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Protein

Succinate dehydrogenase flavoprotein subunit

Gene

sdhA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.By similarity

Cofactori

FADBy similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (bacterial route).By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase flavoprotein subunit (sdhA), Succinate dehydrogenase iron-sulfur subunit (sdhB)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (bacterial route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei236SubstrateBy similarity1
Binding sitei250SubstrateBy similarity1
Active sitei285Proton acceptorBy similarity1
Binding sitei352SubstrateBy similarity1
Binding sitei376FADBy similarity1
Binding sitei386SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15FADBy similarity6
Nucleotide bindingi33 – 48FADBy similarityAdd BLAST16
Nucleotide bindingi391 – 392FADBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport, Tricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciBSUB:BSU28440-MONOMER
UniPathwayiUPA00223; UER01005

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase flavoprotein subunit (EC:1.3.5.1By similarity)
Gene namesi
Name:sdhA
Synonyms:citF
Ordered Locus Names:BSU28440
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

  • Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001586502 – 586Succinate dehydrogenase flavoprotein subunitAdd BLAST585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41Tele-8alpha-FAD histidineBy similarity1

Proteomic databases

PaxDbiP08065
PRIDEiP08065

Interactioni

Subunit structurei

In B.subtilis succinate dehydrogenase forms part of an enzyme complex containing three subunits: a flavoprotein, an iron-sulfur protein and cytochrome b-558.

Protein-protein interaction databases

IntActiP08065, 1 interactor
MINTiP08065
STRINGi224308.Bsubs1_010100015531

Structurei

3D structure databases

ProteinModelPortaliP08065
SMRiP08065
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1053 LUCA
HOGENOMiHOG000160477
InParanoidiP08065
KOiK00239
OMAiGDSPWEH
PhylomeDBiP08065

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR011280 Succ_DH/Fum_Rdt_flav_su
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
PANTHERiPTHR11632:SF53 PTHR11632:SF53, 1 hit
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01811 sdhA_Bsu, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08065-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQSSIIVVG GGLAGLMATI KAAESGMAVK LFSIVPVKRS HSVCAQGGIN
60 70 80 90 100
GAVNTKGEGD SPWEHFDDTV YGGDFLANQP PVKAMCEAAP SIIHLLDRMG
110 120 130 140 150
VMFNRTPEGL LDFRRFGGTQ HHRTAYAGAT TGQQLLYALD EQVRRYEVAG
160 170 180 190 200
LVTKYEGWEF LGAVLDDDRT CRGIVAQNLT NMQIESFRSD AVIMATGGPG
210 220 230 240 250
IIFGKSTNSM INTGSAASIV YQQGAYYANG EFIQIHPTAI PGDDKLRLMS
260 270 280 290 300
ESARGEGGRV WTYKDGKPWY FLEEKYPAYG NLVPRDIATR EIFDVCVNQK
310 320 330 340 350
LGINGENMVY LDLSHKDPKE LDIKLGGIIE IYEKFMGDDP RKLPMKIFPA
360 370 380 390 400
VHYSMGGLWV DYDQMTNIPG LFAAGECDYS MHGGNRLGAN SLLSAIYGGM
410 420 430 440 450
VAGPNAVKYV NGLESSAEDM SSSLFDAHVK KEEEKWADIM SMDGTENAYV
460 470 480 490 500
LHKELGEWMT ANVTVVRHND KLLKTDDKIQ ELMERFKKIN INDTTKWSNQ
510 520 530 540 550
GAMFTRQFSN MLQLARVITL GAYNRNESRG AHYKPDYPER NDDEWLKTTM
560 570 580
AKHVSPYEAP EFEYQDVDVS LITPRKRDYS KKKVAK
Length:586
Mass (Da):65,152
Last modified:July 7, 2009 - v4
Checksum:iF2327C2B383DE671
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82V → L in AAA22746 (PubMed:3027051).Curated1
Sequence conflicti82V → L in CAA99547 (PubMed:8969504).Curated1
Sequence conflicti100G → A in AAA22746 (PubMed:3027051).Curated1
Sequence conflicti100G → A in CAA99547 (PubMed:8969504).Curated1
Sequence conflicti388 – 390GAN → ERT in AAA22746 (PubMed:3027051).Curated3
Sequence conflicti388 – 390GAN → ERT in CAA99547 (PubMed:8969504).Curated3
Sequence conflicti441S → I in AAA22746 (PubMed:3027051).Curated1
Sequence conflicti441S → I in CAA99547 (PubMed:8969504).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti48G → D in a defective mutant. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13470 Genomic DNA Translation: AAA22746.1
Z75208 Genomic DNA Translation: CAA99547.1
AL009126 Genomic DNA Translation: CAB14804.2
PIRiA27763
RefSeqiNP_390722.2, NC_000964.3
WP_003229567.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB14804; CAB14804; BSU28440
GeneIDi937600
KEGGibsu:BSU28440
PATRICifig|224308.179.peg.3089

Similar proteinsi

Entry informationi

Entry nameiSDHA_BACSU
AccessioniPrimary (citable) accession number: P08065
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: July 7, 2009
Last modified: March 28, 2018
This is version 149 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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