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P08080

- HEM1_RHIME

UniProt

P08080 - HEM1_RHIME

Protein

5-aminolevulinate synthase

Gene

hemA

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (18 Oct 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

    Cofactori

    Pyridoxal phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei21 – 211SubstrateBy similarity
    Binding sitei136 – 1361SubstrateBy similarity
    Binding sitei188 – 1881Pyridoxal phosphateBy similarity
    Binding sitei216 – 2161Pyridoxal phosphateBy similarity
    Binding sitei244 – 2441Pyridoxal phosphateBy similarity
    Active sitei247 – 2471By similarity
    Binding sitei276 – 2761Pyridoxal phosphateBy similarity
    Binding sitei277 – 2771Pyridoxal phosphateBy similarity
    Binding sitei362 – 3621SubstrateBy similarity

    GO - Molecular functioni

    1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Heme biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-3931-MONOMER.
    RETL1328306-WGS:GSTH-4473-MONOMER.
    SMEL266834:GJF6-3065-MONOMER.
    UniPathwayiUPA00251; UER00375.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-aminolevulinate synthase (EC:2.3.1.37)
    Alternative name(s):
    5-aminolevulinic acid synthase
    Delta-ALA synthase
    Delta-aminolevulinate synthase
    Gene namesi
    Name:hemA
    Ordered Locus Names:R02989
    ORF Names:SMc03104
    OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
    Taxonomic identifieri266834 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001976: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4044045-aminolevulinate synthasePRO_0000163827Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei247 – 2471N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi266834.SMc03104.

    Structurei

    3D structure databases

    ProteinModelPortaliP08080.
    SMRiP08080. Positions 2-394.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0156.
    HOGENOMiHOG000221020.
    KOiK00643.
    OMAiHYLQSIN.
    OrthoDBiEOG6Q8HZD.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P08080-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFESFFKNE LDGLHQEGRY RVFADLARHR GSFPKATRYT ADGAQEVTVW    50
    CSNDYLGMGQ CPIVTEAMKN AIDECGAGAG GTRNISGTNH YHVLLERELA 100
    DLHGKESALL FTSGYVSNWA ALGTLCSKIP GVIVFSDAGN HASMIEGIRH 150
    SKCERVIFKH NSVADLEAKL AAADPRAPKI IAFESVYSMD GDIAPIREFC 200
    DLADKYGAMT YLDEVHAVGM YGPRGGGIAE REGLMHRLTV IEGTLGKAFG 250
    VMGGYITGSA ALCDFIRSFA SGFIFTTALP PALAAGALAS IRHLKESQVE 300
    RFAHQERVRR LRSLLDQRGI PHMVNPSHIV PVIVGDAAKC KWISDLLLDN 350
    FGIYVQPINY PTVPKKTERL RITPTPMHSD ADIDHLVSAL HSLWSRCALA 400
    RAVA 404
    Length:404
    Mass (Da):44,116
    Last modified:October 18, 2001 - v2
    Checksum:i826BC15187083E07
    GO

    Sequence cautioni

    The sequence CAA26610.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAC47568.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591688 Genomic DNA. Translation: CAC47568.1. Different initiation.
    X02853 Genomic DNA. Translation: CAA26610.1. Different initiation.
    PIRiA24077.
    RefSeqiNP_387095.1. NC_003047.1.
    WP_010970337.1. NC_003047.1.

    Genome annotation databases

    EnsemblBacteriaiCAC47568; CAC47568; SMc03104.
    GeneIDi1234673.
    KEGGisme:SMc03104.
    PATRICi23635586. VBISinMel96828_4516.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591688 Genomic DNA. Translation: CAC47568.1 . Different initiation.
    X02853 Genomic DNA. Translation: CAA26610.1 . Different initiation.
    PIRi A24077.
    RefSeqi NP_387095.1. NC_003047.1.
    WP_010970337.1. NC_003047.1.

    3D structure databases

    ProteinModelPortali P08080.
    SMRi P08080. Positions 2-394.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266834.SMc03104.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC47568 ; CAC47568 ; SMc03104 .
    GeneIDi 1234673.
    KEGGi sme:SMc03104.
    PATRICi 23635586. VBISinMel96828_4516.

    Phylogenomic databases

    eggNOGi COG0156.
    HOGENOMi HOG000221020.
    KOi K00643.
    OMAi HYLQSIN.
    OrthoDBi EOG6Q8HZD.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00375 .
    BioCyci RETL1328306-WGS:GSTH-3931-MONOMER.
    RETL1328306-WGS:GSTH-4473-MONOMER.
    SMEL266834:GJF6-3065-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.
    3. "Analysis of the 5' regulatory region of the gene for delta-aminolevulinic acid synthetase of Rhizobium meliloti."
      Leong S.A., Williams P.H., Ditta G.S.
      Nucleic Acids Res. 13:5965-5976(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-74.

    Entry informationi

    Entry nameiHEM1_RHIME
    AccessioniPrimary (citable) accession number: P08080
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: October 18, 2001
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3