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Protein

Growth factor

Gene

MGF

Organism
Myxoma virus (strain Lausanne) (MYXV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates the growth of some tissues.1 Publication

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Growth factor
Alternative name(s):
Secreted epidermal growth factor-like
Gene namesi
Name:MGF
Ordered Locus Names:m010L
OrganismiMyxoma virus (strain Lausanne) (MYXV)
Taxonomic identifieri31530 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeLeporipoxvirus
Virus hostiOryctolagus cuniculus (Rabbit) [TaxID: 9986]
Proteomesi
  • UP000000867 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 8566Growth factorPRO_0000007603Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 51PROSITE-ProRule annotation1 Publication
Disulfide bondi45 ↔ 65PROSITE-ProRule annotation1 Publication
Glycosylationi48 – 481N-linked (GlcNAc...); by hostSequence analysis
Glycosylationi58 – 581N-linked (GlcNAc...); by hostSequence analysis
Disulfide bondi67 ↔ 76PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP08072.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 7745EGF-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 EGF-like domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08072-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPRDLVATL LCAMCIVQAT MPSLDNYLYI IKRIKLCNDD YKNYCLNNGT
60 70 80
CFTVALNNVS LNPFCACHIN YVGSRCQFIN LITIK
Length:85
Mass (Da):9,629
Last modified:August 1, 1988 - v1
Checksum:iEDD4E94E41E9D4D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15806 Genomic DNA. Translation: AAA46626.1.
AF170726 Genomic DNA. Translation: AAF14898.1.
PIRiA26131. EGVZM1.
RefSeqiNP_051724.1. NC_001132.2.

Genome annotation databases

GeneIDi932144.
KEGGivg:932144.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15806 Genomic DNA. Translation: AAA46626.1.
AF170726 Genomic DNA. Translation: AAF14898.1.
PIRiA26131. EGVZM1.
RefSeqiNP_051724.1. NC_001132.2.

3D structure databases

ProteinModelPortaliP08072.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi932144.
KEGGivg:932144.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mapping and sequencing of a gene from myxoma virus that is related to those encoding epidermal growth factor and transforming growth factor alpha."
    Upton C., Macen J.L., McFadden G.
    J. Virol. 61:1271-1275(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Synthesis and structure-activity study of myxoma virus growth factor."
    Lin Y.-Z., Ke X.-H., Tam J.P.
    Biochemistry 30:3310-3314(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: SYNTHESIS OF 30-83, DISULFIDE BONDS, FUNCTION.

Entry informationi

Entry nameiGRFA_MYXVL
AccessioniPrimary (citable) accession number: P08072
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: May 11, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.