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P08091

- PPA1_SCHPO

UniProt

P08091 - PPA1_SCHPO

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Protein

Acid phosphatase

Gene

pho1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei69 – 691NucleophileBy similarity
Active sitei331 – 3311Proton donorBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: PomBase

GO - Biological processi

  1. cellular response to phosphate starvation Source: PomBase
  2. dephosphorylation Source: PomBase
  3. organophosphate catabolic process Source: PomBase
  4. positive regulation of glycine import Source: PomBase
  5. positive regulation of L-glutamate import Source: PomBase
  6. positive regulation of L-glutamine import Source: PomBase
  7. positive regulation of L-threonine import Source: PomBase
  8. positive regulation of L-tyrosine import Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acid phosphatase (EC:3.1.3.2)
Gene namesi
Name:pho1
ORF Names:SPBP4G3.02
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBP4G3.02.

Subcellular locationi

GO - Cellular componenti

  1. cell wall-bounded periplasmic space Source: PomBase
  2. cytoplasm Source: PomBase
  3. endoplasmic reticulum Source: PomBase
  4. external side of plasma membrane Source: PomBase
  5. extracellular region Source: PomBase
  6. fungal-type cell wall Source: PomBase
  7. intracellular Source: PomBase
  8. membrane Source: PomBase
  9. plasma membrane Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Add
BLAST
Chaini19 – 453435Acid phosphatasePRO_0000023951Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi319 – 3191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi410 – 4101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi429 – 4291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi443 – 4431N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP08091.

Expressioni

Inductioni

Repressed by phosphate and weakly by thiamine.

Interactioni

Protein-protein interaction databases

BioGridi277850. 17 interactions.
MINTiMINT-4686981.
STRINGi4896.SPBP4G3.02-1.

Structurei

3D structure databases

ProteinModelPortaliP08091.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000115655.
InParanoidiP08091.
KOiK01078.
OrthoDBiEOG7SN8N6.
PhylomeDBiP08091.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
IPR016274. Histidine_acid_Pase_euk.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000894. Acid_phosphatase. 1 hit.
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08091-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFLQNLFLGF LAVVCANAQF AEFTAFDGKF DFKEHLTSRS PYHKPYFYGP
60 70 80 90 100
SIDFPTTCKI KQVHTLQRHG SRNPTGGNAA FDAVGIANFQ QRLLNGSVPI
110 120 130 140 150
DYSVSGNPLS FVPTWTPVIE AANADALSSS GRVELFDMGR QFYERYHELF
160 170 180 190 200
NASTYNIYTA AQQRVVDSAL WYGYGMFGED VHNFTNYILV SENATAGSNS
210 220 230 240 250
LSSYNACPAS DADDFTTPAL EAWRNVYMPP IRQRLNPYFS NYNLTNDDIL
260 270 280 290 300
NLYGICSYEI ALQDYSEFCK LFNSVDFLNF EYEGDLSFSY GMGNSVKWGS
310 320 330 340 350
IFGGAYANSL ANSLRSVENN TQQVFFAFTH DANIIPVETA LGFFTDNTPE
360 370 380 390 400
NPLPTSYQVH SHSMKASEFV PFAGNLITEL FQCEDSKYYV RHLVNEEVFP
410 420 430 440 450
LSDCGFGPSN TSDGMCELYA YLNSPVRVNG TSNGIQNFDT LCNASAVAAV

YPY
Length:453
Mass (Da):50,557
Last modified:August 1, 1988 - v1
Checksum:i7CF891256EB154D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11857 Genomic DNA. Translation: AAA35321.1.
CU329671 Genomic DNA. Translation: CAB68657.1.
AB027949 Genomic DNA. Translation: BAA87253.1.
PIRiA25326.
RefSeqiNP_596847.1. NM_001023870.2.

Genome annotation databases

EnsemblFungiiSPBP4G3.02.1; SPBP4G3.02.1:pep; SPBP4G3.02.
GeneIDi2541339.
KEGGispo:SPBP4G3.02.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11857 Genomic DNA. Translation: AAA35321.1 .
CU329671 Genomic DNA. Translation: CAB68657.1 .
AB027949 Genomic DNA. Translation: BAA87253.1 .
PIRi A25326.
RefSeqi NP_596847.1. NM_001023870.2.

3D structure databases

ProteinModelPortali P08091.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 277850. 17 interactions.
MINTi MINT-4686981.
STRINGi 4896.SPBP4G3.02-1.

Proteomic databases

MaxQBi P08091.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBP4G3.02.1 ; SPBP4G3.02.1:pep ; SPBP4G3.02 .
GeneIDi 2541339.
KEGGi spo:SPBP4G3.02.

Organism-specific databases

PomBasei SPBP4G3.02.

Phylogenomic databases

HOGENOMi HOG000115655.
InParanoidi P08091.
KOi K01078.
OrthoDBi EOG7SN8N6.
PhylomeDBi P08091.

Miscellaneous databases

NextBioi 20802448.

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
InterProi IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
IPR016274. Histidine_acid_Pase_euk.
[Graphical view ]
Pfami PF00328. His_Phos_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000894. Acid_phosphatase. 1 hit.
SUPFAMi SSF53254. SSF53254. 1 hit.
PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the structural gene for secreted acid phosphatase from Schizosaccharomyces pombe."
    Elliott S., Chang C., Schweingruber M.E., Schaller J., Rickli E.E., Carbon J.
    J. Biol. Chem. 261:2936-2941(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
    Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
    Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 88-285.
    Strain: ATCC 38364 / 968.

Entry informationi

Entry nameiPPA1_SCHPO
AccessioniPrimary (citable) accession number: P08091
Secondary accession number(s): Q9UTX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3