Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P08009 (GSTM4_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase Yb-3

EC=2.5.1.18
Alternative name(s):
Chain 4
GST Yb3
GST class-mu 3
Gene names
Name:Gstm3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length218 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer.

Subcellular location

Cytoplasm.

Miscellaneous

Yb subclass selectively binds steroid hormones.

Sequence similarities

Belongs to the GST superfamily. Mu family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 218217Glutathione S-transferase Yb-3
PRO_0000185833

Regions

Domain2 – 8887GST N-terminal
Domain90 – 208119GST C-terminal
Region7 – 82Glutathione binding By similarity
Region46 – 505Glutathione binding By similarity
Region59 – 602Glutathione binding By similarity
Region72 – 732Glutathione binding By similarity

Sites

Binding site1161Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P08009 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: BBC0B61288AB069A

FASTA21825,681
        10         20         30         40         50         60 
MPMTLGYWDI RGLAHAIRLL LEYTDSSYEE KRYTMGDAPD FDRSQWLNEK FKLGLDFPNL 

        70         80         90        100        110        120 
PYLIDGSHKI TQSNAILRYL GRKHNLCGET EEERIRVDIL ENQLMDNRMV LARLCYNPDF 

       130        140        150        160        170        180 
EKLKPGYLEQ LPGMMRLYSE FLGKRPWFAG DKITFVDFIA YDVLERNQVF EATCLDAFPN 

       190        200        210 
LKDFIARFEG LKKISDYMKS SRFLPRPLFT KMAIWGSK 

« Hide

References

« Hide 'large scale' references
[1]"Selective expression of a unique glutathione S-transferase Yb3 gene in rat brain."
Abramovitz M., Listowsky I.
J. Biol. Chem. 262:7770-7773(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Brain and testis selective expression of the glutathione S-transferase Yb3 subunit is governed by tandem direct repeat octamer motifs in the 5'-flanking region of its gene."
Abramovitz M., Testori A., Angelov I.V., Darmon A., Listowsky I.
Brain Res. Mol. Brain Res. 28:37-46(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Sprague-Dawley.
Tissue: Tail.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pituitary.
[4]Lubec G., Afjehi-Sadat L., Chen W.-Q., Kang S.U.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 19-50; 53-69; 137-144 AND 153-182, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Brain, Hippocampus and Spinal cord.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J02744 mRNA. Translation: AAA41292.1.
L35330 Genomic DNA. Translation: AAB00123.1.
BC059130 mRNA. Translation: AAH59130.1.
PIRA29036.
RefSeqNP_112416.1. NM_031154.1.
UniGeneRn.6036.

3D structure databases

ProteinModelPortalP08009.
SMRP08009. Positions 1-217.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4565175.
STRING10116.ENSRNOP00000025689.

PTM databases

PhosphoSiteP08009.

2D gel databases

World-2DPAGE0004:P08009.

Proteomic databases

PaxDbP08009.
PRIDEP08009.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000025689; ENSRNOP00000025689; ENSRNOG00000018937.
GeneID81869.
KEGGrno:81869.
UCSCRGD:621287. rat.

Organism-specific databases

CTD68312.
RGD621287. Gstm3.

Phylogenomic databases

eggNOGNOG300089.
GeneTreeENSGT00550000074559.
HOGENOMHOG000115735.
HOVERGENHBG106842.
InParanoidP08009.
KOK00799.
OMARITESWA.
OrthoDBEOG7KH9M3.
PhylomeDBP08009.
TreeFamTF353040.

Gene expression databases

GenevestigatorP08009.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSPR01267. GSTRNSFRASEM.
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio615787.
PROP08009.

Entry information

Entry nameGSTM4_RAT
AccessionPrimary (citable) accession number: P08009
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families