Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger Y-chromosomal protein

Gene

ZFY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3'.1 Publication

Caution

Was originally thought to be the testis determining factor (TDF).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri421 – 443C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 538C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri544 – 566C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 595C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri601 – 623C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri629 – 652C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri658 – 680C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri686 – 709C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri715 – 737C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri743 – 766C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri772 – 795C2H2-type 13PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger Y-chromosomal protein
Gene namesi
Name:ZFY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome Y

Organism-specific databases

EuPathDBiHostDB:ENSG00000067646.11
HGNCiHGNC:12870 ZFY
MIMi490000 gene
neXtProtiNX_P08048

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7544
OpenTargetsiENSG00000067646
PharmGKBiPA37459

Chemistry databases

DrugBankiDB02884 Beta-Cyclohexyl-Alanine
DB05483 PCL-016

Polymorphism and mutation databases

BioMutaiZFY
DMDMi51338719

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472611 – 801Zinc finger Y-chromosomal proteinAdd BLAST801

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei270PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP08048
PaxDbiP08048
PeptideAtlasiP08048
PRIDEiP08048

PTM databases

iPTMnetiP08048
PhosphoSitePlusiP08048

Expressioni

Gene expression databases

BgeeiENSG00000067646
CleanExiHS_ZFY
ExpressionAtlasiP08048 baseline and differential
GenevisibleiP08048 HS

Organism-specific databases

HPAiHPA001748
HPA071863

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
L3MBTL2Q969R55EBI-12239601,EBI-739909

Protein-protein interaction databases

BioGridi113376, 5 interactors
IntActiP08048, 4 interactors
STRINGi9606.ENSP00000155093

Structurei

Secondary structure

1801
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi575 – 578Combined sources4
Beta strandi580 – 583Combined sources4
Helixi585 – 594Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KLRNMR-A570-598[»]
1KLSNMR-A570-598[»]
1XRZNMR-A570-598[»]
5ZNFNMR-A570-598[»]
7ZNFNMR-A570-598[»]
ProteinModelPortaliP08048
SMRiP08048
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08048

Family & Domainsi

Domaini

The binding of ZFY to DNA is mediated by the interaction of the GGCC core base pairs with zinc fingers 12 and 13.1 Publication

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri421 – 443C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 538C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri544 – 566C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 595C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri601 – 623C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri629 – 652C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri658 – 680C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri686 – 709C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri715 – 737C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri743 – 766C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri772 – 795C2H2-type 13PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063297
HOGENOMiHOG000231717
HOVERGENiHBG000337
InParanoidiP08048
OMAiDYPHKCA
OrthoDBiEOG091G02CA
PhylomeDBiP08048
TreeFamiTF335557

Family and domain databases

InterProiView protein in InterPro
IPR006794 Transcrp_activ_Zfx/Zfy-dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF04704 Zfx_Zfy_act, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P08048-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDEDEFELQP QEPNSFFDGI GADATHMDGD QIVVEIQEAV FVSNIVDSDI
60 70 80 90 100
TVHNFVPDDP DSVVIQDVVE DVVIEEDVQC SDILEEADVS ENVIIPEQVL
110 120 130 140 150
DSDVTEEVSL PHCTVPDDVL ASDITSTSMS MPEHVLTSES MHVCDIGHVE
160 170 180 190 200
HMVHDSVVEA EIITDPLTSD IVSEEVLVAD CAPEAVIDAS GISVDQQDND
210 220 230 240 250
KASCEDYLMI SLDDAGKIEH DGSTGVTIDA ESEMDPCKVD STCPEVIKVY
260 270 280 290 300
IFKADPGEDD LGGTVDIVES EPENDHGVEL LDQNSSIRVP REKMVYMTVN
310 320 330 340 350
DSQQEDEDLN VAEIADEVYM EVIVGEEDAA VAAAAAAVHE QQIDEDEMKT
360 370 380 390 400
FVPIAWAAAY GNNSDGIENR NGTASALLHI DESAGLGRLA KQKPKKKRRP
410 420 430 440 450
DSRQYQTAII IGPDGHPLTV YPCMICGKKF KSRGFLKRHM KNHPEHLAKK
460 470 480 490 500
KYHCTDCDYT TNKKISLHNH LESHKLTSKA EKAIECDECG KHFSHAGALF
510 520 530 540 550
THKMVHKEKG ANKMHKCKFC EYETAEQGLL NRHLLAVHSK NFPHICVECG
560 570 580 590 600
KGFRHPSELR KHMRIHTGEK PYQCQYCEYR SADSSNLKTH IKTKHSKEMP
610 620 630 640 650
FKCDICLLTF SDTKEVQQHT LVHQESKTHQ CLHCDHKSSN SSDLKRHVIS
660 670 680 690 700
VHTKDYPHKC EMCEKGFHRP SELKKHVAVH KGKKMHQCRH CDFKIADPFV
710 720 730 740 750
LSRHILSVHT KDLPFRCKRC RKGFRQQNEL KKHMKTHSGR KVYQCEYCEY
760 770 780 790 800
STTDASGFKR HVISIHTKDY PHRCEYCKKG FRRPSEKNQH IMRHHKEVGL

P
Length:801
Mass (Da):90,505
Last modified:August 16, 2004 - v3
Checksum:i956B9B3DA16648FA
GO
Isoform 2 (identifier: P08048-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-21: G → V
     22-212: Missing.

Note: No experimental confirmation available.
Show »
Length:610
Mass (Da):69,907
Checksum:iFA9C3797807D5C3C
GO
Isoform 3 (identifier: P08048-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.
     310-310: N → S
     311-361: Missing.

Note: No experimental confirmation available.
Show »
Length:724
Mass (Da):82,165
Checksum:i95DDCD4D9E11A43C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti333A → R in AAA72344 (PubMed:2511751).Curated1
Sequence conflicti398 – 407RRPDSRQYQT → ALILLSFPFL (PubMed:2498838).Curated10
Sequence conflicti554R → S (PubMed:2041734).Curated1
Sequence conflicti555H → Y in AAA61310 (PubMed:2308929).Curated1
Sequence conflicti630Missing (PubMed:2041734).Curated1
Sequence conflicti767T → R (PubMed:2041734).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0428241 – 26Missing in isoform 3. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_04277421G → V in isoform 2. 1 Publication1
Alternative sequenceiVSP_04277522 – 212Missing in isoform 2. 1 PublicationAdd BLAST191
Alternative sequenceiVSP_042825310N → S in isoform 3. 1 Publication1
Alternative sequenceiVSP_042826311 – 361Missing in isoform 3. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10393 mRNA Translation: AAA72344.1
M30607 mRNA Translation: AAA61310.1
AF114156 Genomic DNA Translation: AAF21973.1
AK301061 mRNA Translation: BAG62669.1
AC006157 Genomic DNA Translation: AAD15612.1
BC114526 mRNA Translation: AAI14527.1
BC114960 mRNA Translation: AAI14961.1
X15470 Genomic DNA Translation: CAA33498.1
CCDSiCCDS14774.1 [P08048-1]
CCDS48200.1 [P08048-2]
CCDS48201.1 [P08048-3]
PIRiA33630
RefSeqiNP_001138747.1, NM_001145275.1 [P08048-3]
NP_001138748.1, NM_001145276.1 [P08048-2]
NP_003402.2, NM_003411.3 [P08048-1]
XP_005262627.1, XM_005262570.2 [P08048-1]
XP_016885564.1, XM_017030075.1 [P08048-1]
XP_016885566.1, XM_017030077.1 [P08048-3]
UniGeneiHs.522845

Genome annotation databases

EnsembliENST00000155093; ENSP00000155093; ENSG00000067646 [P08048-1]
ENST00000383052; ENSP00000372525; ENSG00000067646 [P08048-1]
ENST00000449237; ENSP00000393908; ENSG00000067646 [P08048-3]
ENST00000625061; ENSP00000485605; ENSG00000067646 [P08048-2]
GeneIDi7544
KEGGihsa:7544
UCSCiuc004fqj.4 human [P08048-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZFY_HUMAN
AccessioniPrimary (citable) accession number: P08048
Secondary accession number(s): B4DVF7
, Q14021, Q15558, Q1RME9, Q24JR0, Q96TF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 187 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health