SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P07997

- HEM1_CHICK

UniProt

P07997 - HEM1_CHICK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

5-aminolevulinate synthase, nonspecific, mitochondrial

Gene
ALAS1, ALASN
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactori

Pyridoxal phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei212 – 2121Substrate By similarity
Binding sitei329 – 3291Substrate By similarity
Binding sitei348 – 3481Substrate By similarity
Binding sitei381 – 3811Pyridoxal phosphate By similarity
Binding sitei409 – 4091Pyridoxal phosphate By similarity
Binding sitei437 – 4371Pyridoxal phosphate By similarity
Active sitei440 – 4401 By similarity
Binding sitei469 – 4691Pyridoxal phosphate By similarity
Binding sitei470 – 4701Pyridoxal phosphate By similarity
Binding sitei557 – 5571Substrate By similarity

GO - Molecular functioni

  1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. heme biosynthetic process Source: Reactome
  2. heme metabolic process Source: Reactome
  3. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
  4. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Heme biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiREACT_115611. Heme synthesis.
UniPathwayiUPA00251; UER00375.

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthase, nonspecific, mitochondrial (EC:2.3.1.37)
Short name:
ALAS-H
Alternative name(s):
5-aminolevulinic acid synthase 1
Delta-ALA synthase 1
Delta-aminolevulinate synthase 1
Gene namesi
Name:ALAS1
Synonyms:ALASN
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. mitochondrial matrix Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5656MitochondrionAdd
BLAST
Chaini57 – 6355795-aminolevulinate synthase, nonspecific, mitochondrialPRO_0000001233Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei440 – 4401N6-(pyridoxal phosphate)lysine Inferred

Proteomic databases

PaxDbiP07997.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006285.

Structurei

3D structure databases

ProteinModelPortaliP07997.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0156.
HOVERGENiHBG005954.
KOiK00643.
PhylomeDBiP07997.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR015118. 5aminolev_synth_preseq.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
PF09029. Preseq_ALAS. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07997-1 [UniParc]FASTAAdd to Basket

« Hide

MEAVVRRCPF LARVSQAFLQ KAGPSLLFYA QHCPKMMEAA PPAAARGLAT    50
SASRGQQVEE TPAAQPEAKK AKEVAQQNTD GSQPPAGHPP AAAVQSSATK 100
CPFLAAQMNH KSSNVFCKAS LELQEDVKEM QVDRKGKEFA KIPTNSVVRN 150
TEAEGEEQSG LLKKFKDIML KQRPESVSHL LQDNLPKSVS TFQYDQFFEK 200
KIDEKKKDHT YRVFKTVNRK AQIFPMADDY SDSLITKKEV SVWCSNDYLG 250
MSRHPRVCGA VMDTLKQHGA GAGGTRNISG TSKFHVDLEK ELADLHGKDA 300
ALLFSSCFVA NDSTLFTLAK MLPGCEIYSD SGNHASMIQG IRNSRVPKHI 350
FRHNDVNHLR ELLKKSDPST PKIVAFETVH SMDGAVCPLE ELCDVAHEHG 400
AITFVDEVHA VGLYGARGGG IGDRDGVMHK MDIISGTLGK AFACVGGYIS 450
STSALIDTVR SYAAGFIFTT SLPPMLLAGA LESVRTLKSA EGQVLRRQHQ 500
RNVKLMRQML MDAGLPVVHC PSHIIPIRVA DAAKNTEICD KLMSQHSIYV 550
QAINYPTVPR GEELLRIAPT PHHTPQMMSY FLEKLLATWK DVGLELKPHS 600
SAECNFCRRP LHFEVMSERE RSYFSGMSKL LSVSA 635
Length:635
Mass (Da):69,948
Last modified:January 1, 1990 - v2
Checksum:iEEE708B85C1539BA
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531S → A in CAA26595. 1 Publication
Sequence conflicti53 – 531S → A no nucleotide entry 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X02827 mRNA. Translation: CAA26595.1.
X03517, X03627 Genomic DNA. Translation: CAA27223.1.
PIRiA23538. SYCHAL.
RefSeqiNP_001018012.1. NM_001018012.1.
UniGeneiGga.1399.

Genome annotation databases

GeneIDi552895.
KEGGigga:552895.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X02827 mRNA. Translation: CAA26595.1 .
X03517 , X03627 Genomic DNA. Translation: CAA27223.1 .
PIRi A23538. SYCHAL.
RefSeqi NP_001018012.1. NM_001018012.1.
UniGenei Gga.1399.

3D structure databases

ProteinModelPortali P07997.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000006285.

Proteomic databases

PaxDbi P07997.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 552895.
KEGGi gga:552895.

Organism-specific databases

CTDi 211.

Phylogenomic databases

eggNOGi COG0156.
HOVERGENi HBG005954.
KOi K00643.
PhylomeDBi P07997.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00375 .
Reactomei REACT_115611. Heme synthesis.

Miscellaneous databases

NextBioi 20879866.
PROi P07997.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR015118. 5aminolev_synth_preseq.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
PF09029. Preseq_ALAS. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete nucleotide sequence of hepatic 5-aminolaevulinate synthase precursor."
    Borthwick I.A., Srivastava G., Day A.R., Pirola B.A., Snoswell M.A., May B.K., Elliott W.H.
    Eur. J. Biochem. 150:481-484(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  3. "Expression of delta-aminolevulinate synthase in avian cells: separate genes encode erythroid-specific and nonspecific isozymes."
    Riddle R.D., Yamamoto M., Engel J.D.
    Proc. Natl. Acad. Sci. U.S.A. 86:792-796(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiHEM1_CHICK
AccessioniPrimary (citable) accession number: P07997
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 1, 1990
Last modified: September 3, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi