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Protein

Opsin Rh2

Gene

Rh2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

Absorptioni

Abs(max)=420 nm1 Publication

GO - Molecular functioni

  • G-protein coupled photoreceptor activity Source: FlyBase

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: FlyBase
  • phototransduction Source: FlyBase
  • protein-chromophore linkage Source: UniProtKB-KW
  • visual perception Source: UniProtKB-KW

Keywordsi

Molecular functionG-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer
Biological processSensory transduction, Vision
LigandChromophore

Enzyme and pathway databases

ReactomeiR-DME-2187335 The retinoid cycle in cones (daylight vision)
R-DME-2453902 The canonical retinoid cycle in rods (twilight vision)
R-DME-2485179 Activation of the phototransduction cascade
R-DME-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-DME-419771 Opsins
R-DME-5620916 VxPx cargo-targeting to cilium

Names & Taxonomyi

Protein namesi
Recommended name:
Opsin Rh2
Alternative name(s):
Ocellar opsin
Gene namesi
Name:Rh2
ORF Names:CG16740
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0003248 Rh2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 56ExtracellularAdd BLAST56
Transmembranei57 – 81Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini82 – 93CytoplasmicAdd BLAST12
Transmembranei94 – 119Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini120 – 133ExtracellularAdd BLAST14
Transmembranei134 – 153Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini154 – 172CytoplasmicAdd BLAST19
Transmembranei173 – 196Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini197 – 220ExtracellularAdd BLAST24
Transmembranei221 – 248Helical; Name=5Sequence analysisAdd BLAST28
Topological domaini249 – 283CytoplasmicAdd BLAST35
Transmembranei284 – 307Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini308 – 314Extracellular7
Transmembranei315 – 339Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini340 – 381CytoplasmicAdd BLAST42

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001976251 – 381Opsin Rh2Add BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi130 ↔ 207PROSITE-ProRule annotation
Modified residuei326N6-(retinylidene)lysine1

Post-translational modificationi

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP08099
PRIDEiP08099

Expressioni

Tissue specificityi

Predominant opsin expressed in the dorsal ocelli.

Gene expression databases

BgeeiFBgn0003248
ExpressionAtlasiP08099 differential
GenevisibleiP08099 DM

Interactioni

Protein-protein interaction databases

BioGridi67266, 4 interactors
DIPiDIP-22447N
IntActiP08099, 1 interactor
STRINGi7227.FBpp0083111

Structurei

3D structure databases

ProteinModelPortaliP08099
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
InParanoidiP08099
KOiK04255
OMAiPRFQAQS
OrthoDBiEOG091G0ALC
PhylomeDBiP08099

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001760 Opsin
IPR001735 Opsin_RH1/RH2
IPR027430 Retinal_BS
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00238 OPSIN
PR00576 OPSINRH1RH2
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS00238 OPSIN, 1 hit

Sequencei

Sequence statusi: Complete.

P08099-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERSHLPETP FDLAHSGPRF QAQSSGNGSV LDNVLPDMAH LVNPYWSRFA
60 70 80 90 100
PMDPMMSKIL GLFTLAIMII SCCGNGVVVY IFGGTKSLRT PANLLVLNLA
110 120 130 140 150
FSDFCMMASQ SPVMIINFYY ETWVLGPLWC DIYAGCGSLF GCVSIWSMCM
160 170 180 190 200
IAFDRYNVIV KGINGTPMTI KTSIMKILFI WMMAVFWTVM PLIGWSAYVP
210 220 230 240 250
EGNLTACSID YMTRMWNPRS YLITYSLFVY YTPLFLICYS YWFIIAAVAA
260 270 280 290 300
HEKAMREQAK KMNVKSLRSS EDCDKSAEGK LAKVALTTIS LWFMAWTPYL
310 320 330 340 350
VICYFGLFKI DGLTPLTTIW GATFAKTSAV YNPIVYGISH PKYRIVLKEK
360 370 380
CPMCVFGNTD EPKPDAPASD TETTSEADSK A
Length:381
Mass (Da):42,722
Last modified:August 1, 1988 - v1
Checksum:i628322D228396F9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12896 Genomic DNA Translation: AAA28734.1
AE014297 Genomic DNA Translation: AAF55601.1
PIRiA24058 OOFF2
RefSeqiNP_524398.1, NM_079674.3
UniGeneiDm.2404

Genome annotation databases

EnsemblMetazoaiFBtr0083697; FBpp0083111; FBgn0003248
GeneIDi42261
KEGGidme:Dmel_CG16740

Similar proteinsi

Entry informationi

Entry nameiOPS2_DROME
AccessioniPrimary (citable) accession number: P08099
Secondary accession number(s): Q9VE29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: May 23, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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