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P08066

- SDHB_BACSU

UniProt

P08066 - SDHB_BACSU

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Protein

Succinate dehydrogenase iron-sulfur subunit

Gene
sdhB, BSU28430
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Binds 1 2Fe-2S cluster.
Binds 1 3Fe-4S cluster.
Binds 1 4Fe-4S cluster.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi69 – 691Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi84 – 841Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi155 – 1551Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi158 – 1581Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi161 – 1611Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi165 – 1651Iron-sulfur 3 (3Fe-4S) By similarity
Metal bindingi212 – 2121Iron-sulfur 3 (3Fe-4S) By similarity
Metal bindingi218 – 2181Iron-sulfur 3 (3Fe-4S) By similarity
Metal bindingi222 – 2221Iron-sulfur 2 (4Fe-4S) By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  4. electron carrier activity Source: InterPro
  5. metal ion binding Source: UniProtKB-KW
  6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciBSUB:BSU28430-MONOMER.
UniPathwayiUPA00223; UER01005.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase iron-sulfur subunit (EC:1.3.5.1)
Gene namesi
Name:sdhB
Ordered Locus Names:BSU28430
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU28430. [Micado]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 253252Succinate dehydrogenase iron-sulfur subunitPRO_0000158686Add
BLAST

Proteomic databases

PaxDbiP08066.

Interactioni

Subunit structurei

In B.subtilis succinate dehydrogenase forms part of an enzyme complex containing three subunits: a flavoprotein, an iron-sulfur protein and cytochrome b-558.

Protein-protein interaction databases

STRINGi224308.BSU28430.

Structurei

3D structure databases

ProteinModelPortaliP08066.
SMRiP08066. Positions 1-243.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini146 – 174294Fe-4S ferredoxin-typeAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0479.
HOGENOMiHOG000160588.
KOiK00240.
OMAiQYEKIRP.
OrthoDBiEOG6CS02W.
PhylomeDBiP08066.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
PF13183. Fer4_8. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08066-1 [UniParc]FASTAAdd to Basket

« Hide

MSEQKTIRFI ITRQDTADST PYDEEFEIPY RPNLNVISAL MEIRRNPVNV    50
KGEKTTPVTW DMNCLEEVCG ACSMVINGKP RQSCTALIDQ LEQPIRLKPM 100
KTFPVVRDLQ VDRSRMFDSL KKVKAWIPID GTYDLGPGPR MPEKRRQWAY 150
ELSKCMTCGV CLEACPNVNS KSKFMGPAPM SQVRLFNAHP TGAMNKSERL 200
EALMDEGGLA DCGNSQNCVQ SCPKGIPLTT SIAALNRDTN LQAFRNFFGS 250
DRV 253
Length:253
Mass (Da):28,418
Last modified:January 23, 2007 - v3
Checksum:iC20E095CDD960B3E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M13470 Genomic DNA. Translation: AAA22747.1.
Z75208 Genomic DNA. Translation: CAA99548.1.
AL009126 Genomic DNA. Translation: CAB14803.1.
M17642 Genomic DNA. Translation: AAA22471.1.
PIRiB27763.
RefSeqiNP_390721.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB14803; CAB14803; BSU28430.
GeneIDi937460.
KEGGibsu:BSU28430.
PATRICi18977570. VBIBacSub10457_2973.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M13470 Genomic DNA. Translation: AAA22747.1 .
Z75208 Genomic DNA. Translation: CAA99548.1 .
AL009126 Genomic DNA. Translation: CAB14803.1 .
M17642 Genomic DNA. Translation: AAA22471.1 .
PIRi B27763.
RefSeqi NP_390721.1. NC_000964.3.

3D structure databases

ProteinModelPortali P08066.
SMRi P08066. Positions 1-243.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU28430.

Proteomic databases

PaxDbi P08066.

Protocols and materials databases

DNASUi 937460.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB14803 ; CAB14803 ; BSU28430 .
GeneIDi 937460.
KEGGi bsu:BSU28430.
PATRICi 18977570. VBIBacSub10457_2973.

Organism-specific databases

GenoListi BSU28430. [Micado ]

Phylogenomic databases

eggNOGi COG0479.
HOGENOMi HOG000160588.
KOi K00240.
OMAi QYEKIRP.
OrthoDBi EOG6CS02W.
PhylomeDBi P08066.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01005 .
BioCyci BSUB:BSU28430-MONOMER.

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view ]
Pfami PF13085. Fer2_3. 1 hit.
PF13183. Fer4_8. 1 hit.
[Graphical view ]
SUPFAMi SSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR00384. dhsB. 1 hit.
PROSITEi PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence encoding the flavoprotein and iron-sulfur protein subunits of the Bacillus subtilis PY79 succinate dehydrogenase complex."
    Phillips M.K., Hederstedt L., Hasnain S., Rutberg L., Guest J.R.
    J. Bacteriol. 169:864-873(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168 / PY79.
  2. "The dnaB-pheA (256 degrees-240 degrees) region of the Bacillus subtilis chromosome containing genes responsible for stress responses, the utilization of plant cell walls and primary metabolism."
    Wipat A., Carter N., Brignell C.S., Guy J.B., Piper K., Sanders J., Emmerson P.T., Harwood C.R.
    Microbiology 142:3067-3078(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  3. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  4. "The nucleotide sequence and the transcription during sporulation of the gerE gene of Bacillus subtilis."
    Cutting S.M., Mandelstam J.
    J. Gen. Microbiol. 132:3013-3024(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 112-253.

Entry informationi

Entry nameiSDHB_BACSU
AccessioniPrimary (citable) accession number: P08066
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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