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P07956

- MCRB_METVA

UniProt

P07956 - MCRB_METVA

Protein

Methyl-coenzyme M reductase subunit beta

Gene

mcrB

Organism
Methanococcus vannielii
Status
Reviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 72 (03 Sep 2014)
      Sequence version 1 (01 Aug 1988)
      Previous versions | rss
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    • Comment

    Functioni

    Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.

    Catalytic activityi

    Methyl-CoM + CoB = CoM-S-S-CoB + methane.

    Pathwayi

    GO - Molecular functioni

    1. coenzyme-B sulfoethylthiotransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. methanogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Methanogenesis

    Enzyme and pathway databases

    UniPathwayiUPA00646; UER00699.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methyl-coenzyme M reductase subunit beta (EC:2.8.4.1)
    Alternative name(s):
    Coenzyme-B sulfoethylthiotransferase beta
    Gene namesi
    Name:mcrB
    OrganismiMethanococcus vannielii
    Taxonomic identifieri2187 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 443443Methyl-coenzyme M reductase subunit betaPRO_0000147471Add
    BLAST

    Interactioni

    Subunit structurei

    Hexamer of two alpha, two beta, and two gamma chains.

    Structurei

    3D structure databases

    ProteinModelPortaliP07956.
    SMRiP07956. Positions 3-443.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    Gene3Di1.20.840.10. 2 hits.
    3.30.70.470. 1 hit.
    InterProiIPR022681. MCR_a/b_chain_a-bundle.
    IPR008924. Me_CoM_Rdtase_asu/bsu_C.
    IPR015823. Me_CoM_Rdtase_asu_N_sub2.
    IPR003179. Me_CoM_Rdtase_bsu.
    IPR022679. Me_CoM_Rdtase_bsu_C.
    IPR022680. Me_CoM_Rdtase_bsu_N.
    IPR009024. Me_CoM_Rdtase_Fd-like_fold.
    [Graphical view]
    PfamiPF02241. MCR_beta. 1 hit.
    PF02783. MCR_beta_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000263. Meth_CoM_rd_beta. 1 hit.
    SUPFAMiSSF48081. SSF48081. 1 hit.
    SSF55088. SSF55088. 1 hit.
    TIGRFAMsiTIGR03257. met_CoM_red_bet. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P07956-1 [UniParc]FASTAAdd to Basket

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    MVKYEDKISL YDAKGNLVAE NVPLEAISPL YNPTIKSMLK NIKRTVAVNL    50
    ADIENTLATG SIGGKGCKVP GRTLDLSVVS NAQAIADEVE KILKVSKDDD 100
    TAIKLINGGK QMAVQVPSER LEVAAEYSVS MLATAMALKE AIIKTFNVDM 150
    FEGSTVHASI MGNYPQVMDY AGGNIASLLG APSNLEGLGY ALRNIPVNHA 200
    VATTKKNMMN AIAFSSVMEQ TATFEMGDAI GSFERQHLLG LAYQGLNADN 250
    LVIEFIKANG KGTVGTVVQS VVERALADGV IVVDKTMGSG FNMYKPADVN 300
    KWNAYAAAGL VAAAAVSCGA ARAAQNIASV ILYYNDILEY ETGLPGVDYG 350
    RSMGTAVGFS FFSHSIYGGG GPGIFNGNHV VTRHSKGFAI PPVCAAMCAD 400
    AGTQMFSPEH TSALVGAVYS AFDEFREPMK YVIERALNIK DKL 443
    Length:443
    Mass (Da):46,954
    Last modified:August 1, 1988 - v1
    Checksum:i7646A0D427A98517
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16893 Genomic DNA. Translation: AAA72594.1.
    PIRiA27793.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16893 Genomic DNA. Translation: AAA72594.1 .
    PIRi A27793.

    3D structure databases

    ProteinModelPortali P07956.
    SMRi P07956. Positions 3-443.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00646 ; UER00699 .

    Family and domain databases

    Gene3Di 1.20.840.10. 2 hits.
    3.30.70.470. 1 hit.
    InterProi IPR022681. MCR_a/b_chain_a-bundle.
    IPR008924. Me_CoM_Rdtase_asu/bsu_C.
    IPR015823. Me_CoM_Rdtase_asu_N_sub2.
    IPR003179. Me_CoM_Rdtase_bsu.
    IPR022679. Me_CoM_Rdtase_bsu_C.
    IPR022680. Me_CoM_Rdtase_bsu_N.
    IPR009024. Me_CoM_Rdtase_Fd-like_fold.
    [Graphical view ]
    Pfami PF02241. MCR_beta. 1 hit.
    PF02783. MCR_beta_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000263. Meth_CoM_rd_beta. 1 hit.
    SUPFAMi SSF48081. SSF48081. 1 hit.
    SSF55088. SSF55088. 1 hit.
    TIGRFAMsi TIGR03257. met_CoM_red_bet. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression of the genes, mcrBDCGA, which encode the subunits of component C of methyl coenzyme M reductase in Methanococcus vannielii."
      Cram D.S., Sherf B.A., Libby R.T., Mattaliano R.J., Ramachandran K.L., Reeve J.N.
      Proc. Natl. Acad. Sci. U.S.A. 84:3992-3996(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiMCRB_METVA
    AccessioniPrimary (citable) accession number: P07956
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: August 1, 1988
    Last modified: September 3, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways

    External Data

    Dasty 3