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P08080

- HEM1_RHIME

UniProt

P08080 - HEM1_RHIME

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Protein

5-aminolevulinate synthase

Gene

hemA

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactori

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei21 – 211SubstrateBy similarity
Binding sitei136 – 1361SubstrateBy similarity
Binding sitei188 – 1881Pyridoxal phosphateBy similarity
Binding sitei216 – 2161Pyridoxal phosphateBy similarity
Binding sitei244 – 2441Pyridoxal phosphateBy similarity
Active sitei247 – 2471By similarity
Binding sitei276 – 2761Pyridoxal phosphateBy similarity
Binding sitei277 – 2771Pyridoxal phosphateBy similarity
Binding sitei362 – 3621SubstrateBy similarity

GO - Molecular functioni

  1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Heme biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-3931-MONOMER.
RETL1328306-WGS:GSTH-4473-MONOMER.
SMEL266834:GJF6-3065-MONOMER.
UniPathwayiUPA00251; UER00375.

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthase (EC:2.3.1.37)
Alternative name(s):
5-aminolevulinic acid synthase
Delta-ALA synthase
Delta-aminolevulinate synthase
Gene namesi
Name:hemA
Ordered Locus Names:R02989
ORF Names:SMc03104
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4044045-aminolevulinate synthasePRO_0000163827Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei247 – 2471N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc03104.

Structurei

3D structure databases

ProteinModelPortaliP08080.
SMRiP08080. Positions 2-394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0156.
HOGENOMiHOG000221020.
KOiK00643.
OMAiHYLQSIN.
OrthoDBiEOG6Q8HZD.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08080-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFESFFKNE LDGLHQEGRY RVFADLARHR GSFPKATRYT ADGAQEVTVW
60 70 80 90 100
CSNDYLGMGQ CPIVTEAMKN AIDECGAGAG GTRNISGTNH YHVLLERELA
110 120 130 140 150
DLHGKESALL FTSGYVSNWA ALGTLCSKIP GVIVFSDAGN HASMIEGIRH
160 170 180 190 200
SKCERVIFKH NSVADLEAKL AAADPRAPKI IAFESVYSMD GDIAPIREFC
210 220 230 240 250
DLADKYGAMT YLDEVHAVGM YGPRGGGIAE REGLMHRLTV IEGTLGKAFG
260 270 280 290 300
VMGGYITGSA ALCDFIRSFA SGFIFTTALP PALAAGALAS IRHLKESQVE
310 320 330 340 350
RFAHQERVRR LRSLLDQRGI PHMVNPSHIV PVIVGDAAKC KWISDLLLDN
360 370 380 390 400
FGIYVQPINY PTVPKKTERL RITPTPMHSD ADIDHLVSAL HSLWSRCALA

RAVA
Length:404
Mass (Da):44,116
Last modified:October 18, 2001 - v2
Checksum:i826BC15187083E07
GO

Sequence cautioni

The sequence CAA26610.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAC47568.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA. Translation: CAC47568.1. Different initiation.
X02853 Genomic DNA. Translation: CAA26610.1. Different initiation.
PIRiA24077.
RefSeqiNP_387095.1. NC_003047.1.
WP_010970337.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC47568; CAC47568; SMc03104.
GeneIDi1234673.
KEGGisme:SMc03104.
PATRICi23635586. VBISinMel96828_4516.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA. Translation: CAC47568.1 . Different initiation.
X02853 Genomic DNA. Translation: CAA26610.1 . Different initiation.
PIRi A24077.
RefSeqi NP_387095.1. NC_003047.1.
WP_010970337.1. NC_003047.1.

3D structure databases

ProteinModelPortali P08080.
SMRi P08080. Positions 2-394.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266834.SMc03104.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC47568 ; CAC47568 ; SMc03104 .
GeneIDi 1234673.
KEGGi sme:SMc03104.
PATRICi 23635586. VBISinMel96828_4516.

Phylogenomic databases

eggNOGi COG0156.
HOGENOMi HOG000221020.
KOi K00643.
OMAi HYLQSIN.
OrthoDBi EOG6Q8HZD.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00375 .
BioCyci RETL1328306-WGS:GSTH-3931-MONOMER.
RETL1328306-WGS:GSTH-4473-MONOMER.
SMEL266834:GJF6-3065-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  3. "Analysis of the 5' regulatory region of the gene for delta-aminolevulinic acid synthetase of Rhizobium meliloti."
    Leong S.A., Williams P.H., Ditta G.S.
    Nucleic Acids Res. 13:5965-5976(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-74.

Entry informationi

Entry nameiHEM1_RHIME
AccessioniPrimary (citable) accession number: P08080
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: October 18, 2001
Last modified: November 26, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3