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P08104

- SCN3A_RAT

UniProt

P08104 - SCN3A_RAT

Protein

Sodium channel protein type 3 subunit alpha

Gene

Scn3a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 1 (01 Aug 1988)
      Previous versions | rss
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    Functioni

    Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.

    GO - Molecular functioni

    1. calmodulin binding Source: RGD
    2. protein binding Source: RGD
    3. sodium ion binding Source: RGD
    4. voltage-gated sodium channel activity Source: RGD

    GO - Biological processi

    1. cellular response to antibiotic Source: RGD
    2. membrane depolarization during action potential Source: RefGenome
    3. nervous system development Source: RGD
    4. neuronal action potential Source: RGD
    5. response to pyrethroid Source: RGD
    6. response to wounding Source: RGD
    7. sensory perception of pain Source: RGD
    8. sodium ion transmembrane transport Source: GOC

    Keywords - Molecular functioni

    Ion channel, Sodium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    BRENDAi2.4.1.19. 2814.

    Protein family/group databases

    TCDBi1.A.1.10.1. the voltage-gated ion channel (vic) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium channel protein type 3 subunit alpha
    Alternative name(s):
    Sodium channel protein brain III subunit alpha
    Sodium channel protein type III subunit alpha
    Voltage-gated sodium channel subtype III
    Voltage-gated sodium channel subunit alpha Nav1.3
    Gene namesi
    Name:Scn3a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3635. Scn3a.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: RGD
    2. neuronal cell body Source: RGD
    3. voltage-gated sodium channel complex Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19511951Sodium channel protein type 3 subunit alphaPRO_0000048494Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi307 – 3071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi339 – 3391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1317 – 13171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1331 – 13311N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1452 – 14521Phosphoserine; by PKCBy similarity

    Post-translational modificationi

    May be ubiquitinated by NEDD4L; which would promote its endocytosis.By similarity
    Phosphorylation at Ser-1452 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiP08104.
    PRIDEiP08104.

    Expressioni

    Gene expression databases

    GenevestigatoriP08104.

    Interactioni

    Subunit structurei

    The sodium channel consists of a large polypeptide and 2-3 smaller ones. This sequence represents a large polypeptide. Interacts with NEDD4L By similarity.By similarity

    Protein-protein interaction databases

    BioGridi269080. 2 interactions.
    STRINGi10116.ENSRNOP00000006646.

    Structurei

    Secondary structure

    1
    1951
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi161 – 17414

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1QG9NMR-A156-176[»]
    ProteinModelPortaliP08104.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP08104.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 123123CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini148 – 1558ExtracellularSequence Analysis
    Topological domaini176 – 18813CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini208 – 2136ExtracellularSequence Analysis
    Topological domaini234 – 24815CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini274 – 400127ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini427 – 705279CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini731 – 74111ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini766 – 7738CytoplasmicSequence Analysis
    Topological domaini794 – 7996ExtracellularSequence Analysis
    Topological domaini821 – 83515CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini857 – 90953ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini936 – 1152217CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1177 – 118913ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1216 – 12216CytoplasmicSequence Analysis
    Topological domaini1244 – 12474ExtracellularSequence Analysis
    Topological domaini1270 – 128819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1311 – 139282ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1420 – 147253CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1497 – 150711ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1532 – 15376CytoplasmicSequence Analysis
    Topological domaini1562 – 157110ExtracellularSequence Analysis
    Topological domaini1594 – 160815CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1632 – 169766ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1723 – 1951229CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei124 – 14724Helical; Name=S1 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei156 – 17520Helical; Name=S2 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei189 – 20719Helical; Name=S3 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei214 – 23320Helical; Voltage-sensor; Name=S4 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei249 – 27325Helical; Name=S5 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei401 – 42626Helical; Name=S6 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei706 – 73025Helical; Name=S1 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei742 – 76524Helical; Name=S2 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei774 – 79320Helical; Name=S3 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei800 – 82021Helical; Voltage-sensor; Name=S4 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei836 – 85621Helical; Name=S5 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei910 – 93526Helical; Name=S6 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei1153 – 117624Helical; Name=S1 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1190 – 121526Helical; Name=S2 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1222 – 124322Helical; Name=S3 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1248 – 126922Helical; Voltage-sensor; Name=S4 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1289 – 131022Helical; Name=S5 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1393 – 141927Helical; Name=S6 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1473 – 149624Helical; Name=S1 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1508 – 153124Helical; Name=S2 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1538 – 156124Helical; Name=S3 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1572 – 159322Helical; Voltage-sensor; Name=S4 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1609 – 163123Helical; Name=S5 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1698 – 172225Helical; Name=S6 of repeat IVSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati110 – 455346IAdd
    BLAST
    Repeati693 – 965273IIAdd
    BLAST
    Repeati1139 – 1450312IIIAdd
    BLAST
    Repeati1459 – 1757299IVAdd
    BLAST
    Domaini1851 – 188030IQAdd
    BLAST

    Domaini

    The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Contains 1 IQ domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    HOVERGENiHBG053100.
    KOiK04836.
    PhylomeDBiP08104.

    Family and domain databases

    Gene3Di1.20.120.350. 4 hits.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR024583. DUF3451.
    IPR005821. Ion_trans_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR028808. Na_channel_a3su.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    [Graphical view]
    PANTHERiPTHR10037:SF200. PTHR10037:SF200. 1 hit.
    PfamiPF11933. DUF3451. 1 hit.
    PF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view]
    PRINTSiPR00170. NACHANNEL.
    SMARTiSM00015. IQ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P08104-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKKE QDIDDENKPK     50
    PNSDLEAGKN LPFIYGDIPP EMVSEPLEDL DPYYVSKKTF VVLNKGKAIF 100
    RFSATSALYI LTPLNPVRKI AIKILVHSLF SMLIMCTILT NCVFMTLSNP 150
    PDWTKNVEYT FTGIYTFESL IKILARGFCL EDFTFLRDPW NWLDFSVIVM 200
    AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL IQSVKKLSDV 250
    MILTVFCLSV FALIGLQLFM GNLRNKCSQW PPSDSAFETN TTSYFNGTMD 300
    SNGTFVNVTM STFNWKDYIA DDSHFYVLDG QKDPLLCGNG SDAGQCPEGY 350
    ICVKAGRNPN YGYTSFDTFS WAFLSLFRLM TQDYWENLYQ LTLRAAGKTY 400
    MIFFVLVIFL GSFYLVNLIL AVVAMAYEEQ NQATLEEAEQ KEAEFQQMLE 450
    QLKKQQEEAQ AVAAASAASR DFSGIGGLGE LLESSSEASK LSSKSAKEWR 500
    NRRKKRRQRE HLEGNHRADG DRFPKSESED SVKRRSFLLS LDGNPLTGDK 550
    KLCSPHQSLL SIRGSLFSPR RNSKTSIFSF RGRAKDVGSE NDFADDEHST 600
    FEDSESRRDS LFVPHRPGER RNSNGTTTET EVRKRRLSSY QISMEMLEDS 650
    SGRQRSMSIA SILTNTMEEL EESRQKCPPC WYRFANVFLI WDCCDAWLKV 700
    KHLVNLIVMD PFVDLAITIC IVLNTLFMAM EHYPMTQQFS SVLTVGNLVF 750
    TGIFTAEMVL KIIAMDPYYY FQEGWNIFDG IIVSLSLMEL GLANVEGLSV 800
    LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV 850
    GMQLFGKSYK ECVCKINVDC KLPRWHMNDF FHSFLIVFRV LCGEWIETMW 900
    DCMEVAGQTM CLIVFMLVMV IGNLVVLNLF LALLLSSFSS DNLAATDDDN 950
    EMNNLQIAVG RMQKGIDFVK NKIRECFRKA FFRKPKVIEI QEGNKIDSCM 1000
    SNNTGIEISK ELNYLKDGNG TTSGVGTGSS VEKYVIDEND YMSFINNPSL 1050
    TVTVPIAVGE SDFENLNTEE FSSESELEES KEKLNATSSS EGSTVDVAPP 1100
    REGEQAEIEP EEDLKPEACF TEGCIKKFPF CQVSTEEGKG KIWWNLRKTC 1150
    YSIVEHNWFE TFIVFMILLS SGALAFEDIY IEQRKTIKTM LEYADKVFTY 1200
    IFILEMLLKW VAYGFQTYFT NAWCWLDFLI VDVSLVSLVA NALGYSELGA 1250
    IKSLRTLRAL RPLRALSRFE GMRVVVNALV GAIPSIMNVL LVCLIFWLIF 1300
    SIMGVNLFAG KFYHCVNTTT GNMFEIKEVN NFSDCQALGK QARWKNVKVN 1350
    FDNVGAGYLA LLQVATFKGW MDIMYAAVDS RDVKLQPIYE ENLYMYLYFV 1400
    IFIIFGSFFT LNLFIGVIID NFNQQKKKFG GQDIFMTEEQ KKYYNAMKKL 1450
    GSKKPQKPIP RPANKFQGMV FDFVTRQVFD ISIMILICLN MVTMMVETDD 1500
    QSKYMTLVLS RINLVFIVLF TGEFLLKLIS LRYYYFTIGW NIFDFVVVIL 1550
    SIVGMFLAEL IEKYFVSPTL FRVIRLARIG RILRLIKGAK GIRTLLFALM 1600
    MSLPALFNIG LLLFLVMFIY AIFGMSNFAY VKKEAGIDDM FNFETFGNSM 1650
    ICLFQITTSA GWDGLLAPIL NSAPPDCDPD AIHPGSSVKG DCGNPSVGIF 1700
    FFVSYIIISF LVVVNMYIAV ILENFSVATE ESAEPLSEDD FEMFYEVWEK 1750
    FDPDATQFIE FCKLSDFAAA LDPPLLIAKP NKVQLIAMDL PMVSGDRIHC 1800
    LDILFAFTKR VLGESGEMDA LRIQMEDRFM ASNPSKVSYE PITTTLKRKQ 1850
    EEVSAAIIQR NYRCYLLKQR LKNISSKYDK ETIKGRIDLP IKGDMVIDKL 1900
    NGNSTPEKTD GSSSTTSPPS YDSVTKPDKE KFEKDKPEKE IKGKEVRENQ 1950
    K 1951
    Length:1,951
    Mass (Da):221,387
    Last modified:August 1, 1988 - v1
    Checksum:i74E5E851524BD10E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00766 mRNA. Translation: CAA68735.1.
    PIRiS00320.
    RefSeqiNP_037251.1. NM_013119.1.
    UniGeneiRn.87394.

    Genome annotation databases

    GeneIDi497770.
    KEGGirno:497770.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00766 mRNA. Translation: CAA68735.1 .
    PIRi S00320.
    RefSeqi NP_037251.1. NM_013119.1.
    UniGenei Rn.87394.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1QG9 NMR - A 156-176 [» ]
    ProteinModelPortali P08104.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 269080. 2 interactions.
    STRINGi 10116.ENSRNOP00000006646.

    Chemistry

    BindingDBi P08104.
    ChEMBLi CHEMBL2095171.
    GuidetoPHARMACOLOGYi 580.

    Protein family/group databases

    TCDBi 1.A.1.10.1. the voltage-gated ion channel (vic) superfamily.

    Proteomic databases

    PaxDbi P08104.
    PRIDEi P08104.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 497770.
    KEGGi rno:497770.

    Organism-specific databases

    CTDi 6328.
    RGDi 3635. Scn3a.

    Phylogenomic databases

    eggNOGi COG1226.
    HOVERGENi HBG053100.
    KOi K04836.
    PhylomeDBi P08104.

    Enzyme and pathway databases

    BRENDAi 2.4.1.19. 2814.

    Miscellaneous databases

    EvolutionaryTracei P08104.
    NextBioi 697756.
    PROi P08104.

    Gene expression databases

    Genevestigatori P08104.

    Family and domain databases

    Gene3Di 1.20.120.350. 4 hits.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR024583. DUF3451.
    IPR005821. Ion_trans_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR028808. Na_channel_a3su.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    [Graphical view ]
    PANTHERi PTHR10037:SF200. PTHR10037:SF200. 1 hit.
    Pfami PF11933. DUF3451. 1 hit.
    PF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view ]
    PRINTSi PR00170. NACHANNEL.
    SMARTi SM00015. IQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of rat brain sodium channel III deduced from the cDNA sequence."
      Kayano T., Noda M., Flockerzi V., Takahashi H., Numa S.
      FEBS Lett. 228:187-194(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.

    Entry informationi

    Entry nameiSCN3A_RAT
    AccessioniPrimary (citable) accession number: P08104
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: August 1, 1988
    Last modified: October 1, 2014
    This is version 133 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3