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P08048

- ZFY_HUMAN

UniProt

P08048 - ZFY_HUMAN

Protein

Zinc finger Y-chromosomal protein

Gene

ZFY

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 154 (01 Oct 2014)
      Sequence version 3 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3'.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri421 – 44323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri452 – 47423C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri484 – 50623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri515 – 53824C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri544 – 56623C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri572 – 59524C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri601 – 62323C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri629 – 65224C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri658 – 68023C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri686 – 70924C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri715 – 73723C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri743 – 76624C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri772 – 79524C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger Y-chromosomal protein
    Gene namesi
    Name:ZFY
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome Y

    Organism-specific databases

    HGNCiHGNC:12870. ZFY.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37459.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 801801Zinc finger Y-chromosomal proteinPRO_0000047261Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei270 – 2701PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP08048.
    PaxDbiP08048.
    PRIDEiP08048.

    PTM databases

    PhosphoSiteiP08048.

    Expressioni

    Gene expression databases

    ArrayExpressiP08048.
    BgeeiP08048.
    CleanExiHS_ZFY.
    GenevestigatoriP08048.

    Organism-specific databases

    HPAiHPA001748.

    Interactioni

    Protein-protein interaction databases

    BioGridi113376. 3 interactions.
    STRINGi9606.ENSP00000155093.

    Structurei

    Secondary structure

    1
    801
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi575 – 5784
    Beta strandi580 – 5834
    Helixi585 – 59410

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1KLRNMR-A570-598[»]
    1KLSNMR-A570-598[»]
    1XRZNMR-A570-598[»]
    5ZNFNMR-A570-598[»]
    7ZNFNMR-A570-598[»]
    ProteinModelPortaliP08048.
    SMRiP08048. Positions 421-794.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP08048.

    Family & Domainsi

    Domaini

    The binding of ZFY to DNA is mediated by the interaction of the GGCC core base pairs with zinc fingers 12 and 13.1 Publication

    Sequence similaritiesi

    Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri421 – 44323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri452 – 47423C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri484 – 50623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri515 – 53824C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri544 – 56623C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri572 – 59524C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri601 – 62323C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri629 – 65224C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri658 – 68023C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri686 – 70924C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri715 – 73723C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri743 – 76624C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri772 – 79524C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000231717.
    HOVERGENiHBG000337.
    InParanoidiP08048.
    OMAiTCVMALE.
    OrthoDBiEOG7P8P73.
    PhylomeDBiP08048.
    TreeFamiTF335557.

    Family and domain databases

    Gene3Di3.30.160.60. 7 hits.
    InterProiIPR006794. Transcrp_activ_Zfx/Zfy-dom.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 4 hits.
    PF04704. Zfx_Zfy_act. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 13 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
    PS50157. ZINC_FINGER_C2H2_2. 12 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P08048-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDEDEFELQP QEPNSFFDGI GADATHMDGD QIVVEIQEAV FVSNIVDSDI    50
    TVHNFVPDDP DSVVIQDVVE DVVIEEDVQC SDILEEADVS ENVIIPEQVL 100
    DSDVTEEVSL PHCTVPDDVL ASDITSTSMS MPEHVLTSES MHVCDIGHVE 150
    HMVHDSVVEA EIITDPLTSD IVSEEVLVAD CAPEAVIDAS GISVDQQDND 200
    KASCEDYLMI SLDDAGKIEH DGSTGVTIDA ESEMDPCKVD STCPEVIKVY 250
    IFKADPGEDD LGGTVDIVES EPENDHGVEL LDQNSSIRVP REKMVYMTVN 300
    DSQQEDEDLN VAEIADEVYM EVIVGEEDAA VAAAAAAVHE QQIDEDEMKT 350
    FVPIAWAAAY GNNSDGIENR NGTASALLHI DESAGLGRLA KQKPKKKRRP 400
    DSRQYQTAII IGPDGHPLTV YPCMICGKKF KSRGFLKRHM KNHPEHLAKK 450
    KYHCTDCDYT TNKKISLHNH LESHKLTSKA EKAIECDECG KHFSHAGALF 500
    THKMVHKEKG ANKMHKCKFC EYETAEQGLL NRHLLAVHSK NFPHICVECG 550
    KGFRHPSELR KHMRIHTGEK PYQCQYCEYR SADSSNLKTH IKTKHSKEMP 600
    FKCDICLLTF SDTKEVQQHT LVHQESKTHQ CLHCDHKSSN SSDLKRHVIS 650
    VHTKDYPHKC EMCEKGFHRP SELKKHVAVH KGKKMHQCRH CDFKIADPFV 700
    LSRHILSVHT KDLPFRCKRC RKGFRQQNEL KKHMKTHSGR KVYQCEYCEY 750
    STTDASGFKR HVISIHTKDY PHRCEYCKKG FRRPSEKNQH IMRHHKEVGL 800
    P 801
    Length:801
    Mass (Da):90,505
    Last modified:August 16, 2004 - v3
    Checksum:i956B9B3DA16648FA
    GO
    Isoform 2 (identifier: P08048-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         21-21: G → V
         22-212: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:610
    Mass (Da):69,907
    Checksum:iFA9C3797807D5C3C
    GO
    Isoform 3 (identifier: P08048-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-26: Missing.
         310-310: N → S
         311-361: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:724
    Mass (Da):82,165
    Checksum:i95DDCD4D9E11A43C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti333 – 3331A → R in AAA72344. (PubMed:2511751)Curated
    Sequence conflicti398 – 40710RRPDSRQYQT → ALILLSFPFL(PubMed:2498838)Curated
    Sequence conflicti554 – 5541R → S(PubMed:2041734)Curated
    Sequence conflicti555 – 5551H → Y in AAA61310. (PubMed:2308929)Curated
    Sequence conflicti630 – 6301Missing(PubMed:2041734)Curated
    Sequence conflicti767 – 7671T → R(PubMed:2041734)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2626Missing in isoform 3. 1 PublicationVSP_042824Add
    BLAST
    Alternative sequencei21 – 211G → V in isoform 2. 1 PublicationVSP_042774
    Alternative sequencei22 – 212191Missing in isoform 2. 1 PublicationVSP_042775Add
    BLAST
    Alternative sequencei310 – 3101N → S in isoform 3. 1 PublicationVSP_042825
    Alternative sequencei311 – 36151Missing in isoform 3. 1 PublicationVSP_042826Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L10393 mRNA. Translation: AAA72344.1.
    M30607 mRNA. Translation: AAA61310.1.
    AF114156 Genomic DNA. Translation: AAF21973.1.
    AK301061 mRNA. Translation: BAG62669.1.
    AC006157 Genomic DNA. Translation: AAD15612.1.
    BC114526 mRNA. Translation: AAI14527.1.
    BC114960 mRNA. Translation: AAI14961.1.
    X15470 Genomic DNA. Translation: CAA33498.1.
    CCDSiCCDS14774.1. [P08048-1]
    CCDS48200.1. [P08048-2]
    CCDS48201.1. [P08048-3]
    PIRiA33630.
    RefSeqiNP_001138747.1. NM_001145275.1. [P08048-3]
    NP_001138748.1. NM_001145276.1. [P08048-2]
    NP_003402.2. NM_003411.3. [P08048-1]
    XP_005262627.1. XM_005262570.1. [P08048-1]
    XP_006724936.1. XM_006724873.1. [P08048-1]
    UniGeneiHs.522845.

    Genome annotation databases

    EnsembliENST00000155093; ENSP00000155093; ENSG00000067646. [P08048-1]
    ENST00000383052; ENSP00000372525; ENSG00000067646. [P08048-1]
    ENST00000431102; ENSP00000402502; ENSG00000067646. [P08048-2]
    ENST00000449237; ENSP00000393908; ENSG00000067646. [P08048-3]
    GeneIDi7544.
    KEGGihsa:7544.
    UCSCiuc004fqj.3. human. [P08048-1]
    uc010nwe.3. human. [P08048-3]
    uc011nan.2. human. [P08048-2]

    Polymorphism databases

    DMDMi51338719.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L10393 mRNA. Translation: AAA72344.1 .
    M30607 mRNA. Translation: AAA61310.1 .
    AF114156 Genomic DNA. Translation: AAF21973.1 .
    AK301061 mRNA. Translation: BAG62669.1 .
    AC006157 Genomic DNA. Translation: AAD15612.1 .
    BC114526 mRNA. Translation: AAI14527.1 .
    BC114960 mRNA. Translation: AAI14961.1 .
    X15470 Genomic DNA. Translation: CAA33498.1 .
    CCDSi CCDS14774.1. [P08048-1 ]
    CCDS48200.1. [P08048-2 ]
    CCDS48201.1. [P08048-3 ]
    PIRi A33630.
    RefSeqi NP_001138747.1. NM_001145275.1. [P08048-3 ]
    NP_001138748.1. NM_001145276.1. [P08048-2 ]
    NP_003402.2. NM_003411.3. [P08048-1 ]
    XP_005262627.1. XM_005262570.1. [P08048-1 ]
    XP_006724936.1. XM_006724873.1. [P08048-1 ]
    UniGenei Hs.522845.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1KLR NMR - A 570-598 [» ]
    1KLS NMR - A 570-598 [» ]
    1XRZ NMR - A 570-598 [» ]
    5ZNF NMR - A 570-598 [» ]
    7ZNF NMR - A 570-598 [» ]
    ProteinModelPortali P08048.
    SMRi P08048. Positions 421-794.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113376. 3 interactions.
    STRINGi 9606.ENSP00000155093.

    PTM databases

    PhosphoSitei P08048.

    Polymorphism databases

    DMDMi 51338719.

    Proteomic databases

    MaxQBi P08048.
    PaxDbi P08048.
    PRIDEi P08048.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000155093 ; ENSP00000155093 ; ENSG00000067646 . [P08048-1 ]
    ENST00000383052 ; ENSP00000372525 ; ENSG00000067646 . [P08048-1 ]
    ENST00000431102 ; ENSP00000402502 ; ENSG00000067646 . [P08048-2 ]
    ENST00000449237 ; ENSP00000393908 ; ENSG00000067646 . [P08048-3 ]
    GeneIDi 7544.
    KEGGi hsa:7544.
    UCSCi uc004fqj.3. human. [P08048-1 ]
    uc010nwe.3. human. [P08048-3 ]
    uc011nan.2. human. [P08048-2 ]

    Organism-specific databases

    CTDi 7544.
    GeneCardsi GC0YP002846.
    HGNCi HGNC:12870. ZFY.
    HPAi HPA001748.
    MIMi 490000. gene.
    neXtProti NX_P08048.
    PharmGKBi PA37459.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000231717.
    HOVERGENi HBG000337.
    InParanoidi P08048.
    OMAi TCVMALE.
    OrthoDBi EOG7P8P73.
    PhylomeDBi P08048.
    TreeFami TF335557.

    Miscellaneous databases

    EvolutionaryTracei P08048.
    GeneWikii ZFY.
    GenomeRNAii 7544.
    NextBioi 29517.
    PROi P08048.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P08048.
    Bgeei P08048.
    CleanExi HS_ZFY.
    Genevestigatori P08048.

    Family and domain databases

    Gene3Di 3.30.160.60. 7 hits.
    InterProi IPR006794. Transcrp_activ_Zfx/Zfy-dom.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 4 hits.
    PF04704. Zfx_Zfy_act. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 13 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 8 hits.
    PS50157. ZINC_FINGER_C2H2_2. 12 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues."
      Lau Y.-F.C., Chan K.
      Am. J. Hum. Genet. 45:942-952(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans."
      Erlandsson R., Wilson J.F., Paabo S.
      Mol. Biol. Evol. 17:804-812(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Spleen.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    7. "The sex-determining region of the human Y chromosome encodes a finger protein."
      Page D.C., Mosher R., Simpson E.M., Fisher E.M.C., Mardon G., Pollack J., McGillivray B., de la Chapelle A., Brown L.G.
      Cell 51:1091-1104(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 408-801.
    8. "Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY."
      North M., Sargent C., O'Brien J., Taylor K., Wolfe J., Affara N.A., Ferguson-Smith M.A.
      Nucleic Acids Res. 19:2579-2586(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 423-801.
    9. "Evidence for distinguishable transcripts of the putative testis determining gene (ZFY) and mapping of homologous cDNA sequences to chromosomes X,Y and 9."
      Affara N.A., Chambers D., O'Brien J., Habeebu S.S.M., Kalaitsidaki M., Bishop C.E., Ferguson-Smith M.A.
      Nucleic Acids Res. 17:2987-2999(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 397-446.
    10. "Characterization of the DNA binding activity of the ZFY zinc finger domain."
      Grants J., Flanagan E., Yee A., Romaniuk P.J.
      Biochemistry 49:679-686(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DOMAIN DNA-BINDING.
    11. "Alternating zinc fingers in the human male associated protein ZFY: 2D NMR structure of an even finger and implications for 'jumping-linker' DNA recognition."
      Kochoyan M., Havel T.F., Nguyen D.Z., Dahl C.E., Keutmann H.T., Weiss M.A.
      Biochemistry 30:3371-3386(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF ZINC-FINGERS.
    12. "Alternating zinc fingers in the human male associated protein ZFY: refinement of the NMR structure of an even finger by selective deuterium labeling and implications for DNA recognition."
      Kochoyan M., Keutmann H.T., Weiss M.A.
      Biochemistry 30:7063-7072(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF ZINC-FINGERS.
    13. "Solvation and the hidden thermodynamics of a zinc finger probed by nonstandard repair of a protein crevice."
      Lachenmann M.J., Ladbury J.E., Qian X., Huang K., Singh R., Weiss M.A.
      Protein Sci. 13:3115-3126(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 572-598.

    Entry informationi

    Entry nameiZFY_HUMAN
    AccessioniPrimary (citable) accession number: P08048
    Secondary accession number(s): B4DVF7
    , Q14021, Q15558, Q1RME9, Q24JR0, Q96TF3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 154 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome Y
      Human chromosome Y: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3