Aprt

Functionⁱ

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.

Catalytic activityⁱ

AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathwayⁱ: AMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes AMP from adenine.
Proteins known to be involved in this subpathway in this organism are:

Adenine phosphoribosyltransferase (Aprt)

This subpathway is part of the pathway AMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from adenine, the pathway AMP biosynthesis via salvage pathway and in Purine metabolism.

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenine metabolic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 8643571
- 8894695
adenine salvage
Source: MGI
Inferred from mutant phenotypeⁱ
- 8864750
AMP salvage Source: UniProtKB-UniPathway
cellular response to insulin stimulus Source: Ensembl
grooming behavior
Source: MGI
Inferred from genetic interactionⁱ
- 8485579
lactation Source: Ensembl
purine ribonucleoside salvage
Source: MGI
Inferred from mutant phenotypeⁱ
- 8485579

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosyltransferase, Transferase
Biological process	Purine salvage

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6798695 Neutrophil degranulation R-MMU-74217 Purine salvage
UniPathwayⁱ	UPA00588; UER00646

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Adenine phosphoribosyltransferase (EC:2.4.2.7) Short name: APRT
Gene namesⁱ	Name:Aprt
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 8

Organism-specific databases

MGIⁱ	MGI:88061 Aprt

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000149506	2 – 180	Adenine phosphoribosyltransferaseAdd BLAST		179

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineBy similarity	1
Modified residueⁱ	15	PhosphoserineCombined sources	1
Modified residueⁱ	30	PhosphoserineBy similarity	1
Modified residueⁱ	60	PhosphotyrosineBy similarity	1
Modified residueⁱ	66	PhosphoserineBy similarity	1
Modified residueⁱ	114	N6-acetyllysineBy similarity	1
Modified residueⁱ	135	PhosphothreonineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P08030
PaxDbⁱ	P08030
PeptideAtlas More...PeptideAtlasⁱ	P08030
PRIDEⁱ	P08030

PTM databases

iPTMnetⁱ	P08030
PhosphoSitePlusⁱ	P08030

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000006589
CleanExⁱ	MM_APRT
ExpressionAtlasⁱ	P08030 baseline and differential
Genevisibleⁱ	P08030 MM

Interactionⁱ

Subunit structureⁱ

Homodimer.

Protein-protein interaction databases

BioGridⁱ	1981683 interactors.
IntActⁱ	P08030 4 interactors.
Molecular INTeraction database More...MINTⁱ	P08030
STRINGⁱ	10090.ENSMUSP00000006764

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P08030
SMRⁱ	P08030
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the purine/pyrimidine phosphoribosyltransferase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1712 Eukaryota COG0503 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017259
HOGENOMⁱ	HOG000036776
HOVERGENⁱ	HBG003144
InParanoidⁱ	P08030
KEGG Orthology (KO) More...KOⁱ	K00759
OMAⁱ	CAPIRKK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XZC
TreeFamⁱ	TF300227

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06223 PRTases_typeI, 1 hit
HAMAPⁱ	MF_00004 Aden_phosphoribosyltr, 1 hit
InterProⁱ	View protein in InterPro IPR005764 Ade_phspho_trans IPR000836 PRibTrfase_dom IPR029057 PRTase-like
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00156 Pribosyltran, 1 hit
SUPFAMⁱ	SSF53271 SSF53271, 1 hit
TIGRFAMsⁱ	TIGR01090 apt, 1 hit
PROSITEⁱ	View protein in PROSITE PS00103 PUR_PYR_PR_TRANSFER, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P08030-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSEPELKLVA RRIRSFPDFP IPGVLFRDIS PLLKDPDSFR ASIRLLASHL 
        60         70         80         90        100
KSTHSGKIDY IAGLDSRGFL FGPSLAQELG VGCVLIRKQG KLPGPTVSAS 
       110        120        130        140        150
YSLEYGKAEL EIQKDALEPG QRVVIVDDLL ATGGTMFAAC DLLHQLRAEV 
       160        170        180
VECVSLVELT SLKGRERLGP IPFFSLLQYD

Length:180

Mass (Da):19,724

Last modified:February 6, 2013 - v2

Checksum:ⁱA6AE4DBE0B456E42

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	6 – 7	LK → FE in BAB22029 (PubMed:16141072).Curated	2
Sequence conflictⁱ	15	S → V in AAA37255 (PubMed:3921964).Curated	1
Sequence conflictⁱ	24	V → A in BAB22029 (PubMed:16141072).Curated	1
Sequence conflictⁱ	46	L → S in BAB22029 (PubMed:16141072).Curated	1
Sequence conflictⁱ	72	G → A in BAB22029 (PubMed:16141072).Curated	1
Sequence conflictⁱ	107	K → KVR in AAA37256 (PubMed:8433377).Curated	1
Sequence conflictⁱ	135	T → I in BAD95572 (Ref. 2) Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M11310 mRNA Translation: AAA37255.1 AB033539 mRNA Translation: BAD95571.1 AB033540 mRNA Translation: BAD95572.1 AK002350 mRNA Translation: BAB22029.1 AK153201 mRNA Translation: BAE31801.1 AC114917 Genomic DNA No translation available. CH466525 Genomic DNA Translation: EDL11692.1 BC005667 mRNA Translation: AAH05667.1 M86439 Genomic DNA Translation: AAA37256.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS40503.1
PIRⁱ	A22670 RTMSA
NCBI Reference Sequences More...RefSeqⁱ	NP_033828.2, NM_009698.2
UniGeneⁱ	Mm.1786

Genome annotation databases

Ensemblⁱ	ENSMUST00000006764; ENSMUSP00000006764; ENSMUSG00000006589
GeneIDⁱ	11821
KEGGⁱ	mmu:11821
UCSC genome browser More...UCSCⁱ	uc009ntf.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P08030	P47957 A0A1L2D330 A0A0P6DC66	Mus spicilegus (Steppe mouse) Mus spretus (Western Mediterranean mouse) (Algerian mouse) Daphnia magna	180	UniRef100_P08030	Cluster: Adenine phosphoribosyltransferase	4

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P08030	P47957 A0A1L2D330 A0A0P6DC66 P47956 P47958 UPI000A30FADB UPI000A317AF8	Mus spicilegus (Steppe mouse) Mus spretus (Western Mediterranean mouse) (Algerian mouse) Daphnia magna Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Stochomys longicaudatus (Target rat) Mus caroli (Ryukyu mouse) (Ricefield mouse)	180	UniRef90_P08030	Cluster: Adenine phosphoribosyltransferase	8

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P08030	P47957 A0A1L2D330 A0A0P6DC66 UPI000A30FADB P47956 P47958 UPI000A317AF8 H0ZBM0 B5FX92 A0A1B6LPU1 +119	Mus spicilegus (Steppe mouse) Mus spretus (Western Mediterranean mouse) (Algerian mouse) Daphnia magna Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Stochomys longicaudatus (Target rat) Mus caroli (Ryukyu mouse) (Ricefield mouse) Taeniopygia guttata (Zebra finch) (Poephila guttata) Graphocephala atropunctata Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi) Erinaceus europaeus (Western European hedgehog) And more	180	UniRef50_P08030	Cluster: Adenine phosphoribosyltransferase	130

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M11310 mRNA Translation: AAA37255.1 AB033539 mRNA Translation: BAD95571.1 AB033540 mRNA Translation: BAD95572.1 AK002350 mRNA Translation: BAB22029.1 AK153201 mRNA Translation: BAE31801.1 AC114917 Genomic DNA No translation available. CH466525 Genomic DNA Translation: EDL11692.1 BC005667 mRNA Translation: AAH05667.1 M86439 Genomic DNA Translation: AAA37256.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS40503.1
PIRⁱ	A22670 RTMSA
NCBI Reference Sequences More...RefSeqⁱ	NP_033828.2, NM_009698.2
UniGeneⁱ	Mm.1786

3D structure databases

ProteinModelPortalⁱ	P08030
SMRⁱ	P08030
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	1981683 interactors.
IntActⁱ	P08030 4 interactors.
Molecular INTeraction database More...MINTⁱ	P08030
STRINGⁱ	10090.ENSMUSP00000006764

PTM databases

iPTMnetⁱ	P08030
PhosphoSitePlusⁱ	P08030

Proteomic databases

EPDⁱ	P08030
PaxDbⁱ	P08030
PeptideAtlas More...PeptideAtlasⁱ	P08030
PRIDEⁱ	P08030

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000006764; ENSMUSP00000006764; ENSMUSG00000006589
GeneIDⁱ	11821
KEGGⁱ	mmu:11821
UCSC genome browser More...UCSCⁱ	uc009ntf.1 mouse

Organism-specific databases

CTDⁱ	353
MGIⁱ	MGI:88061 Aprt

Phylogenomic databases

eggNOGⁱ	KOG1712 Eukaryota COG0503 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017259
HOGENOMⁱ	HOG000036776
HOVERGENⁱ	HBG003144
InParanoidⁱ	P08030
KEGG Orthology (KO) More...KOⁱ	K00759
OMAⁱ	CAPIRKK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XZC
TreeFamⁱ	TF300227

Enzyme and pathway databases

UniPathwayⁱ	UPA00588; UER00646
Reactomeⁱ	R-MMU-6798695 Neutrophil degranulation R-MMU-74217 Purine salvage

Miscellaneous databases

ChiTaRSⁱ	Aprt mouse
Protein Ontology More...PROⁱ	PR:P08030
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000006589
CleanExⁱ	MM_APRT
ExpressionAtlasⁱ	P08030 baseline and differential
Genevisibleⁱ	P08030 MM

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06223 PRTases_typeI, 1 hit
HAMAPⁱ	MF_00004 Aden_phosphoribosyltr, 1 hit
InterProⁱ	View protein in InterPro IPR005764 Ade_phspho_trans IPR000836 PRibTrfase_dom IPR029057 PRTase-like
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00156 Pribosyltran, 1 hit
SUPFAMⁱ	SSF53271 SSF53271, 1 hit
TIGRFAMsⁱ	TIGR01090 apt, 1 hit
PROSITEⁱ	View protein in PROSITE PS00103 PUR_PYR_PR_TRANSFER, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	APT_MOUSE
Accessionⁱ	P08030Primary (citable) accession number: P08030 Secondary accession number(s): Q564P4 , Q61319, Q6PK77, Q9DCY3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
	Last sequence update:	February 6, 2013
	Last modified:	February 28, 2018
	This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P08030 (APT_MOUSE)

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Adenine phosphoribosyltransferase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: AMP biosynthesis via salvage pathway

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: AMP biosynthesis via salvage pathway

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ