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Protein

Clathrin light chain B

Gene

Cltb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.

GO - Molecular functioni

  • neurotransmitter transporter activity Source: UniProtKB
  • peptide binding Source: RGD
  • structural molecule activity Source: InterPro

GO - Biological processi

  • intracellular protein transport Source: InterPro
  • neurotransmitter secretion Source: UniProtKB
  • neurotransmitter transport Source: UniProtKB
  • synaptic vesicle coating Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-RNO-190873. Gap junction degradation.
R-RNO-196025. Formation of annular gap junctions.
R-RNO-432720. Lysosome Vesicle Biogenesis.
R-RNO-5099900. WNT5A-dependent internalization of FZD4.

Names & Taxonomyi

Protein namesi
Recommended name:
Clathrin light chain B
Short name:
Lcb
Gene namesi
Name:Cltb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi621353. Cltb.

Subcellular locationi

GO - Cellular componenti

  • ciliary membrane Source: Ensembl
  • clathrin coat Source: RGD
  • clathrin coat of coated pit Source: UniProtKB
  • clathrin coat of trans-Golgi network vesicle Source: InterPro
  • clathrin vesicle coat Source: UniProtKB
  • presynapse Source: GOC
  • trans-Golgi network Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Coated pit, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Clathrin light chain BPRO_0000205773Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei11 – 111PhosphoserineBy similarity
Modified residuei13 – 131PhosphoserineBy similarity
Disulfide bondi199 ↔ 209By similarity
Modified residuei204 – 2041N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP08082.
PRIDEiP08082.

PTM databases

iPTMnetiP08082.
PhosphoSiteiP08082.

Expressioni

Gene expression databases

GenevisibleiP08082. RN.

Interactioni

Subunit structurei

Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts (via N-terminus) with HIP1. Interacts with HIP1R.

Protein-protein interaction databases

IntActiP08082. 1 interaction.
STRINGi10116.ENSRNOP00000023651.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni93 – 15563Involved in binding clathrin heavy chainAdd
BLAST

Sequence similaritiesi

Belongs to the clathrin light chain family.Curated

Phylogenomic databases

eggNOGiKOG4031. Eukaryota.
ENOG4111J5K. LUCA.
GeneTreeiENSGT00390000010441.
HOGENOMiHOG000008147.
HOVERGENiHBG003386.
InParanoidiP08082.
KOiK04645.
OMAiLEDWHVH.
OrthoDBiEOG79KPH4.
PhylomeDBiP08082.
TreeFamiTF313162.

Family and domain databases

InterProiIPR000996. Clathrin_L-chain.
[Graphical view]
PANTHERiPTHR10639. PTHR10639. 1 hit.
PfamiPF01086. Clathrin_lg_ch. 1 hit.
[Graphical view]
PROSITEiPS00224. CLATHRIN_LIGHT_CHN_1. 1 hit.
PS00581. CLATHRIN_LIGHT_CHN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Brain (identifier: P08082-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEDFGFFSS SESGAPEAAE EDPAAAFLAQ QESEIAGIEN DSGFGAPAAS
60 70 80 90 100
QVASAQPGLA SGGGSEDMGT TVNGDVFQEA NGPADGYAAI AQADRLTQEP
110 120 130 140 150
ESIRKWREEQ KKRLQELDAA SKVTEQEWRE KAKKDLEEWN QRQSEQVEKN
160 170 180 190 200
KINNRIADKA FYQQPDADTI GYVASEEAFV KESKEETPGT EWEKVAQLCD
210 220
FNPKSSKQCK DVSRLRSVLM SLKQTPLSR
Length:229
Mass (Da):25,117
Last modified:August 1, 1988 - v1
Checksum:iC4A05B07CEB92A85
GO
Isoform Non-brain (identifier: P08082-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-173: Missing.

Show »
Length:211
Mass (Da):23,120
Checksum:iDD930630006B9A52
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei156 – 17318Missing in isoform Non-brain. 1 PublicationVSP_001099Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15883 mRNA. Translation: AAA40890.1.
M19262 mRNA. Translation: AAA40891.1.
PIRiB25994. LRRTB2.
RefSeqiNP_446287.1. NM_053835.1. [P08082-1]
XP_006253657.1. XM_006253595.2. [P08082-2]
UniGeneiRn.3440.

Genome annotation databases

EnsembliENSRNOT00000023651; ENSRNOP00000023651; ENSRNOG00000017506. [P08082-1]
GeneIDi116561.
KEGGirno:116561.
UCSCiRGD:621353. rat. [P08082-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15883 mRNA. Translation: AAA40890.1.
M19262 mRNA. Translation: AAA40891.1.
PIRiB25994. LRRTB2.
RefSeqiNP_446287.1. NM_053835.1. [P08082-1]
XP_006253657.1. XM_006253595.2. [P08082-2]
UniGeneiRn.3440.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP08082. 1 interaction.
STRINGi10116.ENSRNOP00000023651.

PTM databases

iPTMnetiP08082.
PhosphoSiteiP08082.

Proteomic databases

PaxDbiP08082.
PRIDEiP08082.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023651; ENSRNOP00000023651; ENSRNOG00000017506. [P08082-1]
GeneIDi116561.
KEGGirno:116561.
UCSCiRGD:621353. rat. [P08082-1]

Organism-specific databases

CTDi1212.
RGDi621353. Cltb.

Phylogenomic databases

eggNOGiKOG4031. Eukaryota.
ENOG4111J5K. LUCA.
GeneTreeiENSGT00390000010441.
HOGENOMiHOG000008147.
HOVERGENiHBG003386.
InParanoidiP08082.
KOiK04645.
OMAiLEDWHVH.
OrthoDBiEOG79KPH4.
PhylomeDBiP08082.
TreeFamiTF313162.

Enzyme and pathway databases

ReactomeiR-RNO-190873. Gap junction degradation.
R-RNO-196025. Formation of annular gap junctions.
R-RNO-432720. Lysosome Vesicle Biogenesis.
R-RNO-5099900. WNT5A-dependent internalization of FZD4.

Miscellaneous databases

NextBioi619229.
PROiP08082.

Gene expression databases

GenevisibleiP08082. RN.

Family and domain databases

InterProiIPR000996. Clathrin_L-chain.
[Graphical view]
PANTHERiPTHR10639. PTHR10639. 1 hit.
PfamiPF01086. Clathrin_lg_ch. 1 hit.
[Graphical view]
PROSITEiPS00224. CLATHRIN_LIGHT_CHN_1. 1 hit.
PS00581. CLATHRIN_LIGHT_CHN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Clathrin light chains LCA and LCB are similar, polymorphic, and share repeated heptad motifs."
    Kirchhausen T., Scarmato P., Harrison S.C., Monroe J.J., Chow E.P., Mattaliano R.J., Ramachandran K.L., Smart J.E., Ahn A.H., Brosius J.
    Science 236:320-324(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BRAIN AND NON-BRAIN).
  2. Lubec G., Afjehi-Sadat L., Chen W.-Q.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 160-181, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus and Spinal cord.

Entry informationi

Entry nameiCLCB_RAT
AccessioniPrimary (citable) accession number: P08082
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: May 11, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.