P07963 (MCRG_METVA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Methyl-coenzyme M reductase subunit gamma
EC=2.8.4.1

Alternative name(s):
Coenzyme-B sulfoethylthiotransferase gamma

Gene names

Name:

mcrG

Organism

Methanococcus vannielii

Taxonomic identifier

2187 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and an heterodisulfide.
Catalytic activity	Methyl-CoM + CoB = CoM-S-S-CoB + methane.
Cofactor	Binds 2 coenzyme F430 noncovalently per hexamer. Coenzyme F430 is a yellow nickel porphinoid By similarity.
Pathway	One-carbon metabolism; methyl-coenzyme M reduction; methane from methyl-coenzyme M: step 1/1.
Subunit structure	Hexamer of two alpha, two beta, and two gamma chains.

Ontologies

Keywords
Biological process	Methanogenesis
Molecular function	Transferase
Gene Ontology (GO)
Biological process	methanogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme-B sulfoethylthiotransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 260	260	Methyl-coenzyme M reductase subunit gamma		PRO_0000147483

Sequences

	Sequence		Length	Mass (Da)
	P07963 [UniParc]. Last modified August 1, 1988. Version 1. Checksum: ED8EB1C593B5D9A6	FASTA	260	29,782
	10 20 30 40 50 60 MAYKPQFYPG ATKVAENRRN HLNPNYELEK LREIPDEDVV KIMGHRQPGE DYKTVHPPLE 70 80 90 100 110 120 EMDMPADYVR DLVEPLNGAK EGHRVRYIQF ADSMYFAPAQ PYDRSRLYMI RLRGVDAGTL 130 140 150 160 170 180 SGRQVVECRE SDLEEFSKNL LMDTELFDPA TSGVRGATVH GHSLRLDENG MMFDALQRCV 190 200 210 220 230 240 FDEKTGHVMY VKDQVGKPLD QPVDVGEPMP EAKLREITTI YRKDGIAMRT DPEVIEVVKR 250 260 IHRARTLGGY IPTNEIFKGL

References

[1]	"Structure and expression of the genes, mcrBDCGA, which encode the subunits of component C of methyl coenzyme M reductase in Methanococcus vannielii." Cram D.S., Sherf B.A., Libby R.T., Mattaliano R.J., Ramachandran K.L., Reeve J.N. Proc. Natl. Acad. Sci. U.S.A. 84:3992-3996(1987) [PubMed: 16593847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M16893 Genomic DNA. Translation: AAA72597.1.
PIR	D27793.
3D structure databases
ProteinModelPortal	P07963.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR009024. Me_CoM_Rdtase_Fd-like_fold. IPR003178. Me_CoM_Rdtase_gsu. [Graphical view]
Gene3D	G3DSA:3.90.320.20. MCR_gamma. 1 hit.
Pfam	PF02240. MCR_gamma. 1 hit. [Graphical view]
PIRSF	PIRSF000264. Meth_CoM_rd_gama. 1 hit.
ProDom	PD005845. Me_CoM_Rdtase_gsu. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF55088. MCR_fer_like. 1 hit.
TIGRFAMs	TIGR03259. Met_CoM_red_gam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MCRG_METVA

Accession

Primary (citable) accession number: P07963

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	August 1, 1988
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program