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Protein

Clathrin light chain A

Gene

Clta

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.

GO - Molecular functioni

  • peptide binding Source: RGD
  • structural molecule activity Source: InterPro

GO - Biological processi

  • endocytosis Source: RGD
  • intracellular protein transport Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-RNO-177504. Retrograde neurotrophin signalling.
R-RNO-182971. EGFR downregulation.
R-RNO-190873. Gap junction degradation.
R-RNO-196025. Formation of annular gap junctions.
R-RNO-2132295. MHC class II antigen presentation.
R-RNO-432720. Lysosome Vesicle Biogenesis.
R-RNO-432722. Golgi Associated Vesicle Biogenesis.
R-RNO-437239. Recycling pathway of L1.
R-RNO-5099900. WNT5A-dependent internalization of FZD4.

Names & Taxonomyi

Protein namesi
Recommended name:
Clathrin light chain A
Short name:
Lca
Gene namesi
Name:Clta
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi70919. Clta.

Subcellular locationi

GO - Cellular componenti

  • clathrin coat Source: RGD
  • clathrin-coated endocytic vesicle membrane Source: Reactome
  • clathrin-coated vesicle Source: RGD
  • clathrin coat of coated pit Source: RGD
  • clathrin coat of trans-Golgi network vesicle Source: InterPro
  • clathrin complex Source: Ensembl
  • clathrin vesicle coat Source: RGD
  • coated pit Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Coated pit, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Clathrin light chain APRO_0000205769Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei105 – 1051PhosphoserineBy similarity
Modified residuei206 – 2061PhosphoserineBy similarity
Modified residuei236 – 2361PhosphoserineBy similarity
Modified residuei242 – 2421N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP08081.
PRIDEiP08081.

PTM databases

iPTMnetiP08081.

Expressioni

Gene expression databases

ExpressionAtlasiP08081. baseline.
GenevisibleiP08081. RN.

Interactioni

Subunit structurei

Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts with CALY; the interaction stimulates clathrin self-assembly and clathrin-mediated endocytosis (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AMPHP494183EBI-916140,EBI-7121510From a different organism.

Protein-protein interaction databases

BioGridi249837. 9 interactions.
DIPiDIP-36947N.
IntActiP08081. 4 interactions.
MINTiMINT-4996128.
STRINGi10116.ENSRNOP00000019737.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni100 – 16263Involved in binding clathrin heavy chainAdd
BLAST

Sequence similaritiesi

Belongs to the clathrin light chain family.Curated

Phylogenomic databases

eggNOGiKOG4031. Eukaryota.
ENOG4111J5K. LUCA.
GeneTreeiENSGT00390000010441.
HOGENOMiHOG000008147.
HOVERGENiHBG003386.
InParanoidiP08081.
KOiK04644.
OMAiDEWYARQ.
OrthoDBiEOG79KPH4.
PhylomeDBiP08081.
TreeFamiTF313162.

Family and domain databases

InterProiIPR000996. Clathrin_L-chain.
[Graphical view]
PANTHERiPTHR10639. PTHR10639. 2 hits.
PfamiPF01086. Clathrin_lg_ch. 1 hit.
[Graphical view]
PROSITEiPS00224. CLATHRIN_LIGHT_CHN_1. 1 hit.
PS00581. CLATHRIN_LIGHT_CHN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Brain (identifier: P08081-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELDPFGAP AGAPGGPALG NGVAGAGEED PAAAFLAQQE SEIAGIENDE
60 70 80 90 100
AFAILDGGAP GPQAHGEPPG GPDAVDGVMN GEYYQESNGP TDSYAAISEV
110 120 130 140 150
DRLQSEPESI RKWREEQTER LEALDANSRK QEAEWKEKAV KELEEWYARQ
160 170 180 190 200
DEQLQKTKAS NRVADEAFYK QPFADVIGYV TNINHPCYSL EQAAEEAFVN
210 220 230 240
DIDESSPGTE WERVARLCDF NPKSSKQAKD VSRMRSVLIS LKQAPLVH
Length:248
Mass (Da):26,981
Last modified:August 1, 1988 - v1
Checksum:iC939E85B0FD2E124
GO
Isoform Non-brain (identifier: P08081-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-192: Missing.

Show »
Length:218
Mass (Da):23,566
Checksum:iFEFE0F820F074C7B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei163 – 19230Missing in isoform Non-brain. 1 PublicationVSP_001096Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15882 mRNA. Translation: AAA40868.1.
M19261 mRNA. Translation: AAA40870.1.
M19260 mRNA. Translation: AAA40869.1.
PIRiA25994. LRRTA1.
RefSeqiNP_114180.1. NM_031974.1. [P08081-1]
XP_006238166.1. XM_006238104.1.
XP_006238168.1. XM_006238106.1. [P08081-2]
UniGeneiRn.112599.

Genome annotation databases

EnsembliENSRNOT00000019737; ENSRNOP00000019737; ENSRNOG00000014635. [P08081-1]
ENSRNOT00000036366; ENSRNOP00000035138; ENSRNOG00000014635. [P08081-2]
GeneIDi83800.
KEGGirno:83800.
UCSCiRGD:70919. rat. [P08081-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15882 mRNA. Translation: AAA40868.1.
M19261 mRNA. Translation: AAA40870.1.
M19260 mRNA. Translation: AAA40869.1.
PIRiA25994. LRRTA1.
RefSeqiNP_114180.1. NM_031974.1. [P08081-1]
XP_006238166.1. XM_006238104.1.
XP_006238168.1. XM_006238106.1. [P08081-2]
UniGeneiRn.112599.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249837. 9 interactions.
DIPiDIP-36947N.
IntActiP08081. 4 interactions.
MINTiMINT-4996128.
STRINGi10116.ENSRNOP00000019737.

PTM databases

iPTMnetiP08081.

Proteomic databases

PaxDbiP08081.
PRIDEiP08081.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019737; ENSRNOP00000019737; ENSRNOG00000014635. [P08081-1]
ENSRNOT00000036366; ENSRNOP00000035138; ENSRNOG00000014635. [P08081-2]
GeneIDi83800.
KEGGirno:83800.
UCSCiRGD:70919. rat. [P08081-1]

Organism-specific databases

CTDi1211.
RGDi70919. Clta.

Phylogenomic databases

eggNOGiKOG4031. Eukaryota.
ENOG4111J5K. LUCA.
GeneTreeiENSGT00390000010441.
HOGENOMiHOG000008147.
HOVERGENiHBG003386.
InParanoidiP08081.
KOiK04644.
OMAiDEWYARQ.
OrthoDBiEOG79KPH4.
PhylomeDBiP08081.
TreeFamiTF313162.

Enzyme and pathway databases

ReactomeiR-RNO-177504. Retrograde neurotrophin signalling.
R-RNO-182971. EGFR downregulation.
R-RNO-190873. Gap junction degradation.
R-RNO-196025. Formation of annular gap junctions.
R-RNO-2132295. MHC class II antigen presentation.
R-RNO-432720. Lysosome Vesicle Biogenesis.
R-RNO-432722. Golgi Associated Vesicle Biogenesis.
R-RNO-437239. Recycling pathway of L1.
R-RNO-5099900. WNT5A-dependent internalization of FZD4.

Miscellaneous databases

PROiP08081.

Gene expression databases

ExpressionAtlasiP08081. baseline.
GenevisibleiP08081. RN.

Family and domain databases

InterProiIPR000996. Clathrin_L-chain.
[Graphical view]
PANTHERiPTHR10639. PTHR10639. 2 hits.
PfamiPF01086. Clathrin_lg_ch. 1 hit.
[Graphical view]
PROSITEiPS00224. CLATHRIN_LIGHT_CHN_1. 1 hit.
PS00581. CLATHRIN_LIGHT_CHN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Clathrin light chains LCA and LCB are similar, polymorphic, and share repeated heptad motifs."
    Kirchhausen T., Scarmato P., Harrison S.C., Monroe J.J., Chow E.P., Mattaliano R.J., Ramachandran K.L., Smart J.E., Ahn A.H., Brosius J.
    Science 236:320-324(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BRAIN AND NON-BRAIN).
  2. Lubec G., Chen W.-Q.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 103-111; 121-129; 142-149; 163-170; 217-223 AND 236-242, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCLCA_RAT
AccessioniPrimary (citable) accession number: P08081
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: June 8, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.