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Protein

Zinc finger protein Xfin

Gene
N/A
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to poly-G sequences in RNA. May function in post-translational regulation processes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri108 – 130C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri136 – 158C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri164 – 186C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri192 – 214C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri220 – 242C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri248 – 270C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri276 – 298C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri559 – 581C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri587 – 609C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri615 – 637C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri643 – 665C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri671 – 693C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri699 – 721C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri750 – 772C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri778 – 800C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri806 – 828C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri834 – 856C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri862 – 884C2H2-type 26PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri890 – 912C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri918 – 940C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri988 – 1010C2H2-type 29PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1016 – 1038C2H2-type 30PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1044 – 1066C2H2-type 31PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1136 – 1158C2H2-type 32PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1164 – 1186C2H2-type 33PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1192 – 1214C2H2-type 34PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1220 – 1242C2H2-type 35PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1248 – 1270C2H2-type 36PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1276 – 1298C2H2-type 37PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein Xfin
Alternative name(s):
Xenopus fingers protein
Short name:
Xfin
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252152. znf208.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470871 – 1350Zinc finger protein XfinAdd BLAST1350

Post-translational modificationi

Phosphorylated. Phosphorylation enhances RNA binding.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP08045.

Expressioni

Tissue specificityi

Expressed in oocytes, and in specialized cell types such as neural retina cones in adults.2 Publications

Developmental stagei

Expressed both maternally and zygotically throughout oogenesis and embryogenesis through to at least the tadpole stage. Also expressed in adults.2 Publications

Structurei

Secondary structure

11350
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1047 – 1049Combined sources3
Helixi1056 – 1062Combined sources7
Helixi1063 – 1065Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZNFNMR-A1044-1068[»]
ProteinModelPortaliP08045.
SMRiP08045.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08045.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 58KRABPROSITE-ProRule annotationAdd BLAST58

Sequence similaritiesi

Contains 37 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri108 – 130C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri136 – 158C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri164 – 186C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri192 – 214C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri220 – 242C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri248 – 270C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri276 – 298C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri559 – 581C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri587 – 609C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri615 – 637C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri643 – 665C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri671 – 693C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri699 – 721C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri750 – 772C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri778 – 800C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri806 – 828C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri834 – 856C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri862 – 884C2H2-type 26PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri890 – 912C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri918 – 940C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri988 – 1010C2H2-type 29PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1016 – 1038C2H2-type 30PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1044 – 1066C2H2-type 31PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1136 – 1158C2H2-type 32PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1164 – 1186C2H2-type 33PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1192 – 1214C2H2-type 34PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1220 – 1242C2H2-type 35PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1248 – 1270C2H2-type 36PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1276 – 1298C2H2-type 37PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG018163.
KOiK09228.

Family and domain databases

Gene3Di3.30.160.60. 36 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 14 hits.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 37 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 35 hits.
PS50157. ZINC_FINGER_C2H2_2. 37 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08045-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEPKCLQRE MYKSVMTENY QCVLSLGYPI RKPEIVSMME VGEELWSKND
60 70 80 90 100
SARPGQKEVE GETPKESDWA AENCKRAQMH KEVLDLDTLA AVKSEPVEEG
110 120 130 140 150
SNSAKKSHIC SHYGKLFSCY AAVVRHQRMH QLQKSHHCPH CKKSFVQRSD
160 170 180 190 200
FIKHQRTHTG ERPYQCVECQ KKFTERSALV NHQRTHTGER PYTCLDCQKT
210 220 230 240 250
FNQRSALTKH RRTHTGERPY RCSVCSKSFI QNSDLVKHLR THTGEKPYEC
260 270 280 290 300
PLCVKRFAES SALMKHKRTH STHRPFRCSE CSRSFTHNSD LTAHMRKHTE
310 320 330 340 350
FRNVLNLDSV VGTDPLSSQN VASSPYSCSK CRKTFKRWKS FLNHQQTHSR
360 370 380 390 400
EKPYLCSHCN KGFIQNSDLV KHFRTHTGER PYQCAECHKG FIQKSDLVKH
410 420 430 440 450
LRTHTGEKPF KCSHCDKKFT ERSALAKHQR THTGEKPYKC SDCGKEFTQR
460 470 480 490 500
SNLILHQRIH TGERPYKCTL CDRTFIQNSD LVKHQKVHAN LPLSDPHTAN
510 520 530 540 550
SPHKCSKCDL TFSHWSTFMK HSKLHSGEKK FQCAECKKGF TQKSDLVKHI
560 570 580 590 600
RVHTGEKPFK CLLCKKSFSQ NSDLHKHWRI HTGEKPFPCY TCDKSFTERS
610 620 630 640 650
ALIKHHRTHT GERPHKCSVC QKGFIQKSAL TKHSRTHTGE KPYPCTQCGK
660 670 680 690 700
SFIQNSDLVK HQRIHTGEKP YHCTECNKRF TEGSSLVKHR RTHSGEKPYR
710 720 730 740 750
CPQCEKTFIQ SSDLVKHLVV HNGENPPAAT AFHEILIRRE NLTRSEPDPY
760 770 780 790 800
PCTECGKVFH QRPALLKHLR THKTEKRYPC NECDKSFFQT SDLVKHLRTH
810 820 830 840 850
TGERPYHCPE CNKGFIQNSD LVKHQRTHTG ERPYTCSQCD KGFIQRSALT
860 870 880 890 900
KHMRTHTGEK PYKCEQCQKC FIQNSDLVKH QRIHTGEKPY HCPDCDKRFT
910 920 930 940 950
EGSSLIKHQR IHSRIKPYPC GVCGKSFSQS SNLLKHLKCH SEQNPPVALS
960 970 980 990 1000
SELGFVAETQ THPDPVDHIV YGDTASYISP EAAGERSFKC NDCGKCFAHR
1010 1020 1030 1040 1050
SVLIKHVRIH TGERPYKCSQ CTRSFIQKSD LVKHYRTHTG ERPYKCGLCE
1060 1070 1080 1090 1100
RSFVEKSALS RHQRVHKNES PVLNSAMEQQ QVTYWGESKD DPNSLVPQLH
1110 1120 1130 1140 1150
VIKEEESPHI VNAYSPLSIL QSYFPPILEP KGTPRYSCSE CGKCFTHRSV
1160 1170 1180 1190 1200
FLKHWRMHTG EQPYTCKECG KSFSQSSALV KHVRIHTGEK PYPCSTCGKS
1210 1220 1230 1240 1250
FIQKSDLAKH QRIHTGEKPY TCTVCGKKFI DRSSVVKHSR THTGERPYKC
1260 1270 1280 1290 1300
NECTKGFVQK SDLVKHMRTH TGEKPYGCNC CDRSFSTHSA SVRHQRMCNT
1310 1320 1330 1340 1350
GRPYQDEEYE NSLFYSADIT WKGDYAQLLQ IPCGLEEPMK AIGWISEVAL
Length:1,350
Mass (Da):155,805
Last modified:August 1, 1988 - v1
Checksum:i27F10AB0851E0AD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06021 mRNA. Translation: CAA29425.1.
PIRiS00647.
RefSeqiNP_001095247.1. NM_001101777.1.
UniGeneiXl.25.

Genome annotation databases

GeneIDi397958.
KEGGixla:397958.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06021 mRNA. Translation: CAA29425.1.
PIRiS00647.
RefSeqiNP_001095247.1. NM_001101777.1.
UniGeneiXl.25.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZNFNMR-A1044-1068[»]
ProteinModelPortaliP08045.
SMRiP08045.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP08045.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397958.
KEGGixla:397958.

Organism-specific databases

CTDi7757.
XenbaseiXB-GENE-6252152. znf208.

Phylogenomic databases

HOVERGENiHBG018163.
KOiK09228.

Miscellaneous databases

EvolutionaryTraceiP08045.

Family and domain databases

Gene3Di3.30.160.60. 36 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 14 hits.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 37 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 35 hits.
PS50157. ZINC_FINGER_C2H2_2. 37 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXFIN_XENLA
AccessioniPrimary (citable) accession number: P08045
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.