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P07997

- HEM1_CHICK

UniProt

P07997 - HEM1_CHICK

Protein

5-aminolevulinate synthase, nonspecific, mitochondrial

Gene

ALAS1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

    Cofactori

    Pyridoxal phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei212 – 2121SubstrateBy similarity
    Binding sitei329 – 3291SubstrateBy similarity
    Binding sitei348 – 3481SubstrateBy similarity
    Binding sitei381 – 3811Pyridoxal phosphateBy similarity
    Binding sitei409 – 4091Pyridoxal phosphateBy similarity
    Binding sitei437 – 4371Pyridoxal phosphateBy similarity
    Active sitei440 – 4401By similarity
    Binding sitei469 – 4691Pyridoxal phosphateBy similarity
    Binding sitei470 – 4701Pyridoxal phosphateBy similarity
    Binding sitei557 – 5571SubstrateBy similarity

    GO - Molecular functioni

    1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. heme biosynthetic process Source: Reactome
    2. heme metabolic process Source: Reactome
    3. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
    4. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Heme biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    ReactomeiREACT_115611. Heme synthesis.
    UniPathwayiUPA00251; UER00375.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-aminolevulinate synthase, nonspecific, mitochondrial (EC:2.3.1.37)
    Short name:
    ALAS-H
    Alternative name(s):
    5-aminolevulinic acid synthase 1
    Delta-ALA synthase 1
    Delta-aminolevulinate synthase 1
    Gene namesi
    Name:ALAS1
    Synonyms:ALASN
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. mitochondrial matrix Source: Reactome

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 5656MitochondrionAdd
    BLAST
    Chaini57 – 6355795-aminolevulinate synthase, nonspecific, mitochondrialPRO_0000001233Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei440 – 4401N6-(pyridoxal phosphate)lysineCurated

    Proteomic databases

    PaxDbiP07997.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000006285.

    Structurei

    3D structure databases

    ProteinModelPortaliP07997.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0156.
    HOVERGENiHBG005954.
    KOiK00643.
    PhylomeDBiP07997.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR015118. 5aminolev_synth_preseq.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    PF09029. Preseq_ALAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07997-1 [UniParc]FASTAAdd to Basket

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    MEAVVRRCPF LARVSQAFLQ KAGPSLLFYA QHCPKMMEAA PPAAARGLAT    50
    SASRGQQVEE TPAAQPEAKK AKEVAQQNTD GSQPPAGHPP AAAVQSSATK 100
    CPFLAAQMNH KSSNVFCKAS LELQEDVKEM QVDRKGKEFA KIPTNSVVRN 150
    TEAEGEEQSG LLKKFKDIML KQRPESVSHL LQDNLPKSVS TFQYDQFFEK 200
    KIDEKKKDHT YRVFKTVNRK AQIFPMADDY SDSLITKKEV SVWCSNDYLG 250
    MSRHPRVCGA VMDTLKQHGA GAGGTRNISG TSKFHVDLEK ELADLHGKDA 300
    ALLFSSCFVA NDSTLFTLAK MLPGCEIYSD SGNHASMIQG IRNSRVPKHI 350
    FRHNDVNHLR ELLKKSDPST PKIVAFETVH SMDGAVCPLE ELCDVAHEHG 400
    AITFVDEVHA VGLYGARGGG IGDRDGVMHK MDIISGTLGK AFACVGGYIS 450
    STSALIDTVR SYAAGFIFTT SLPPMLLAGA LESVRTLKSA EGQVLRRQHQ 500
    RNVKLMRQML MDAGLPVVHC PSHIIPIRVA DAAKNTEICD KLMSQHSIYV 550
    QAINYPTVPR GEELLRIAPT PHHTPQMMSY FLEKLLATWK DVGLELKPHS 600
    SAECNFCRRP LHFEVMSERE RSYFSGMSKL LSVSA 635
    Length:635
    Mass (Da):69,948
    Last modified:January 1, 1990 - v2
    Checksum:iEEE708B85C1539BA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti53 – 531S → A in CAA26595. (PubMed:3839458)Curated
    Sequence conflicti53 – 531S → A no nucleotide entry (PubMed:2915978)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02827 mRNA. Translation: CAA26595.1.
    X03517, X03627 Genomic DNA. Translation: CAA27223.1.
    PIRiA23538. SYCHAL.
    RefSeqiNP_001018012.1. NM_001018012.1.
    UniGeneiGga.1399.

    Genome annotation databases

    GeneIDi552895.
    KEGGigga:552895.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02827 mRNA. Translation: CAA26595.1 .
    X03517 , X03627 Genomic DNA. Translation: CAA27223.1 .
    PIRi A23538. SYCHAL.
    RefSeqi NP_001018012.1. NM_001018012.1.
    UniGenei Gga.1399.

    3D structure databases

    ProteinModelPortali P07997.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000006285.

    Proteomic databases

    PaxDbi P07997.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 552895.
    KEGGi gga:552895.

    Organism-specific databases

    CTDi 211.

    Phylogenomic databases

    eggNOGi COG0156.
    HOVERGENi HBG005954.
    KOi K00643.
    PhylomeDBi P07997.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00375 .
    Reactomei REACT_115611. Heme synthesis.

    Miscellaneous databases

    NextBioi 20879866.
    PROi P07997.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR015118. 5aminolev_synth_preseq.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    PF09029. Preseq_ALAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide sequence of hepatic 5-aminolaevulinate synthase precursor."
      Borthwick I.A., Srivastava G., Day A.R., Pirola B.A., Snoswell M.A., May B.K., Elliott W.H.
      Eur. J. Biochem. 150:481-484(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Liver.
    3. "Expression of delta-aminolevulinate synthase in avian cells: separate genes encode erythroid-specific and nonspecific isozymes."
      Riddle R.D., Yamamoto M., Engel J.D.
      Proc. Natl. Acad. Sci. U.S.A. 86:792-796(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiHEM1_CHICK
    AccessioniPrimary (citable) accession number: P07997
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3