##gff-version 3 P07975 UniProtKB Signal peptide 1 14 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Chain 15 655 . . . ID=PRO_0000440555;Note=Hemagglutinin-esterase-fusion glycoprotein;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Chain 15 446 . . . ID=PRO_0000039152;Note=Hemagglutinin-esterase-fusion glycoprotein chain 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Chain 447 655 . . . ID=PRO_0000039153;Note=Hemagglutinin-esterase-fusion glycoprotein chain 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Topological domain 15 630 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Transmembrane 631 651 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Topological domain 652 655 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Region 15 40 . . . Note=Fusion domain-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Region 41 158 . . . Note=Esterase domain-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Region 41 151 . . . Note=Esterase domain-1 P07975 UniProtKB Region 151 310 . . . Note=N-acetyl-9-O-acetylneuraminic acid binding P07975 UniProtKB Region 158 310 . . . Note=N-acetyl-9-O-acetylneuraminic acid binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Region 310 364 . . . Note=Esterase domain-2;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Region 311 365 . . . Note=Esterase domain-2 P07975 UniProtKB Region 365 650 . . . Note=Fusion domain-2;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Region 366 651 . . . Note=Fusion domain-2 P07975 UniProtKB Active site 71 71 . . . Note=Nucleophile;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Active site 366 366 . . . Note=Charge relay system;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Active site 369 369 . . . Note=Charge relay system;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Glycosylation 26 26 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Glycosylation 61 61 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Glycosylation 144 144 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Glycosylation 189 189 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Glycosylation 395 395 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Glycosylation 552 552 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Glycosylation 603 603 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Disulfide bond 20 583 . . . Note=Interchain (between HEF1 and HEF2 chains);Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Disulfide bond 120 165 . . . . P07975 UniProtKB Disulfide bond 140 188 . . . . P07975 UniProtKB Disulfide bond 210 252 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Disulfide bond 229 316 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Disulfide bond 237 289 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04072 P07975 UniProtKB Disulfide bond 346 352 . . . . P07975 UniProtKB Natural variant 96 96 . . . Note=F->S P07975 UniProtKB Natural variant 263 263 . . . Note=F->S P07975 UniProtKB Natural variant 457 457 . . . Note=V->L P07975 UniProtKB Natural variant 465 465 . . . Note=T->A P07975 UniProtKB Mutagenesis 71 71 . . . Note=96%25 loss of esterase activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7595356;Dbxref=PMID:7595356 P07975 UniProtKB Mutagenesis 261 261 . . . Note=64%25 loss of esterase activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7595356;Dbxref=PMID:7595356 P07975 UniProtKB Mutagenesis 280 280 . . . Note=Complete loss of esterase activity. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7595356;Dbxref=PMID:7595356 P07975 UniProtKB Mutagenesis 368 368 . . . Note=Complete loss of esterase activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7595356;Dbxref=PMID:7595356 P07975 UniProtKB Mutagenesis 369 369 . . . Note=Complete loss of esterase activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7595356;Dbxref=PMID:7595356 P07975 UniProtKB Beta strand 19 25 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 39 48 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 59 69 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 71 73 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Helix 80 83 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Helix 88 92 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 94 96 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Helix 102 107 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 110 112 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 118 120 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 122 126 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Helix 130 132 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Helix 134 136 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Helix 146 160 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 164 169 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 186 188 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 194 197 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Turn 205 208 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 214 220 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 222 224 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 230 240 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Helix 244 250 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 256 260 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 262 264 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 266 271 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Turn 272 274 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 286 294 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 296 303 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 314 317 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 325 328 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Helix 341 347 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 352 355 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 364 366 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Helix 372 377 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Helix 378 382 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 386 389 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 392 394 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 399 403 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 407 412 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Turn 419 421 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 424 432 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 452 454 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 459 462 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Beta strand 469 474 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Turn 488 490 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Helix 497 549 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WKO P07975 UniProtKB Helix 555 571 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WKO P07975 UniProtKB Turn 573 575 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Turn 588 590 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC P07975 UniProtKB Helix 593 599 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FLC