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P08060

- CAH6_SHEEP

UniProt

P08060 - CAH6_SHEEP

Protein

Carbonic anhydrase 6

Gene

CA6

Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Aug 1988)
      Previous versions | rss
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    • Comment

    Functioni

    Reversible hydration of carbon dioxide. Its role in saliva is unknown.

    Catalytic activityi

    H2CO3 = CO2 + H2O.

    Cofactori

    Zinc.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei68 – 681Proton acceptorBy similarity
    Metal bindingi94 – 941Zinc; catalyticBy similarity
    Metal bindingi96 – 961Zinc; catalyticBy similarity
    Metal bindingi121 – 1211Zinc; catalyticBy similarity
    Active sitei129 – 1291By similarity

    GO - Molecular functioni

    1. carbonate dehydratase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. one-carbon metabolic process Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carbonic anhydrase 6 (EC:4.2.1.1)
    Alternative name(s):
    Carbonate dehydratase VI
    Carbonic anhydrase VI
    Short name:
    CA-VI
    Salivary carbonic anhydrase
    Secreted carbonic anhydrase
    Gene namesi
    Name:CA6
    OrganismiOvis aries (Sheep)
    Taxonomic identifieri9940 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
    ProteomesiUP000002356: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 307307Carbonic anhydrase 6PRO_0000077430Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi25 ↔ 207Sequence Analysis
    Glycosylationi50 – 501N-linked (GlcNAc...)
    Glycosylationi239 – 2391N-linked (GlcNAc...)

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Tissue specificityi

    Major constituent of saliva.

    Structurei

    3D structure databases

    ProteinModelPortaliP08060.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni203 – 2042Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the alpha-carbonic anhydrase family.Curated

    Phylogenomic databases

    HOVERGENiHBG002837.

    Family and domain databases

    Gene3Di3.10.200.10. 1 hit.
    InterProiIPR001148. Carbonic_anhydrase_a.
    IPR023561. Carbonic_anhydrase_a-class.
    IPR018338. Carbonic_anhydrase_a-class_CS.
    IPR018428. Carbonic_anhydrase_CA6.
    [Graphical view]
    PANTHERiPTHR18952. PTHR18952. 1 hit.
    PTHR18952:SF17. PTHR18952:SF17. 1 hit.
    PfamiPF00194. Carb_anhydrase. 1 hit.
    [Graphical view]
    SMARTiSM01057. Carb_anhydrase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51069. SSF51069. 1 hit.
    PROSITEiPS00162. ALPHA_CA_1. 1 hit.
    PS51144. ALPHA_CA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P08060-1 [UniParc]FASTAAdd to Basket

    « Hide

    GHGVEWTYSE GMLDEAHWPL EYPKCGGRRQ SPIDLQMKKV QYNPSLRALN    50
    LTGYGLWHGE FPVTNNGHTV QISLPSTMSM TTSDGTQYLA KQMHFHWGGA 100
    SSEISGSEHT VDGMRYVIEI HVVHYNSKYN SYEEAQKEPD GLAVLAALVE 150
    VKDYTENAYY SKFISHLEDI RYAGQSTVLR GLDIEDMLPG DLRYYYSYLG 200
    SLTTPPCTEN VHWFVVADTV KLSKTQVEKL ENSLLNHQNK TIQNDYRRTQ 250
    PLNHRVVEAN FMSRPHQEYT LASKLHFYLN NIDQTLEYLR RFIEQKIPKR 300
    KKQENWP 307
    Length:307
    Mass (Da):35,555
    Last modified:August 1, 1988 - v1
    Checksum:i338682C2D45E5D6C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti63 – 631V → M.
    Natural varianti297 – 2971I → M.

    Sequence databases

    PIRiA29993.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    PIRi A29993.

    3D structure databases

    ProteinModelPortali P08060.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG002837.

    Family and domain databases

    Gene3Di 3.10.200.10. 1 hit.
    InterProi IPR001148. Carbonic_anhydrase_a.
    IPR023561. Carbonic_anhydrase_a-class.
    IPR018338. Carbonic_anhydrase_a-class_CS.
    IPR018428. Carbonic_anhydrase_CA6.
    [Graphical view ]
    PANTHERi PTHR18952. PTHR18952. 1 hit.
    PTHR18952:SF17. PTHR18952:SF17. 1 hit.
    Pfami PF00194. Carb_anhydrase. 1 hit.
    [Graphical view ]
    SMARTi SM01057. Carb_anhydrase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51069. SSF51069. 1 hit.
    PROSITEi PS00162. ALPHA_CA_1. 1 hit.
    PS51144. ALPHA_CA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete amino acid sequence of ovine salivary carbonic anhydrase."
      Fernley R.T., Wright R.D., Coghlan J.P.
      Biochemistry 27:2815-2820(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Saliva.

    Entry informationi

    Entry nameiCAH6_SHEEP
    AccessioniPrimary (citable) accession number: P08060
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: August 1, 1988
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3