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Protein

Protein snail

Gene

sna

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the correct specification of ventral-dorsal patterns.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri245 – 267C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 385C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

  • DNA binding Source: FlyBase
  • metal ion binding Source: UniProtKB-KW
  • regulatory region DNA binding Source: FlyBase
  • repressing transcription factor binding Source: FlyBase
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: FlyBase
  • sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • adherens junction organization Source: FlyBase
  • asymmetric neuroblast division Source: FlyBase
  • central nervous system development Source: FlyBase
  • compound eye development Source: FlyBase
  • dendrite morphogenesis Source: FlyBase
  • dorsal/ventral axis specification Source: FlyBase
  • ectoderm and mesoderm interaction Source: FlyBase
  • gastrulation Source: FlyBase
  • gastrulation involving germ band extension Source: FlyBase
  • Malpighian tubule morphogenesis Source: FlyBase
  • mesodermal cell fate determination Source: FlyBase
  • mesodermal cell fate specification Source: FlyBase
  • mesoderm development Source: FlyBase
  • muscle organ development Source: FlyBase
  • negative regulation of gene expression Source: FlyBase
  • negative regulation of transcription, DNA-templated Source: FlyBase
  • negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • positive regulation of histone deacetylation Source: FlyBase
  • positive regulation of transcription, DNA-templated Source: FlyBase
  • positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • ventral furrow formation Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiP08044.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein snail
Gene namesi
Name:sna
ORF Names:CG3956
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0003448. sna.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470281 – 390Protein snailAdd BLAST390

Proteomic databases

PaxDbiP08044.
PRIDEiP08044.

Expressioni

Gene expression databases

BgeeiFBgn0003448.
GenevisibleiP08044. DM.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • repressing transcription factor binding Source: FlyBase

Protein-protein interaction databases

BioGridi60924. 12 interactors.
DIPiDIP-21498N.
IntActiP08044. 2 interactors.
MINTiMINT-883963.
STRINGi7227.FBpp0080298.

Structurei

3D structure databases

ProteinModelPortaliP08044.
SMRiP08044.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 20SNAG domainBy similarityAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi209 – 234Ser-richAdd BLAST26

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri245 – 267C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 385C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2462. Eukaryota.
ENOG41106JS. LUCA.
GeneTreeiENSGT00390000011027.
InParanoidiP08044.
KOiK09218.
OMAiNCTITIA.
OrthoDBiEOG091G0Q0V.

Family and domain databases

InterProiView protein in InterPro
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 5 hits.
SUPFAMiSSF57667. SSF57667. 3 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.

Sequencei

Sequence statusi: Complete.

P08044-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANYKSCPL KKRPIVFVEE RLPQTEALAL TKDSQFAQDQ PQDLSLKRGR
60 70 80 90 100
DEETQDYQQP EPKRDYVLNL SKTPERNSSS SSNSCLLSPP VEAQDYLPTE
110 120 130 140 150
IHMRGLTAGT TGYTTATPTT INPFQSAFVM AAGCNPISAL WSSYQPHLAA
160 170 180 190 200
FPSPASSMAS PQSVYSYQQM TPPSSPGSDL ETGSEPEDLS VRNDIPLPAL
210 220 230 240 250
FHLFDEAKSS SSGASVSSSS GYSYTPAMSA SSASVAANHA KNYRFKCDEC
260 270 280 290 300
QKMYSTSMGL SKHRQFHCPA AECNQEKKTH SCEECGKLYT TIGALKMHIR
310 320 330 340 350
THTLPCKCPI CGKAFSRPWL LQGHIRTHTG EKPFQCPDCP RSFADRSNLR
360 370 380 390
AHQQTHVDVK KYACQVCHKS FSRMSLLNKH SSSNCTITIA
Length:390
Mass (Da):42,955
Last modified:November 2, 2001 - v2
Checksum:iE50611680EC6F6EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93A → T (PubMed:3683556).Curated1
Sequence conflicti93A → T (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00288 mRNA. Translation: CAA68397.1.
AJ251486 Genomic DNA. Translation: CAB62556.1.
AE014134 Genomic DNA. Translation: AAF53463.1.
BT010255 mRNA. Translation: AAQ23573.1.
PIRiS06222.
RefSeqiNP_476732.1. NM_057384.4.
UniGeneiDm.3035.

Genome annotation databases

EnsemblMetazoaiFBtr0080739; FBpp0080298; FBgn0003448.
GeneIDi34908.
KEGGidme:Dmel_CG3956.
UCSCiCG3956-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiSNAI_DROME
AccessioniPrimary (citable) accession number: P08044
Secondary accession number(s): Q9V3D3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: November 2, 2001
Last modified: October 25, 2017
This is version 177 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families