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P08060 (CAH6_SHEEP) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carbonic anhydrase 6

EC=4.2.1.1
Alternative name(s):
Carbonate dehydratase VI
Carbonic anhydrase VI
Short name=CA-VI
Salivary carbonic anhydrase
Secreted carbonic anhydrase
Gene names
Name:CA6
OrganismOvis aries (Sheep) [Complete proteome]
Taxonomic identifier9940 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Reversible hydration of carbon dioxide. Its role in saliva is unknown.

Catalytic activity

H2CO3 = CO2 + H2O.

Cofactor

Zinc By similarity.

Subcellular location

Secreted.

Tissue specificity

Major constituent of saliva.

Sequence similarities

Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   LigandMetal-binding
Zinc
   Molecular functionLyase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological_processone-carbon metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncarbonate dehydratase activity

Inferred from electronic annotation. Source: UniProtKB-EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307Carbonic anhydrase 6
PRO_0000077430

Regions

Region203 – 2042Substrate binding By similarity

Sites

Active site681Proton acceptor By similarity
Active site1291 By similarity
Metal binding941Zinc; catalytic By similarity
Metal binding961Zinc; catalytic By similarity
Metal binding1211Zinc; catalytic By similarity

Amino acid modifications

Glycosylation501N-linked (GlcNAc...)
Glycosylation2391N-linked (GlcNAc...)
Disulfide bond25 ↔ 207 Potential

Natural variations

Natural variant631V → M.
Natural variant2971I → M.

Sequences

Sequence LengthMass (Da)Tools
P08060 [UniParc].

Last modified August 1, 1988. Version 1.
Checksum: 338682C2D45E5D6C

FASTA30735,555
        10         20         30         40         50         60 
GHGVEWTYSE GMLDEAHWPL EYPKCGGRRQ SPIDLQMKKV QYNPSLRALN LTGYGLWHGE 

        70         80         90        100        110        120 
FPVTNNGHTV QISLPSTMSM TTSDGTQYLA KQMHFHWGGA SSEISGSEHT VDGMRYVIEI 

       130        140        150        160        170        180 
HVVHYNSKYN SYEEAQKEPD GLAVLAALVE VKDYTENAYY SKFISHLEDI RYAGQSTVLR 

       190        200        210        220        230        240 
GLDIEDMLPG DLRYYYSYLG SLTTPPCTEN VHWFVVADTV KLSKTQVEKL ENSLLNHQNK 

       250        260        270        280        290        300 
TIQNDYRRTQ PLNHRVVEAN FMSRPHQEYT LASKLHFYLN NIDQTLEYLR RFIEQKIPKR 


KKQENWP 

« Hide

References

[1]"Complete amino acid sequence of ovine salivary carbonic anhydrase."
Fernley R.T., Wright R.D., Coghlan J.P.
Biochemistry 27:2815-2820(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Saliva.

Cross-references

Sequence databases

PIRA29993.

3D structure databases

ProteinModelPortalP08060.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG002837.

Family and domain databases

Gene3D3.10.200.10. 1 hit.
InterProIPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
IPR018428. Carbonic_anhydrase_CA6.
[Graphical view]
PANTHERPTHR18952. PTHR18952. 1 hit.
PTHR18952:SF37. PTHR18952:SF37. 1 hit.
PfamPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMSSF51069. SSF51069. 1 hit.
PROSITEPS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCAH6_SHEEP
AccessionPrimary (citable) accession number: P08060
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: February 19, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families