Reviewed, UniProtKB/Swiss-Prot P07952 (PMGE_RABIT)

Names and origin

Protein names

Recommended name:
    Bisphosphoglycerate mutase
      Short name=BPGM
    EC=5.4.2.4
Alternative name(s):
    2,3-bisphosphoglycerate mutase, erythrocyte
    2,3-bisphosphoglycerate synthase
    EC=5.4.2.1
    EC=3.1.3.13
    BPG-dependent PGAM

Gene names

Name:

BPGM

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Plays a major role in regulating hemoglobin oxygen affinity as a consequence of controlling 2,3-BPG concentration. Can also catalyze the reaction of EC 5.4.2.1 (mutase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.
Catalytic activity	3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate. 2-phospho-D-glycerate = 3-phospho-D-glycerate. 2,3-bisphospho-D-glycerate + H2O = 3-phospho-D-glycerate + phosphate.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Hydrolase Isomerase
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2,3-bisphospho-D-glycerate 2-phosphohydrolase activity Inferred from electronic annotation. Source: EC bisphosphoglycerate mutase activity Inferred from electronic annotation. Source: EC phosphoglycerate mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 259	258	Bisphosphoglycerate mutase		PRO_0000179836
Sites
	Active site	11	1	Tele-phosphohistidine intermediate
	Active site	188	1
	Site	62	1	Interaction with carboxyl group of phosphoglycerates

Sequences

	Sequence		Length	Mass (Da)
	P07952-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 350A0290D24AE528	FASTA	259	30,030
	10 20 30 40 50 60 MSKYKLIMLR HGEGAWNKEN RFCSWVDQKL NSEGMEEARN CGKQLKALNF EFDLVFTSVL 70 80 90 100 110 120 NRSIHTAWLI LEELGQEWVP VESSWRLNER HYGALIGLNR EKMALNHGEE QVRIWRRSYN 130 140 150 160 170 180 VTPPPIEESH PYYHEIYSDR RYRVCDVPLD QLPRSESLKD VLERLLPYWN ERIAPEVLRG 190 200 210 220 230 240 KTVLISAHGN SSRALLKHLE GISDEDIINI TLPTGVPILL ELDENLRAVG PHQFLGDQEA 250 IQAAIKKVED QGKVKRAEK

References

[1]	"Isolation and characterization of cDNA encoding rabbit reticulocyte 2,3-bisphosphoglycerate synthase." Yanagawa S., Hitomi K., Sasaki R., Chiba H. Gene 44:185-191(1986) [PubMed: 3023182] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M15884 mRNA. Translation: AAA31240.1.
PIR	PMRBBM. A24973.
RefSeq	NP_001075738.1.
UniGene	Ocu.1868
3D structure databases
HSSP	HSSP built from PDB template 1E58 based on UniProtKB P31217.
SMR	P07952. Positions 2-256.
ModBase	Search...
Genome annotation databases
Ensembl	ENSOCUG00000003144. Oryctolagus cuniculus. [Contig view]
GeneID	100009096.
Phylogenomic databases
HOVERGEN	P07952.
Enzyme and pathway databases
BRENDA	3.1.3.13. 255. 5.4.2.1. 255. 5.4.2.4. 255.
Family and domain databases
InterPro	IPR001345. PG/BPGM_mutase. IPR013078. PG_mutase. IPR005952. Phosphogly_mut1. [Graphical view]
PANTHER	PTHR11931. Phosphogly_mut1. 1 hit.
Pfam	PF00300. PGAM. 1 hit. [Graphical view]
TIGRFAMs	TIGR01258. pgm_1. 1 hit.
PROSITE	PS00175. PG_MUTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PMGE_RABIT

Accession

Primary (citable) accession number: P07952

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)