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P07956

- MCRB_METVA

UniProt

P07956 - MCRB_METVA

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Protein

Methyl-coenzyme M reductase subunit beta

Gene

mcrB

Organism
Methanococcus vannielii
Status
Reviewed - Annotation score: 3 out of 5- Protein predictedi

Functioni

Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.

Catalytic activityi

Methyl-CoM + CoB = CoM-S-S-CoB + methane.

Pathwayi

GO - Molecular functioni

  1. coenzyme-B sulfoethylthiotransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. methanogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Methanogenesis

Enzyme and pathway databases

UniPathwayiUPA00646; UER00699.

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-coenzyme M reductase subunit beta (EC:2.8.4.1)
Alternative name(s):
Coenzyme-B sulfoethylthiotransferase beta
Gene namesi
Name:mcrB
OrganismiMethanococcus vannielii
Taxonomic identifieri2187 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Methyl-coenzyme M reductase subunit betaPRO_0000147471Add
BLAST

Interactioni

Subunit structurei

Hexamer of two alpha, two beta, and two gamma chains.

Structurei

3D structure databases

ProteinModelPortaliP07956.
SMRiP07956. Positions 3-443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di1.20.840.10. 2 hits.
3.30.70.470. 1 hit.
InterProiIPR022681. MCR_a/b_chain_a-bundle.
IPR008924. Me_CoM_Rdtase_asu/bsu_C.
IPR015823. Me_CoM_Rdtase_asu_N_sub2.
IPR003179. Me_CoM_Rdtase_bsu.
IPR022679. Me_CoM_Rdtase_bsu_C.
IPR022680. Me_CoM_Rdtase_bsu_N.
IPR009024. Me_CoM_Rdtase_Fd-like_fold.
[Graphical view]
PfamiPF02241. MCR_beta. 1 hit.
PF02783. MCR_beta_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000263. Meth_CoM_rd_beta. 1 hit.
SUPFAMiSSF48081. SSF48081. 1 hit.
SSF55088. SSF55088. 1 hit.
TIGRFAMsiTIGR03257. met_CoM_red_bet. 1 hit.

Sequencei

Sequence statusi: Complete.

P07956-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MVKYEDKISL YDAKGNLVAE NVPLEAISPL YNPTIKSMLK NIKRTVAVNL
60 70 80 90 100
ADIENTLATG SIGGKGCKVP GRTLDLSVVS NAQAIADEVE KILKVSKDDD
110 120 130 140 150
TAIKLINGGK QMAVQVPSER LEVAAEYSVS MLATAMALKE AIIKTFNVDM
160 170 180 190 200
FEGSTVHASI MGNYPQVMDY AGGNIASLLG APSNLEGLGY ALRNIPVNHA
210 220 230 240 250
VATTKKNMMN AIAFSSVMEQ TATFEMGDAI GSFERQHLLG LAYQGLNADN
260 270 280 290 300
LVIEFIKANG KGTVGTVVQS VVERALADGV IVVDKTMGSG FNMYKPADVN
310 320 330 340 350
KWNAYAAAGL VAAAAVSCGA ARAAQNIASV ILYYNDILEY ETGLPGVDYG
360 370 380 390 400
RSMGTAVGFS FFSHSIYGGG GPGIFNGNHV VTRHSKGFAI PPVCAAMCAD
410 420 430 440
AGTQMFSPEH TSALVGAVYS AFDEFREPMK YVIERALNIK DKL
Length:443
Mass (Da):46,954
Last modified:August 1, 1988 - v1
Checksum:i7646A0D427A98517
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16893 Genomic DNA. Translation: AAA72594.1.
PIRiA27793.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16893 Genomic DNA. Translation: AAA72594.1 .
PIRi A27793.

3D structure databases

ProteinModelPortali P07956.
SMRi P07956. Positions 3-443.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00646 ; UER00699 .

Family and domain databases

Gene3Di 1.20.840.10. 2 hits.
3.30.70.470. 1 hit.
InterProi IPR022681. MCR_a/b_chain_a-bundle.
IPR008924. Me_CoM_Rdtase_asu/bsu_C.
IPR015823. Me_CoM_Rdtase_asu_N_sub2.
IPR003179. Me_CoM_Rdtase_bsu.
IPR022679. Me_CoM_Rdtase_bsu_C.
IPR022680. Me_CoM_Rdtase_bsu_N.
IPR009024. Me_CoM_Rdtase_Fd-like_fold.
[Graphical view ]
Pfami PF02241. MCR_beta. 1 hit.
PF02783. MCR_beta_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000263. Meth_CoM_rd_beta. 1 hit.
SUPFAMi SSF48081. SSF48081. 1 hit.
SSF55088. SSF55088. 1 hit.
TIGRFAMsi TIGR03257. met_CoM_red_bet. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Structure and expression of the genes, mcrBDCGA, which encode the subunits of component C of methyl coenzyme M reductase in Methanococcus vannielii."
    Cram D.S., Sherf B.A., Libby R.T., Mattaliano R.J., Ramachandran K.L., Reeve J.N.
    Proc. Natl. Acad. Sci. U.S.A. 84:3992-3996(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMCRB_METVA
AccessioniPrimary (citable) accession number: P07956
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

External Data

Dasty 3