ
Add
BLAST

Domaini

The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Contains 1 IQ domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
HOVERGENiHBG053100.
KOiK04836.
PhylomeDBiP08104.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR028808. Na_channel_a3su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PANTHERiPTHR10037:SF200. PTHR10037:SF200. 1 hit.
PfamiPF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08104-1 [UniParc]FASTAAdd to Basket

« Hide

MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKKE QDIDDENKPK     50
PNSDLEAGKN LPFIYGDIPP EMVSEPLEDL DPYYVSKKTF VVLNKGKAIF 100
RFSATSALYI LTPLNPVRKI AIKILVHSLF SMLIMCTILT NCVFMTLSNP 150
PDWTKNVEYT FTGIYTFESL IKILARGFCL EDFTFLRDPW NWLDFSVIVM 200
AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL IQSVKKLSDV 250
MILTVFCLSV FALIGLQLFM GNLRNKCSQW PPSDSAFETN TTSYFNGTMD 300
SNGTFVNVTM STFNWKDYIA DDSHFYVLDG QKDPLLCGNG SDAGQCPEGY 350
ICVKAGRNPN YGYTSFDTFS WAFLSLFRLM TQDYWENLYQ LTLRAAGKTY 400
MIFFVLVIFL GSFYLVNLIL AVVAMAYEEQ NQATLEEAEQ KEAEFQQMLE 450
QLKKQQEEAQ AVAAASAASR DFSGIGGLGE LLESSSEASK LSSKSAKEWR 500
NRRKKRRQRE HLEGNHRADG DRFPKSESED SVKRRSFLLS LDGNPLTGDK 550
KLCSPHQSLL SIRGSLFSPR RNSKTSIFSF RGRAKDVGSE NDFADDEHST 600
FEDSESRRDS LFVPHRPGER RNSNGTTTET EVRKRRLSSY QISMEMLEDS 650
SGRQRSMSIA SILTNTMEEL EESRQKCPPC WYRFANVFLI WDCCDAWLKV 700
KHLVNLIVMD PFVDLAITIC IVLNTLFMAM EHYPMTQQFS SVLTVGNLVF 750
TGIFTAEMVL KIIAMDPYYY FQEGWNIFDG IIVSLSLMEL GLANVEGLSV 800
LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV 850
GMQLFGKSYK ECVCKINVDC KLPRWHMNDF FHSFLIVFRV LCGEWIETMW 900
DCMEVAGQTM CLIVFMLVMV IGNLVVLNLF LALLLSSFSS DNLAATDDDN 950
EMNNLQIAVG RMQKGIDFVK NKIRECFRKA FFRKPKVIEI QEGNKIDSCM 1000
SNNTGIEISK ELNYLKDGNG TTSGVGTGSS VEKYVIDEND YMSFINNPSL 1050
TVTVPIAVGE SDFENLNTEE FSSESELEES KEKLNATSSS EGSTVDVAPP 1100
REGEQAEIEP EEDLKPEACF TEGCIKKFPF CQVSTEEGKG KIWWNLRKTC 1150
YSIVEHNWFE TFIVFMILLS SGALAFEDIY IEQRKTIKTM LEYADKVFTY 1200
IFILEMLLKW VAYGFQTYFT NAWCWLDFLI VDVSLVSLVA NALGYSELGA 1250
IKSLRTLRAL RPLRALSRFE GMRVVVNALV GAIPSIMNVL LVCLIFWLIF 1300
SIMGVNLFAG KFYHCVNTTT GNMFEIKEVN NFSDCQALGK QARWKNVKVN 1350
FDNVGAGYLA LLQVATFKGW MDIMYAAVDS RDVKLQPIYE ENLYMYLYFV 1400
IFIIFGSFFT LNLFIGVIID NFNQQKKKFG GQDIFMTEEQ KKYYNAMKKL 1450
GSKKPQKPIP RPANKFQGMV FDFVTRQVFD ISIMILICLN MVTMMVETDD 1500
QSKYMTLVLS RINLVFIVLF TGEFLLKLIS LRYYYFTIGW NIFDFVVVIL 1550
SIVGMFLAEL IEKYFVSPTL FRVIRLARIG RILRLIKGAK GIRTLLFALM 1600
MSLPALFNIG LLLFLVMFIY AIFGMSNFAY VKKEAGIDDM FNFETFGNSM 1650
ICLFQITTSA GWDGLLAPIL NSAPPDCDPD AIHPGSSVKG DCGNPSVGIF 1700
FFVSYIIISF LVVVNMYIAV ILENFSVATE ESAEPLSEDD FEMFYEVWEK 1750
FDPDATQFIE FCKLSDFAAA LDPPLLIAKP NKVQLIAMDL PMVSGDRIHC 1800
LDILFAFTKR VLGESGEMDA LRIQMEDRFM ASNPSKVSYE PITTTLKRKQ 1850
EEVSAAIIQR NYRCYLLKQR LKNISSKYDK ETIKGRIDLP IKGDMVIDKL 1900
NGNSTPEKTD GSSSTTSPPS YDSVTKPDKE KFEKDKPEKE IKGKEVRENQ 1950
K 1951
Length:1,951
Mass (Da):221,387
Last modified:August 1, 1988 - v1
Checksum:i74E5E851524BD10E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00766 mRNA. Translation: CAA68735.1.
PIRiS00320.
RefSeqiNP_037251.1. NM_013119.1.
UniGeneiRn.87394.

Genome annotation databases

GeneIDi497770.
KEGGirno:497770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00766 mRNA. Translation: CAA68735.1 .
PIRi S00320.
RefSeqi NP_037251.1. NM_013119.1.
UniGenei Rn.87394.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1QG9 NMR - A 156-176 [» ]
ProteinModelPortali P08104.
ModBasei Search...

Protein-protein interaction databases

BioGridi 269080. 2 interactions.
STRINGi 10116.ENSRNOP00000006646.

Chemistry

BindingDBi P08104.
ChEMBLi CHEMBL2095171.
GuidetoPHARMACOLOGYi 580.

Protein family/group databases

TCDBi 1.A.1.10.1. the voltage-gated ion channel (vic) superfamily.

Proteomic databases

PaxDbi P08104.
PRIDEi P08104.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 497770.
KEGGi rno:497770.

Organism-specific databases

CTDi 6328.
RGDi 3635. Scn3a.

Phylogenomic databases

eggNOGi COG1226.
HOVERGENi HBG053100.
KOi K04836.
PhylomeDBi P08104.

Enzyme and pathway databases

BRENDAi 2.4.1.19. 2814.

Miscellaneous databases

EvolutionaryTracei P08104.
NextBioi 697756.
PROi P08104.

Gene expression databases

Genevestigatori P08104.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR028808. Na_channel_a3su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view ]
PANTHERi PTHR10037:SF200. PTHR10037:SF200. 1 hit.
Pfami PF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view ]
PRINTSi PR00170. NACHANNEL.
SMARTi SM00015. IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary structure of rat brain sodium channel III deduced from the cDNA sequence."
    Kayano T., Noda M., Flockerzi V., Takahashi H., Numa S.
    FEBS Lett. 228:187-194(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.

Entry informationi

Entry nameiSCN3A_RAT
AccessioniPrimary (citable) accession number: P08104
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: September 3, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi