UniProtKB - P08030 (APT_MOUSE)
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Protein
Adenine phosphoribosyltransferase
Gene
Aprt
Organism
Mus musculus (Mouse)
Status
Functioni
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
Catalytic activityi
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.
: AMP biosynthesis via salvage pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes AMP from adenine.Proteins known to be involved in this subpathway in this organism are:
- Adenine phosphoribosyltransferase (Aprt)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from adenine, the pathway AMP biosynthesis via salvage pathway and in Purine metabolism.
GO - Molecular functioni
- adenine binding Source: MGI
- adenine phosphoribosyltransferase activity Source: MGI
- AMP binding Source: MGI
GO - Biological processi
- adenine metabolic process Source: MGI
- adenine salvage Source: MGI
- AMP salvage Source: UniProtKB-UniPathway
- cellular response to insulin stimulus Source: Ensembl
- grooming behavior Source: MGI
- lactation Source: Ensembl
- purine ribonucleoside salvage Source: MGI
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Biological process | Purine salvage |
Enzyme and pathway databases
Reactomei | R-MMU-6798695 Neutrophil degranulation R-MMU-74217 Purine salvage |
UniPathwayi | UPA00588; UER00646 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Aprt |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88061 Aprt |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000149506 | 2 – 180 | Adenine phosphoribosyltransferaseAdd BLAST | 179 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 15 | PhosphoserineCombined sources | 1 | |
Modified residuei | 30 | PhosphoserineBy similarity | 1 | |
Modified residuei | 60 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 66 | PhosphoserineBy similarity | 1 | |
Modified residuei | 114 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 135 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P08030 |
PaxDbi | P08030 |
PeptideAtlasi | P08030 |
PRIDEi | P08030 |
PTM databases
iPTMneti | P08030 |
PhosphoSitePlusi | P08030 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000006589 |
CleanExi | MM_APRT |
ExpressionAtlasi | P08030 baseline and differential |
Genevisiblei | P08030 MM |
Interactioni
Subunit structurei
Homodimer.
Protein-protein interaction databases
BioGridi | 1981683 interactors. |
IntActi | P08030 4 interactors. |
MINTi | P08030 |
STRINGi | 10090.ENSMUSP00000006764 |
Structurei
3D structure databases
ProteinModelPortali | P08030 |
SMRi | P08030 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the purine/pyrimidine phosphoribosyltransferase family.Curated
Phylogenomic databases
eggNOGi | KOG1712 Eukaryota COG0503 LUCA |
GeneTreei | ENSGT00390000017259 |
HOGENOMi | HOG000036776 |
HOVERGENi | HBG003144 |
InParanoidi | P08030 |
KOi | K00759 |
OMAi | CAPIRKK |
OrthoDBi | EOG091G0XZC |
TreeFami | TF300227 |
Family and domain databases
CDDi | cd06223 PRTases_typeI, 1 hit |
HAMAPi | MF_00004 Aden_phosphoribosyltr, 1 hit |
InterProi | View protein in InterPro IPR005764 Ade_phspho_trans IPR000836 PRibTrfase_dom IPR029057 PRTase-like |
Pfami | View protein in Pfam PF00156 Pribosyltran, 1 hit |
SUPFAMi | SSF53271 SSF53271, 1 hit |
TIGRFAMsi | TIGR01090 apt, 1 hit |
PROSITEi | View protein in PROSITE PS00103 PUR_PYR_PR_TRANSFER, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P08030-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEPELKLVA RRIRSFPDFP IPGVLFRDIS PLLKDPDSFR ASIRLLASHL
60 70 80 90 100
KSTHSGKIDY IAGLDSRGFL FGPSLAQELG VGCVLIRKQG KLPGPTVSAS
110 120 130 140 150
YSLEYGKAEL EIQKDALEPG QRVVIVDDLL ATGGTMFAAC DLLHQLRAEV
160 170 180
VECVSLVELT SLKGRERLGP IPFFSLLQYD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 6 – 7 | LK → FE in BAB22029 (PubMed:16141072).Curated | 2 | |
Sequence conflicti | 15 | S → V in AAA37255 (PubMed:3921964).Curated | 1 | |
Sequence conflicti | 24 | V → A in BAB22029 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 46 | L → S in BAB22029 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 72 | G → A in BAB22029 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 107 | K → KVR in AAA37256 (PubMed:8433377).Curated | 1 | |
Sequence conflicti | 135 | T → I in BAD95572 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M11310 mRNA Translation: AAA37255.1 AB033539 mRNA Translation: BAD95571.1 AB033540 mRNA Translation: BAD95572.1 AK002350 mRNA Translation: BAB22029.1 AK153201 mRNA Translation: BAE31801.1 AC114917 Genomic DNA No translation available. CH466525 Genomic DNA Translation: EDL11692.1 BC005667 mRNA Translation: AAH05667.1 M86439 Genomic DNA Translation: AAA37256.1 |
CCDSi | CCDS40503.1 |
PIRi | A22670 RTMSA |
RefSeqi | NP_033828.2, NM_009698.2 |
UniGenei | Mm.1786 |
Genome annotation databases
Ensembli | ENSMUST00000006764; ENSMUSP00000006764; ENSMUSG00000006589 |
GeneIDi | 11821 |
KEGGi | mmu:11821 |
UCSCi | uc009ntf.1 mouse |
Similar proteinsi
Entry informationi
Entry namei | APT_MOUSE | |
Accessioni | P08030Primary (citable) accession number: P08030 Secondary accession number(s): Q564P4 Q9DCY3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | February 6, 2013 | |
Last modified: | February 28, 2018 | |
This is version 142 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |