Reviewed, UniProtKB/Swiss-Prot P08057 (TNNI3_BOVIN)

Names and origin

Protein names

Recommended name:
    Troponin I, cardiac muscle
Alternative name(s):
    Cardiac troponin I

Gene names

Name:

TNNI3

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Subunit structure	Interacts with TRIM63 By similarity. Binds to actin and tropomyosin.
Sequence similarities	Belongs to the troponin I family.

Ontologies

Keywords
Ligand	Actin-binding
Molecular function	Muscle protein
PTM	Acetylation Phosphoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular function	actin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.2 Ref.3
	Chain	2 – 212	211	Troponin I, cardiac muscle		PRO_0000186149
Regions
	Region	34 – 81	48	Involved in binding TNC
	Region	131 – 151	21	Involved in binding TNC and actin
Sites
	Site	82	1	Involved in TNI-TNT interactions
	Site	99	1	Involved in TNI-TNT interactions
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.2
Experimental info
	Sequence conflict	17	1	P → M AA sequence Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P08057-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: B4B15DCCA7BA2B5E	FASTA	212	24,054
	10 20 30 40 50 60 MADRSGGSTA GDTVPAPPPV RRRSSANYRA YATEPHAKKK SKISASRKLQ LKTLMLQIAK 70 80 90 100 110 120 QELEREAEER RGEKGRALST RCQPLELAGL GFAELQDLCR QLHARVDKVD EERYDVEAKV 130 140 150 160 170 180 TKNITEIADL NQKIFDLRGK FKRPTLRRVR ISADAMMQAL LGARAKETLD LRAHLKQVKK 190 200 210 EDTEKENREV GDWRKNIDAL SGMEGRKKKF EG

References

[1]	"Bovine dilated cardiomyopathy: evidence for a major gene on BTA18." Guziewicz K. Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Peripheral blood.
[2]	"Amino acid sequence of bovine cardiac troponin I." Leszyk J., Dumaswala R., Potter J.D., Collins J.H. Biochemistry 27:2821-2827(1988) [PubMed: 3042023] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-212.
[3]	"Pattern of repeating aromatic residues in synexin. Similarity to the cytoplasmic domain of synaptophysin." Creutz C.E., Snyder S.L., Husted L.D., Beggerly L.K., Fox J.W. Biochem. Biophys. Res. Commun. 152:1298-1303(1988) [PubMed: 2967699] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-212.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ842179 Genomic DNA. Translation: CAH57016.1.
IPI	IPI00706574.
PIR	A29994.
RefSeq	NP_001035607.1.
UniGene	Bt.11438
3D structure databases
SMR	P08057. Positions 1-33, 42-193.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000008425; ENSBTAP00000008425; ENSBTAG00000006424; Bos taurus. [Genome view]
GeneID	511094.
KEGG	bta:511094.
Organism-specific databases
CTD	511094.
Phylogenomic databases
eggNOG	maNOG17699.
HOVERGEN	P08057.
InParanoid	P08057.
PhylomeDB	P08057.
Family and domain databases
InterPro	IPR001978. Troponin. [Graphical view]
Pfam	PF00992. Troponin. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TNNI3_BOVIN

Accession

Primary (citable) accession number: P08057
Secondary accession number(s): Q5ZG22

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	January 23, 2007
Last modified:	January 19, 2010
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)