Acid phosphatase precursor - Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

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P08091 (PPA1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 101. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Acid phosphatase
EC=3.1.3.2

Gene names

Name:	pho1
ORF Names:	SPBP4G3.02

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›

Protein attributes

Sequence length	453 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	A phosphate monoester + H₂O = an alcohol + phosphate.
Subcellular location	Secreted › cell wall.
Induction	Repressed by phosphate and weakly by thiamine.
Sequence similarities	Belongs to the histidine acid phosphatase family.

Ontologies

Keywords
Cellular component	Cell wall Secreted
Domain	Signal
Molecular function	Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to phosphate starvation Inferred from mutant phenotype PubMed 7499352. Source: PomBase positive regulation of L-glutamate import Inferred from direct assay PubMed 3447747. Source: PomBase positive regulation of L-glutamine import Inferred from mutant phenotype PubMed 3447747. Source: PomBase positive regulation of L-threonine import Inferred from mutant phenotype PubMed 3447747. Source: PomBase positive regulation of L-tyrosine import Inferred from mutant phenotype PubMed 3447747. Source: PomBase positive regulation of glycine import Inferred from direct assay PubMed 3447747. Source: PomBase
Cellular_component	cell wall-bounded periplasmic space Inferred from sequence orthology. Source: PomBase endoplasmic reticulum Inferred from direct assay PubMed 16823372. Source: PomBase external side of plasma membrane Non-traceable author statement. Source: PomBase extracellular region Inferred from sequence orthology. Source: PomBase fungal-type cell wall Inferred from sequence orthology. Source: PomBase
Molecular_function	acid phosphatase activity Inferred from sequence orthology. Source: PomBase
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

18

Chain

435

Acid phosphatase

PRO_0000023951

Sites

Active site

1

Nucleophile By similarity

Active site

1

Proton donor By similarity

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

P08091 [UniParc].

Last modified August 1, 1988. Version 1.
Checksum: 7CF891256EB154D1
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453

50,557

        10         20         30         40         50         60 
MFLQNLFLGF LAVVCANAQF AEFTAFDGKF DFKEHLTSRS PYHKPYFYGP SIDFPTTCKI 

        70         80         90        100        110        120 
KQVHTLQRHG SRNPTGGNAA FDAVGIANFQ QRLLNGSVPI DYSVSGNPLS FVPTWTPVIE 

       130        140        150        160        170        180 
AANADALSSS GRVELFDMGR QFYERYHELF NASTYNIYTA AQQRVVDSAL WYGYGMFGED 

       190        200        210        220        230        240 
VHNFTNYILV SENATAGSNS LSSYNACPAS DADDFTTPAL EAWRNVYMPP IRQRLNPYFS 

       250        260        270        280        290        300 
NYNLTNDDIL NLYGICSYEI ALQDYSEFCK LFNSVDFLNF EYEGDLSFSY GMGNSVKWGS 

       310        320        330        340        350        360 
IFGGAYANSL ANSLRSVENN TQQVFFAFTH DANIIPVETA LGFFTDNTPE NPLPTSYQVH 

       370        380        390        400        410        420 
SHSMKASEFV PFAGNLITEL FQCEDSKYYV RHLVNEEVFP LSDCGFGPSN TSDGMCELYA 

       430        440        450 
YLNSPVRVNG TSNGIQNFDT LCNASAVAAV YPY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of the structural gene for secreted acid phosphatase from Schizosaccharomyces pombe." Elliott S., Chang C., Schweingruber M.E., Schaller J., Rickli E.E., Carbon J. J. Biol. Chem. 261:2936-2941(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P. Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.
[3]	"Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library." Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y. Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 88-285. Strain: ATCC 38364 / 968.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M11857 Genomic DNA. Translation: AAA35321.1. CU329671 Genomic DNA. Translation: CAB68657.1. AB027949 Genomic DNA. Translation: BAA87253.1.
PIR	A25326.
RefSeq	NP_596847.1. NM_001023870.2.
3D structure databases
ProteinModelPortal	P08091.
ModBase	Search...
Protein-protein interaction databases
STRING	4896.SPBP4G3.02-1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPBP4G3.02.1; SPBP4G3.02.1:pep; SPBP4G3.02.
GeneID	2541339.
KEGG	spo:SPBP4G3.02.
Organism-specific databases
PomBase	SPBP4G3.02.
Phylogenomic databases
HOGENOM	HOG000115655.
KO	K01078.
OMA	FTHDANI.
OrthoDB	EOG4SXRMX.
Family and domain databases
InterPro	IPR000560. His_Pase_superF_clade-2. IPR016274. Histidine_acid_Pase_euk. [Graphical view]
Pfam	PF00328. His_Phos_2. 1 hit. [Graphical view]
PIRSF	PIRSF000894. Acid_phosphatase. 1 hit.
PROSITE	PS00616. HIS_ACID_PHOSPHAT_1. 1 hit. PS00778. HIS_ACID_PHOSPHAT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20802448.

Entry information

Entry name

PPA1_SCHPO

Accession

Primary (citable) accession number: P08091
Secondary accession number(s): Q9UTX1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	August 1, 1988
Last modified:	May 1, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents