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Protein

Clathrin light chain A

Gene

Clta

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (By similarity).By similarity

GO - Molecular functioni

  • clathrin heavy chain binding Source: RGD
  • GTPase binding Source: CAFA
  • peptide binding Source: RGD
  • protein complex binding Source: RGD
  • structural molecule activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis
LigandCalcium

Enzyme and pathway databases

ReactomeiR-RNO-177504. Retrograde neurotrophin signalling.
R-RNO-190873. Gap junction degradation.
R-RNO-196025. Formation of annular gap junctions.
R-RNO-2132295. MHC class II antigen presentation.
R-RNO-432720. Lysosome Vesicle Biogenesis.
R-RNO-432722. Golgi Associated Vesicle Biogenesis.
R-RNO-437239. Recycling pathway of L1.
R-RNO-5099900. WNT5A-dependent internalization of FZD4.
R-RNO-5140745. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
R-RNO-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-RNO-8856828. Clathrin-mediated endocytosis.
R-RNO-8866427. VLDLR internalisation and degradation.
R-RNO-8964038. LDL clearance.

Names & Taxonomyi

Protein namesi
Recommended name:
Clathrin light chain A
Short name:
Lca
Gene namesi
Name:Clta
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi70919. Clta.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Coated pit, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002057691 – 248Clathrin light chain AAdd BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei105PhosphoserineBy similarity1
Modified residuei206PhosphoserineBy similarity1
Modified residuei223N6-acetyllysineBy similarity1
Modified residuei236PhosphoserineBy similarity1
Modified residuei242N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP08081.
PRIDEiP08081.

PTM databases

iPTMnetiP08081.
PhosphoSitePlusiP08081.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014635.
ExpressionAtlasiP08081. baseline and differential.
GenevisibleiP08081. RN.

Interactioni

Subunit structurei

Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts with CALY; the interaction stimulates clathrin self-assembly and clathrin-mediated endocytosis (By similarity). Interacts with CKAP5 and TACC3 forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges; the complex implicates clathrin triskelions (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • clathrin heavy chain binding Source: RGD
  • GTPase binding Source: CAFA
  • protein complex binding Source: RGD

Protein-protein interaction databases

BioGridi249837. 9 interactors.
CORUMiP08081.
DIPiDIP-36947N.
IntActiP08081. 6 interactors.
MINTiMINT-4996128.
STRINGi10116.ENSRNOP00000019737.

Structurei

3D structure databases

SMRiP08081.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni100 – 162Involved in binding clathrin heavy chainAdd BLAST63

Sequence similaritiesi

Belongs to the clathrin light chain family.Curated

Phylogenomic databases

eggNOGiKOG4031. Eukaryota.
ENOG4111J5K. LUCA.
GeneTreeiENSGT00390000010441.
HOGENOMiHOG000008147.
HOVERGENiHBG003386.
InParanoidiP08081.
KOiK04644.
OMAiKTKTNNR.
OrthoDBiEOG091G0WEF.
PhylomeDBiP08081.
TreeFamiTF313162.

Family and domain databases

InterProiView protein in InterPro
IPR000996. Clathrin_L-chain.
PANTHERiPTHR10639. PTHR10639. 1 hit.
PfamiView protein in Pfam
PF01086. Clathrin_lg_ch. 1 hit.
PROSITEiView protein in PROSITE
PS00224. CLATHRIN_LIGHT_CHN_1. 1 hit.
PS00581. CLATHRIN_LIGHT_CHN_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Brain (identifier: P08081-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELDPFGAP AGAPGGPALG NGVAGAGEED PAAAFLAQQE SEIAGIENDE
60 70 80 90 100
AFAILDGGAP GPQAHGEPPG GPDAVDGVMN GEYYQESNGP TDSYAAISEV
110 120 130 140 150
DRLQSEPESI RKWREEQTER LEALDANSRK QEAEWKEKAV KELEEWYARQ
160 170 180 190 200
DEQLQKTKAS NRVADEAFYK QPFADVIGYV TNINHPCYSL EQAAEEAFVN
210 220 230 240
DIDESSPGTE WERVARLCDF NPKSSKQAKD VSRMRSVLIS LKQAPLVH
Length:248
Mass (Da):26,981
Last modified:August 1, 1988 - v1
Checksum:iC939E85B0FD2E124
GO
Isoform Non-brain (identifier: P08081-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-192: Missing.

Show »
Length:218
Mass (Da):23,566
Checksum:iFEFE0F820F074C7B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001096163 – 192Missing in isoform Non-brain. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15882 mRNA. Translation: AAA40868.1.
M19261 mRNA. Translation: AAA40870.1.
M19260 mRNA. Translation: AAA40869.1.
PIRiA25994. LRRTA1.
RefSeqiNP_114180.1. NM_031974.1. [P08081-1]
XP_006238166.1. XM_006238104.2.
XP_006238168.1. XM_006238106.2. [P08081-2]
UniGeneiRn.112599.

Genome annotation databases

EnsembliENSRNOT00000019737; ENSRNOP00000019737; ENSRNOG00000014635. [P08081-1]
ENSRNOT00000036366; ENSRNOP00000035138; ENSRNOG00000014635. [P08081-2]
GeneIDi83800.
KEGGirno:83800.
UCSCiRGD:70919. rat. [P08081-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCLCA_RAT
AccessioniPrimary (citable) accession number: P08081
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 22, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families