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Protein

Carbonic anhydrase 6

Gene

CA6

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reversible hydration of carbon dioxide. Its role in saliva is unknown.

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68Proton acceptorBy similarity1
Metal bindingi94Zinc; catalyticBy similarity1
Metal bindingi96Zinc; catalyticBy similarity1
Metal bindingi121Zinc; catalyticBy similarity1
Active sitei129By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 6 (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase VI
Carbonic anhydrase VI
Short name:
CA-VI
Salivary carbonic anhydrase
Secreted carbonic anhydrase
Gene namesi
Name:CA6
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000774301 – 307Carbonic anhydrase 6Add BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 207Sequence analysis
Glycosylationi50N-linked (GlcNAc...) asparagine1
Glycosylationi239N-linked (GlcNAc...) asparagine1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP08060

Expressioni

Tissue specificityi

Major constituent of saliva.

Structurei

3D structure databases

ProteinModelPortaliP08060
SMRiP08060
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 261Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST258

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni203 – 204Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated

Phylogenomic databases

HOVERGENiHBG002837

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
IPR018338 Carbonic_anhydrase_a-class_CS
IPR018428 Carbonic_anhydrase_CA6
PANTHERiPTHR18952 PTHR18952, 1 hit
PTHR18952:SF110 PTHR18952:SF110, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS00162 ALPHA_CA_1, 1 hit
PS51144 ALPHA_CA_2, 1 hit

Sequencei

Sequence statusi: Complete.

P08060-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GHGVEWTYSE GMLDEAHWPL EYPKCGGRRQ SPIDLQMKKV QYNPSLRALN
60 70 80 90 100
LTGYGLWHGE FPVTNNGHTV QISLPSTMSM TTSDGTQYLA KQMHFHWGGA
110 120 130 140 150
SSEISGSEHT VDGMRYVIEI HVVHYNSKYN SYEEAQKEPD GLAVLAALVE
160 170 180 190 200
VKDYTENAYY SKFISHLEDI RYAGQSTVLR GLDIEDMLPG DLRYYYSYLG
210 220 230 240 250
SLTTPPCTEN VHWFVVADTV KLSKTQVEKL ENSLLNHQNK TIQNDYRRTQ
260 270 280 290 300
PLNHRVVEAN FMSRPHQEYT LASKLHFYLN NIDQTLEYLR RFIEQKIPKR

KKQENWP
Length:307
Mass (Da):35,555
Last modified:August 1, 1988 - v1
Checksum:i338682C2D45E5D6C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti63V → M. 1
Natural varianti297I → M. 1

Sequence databases

PIRiA29993

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCAH6_SHEEP
AccessioniPrimary (citable) accession number: P08060
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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