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P08048

- ZFY_HUMAN

UniProt

P08048 - ZFY_HUMAN

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Protein
Zinc finger Y-chromosomal protein
Gene
ZFY
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3'.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri421 – 44323C2H2-type 1
Add
BLAST
Zinc fingeri452 – 47423C2H2-type 2; atypical
Add
BLAST
Zinc fingeri484 – 50623C2H2-type 3
Add
BLAST
Zinc fingeri515 – 53824C2H2-type 4
Add
BLAST
Zinc fingeri544 – 56623C2H2-type 5
Add
BLAST
Zinc fingeri572 – 59524C2H2-type 6
Add
BLAST
Zinc fingeri601 – 62323C2H2-type 7
Add
BLAST
Zinc fingeri629 – 65224C2H2-type 8
Add
BLAST
Zinc fingeri658 – 68023C2H2-type 9
Add
BLAST
Zinc fingeri686 – 70924C2H2-type 10
Add
BLAST
Zinc fingeri715 – 73723C2H2-type 11
Add
BLAST
Zinc fingeri743 – 76624C2H2-type 12
Add
BLAST
Zinc fingeri772 – 79524C2H2-type 13
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger Y-chromosomal protein
Gene namesi
Name:ZFY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome Y

Organism-specific databases

HGNCiHGNC:12870. ZFY.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37459.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 801801Zinc finger Y-chromosomal protein
PRO_0000047261Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei270 – 2701Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP08048.
PaxDbiP08048.
PRIDEiP08048.

PTM databases

PhosphoSiteiP08048.

Expressioni

Gene expression databases

ArrayExpressiP08048.
BgeeiP08048.
CleanExiHS_ZFY.
GenevestigatoriP08048.

Organism-specific databases

HPAiHPA001748.

Interactioni

Protein-protein interaction databases

BioGridi113376. 3 interactions.
STRINGi9606.ENSP00000155093.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi575 – 5784
Beta strandi580 – 5834
Helixi585 – 59410

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KLRNMR-A570-598[»]
1KLSNMR-A570-598[»]
1XRZNMR-A570-598[»]
5ZNFNMR-A570-598[»]
7ZNFNMR-A570-598[»]
ProteinModelPortaliP08048.
SMRiP08048. Positions 421-794.

Miscellaneous databases

EvolutionaryTraceiP08048.

Family & Domainsi

Domaini

The binding of ZFY to DNA is mediated by the interaction of the GGCC core base pairs with zinc fingers 12 and 13.1 Publication

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000231717.
HOVERGENiHBG000337.
InParanoidiP08048.
OMAiTCVMALE.
OrthoDBiEOG7P8P73.
PhylomeDBiP08048.
TreeFamiTF335557.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR006794. Transcrp_activ_Zfx/Zfy-dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
PF04704. Zfx_Zfy_act. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 13 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P08048-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDEDEFELQP QEPNSFFDGI GADATHMDGD QIVVEIQEAV FVSNIVDSDI    50
TVHNFVPDDP DSVVIQDVVE DVVIEEDVQC SDILEEADVS ENVIIPEQVL 100
DSDVTEEVSL PHCTVPDDVL ASDITSTSMS MPEHVLTSES MHVCDIGHVE 150
HMVHDSVVEA EIITDPLTSD IVSEEVLVAD CAPEAVIDAS GISVDQQDND 200
KASCEDYLMI SLDDAGKIEH DGSTGVTIDA ESEMDPCKVD STCPEVIKVY 250
IFKADPGEDD LGGTVDIVES EPENDHGVEL LDQNSSIRVP REKMVYMTVN 300
DSQQEDEDLN VAEIADEVYM EVIVGEEDAA VAAAAAAVHE QQIDEDEMKT 350
FVPIAWAAAY GNNSDGIENR NGTASALLHI DESAGLGRLA KQKPKKKRRP 400
DSRQYQTAII IGPDGHPLTV YPCMICGKKF KSRGFLKRHM KNHPEHLAKK 450
KYHCTDCDYT TNKKISLHNH LESHKLTSKA EKAIECDECG KHFSHAGALF 500
THKMVHKEKG ANKMHKCKFC EYETAEQGLL NRHLLAVHSK NFPHICVECG 550
KGFRHPSELR KHMRIHTGEK PYQCQYCEYR SADSSNLKTH IKTKHSKEMP 600
FKCDICLLTF SDTKEVQQHT LVHQESKTHQ CLHCDHKSSN SSDLKRHVIS 650
VHTKDYPHKC EMCEKGFHRP SELKKHVAVH KGKKMHQCRH CDFKIADPFV 700
LSRHILSVHT KDLPFRCKRC RKGFRQQNEL KKHMKTHSGR KVYQCEYCEY 750
STTDASGFKR HVISIHTKDY PHRCEYCKKG FRRPSEKNQH IMRHHKEVGL 800
P 801
Length:801
Mass (Da):90,505
Last modified:August 16, 2004 - v3
Checksum:i956B9B3DA16648FA
GO
Isoform 2 (identifier: P08048-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-21: G → V
     22-212: Missing.

Note: No experimental confirmation available.

Show »
Length:610
Mass (Da):69,907
Checksum:iFA9C3797807D5C3C
GO
Isoform 3 (identifier: P08048-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.
     310-310: N → S
     311-361: Missing.

Note: No experimental confirmation available.

Show »
Length:724
Mass (Da):82,165
Checksum:i95DDCD4D9E11A43C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2626Missing in isoform 3.
VSP_042824Add
BLAST
Alternative sequencei21 – 211G → V in isoform 2.
VSP_042774
Alternative sequencei22 – 212191Missing in isoform 2.
VSP_042775Add
BLAST
Alternative sequencei310 – 3101N → S in isoform 3.
VSP_042825
Alternative sequencei311 – 36151Missing in isoform 3.
VSP_042826Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti333 – 3331A → R in AAA72344. 1 Publication
Sequence conflicti398 – 40710RRPDSRQYQT → ALILLSFPFL1 Publication
Sequence conflicti554 – 5541R → S1 Publication
Sequence conflicti555 – 5551H → Y in AAA61310. 1 Publication
Sequence conflicti630 – 6301Missing1 Publication
Sequence conflicti767 – 7671T → R1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10393 mRNA. Translation: AAA72344.1.
M30607 mRNA. Translation: AAA61310.1.
AF114156 Genomic DNA. Translation: AAF21973.1.
AK301061 mRNA. Translation: BAG62669.1.
AC006157 Genomic DNA. Translation: AAD15612.1.
BC114526 mRNA. Translation: AAI14527.1.
BC114960 mRNA. Translation: AAI14961.1.
X15470 Genomic DNA. Translation: CAA33498.1.
CCDSiCCDS14774.1. [P08048-1]
CCDS48200.1. [P08048-2]
CCDS48201.1. [P08048-3]
PIRiA33630.
RefSeqiNP_001138747.1. NM_001145275.1. [P08048-3]
NP_001138748.1. NM_001145276.1. [P08048-2]
NP_003402.2. NM_003411.3. [P08048-1]
XP_005262627.1. XM_005262570.1. [P08048-1]
XP_006724936.1. XM_006724873.1. [P08048-1]
UniGeneiHs.522845.

Genome annotation databases

EnsembliENST00000155093; ENSP00000155093; ENSG00000067646. [P08048-1]
ENST00000383052; ENSP00000372525; ENSG00000067646. [P08048-1]
ENST00000431102; ENSP00000402502; ENSG00000067646. [P08048-2]
ENST00000449237; ENSP00000393908; ENSG00000067646. [P08048-3]
GeneIDi7544.
KEGGihsa:7544.
UCSCiuc004fqj.3. human. [P08048-1]
uc010nwe.3. human. [P08048-3]
uc011nan.2. human. [P08048-2]

Polymorphism databases

DMDMi51338719.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10393 mRNA. Translation: AAA72344.1 .
M30607 mRNA. Translation: AAA61310.1 .
AF114156 Genomic DNA. Translation: AAF21973.1 .
AK301061 mRNA. Translation: BAG62669.1 .
AC006157 Genomic DNA. Translation: AAD15612.1 .
BC114526 mRNA. Translation: AAI14527.1 .
BC114960 mRNA. Translation: AAI14961.1 .
X15470 Genomic DNA. Translation: CAA33498.1 .
CCDSi CCDS14774.1. [P08048-1 ]
CCDS48200.1. [P08048-2 ]
CCDS48201.1. [P08048-3 ]
PIRi A33630.
RefSeqi NP_001138747.1. NM_001145275.1. [P08048-3 ]
NP_001138748.1. NM_001145276.1. [P08048-2 ]
NP_003402.2. NM_003411.3. [P08048-1 ]
XP_005262627.1. XM_005262570.1. [P08048-1 ]
XP_006724936.1. XM_006724873.1. [P08048-1 ]
UniGenei Hs.522845.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1KLR NMR - A 570-598 [» ]
1KLS NMR - A 570-598 [» ]
1XRZ NMR - A 570-598 [» ]
5ZNF NMR - A 570-598 [» ]
7ZNF NMR - A 570-598 [» ]
ProteinModelPortali P08048.
SMRi P08048. Positions 421-794.
ModBasei Search...

Protein-protein interaction databases

BioGridi 113376. 3 interactions.
STRINGi 9606.ENSP00000155093.

PTM databases

PhosphoSitei P08048.

Polymorphism databases

DMDMi 51338719.

Proteomic databases

MaxQBi P08048.
PaxDbi P08048.
PRIDEi P08048.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000155093 ; ENSP00000155093 ; ENSG00000067646 . [P08048-1 ]
ENST00000383052 ; ENSP00000372525 ; ENSG00000067646 . [P08048-1 ]
ENST00000431102 ; ENSP00000402502 ; ENSG00000067646 . [P08048-2 ]
ENST00000449237 ; ENSP00000393908 ; ENSG00000067646 . [P08048-3 ]
GeneIDi 7544.
KEGGi hsa:7544.
UCSCi uc004fqj.3. human. [P08048-1 ]
uc010nwe.3. human. [P08048-3 ]
uc011nan.2. human. [P08048-2 ]

Organism-specific databases

CTDi 7544.
GeneCardsi GC0YP002846.
HGNCi HGNC:12870. ZFY.
HPAi HPA001748.
MIMi 490000. gene.
neXtProti NX_P08048.
PharmGKBi PA37459.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000231717.
HOVERGENi HBG000337.
InParanoidi P08048.
OMAi TCVMALE.
OrthoDBi EOG7P8P73.
PhylomeDBi P08048.
TreeFami TF335557.

Miscellaneous databases

EvolutionaryTracei P08048.
GeneWikii ZFY.
GenomeRNAii 7544.
NextBioi 29517.
PROi P08048.
SOURCEi Search...

Gene expression databases

ArrayExpressi P08048.
Bgeei P08048.
CleanExi HS_ZFY.
Genevestigatori P08048.

Family and domain databases

Gene3Di 3.30.160.60. 7 hits.
InterProi IPR006794. Transcrp_activ_Zfx/Zfy-dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 4 hits.
PF04704. Zfx_Zfy_act. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 13 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues."
    Lau Y.-F.C., Chan K.
    Am. J. Hum. Genet. 45:942-952(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans."
    Erlandsson R., Wilson J.F., Paabo S.
    Mol. Biol. Evol. 17:804-812(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Spleen.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
  7. "The sex-determining region of the human Y chromosome encodes a finger protein."
    Page D.C., Mosher R., Simpson E.M., Fisher E.M.C., Mardon G., Pollack J., McGillivray B., de la Chapelle A., Brown L.G.
    Cell 51:1091-1104(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 408-801.
  8. "Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY."
    North M., Sargent C., O'Brien J., Taylor K., Wolfe J., Affara N.A., Ferguson-Smith M.A.
    Nucleic Acids Res. 19:2579-2586(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 423-801.
  9. "Evidence for distinguishable transcripts of the putative testis determining gene (ZFY) and mapping of homologous cDNA sequences to chromosomes X,Y and 9."
    Affara N.A., Chambers D., O'Brien J., Habeebu S.S.M., Kalaitsidaki M., Bishop C.E., Ferguson-Smith M.A.
    Nucleic Acids Res. 17:2987-2999(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 397-446.
  10. "Characterization of the DNA binding activity of the ZFY zinc finger domain."
    Grants J., Flanagan E., Yee A., Romaniuk P.J.
    Biochemistry 49:679-686(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DOMAIN DNA-BINDING.
  11. "Alternating zinc fingers in the human male associated protein ZFY: 2D NMR structure of an even finger and implications for 'jumping-linker' DNA recognition."
    Kochoyan M., Havel T.F., Nguyen D.Z., Dahl C.E., Keutmann H.T., Weiss M.A.
    Biochemistry 30:3371-3386(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF ZINC-FINGERS.
  12. "Alternating zinc fingers in the human male associated protein ZFY: refinement of the NMR structure of an even finger by selective deuterium labeling and implications for DNA recognition."
    Kochoyan M., Keutmann H.T., Weiss M.A.
    Biochemistry 30:7063-7072(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF ZINC-FINGERS.
  13. "Solvation and the hidden thermodynamics of a zinc finger probed by nonstandard repair of a protein crevice."
    Lachenmann M.J., Ladbury J.E., Qian X., Huang K., Singh R., Weiss M.A.
    Protein Sci. 13:3115-3126(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 572-598.

Entry informationi

Entry nameiZFY_HUMAN
AccessioniPrimary (citable) accession number: P08048
Secondary accession number(s): B4DVF7
, Q14021, Q15558, Q1RME9, Q24JR0, Q96TF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 16, 2004
Last modified: July 9, 2014
This is version 153 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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