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Protein

Methyl-coenzyme M reductase subunit gamma

Gene

mcrG

Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.

Catalytic activityi

Methyl-CoM + CoB = CoM-S-S-CoB + methane.

Pathwayi: methyl-coenzyme M reduction

This protein is involved in step 1 of the subpathway that synthesizes methane from methyl-coenzyme M.
Proteins known to be involved in this subpathway in this organism are:
  1. Methyl-coenzyme M reductase subunit gamma (mcrG), Methyl-coenzyme M reductase subunit beta (mcrB), Methyl-coenzyme M reductase subunit alpha (mcrA)
This subpathway is part of the pathway methyl-coenzyme M reduction, which is itself part of One-carbon metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes methane from methyl-coenzyme M, the pathway methyl-coenzyme M reduction and in One-carbon metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMethanogenesis

Enzyme and pathway databases

BRENDAi2.8.4.1 3250
UniPathwayiUPA00646; UER00699

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-coenzyme M reductase subunit gamma (EC:2.8.4.1)
Alternative name(s):
Coenzyme-B sulfoethylthiotransferase gamma
Gene namesi
Name:mcrG
Ordered Locus Names:Mbar_A0894
OrganismiMethanosarcina barkeri (strain Fusaro / DSM 804)
Taxonomic identifieri269797 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000008156 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001474732 – 248Methyl-coenzyme M reductase subunit gammaAdd BLAST247

Proteomic databases

PRIDEiP07964

Interactioni

Subunit structurei

Hexamer of two alpha, two beta, and two gamma chains.1 Publication

Protein-protein interaction databases

STRINGi269797.Mbar_A0894

Structurei

Secondary structure

1248
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi13 – 23Combined sources11
Helixi34 – 41Combined sources8
Beta strandi52 – 54Combined sources3
Helixi57 – 60Combined sources4
Helixi66 – 70Combined sources5
Helixi75 – 79Combined sources5
Beta strandi83 – 90Combined sources8
Turni92 – 94Combined sources3
Helixi99 – 109Combined sources11
Beta strandi110 – 112Combined sources3
Beta strandi114 – 117Combined sources4
Beta strandi122 – 127Combined sources6
Helixi128 – 140Combined sources13
Turni146 – 148Combined sources3
Beta strandi149 – 151Combined sources3
Beta strandi176 – 179Combined sources4
Beta strandi182 – 187Combined sources6
Beta strandi193 – 199Combined sources7
Helixi206 – 212Combined sources7
Helixi223 – 225Combined sources3
Helixi227 – 245Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E6YX-ray1.60C/F2-248[»]
ProteinModelPortaliP07964
SMRiP07964
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07964

Family & Domainsi

Phylogenomic databases

eggNOGiarCOG04858 Archaea
COG4057 LUCA
HOGENOMiHOG000225820
KOiK00402
OMAiGHRNPGE
OrthoDBiPOG093Z08I2

Family and domain databases

CDDicd00539 MCR_gamma, 1 hit
Gene3Di3.90.320.20, 1 hit
InterProiView protein in InterPro
IPR009024 Me_CoM_Rdtase_Fd-like_fold
IPR003178 Me_CoM_Rdtase_gsu
IPR036994 Me_CoM_Rdtase_gsu_sf
PfamiView protein in Pfam
PF02240 MCR_gamma, 1 hit
PIRSFiPIRSF000264 Meth_CoM_rd_gama, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005845 Me_CoM_Rdtase_gsu, 1 hit
SUPFAMiSSF55088 SSF55088, 1 hit
TIGRFAMsiTIGR03259 met_CoM_red_gam, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07964-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYERQYYPG ATSVAANRRK HMSGKLEKLR EISDEDLTAV LGHRAPGSDY
60 70 80 90 100
PSTHPPLAEM GEPACSTREN VAATPGAAAG DRVRYIQFAD SMYNAPATPY
110 120 130 140 150
FRSYFAAINF RGVDPGTLSG RQIVEARERD MEQCAKVQME TEITDHALAG
160 170 180 190 200
VRGATVHGHS VRLQEDGVMF DMLDRRRLEN GTIIMDKDQV AIPLDRKVDL
210 220 230 240
GKPMSSEEAA KRTTIYRVDN VAFRDDAEVV EWVHRIFDQR TKFGFQPK
Length:248
Mass (Da):27,811
Last modified:January 23, 2007 - v3
Checksum:iAB23870B4BD7160B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00158 Genomic DNA Translation: CAA68356.1
CP000099 Genomic DNA Translation: AAZ69868.1
PIRiD29525
RefSeqiWP_011305917.1, NC_007355.1

Genome annotation databases

EnsemblBacteriaiAAZ69868; AAZ69868; Mbar_A0894
GeneIDi3625939
KEGGimba:Mbar_A0894

Similar proteinsi

Entry informationi

Entry nameiMCRG_METBF
AccessioniPrimary (citable) accession number: P07964
Secondary accession number(s): Q46E24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 121 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health