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Protein

Outer membrane virulence protein YopE

Gene

yopE

Organism
Yersinia pseudotuberculosis serotype I (strain IP32953)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Essential virulence determinant; cytotoxic effector, involved in resistance to phagocytosis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Virulence

Enzyme and pathway databases

BioCyciYPSE273123:GI1M-4121-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane virulence protein YopE
Gene namesi
Name:yopE
Synonyms:yop25
Ordered Locus Names:pYV0025
Encoded oniPlasmid pIB11 Publication
Plasmid pYV1 Publication
OrganismiYersinia pseudotuberculosis serotype I (strain IP32953)
Taxonomic identifieri273123 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
Proteomesi
  • UP000001011 Componenti: Plasmid pYV

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Outer membrane virulence protein YopEPRO_0000066367Add
BLAST

Expressioni

Inductioni

At 37 degrees Celsius in the absence of calcium.

Structurei

Secondary structure

1
219
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi29 – 346Combined sources
Helixi38 – 447Combined sources
Beta strandi60 – 623Combined sources
Helixi68 – 7710Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1L2WX-ray2.00I/J/K/L17-85[»]
ProteinModelPortaliP08008.
SMRiP08008. Positions 23-78, 100-219.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08008.

Family & Domainsi

Sequence similaritiesi

Belongs to the YopE family.Curated

Phylogenomic databases

HOGENOMiHOG000219628.
OMAiKSEQYAN.

Family and domain databases

CDDicd00219. ToxGAP. 1 hit.
Gene3Di1.20.120.260. 1 hit.
InterProiIPR014773. Uncharacterised_dom_YopE.
IPR003537. Vir_YopE.
IPR015110. YopE_N_dom.
[Graphical view]
PfamiPF03545. YopE. 1 hit.
PF09020. YopE_N. 1 hit.
[Graphical view]
PRINTSiPR01372. YERSINIAYOPE.
SUPFAMiSSF47233. SSF47233. 1 hit.

Sequencei

Sequence statusi: Complete.

P08008-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKISSFISTS LPLPTSVSGS SSVGEMSGRS VSQQTSDQYA NNLAGRTESP
60 70 80 90 100
QGSSLASRII ERLSSVAHSV IGFIQRMFSE GSHKPVVTPA PTPAQMPSPT
110 120 130 140 150
SFSDSIKQLA AETLPKYMQQ LNSLDAEMLQ KNHDQFATGS GPLRGSITQC
160 170 180 190 200
QGLMQFCGGE LQAEASAILN TPVCGIPFSQ WGTIGGAASA YVASGVDLTQ
210
AANEIKGLAQ QMQKLLSLM
Length:219
Mass (Da):22,987
Last modified:November 23, 2004 - v2
Checksum:i8E07FF064947B60D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti134 – 1341D → A in CAA68609 (PubMed:2835586).Curated
Sequence conflicti187 – 1871A → V in CAA68609 (PubMed:2835586).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00543 Genomic DNA. Translation: CAA68609.1.
BX936399 Genomic DNA. Translation: CAF25368.1.
PIRiS03766.

Genome annotation databases

EnsemblBacteriaiCAF25368; CAF25368; pYV0025.
KEGGiypo:BZ17_4209.
yps:pYV0025.
PATRICi18637806. VBIYerPse22266_0030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00543 Genomic DNA. Translation: CAA68609.1.
BX936399 Genomic DNA. Translation: CAF25368.1.
PIRiS03766.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1L2WX-ray2.00I/J/K/L17-85[»]
ProteinModelPortaliP08008.
SMRiP08008. Positions 23-78, 100-219.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAF25368; CAF25368; pYV0025.
KEGGiypo:BZ17_4209.
yps:pYV0025.
PATRICi18637806. VBIYerPse22266_0030.

Phylogenomic databases

HOGENOMiHOG000219628.
OMAiKSEQYAN.

Enzyme and pathway databases

BioCyciYPSE273123:GI1M-4121-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP08008.

Family and domain databases

CDDicd00219. ToxGAP. 1 hit.
Gene3Di1.20.120.260. 1 hit.
InterProiIPR014773. Uncharacterised_dom_YopE.
IPR003537. Vir_YopE.
IPR015110. YopE_N_dom.
[Graphical view]
PfamiPF03545. YopE. 1 hit.
PF09020. YopE_N. 1 hit.
[Graphical view]
PRINTSiPR01372. YERSINIAYOPE.
SUPFAMiSSF47233. SSF47233. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYOPE_YERPS
AccessioniPrimary (citable) accession number: P08008
Secondary accession number(s): Q663N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

N-terminal is important for export, C-terminal is indispensable for virulence.

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.