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UniProtKB - P08030 (APT_MOUSE)

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Protein

Adenine phosphoribosyltransferase

Gene

Aprt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.

Catalytic activityi

AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathwayi: AMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes AMP from adenine.
Proteins known to be involved in this subpathway in this organism are:
  1. Adenine phosphoribosyltransferase (Aprt)
This subpathway is part of the pathway AMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from adenine, the pathway AMP biosynthesis via salvage pathway and in Purine metabolism.

GO - Molecular functioni

  • adenine binding Source: MGI
  • adenine phosphoribosyltransferase activity Source: MGI
  • AMP binding Source: MGI
Complete GO annotation...

GO - Biological processi

  • adenine metabolic process Source: MGI
  • adenine salvage Source: MGI
  • AMP salvage Source: UniProtKB-UniPathway
  • cellular response to insulin stimulus Source: Ensembl
  • grooming behavior Source: MGI
  • lactation Source: Ensembl
  • purine ribonucleoside salvage Source: MGI
Complete GO annotation...

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPurine salvage

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.
R-MMU-74217. Purine salvage.
UniPathwayiUPA00588; UER00646.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine phosphoribosyltransferase (EC:2.4.2.7)
Short name:
APRT
Gene namesi
Name:Aprt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:88061. Aprt.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001495062 – 180Adenine phosphoribosyltransferaseAdd BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei15PhosphoserineCombined sources1
Modified residuei30PhosphoserineBy similarity1
Modified residuei60PhosphotyrosineBy similarity1
Modified residuei66PhosphoserineBy similarity1
Modified residuei114N6-acetyllysineBy similarity1
Modified residuei135PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP08030.
PaxDbiP08030.
PeptideAtlasiP08030.
PRIDEiP08030.

PTM databases

iPTMnetiP08030.
PhosphoSitePlusiP08030.

Expressioni

Gene expression databases

BgeeiENSMUSG00000006589.
CleanExiMM_APRT.
ExpressionAtlasiP08030. baseline and differential.
GenevisibleiP08030. MM.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi198168. 3 interactors.
IntActiP08030. 4 interactors.
MINTiMINT-4088065.
STRINGi10090.ENSMUSP00000006764.

Structurei

3D structure databases

ProteinModelPortaliP08030.
SMRiP08030.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family.Curated

Phylogenomic databases

eggNOGiKOG1712. Eukaryota.
COG0503. LUCA.
GeneTreeiENSGT00390000017259.
HOGENOMiHOG000036776.
HOVERGENiHBG003144.
InParanoidiP08030.
KOiK00759.
OMAiCAPIRKK.
OrthoDBiEOG091G0XZC.
TreeFamiTF300227.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
HAMAPiMF_00004. Aden_phosphoribosyltr. 1 hit.
InterProiView protein in InterPro
IPR005764. Ade_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
PfamiView protein in Pfam
PF00156. Pribosyltran. 1 hit.
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01090. apt. 1 hit.
PROSITEiView protein in PROSITE
PS00103. PUR_PYR_PR_TRANSFER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08030-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEPELKLVA RRIRSFPDFP IPGVLFRDIS PLLKDPDSFR ASIRLLASHL 
        60         70         80         90        100
KSTHSGKIDY IAGLDSRGFL FGPSLAQELG VGCVLIRKQG KLPGPTVSAS 
       110        120        130        140        150
YSLEYGKAEL EIQKDALEPG QRVVIVDDLL ATGGTMFAAC DLLHQLRAEV 
       160        170        180
VECVSLVELT SLKGRERLGP IPFFSLLQYD
Length:180
Mass (Da):19,724
Last modified:February 6, 2013 - v2
Checksum:iA6AE4DBE0B456E42
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6 – 7LK → FE in BAB22029 (PubMed:16141072).Curated2
Sequence conflicti15S → V in AAA37255 (PubMed:3921964).Curated1
Sequence conflicti24V → A in BAB22029 (PubMed:16141072).Curated1
Sequence conflicti46L → S in BAB22029 (PubMed:16141072).Curated1
Sequence conflicti72G → A in BAB22029 (PubMed:16141072).Curated1
Sequence conflicti107K → KVR in AAA37256 (PubMed:8433377).Curated1
Sequence conflicti135T → I in BAD95572 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11310 mRNA. Translation: AAA37255.1.
AB033539 mRNA. Translation: BAD95571.1.
AB033540 mRNA. Translation: BAD95572.1.
AK002350 mRNA. Translation: BAB22029.1.
AK153201 mRNA. Translation: BAE31801.1.
AC114917 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL11692.1.
BC005667 mRNA. Translation: AAH05667.1.
M86439 Genomic DNA. Translation: AAA37256.1.
CCDSiCCDS40503.1.
PIRiA22670. RTMSA.
RefSeqiNP_033828.2. NM_009698.2.
UniGeneiMm.1786.

Genome annotation databases

EnsembliENSMUST00000006764; ENSMUSP00000006764; ENSMUSG00000006589.
GeneIDi11821.
KEGGimmu:11821.
UCSCiuc009ntf.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiAPT_MOUSE
AccessioniPrimary (citable) accession number: P08030
Secondary accession number(s): Q564P4
, Q61319, Q6PK77, Q9DCY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: February 6, 2013
Last modified: July 5, 2017
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families