ID   STRD_STRGR              Reviewed;         355 AA.
AC   P08075;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   20-JAN-2009, entry version 48.
DE   RecName: Full=Glucose-1-phosphate thymidylyltransferase;
DE            EC=2.7.7.24;
DE   AltName: Full=dTDP-glucose synthase;
DE   AltName: Full=dTDP-glucose pyrophosphorylase;
DE   AltName: Full=Sugar-nucleotidylation enzyme;
GN   Name=strD;
OS   Streptomyces griseus.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=N2-3-11;
RX   MEDLINE=88040426; PubMed=3118332; DOI=10.1093/nar/15.19.8041;
RA   Distler J., Ebert A., Mansouri K., Pissowotzki K., Stockmann M.,
RA   Piepersberg W.;
RT   "Gene cluster for streptomycin biosynthesis in Streptomyces griseus:
RT   nucleotide sequence of three genes and analysis of transcriptional
RT   activity.";
RL   Nucleic Acids Res. 15:8041-8056(1987).
CC   -!- FUNCTION: Catalyzes the formation of dTDP-glucose, from dTTP and
CC       glucose 1-phosphate, as well as its pyrophosphorolysis (By
CC       similarity).
CC   -!- FUNCTION: Involved in the biosynthesis of the streptose moiety of
CC       streptomycin.
CC   -!- CATALYTIC ACTIVITY: dTTP + alpha-D-glucose 1-phosphate =
CC       diphosphate + dTDP-glucose.
CC   -!- COFACTOR: Binds 1 magnesium ion per subunit (By similarity).
CC   -!- PATHWAY: Antibiotic biosynthesis; streptomycin biosynthesis.
CC   -!- SIMILARITY: Belongs to the glucose-1-phosphate
CC       thymidylyltransferase family.
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DR   EMBL; Y00459; CAA68514.1; -; Genomic_DNA.
DR   PIR; A26984; A26984.
DR   HSSP; Q9F7K6; 1IIN.
DR   BRENDA; 2.7.7.24; 1270.
DR   GO; GO:0008879; F:glucose-1-phosphate thymidylyltransferase a...; IEA:EC.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019872; P:streptomycin biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005908; G1P_thy_trans_s.
DR   InterPro; IPR005835; NTP_transferase.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   TIGRFAMs; TIGR01208; rmlA_long; 1.
PE   3: Inferred from homology;
KW   Antibiotic biosynthesis; Magnesium; Metal-binding;
KW   Nucleotidyltransferase; Streptomycin biosynthesis; Transferase.
FT   CHAIN         1    355       Glucose-1-phosphate
FT                                thymidylyltransferase.
FT                                /FTId=PRO_0000208005.
FT   METAL       107    107       Magnesium (By similarity).
FT   METAL       220    220       Magnesium (By similarity).
SQ   SEQUENCE   355 AA;  38098 MW;  ED136AEA854EB7DA CRC64;
     MKALVLAGGT GTRLRPITHT SAKQLVPVAN KPVLFYGLEA IRAAGIIDVG IVVGDTADEI
     VAAVGDGSRF GLKVSYIPQS KPLGLAHCVL ISRDFLGEDD FIMYLGDNFV VGVVEDSVRE
     FRAARPDAHL MLTRVPEPRS FGVAELSDSG QVLGLEEKPA HPKSDLALVG VYLFSPAIHE
     AVAAITPSWR GELEITDAVQ WLIDAGRDVR STVISGYWKD TGNVTDMLEV NRLVLETTEP
     RCDGLVDERS DLIGRVLVEE GAEVRNSRVM GPTVIGAGTR VTNSYVGPFT SLAEDCVVED
     SEVEFSIVLR GASISGVRRI EASLIGRHVQ VTSAPEVPHA NRLVLGDHSR AQISS
//