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P08009

- GSTM4_RAT

UniProt

P08009 - GSTM4_RAT

Protein

Glutathione S-transferase Yb-3

Gene

Gstm3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei116 – 1161SubstrateBy similarity

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase Yb-3 (EC:2.5.1.18)
    Alternative name(s):
    Chain 4
    GST Yb3
    GST class-mu 3
    Gene namesi
    Name:Gstm3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi621287. Gstm3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 218217Glutathione S-transferase Yb-3PRO_0000185833Add
    BLAST

    Proteomic databases

    PaxDbiP08009.
    PRIDEiP08009.

    2D gel databases

    World-2DPAGE0004:P08009.

    PTM databases

    PhosphoSiteiP08009.

    Expressioni

    Gene expression databases

    GenevestigatoriP08009.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    MINTiMINT-4565175.
    STRINGi10116.ENSRNOP00000025689.

    Structurei

    3D structure databases

    ProteinModelPortaliP08009.
    SMRiP08009. Positions 1-217.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 8887GST N-terminalAdd
    BLAST
    Domaini90 – 208119GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni7 – 82Glutathione bindingBy similarity
    Regioni46 – 505Glutathione bindingBy similarity
    Regioni59 – 602Glutathione bindingBy similarity
    Regioni72 – 732Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Mu family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiNOG300089.
    GeneTreeiENSGT00550000074559.
    HOGENOMiHOG000115735.
    HOVERGENiHBG106842.
    InParanoidiP08009.
    KOiK00799.
    OMAiNSHLEST.
    OrthoDBiEOG7KH9M3.
    PhylomeDBiP08009.
    TreeFamiTF353040.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR003081. GST_mu.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    PRINTSiPR01267. GSTRNSFRASEM.
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P08009-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPMTLGYWDI RGLAHAIRLL LEYTDSSYEE KRYTMGDAPD FDRSQWLNEK    50
    FKLGLDFPNL PYLIDGSHKI TQSNAILRYL GRKHNLCGET EEERIRVDIL 100
    ENQLMDNRMV LARLCYNPDF EKLKPGYLEQ LPGMMRLYSE FLGKRPWFAG 150
    DKITFVDFIA YDVLERNQVF EATCLDAFPN LKDFIARFEG LKKISDYMKS 200
    SRFLPRPLFT KMAIWGSK 218
    Length:218
    Mass (Da):25,681
    Last modified:January 23, 2007 - v2
    Checksum:iBBC0B61288AB069A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02744 mRNA. Translation: AAA41292.1.
    L35330 Genomic DNA. Translation: AAB00123.1.
    BC059130 mRNA. Translation: AAH59130.1.
    PIRiA29036.
    RefSeqiNP_112416.1. NM_031154.1.
    UniGeneiRn.6036.

    Genome annotation databases

    EnsembliENSRNOT00000025689; ENSRNOP00000025689; ENSRNOG00000018937.
    GeneIDi81869.
    KEGGirno:81869.
    UCSCiRGD:621287. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02744 mRNA. Translation: AAA41292.1 .
    L35330 Genomic DNA. Translation: AAB00123.1 .
    BC059130 mRNA. Translation: AAH59130.1 .
    PIRi A29036.
    RefSeqi NP_112416.1. NM_031154.1.
    UniGenei Rn.6036.

    3D structure databases

    ProteinModelPortali P08009.
    SMRi P08009. Positions 1-217.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4565175.
    STRINGi 10116.ENSRNOP00000025689.

    PTM databases

    PhosphoSitei P08009.

    2D gel databases

    World-2DPAGE 0004:P08009.

    Proteomic databases

    PaxDbi P08009.
    PRIDEi P08009.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000025689 ; ENSRNOP00000025689 ; ENSRNOG00000018937 .
    GeneIDi 81869.
    KEGGi rno:81869.
    UCSCi RGD:621287. rat.

    Organism-specific databases

    CTDi 68312.
    RGDi 621287. Gstm3.

    Phylogenomic databases

    eggNOGi NOG300089.
    GeneTreei ENSGT00550000074559.
    HOGENOMi HOG000115735.
    HOVERGENi HBG106842.
    InParanoidi P08009.
    KOi K00799.
    OMAi NSHLEST.
    OrthoDBi EOG7KH9M3.
    PhylomeDBi P08009.
    TreeFami TF353040.

    Miscellaneous databases

    NextBioi 615787.
    PROi P08009.

    Gene expression databases

    Genevestigatori P08009.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR003081. GST_mu.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01267. GSTRNSFRASEM.
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Selective expression of a unique glutathione S-transferase Yb3 gene in rat brain."
      Abramovitz M., Listowsky I.
      J. Biol. Chem. 262:7770-7773(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Brain and testis selective expression of the glutathione S-transferase Yb3 subunit is governed by tandem direct repeat octamer motifs in the 5'-flanking region of its gene."
      Abramovitz M., Testori A., Angelov I.V., Darmon A., Listowsky I.
      Brain Res. Mol. Brain Res. 28:37-46(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Sprague-Dawley.
      Tissue: Tail.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary.
    4. Lubec G., Afjehi-Sadat L., Chen W.-Q., Kang S.U.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 19-50; 53-69; 137-144 AND 153-182, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Brain, Hippocampus and Spinal cord.

    Entry informationi

    Entry nameiGSTM4_RAT
    AccessioniPrimary (citable) accession number: P08009
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Yb subclass selectively binds steroid hormones.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3