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P08091

- PPA1_SCHPO

UniProt

P08091 - PPA1_SCHPO

Protein

Acid phosphatase

Gene

pho1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Aug 1988)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei69 – 691NucleophileBy similarity
    Active sitei331 – 3311Proton donorBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: PomBase

    GO - Biological processi

    1. cellular response to phosphate starvation Source: PomBase
    2. dephosphorylation Source: PomBase
    3. organophosphate catabolic process Source: PomBase
    4. positive regulation of glycine import Source: PomBase
    5. positive regulation of L-glutamate import Source: PomBase
    6. positive regulation of L-glutamine import Source: PomBase
    7. positive regulation of L-threonine import Source: PomBase
    8. positive regulation of L-tyrosine import Source: PomBase

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acid phosphatase (EC:3.1.3.2)
    Gene namesi
    Name:pho1
    ORF Names:SPBP4G3.02
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBP4G3.02.

    Subcellular locationi

    GO - Cellular componenti

    1. cell wall-bounded periplasmic space Source: PomBase
    2. cytoplasm Source: PomBase
    3. endoplasmic reticulum Source: PomBase
    4. external side of plasma membrane Source: PomBase
    5. extracellular region Source: PomBase
    6. fungal-type cell wall Source: PomBase
    7. intracellular Source: PomBase
    8. membrane Source: PomBase
    9. plasma membrane Source: PomBase

    Keywords - Cellular componenti

    Cell wall, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Add
    BLAST
    Chaini19 – 453435Acid phosphatasePRO_0000023951Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi319 – 3191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi410 – 4101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi429 – 4291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi443 – 4431N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP08091.

    Expressioni

    Inductioni

    Repressed by phosphate and weakly by thiamine.

    Interactioni

    Protein-protein interaction databases

    BioGridi277850. 17 interactions.
    MINTiMINT-4686981.
    STRINGi4896.SPBP4G3.02-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP08091.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidine acid phosphatase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOGENOMiHOG000115655.
    KOiK01078.
    OrthoDBiEOG7SN8N6.
    PhylomeDBiP08091.

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    InterProiIPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    IPR016274. Histidine_acid_Pase_euk.
    [Graphical view]
    PfamiPF00328. His_Phos_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000894. Acid_phosphatase. 1 hit.
    SUPFAMiSSF53254. SSF53254. 1 hit.
    PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P08091-1 [UniParc]FASTAAdd to Basket

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    MFLQNLFLGF LAVVCANAQF AEFTAFDGKF DFKEHLTSRS PYHKPYFYGP    50
    SIDFPTTCKI KQVHTLQRHG SRNPTGGNAA FDAVGIANFQ QRLLNGSVPI 100
    DYSVSGNPLS FVPTWTPVIE AANADALSSS GRVELFDMGR QFYERYHELF 150
    NASTYNIYTA AQQRVVDSAL WYGYGMFGED VHNFTNYILV SENATAGSNS 200
    LSSYNACPAS DADDFTTPAL EAWRNVYMPP IRQRLNPYFS NYNLTNDDIL 250
    NLYGICSYEI ALQDYSEFCK LFNSVDFLNF EYEGDLSFSY GMGNSVKWGS 300
    IFGGAYANSL ANSLRSVENN TQQVFFAFTH DANIIPVETA LGFFTDNTPE 350
    NPLPTSYQVH SHSMKASEFV PFAGNLITEL FQCEDSKYYV RHLVNEEVFP 400
    LSDCGFGPSN TSDGMCELYA YLNSPVRVNG TSNGIQNFDT LCNASAVAAV 450
    YPY 453
    Length:453
    Mass (Da):50,557
    Last modified:August 1, 1988 - v1
    Checksum:i7CF891256EB154D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11857 Genomic DNA. Translation: AAA35321.1.
    CU329671 Genomic DNA. Translation: CAB68657.1.
    AB027949 Genomic DNA. Translation: BAA87253.1.
    PIRiA25326.
    RefSeqiNP_596847.1. NM_001023870.2.

    Genome annotation databases

    EnsemblFungiiSPBP4G3.02.1; SPBP4G3.02.1:pep; SPBP4G3.02.
    GeneIDi2541339.
    KEGGispo:SPBP4G3.02.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11857 Genomic DNA. Translation: AAA35321.1 .
    CU329671 Genomic DNA. Translation: CAB68657.1 .
    AB027949 Genomic DNA. Translation: BAA87253.1 .
    PIRi A25326.
    RefSeqi NP_596847.1. NM_001023870.2.

    3D structure databases

    ProteinModelPortali P08091.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 277850. 17 interactions.
    MINTi MINT-4686981.
    STRINGi 4896.SPBP4G3.02-1.

    Proteomic databases

    MaxQBi P08091.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBP4G3.02.1 ; SPBP4G3.02.1:pep ; SPBP4G3.02 .
    GeneIDi 2541339.
    KEGGi spo:SPBP4G3.02.

    Organism-specific databases

    PomBasei SPBP4G3.02.

    Phylogenomic databases

    HOGENOMi HOG000115655.
    KOi K01078.
    OrthoDBi EOG7SN8N6.
    PhylomeDBi P08091.

    Miscellaneous databases

    NextBioi 20802448.

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    InterProi IPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    IPR016274. Histidine_acid_Pase_euk.
    [Graphical view ]
    Pfami PF00328. His_Phos_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000894. Acid_phosphatase. 1 hit.
    SUPFAMi SSF53254. SSF53254. 1 hit.
    PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the structural gene for secreted acid phosphatase from Schizosaccharomyces pombe."
      Elliott S., Chang C., Schweingruber M.E., Schaller J., Rickli E.E., Carbon J.
      J. Biol. Chem. 261:2936-2941(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    3. "Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
      Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
      Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 88-285.
      Strain: ATCC 38364 / 968.

    Entry informationi

    Entry nameiPPA1_SCHPO
    AccessioniPrimary (citable) accession number: P08091
    Secondary accession number(s): Q9UTX1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: August 1, 1988
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3