Reviewed, UniProtKB/Swiss-Prot P08060 (CAH6_SHEEP)

Names and origin

Protein names

Recommended name:
    Carbonic anhydrase 6
    EC=4.2.1.1
Alternative name(s):
    Carbonic anhydrase VI
      Short name=CA-VI
    Carbonate dehydratase VI
    Secreted carbonic anhydrase
    Salivary carbonic anhydrase

Gene names

Name:

CA6

Organism

Ovis aries (Sheep)

Taxonomic identifier

9940 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Reversible hydration of carbon dioxide. Its role in saliva is unknown.
Catalytic activity	H2CO3 = CO2 + H2O.
Cofactor	Zinc By similarity.
Subcellular location	Secreted.
Tissue specificity	Major constituent of saliva.
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
Cellular component	Secreted
Ligand	Metal-binding Zinc
Molecular function	Lyase
PTM	Disulfide bond Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 307	307	Carbonic anhydrase 6		PRO_0000077430
Sites
	Metal binding	94	1	Zinc; catalytic By similarity
	Metal binding	96	1	Zinc; catalytic By similarity
	Metal binding	121	1	Zinc; catalytic By similarity
Amino acid modifications
	Glycosylation	50	1	N-linked (GlcNAc...)
	Glycosylation	239	1	N-linked (GlcNAc...)
	Disulfide bond	25 ↔ 207		Potential
Natural variations
	Natural variant	63	1	V → M
	Natural variant	297	1	I → M

Sequences

	Sequence		Length	Mass (Da)
	P08060-1 [UniParc]. Last modified August 1, 1988. Version 1. Checksum: 338682C2D45E5D6C	FASTA	307	35,555
	10 20 30 40 50 60 GHGVEWTYSE GMLDEAHWPL EYPKCGGRRQ SPIDLQMKKV QYNPSLRALN LTGYGLWHGE 70 80 90 100 110 120 FPVTNNGHTV QISLPSTMSM TTSDGTQYLA KQMHFHWGGA SSEISGSEHT VDGMRYVIEI 130 140 150 160 170 180 HVVHYNSKYN SYEEAQKEPD GLAVLAALVE VKDYTENAYY SKFISHLEDI RYAGQSTVLR 190 200 210 220 230 240 GLDIEDMLPG DLRYYYSYLG SLTTPPCTEN VHWFVVADTV KLSKTQVEKL ENSLLNHQNK 250 260 270 280 290 300 TIQNDYRRTQ PLNHRVVEAN FMSRPHQEYT LASKLHFYLN NIDQTLEYLR RFIEQKIPKR KKQENWP

References

[1]	"Complete amino acid sequence of ovine salivary carbonic anhydrase." Fernley R.T., Wright R.D., Coghlan J.P. Biochemistry 27:2815-2820(1988) [PubMed: 3135834] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Saliva.

Cross-references

Sequence databases
PIR	A29993.
3D structure databases
SMR	P08060. Positions 5-261.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P08060.
Enzyme and pathway databases
BRENDA	4.2.1.1. 271.
Family and domain databases
InterPro	IPR001148. Carbonic_anhydrase_a-class_cat. IPR018338. Carbonic_anhydrase_a-class_CS. IPR018428. Carbonic_anhydrase_CA6. [Graphical view]
Gene3D	G3DSA:3.10.200.10. Euk_COanhd. 1 hit.
PANTHER	PTHR18952:SF17. Carbonic_anhydrase_CA6. 1 hit. PTHR18952. Euk_COanhd. 1 hit.
Pfam	PF00194. Carb_anhydrase. 1 hit. [Graphical view]
PROSITE	PS00162. ALPHA_CA_1. 1 hit. PS51144. ALPHA_CA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAH6_SHEEP

Accession

Primary (citable) accession number: P08060

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	August 1, 1988
Last modified:	January 19, 2010
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)