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P07963

- MCRG_METVA

UniProt

P07963 - MCRG_METVA

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Protein
Methyl-coenzyme M reductase subunit gamma
Gene
mcrG
Organism
Methanococcus vannielii
Status
Reviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.

Catalytic activityi

Methyl-CoM + CoB = CoM-S-S-CoB + methane.

Pathwayi

GO - Molecular functioni

  1. coenzyme-B sulfoethylthiotransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. methanogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Methanogenesis

Enzyme and pathway databases

UniPathwayiUPA00646; UER00699.

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-coenzyme M reductase subunit gamma (EC:2.8.4.1)
Alternative name(s):
Coenzyme-B sulfoethylthiotransferase gamma
Gene namesi
Name:mcrG
OrganismiMethanococcus vannielii
Taxonomic identifieri2187 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Methyl-coenzyme M reductase subunit gamma
PRO_0000147483Add
BLAST

Interactioni

Subunit structurei

Hexamer of two alpha, two beta, and two gamma chains.

Structurei

3D structure databases

ProteinModelPortaliP07963.

Family & Domainsi

Family and domain databases

Gene3Di3.90.320.20. 1 hit.
InterProiIPR009024. Me_CoM_Rdtase_Fd-like_fold.
IPR003178. Me_CoM_Rdtase_gsu.
[Graphical view]
PfamiPF02240. MCR_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF000264. Meth_CoM_rd_gama. 1 hit.
ProDomiPD005845. Me_CoM_Rdtase_gsu. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55088. SSF55088. 1 hit.
TIGRFAMsiTIGR03259. met_CoM_red_gam. 1 hit.

Sequencei

Sequence statusi: Complete.

P07963-1 [UniParc]FASTAAdd to Basket

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MAYKPQFYPG ATKVAENRRN HLNPNYELEK LREIPDEDVV KIMGHRQPGE    50
DYKTVHPPLE EMDMPADYVR DLVEPLNGAK EGHRVRYIQF ADSMYFAPAQ 100
PYDRSRLYMI RLRGVDAGTL SGRQVVECRE SDLEEFSKNL LMDTELFDPA 150
TSGVRGATVH GHSLRLDENG MMFDALQRCV FDEKTGHVMY VKDQVGKPLD 200
QPVDVGEPMP EAKLREITTI YRKDGIAMRT DPEVIEVVKR IHRARTLGGY 250
IPTNEIFKGL 260
Length:260
Mass (Da):29,782
Last modified:August 1, 1988 - v1
Checksum:iED8EB1C593B5D9A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16893 Genomic DNA. Translation: AAA72597.1.
PIRiD27793.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16893 Genomic DNA. Translation: AAA72597.1 .
PIRi D27793.

3D structure databases

ProteinModelPortali P07963.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00646 ; UER00699 .

Family and domain databases

Gene3Di 3.90.320.20. 1 hit.
InterProi IPR009024. Me_CoM_Rdtase_Fd-like_fold.
IPR003178. Me_CoM_Rdtase_gsu.
[Graphical view ]
Pfami PF02240. MCR_gamma. 1 hit.
[Graphical view ]
PIRSFi PIRSF000264. Meth_CoM_rd_gama. 1 hit.
ProDomi PD005845. Me_CoM_Rdtase_gsu. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF55088. SSF55088. 1 hit.
TIGRFAMsi TIGR03259. met_CoM_red_gam. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Structure and expression of the genes, mcrBDCGA, which encode the subunits of component C of methyl coenzyme M reductase in Methanococcus vannielii."
    Cram D.S., Sherf B.A., Libby R.T., Mattaliano R.J., Ramachandran K.L., Reeve J.N.
    Proc. Natl. Acad. Sci. U.S.A. 84:3992-3996(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMCRG_METVA
AccessioniPrimary (citable) accession number: P07963
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: September 3, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

External Data

Dasty 3

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