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Protein

Tropomyosin beta chain

Gene

TPM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity).By similarity

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • structural constituent of muscle Source: ProtInc

GO - Biological processi

  • muscle contraction Source: Reactome
  • muscle filament sliding Source: Reactome
  • regulation of ATPase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

BioCyciZFISH:G66-31495-MONOMER.
ReactomeiR-HSA-390522. Striated Muscle Contraction.
R-HSA-445355. Smooth Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin beta chain
Alternative name(s):
Beta-tropomyosin
Tropomyosin-2
Gene namesi
Name:TPM2
Synonyms:TMSB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:12011. TPM2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • muscle thin filament tropomyosin Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Nemaline myopathy 4 (NEM4)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-like or rod-shaped structures in muscle fibers on histologic examination. Nemaline myopathy type 4 presents from infancy to childhood with hypotonia and moderate-to-severe proximal weakness with minimal or no progression. Major motor milestones are delayed but independent ambulation is usually achieved, although a wheelchair may be needed in later life.
See also OMIM:609285
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0714863A → G in NEM4. 1 Publication1
Natural variantiVAR_0714877Missing in NEM4. 1 Publication1
Natural variantiVAR_07148814D → V in NEM4. 1 Publication1
Natural variantiVAR_07097841E → K in NEM4; also found in a patient with congenital myopathy with fiber-type disproportion and patients with undefined congenital myopathy. 2 PublicationsCorresponds to variant rs137853306dbSNPEnsembl.1
Natural variantiVAR_013468117E → A in NEM4. 1 Publication1
Natural variantiVAR_070981133R → W in DA2B, NEM4 and DA1A; also found in a patient with congenital myopathy with fiber-type disproportion. 2 PublicationsCorresponds to variant rs137853305dbSNPEnsembl.1
Natural variantiVAR_071494143L → P in NEM4; also found in a patient with congenital myopathy with fiber-type disproportion. 1 Publication1
Natural variantiVAR_013469147Q → P in NEM4. 1 PublicationCorresponds to variant rs104894128dbSNPEnsembl.1
Natural variantiVAR_071495148L → P in NEM4; also found in a patient with congenital myopathy with fiber-type disproportion. 1 Publication1
Arthrogryposis, distal, 1A (DA1A)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 1 is characterized largely by camptodactyly and clubfoot. Hypoplasia and/or absence of some interphalangeal creases is common. The shoulders and hips are less frequently affected.
See also OMIM:108120
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01608691R → G in DA1A. 1 PublicationCorresponds to variant rs104894127dbSNPEnsembl.1
Natural variantiVAR_07149093Q → R in DA1A. 1 PublicationCorresponds to variant rs199476151dbSNPEnsembl.1
Natural variantiVAR_071491117E → K in DA1A; also found in a patient with congenital myopathy with fiber-type disproportion. 1 PublicationCorresponds to variant rs104894129dbSNPEnsembl.1
Natural variantiVAR_070981133R → W in DA2B, NEM4 and DA1A; also found in a patient with congenital myopathy with fiber-type disproportion. 2 PublicationsCorresponds to variant rs137853305dbSNPEnsembl.1
Natural variantiVAR_071498261Y → C in DA1A; also found in patients with undefined congenital myopathy. 1 Publication1
Cap myopathy 2 (CAPM2)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare congenital skeletal muscle disorder characterized by the presence of cap-like structures which are well demarcated and peripherally located under the sarcolemma and show abnormal accumulation of sarcomeric proteins. Clinical features are early onset of hypotonia and non-progressive or slowly progressive muscle weakness. Respiratory problems are common.
See also OMIM:609285
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07097949Missing in CAPM2. 1 Publication1
Natural variantiVAR_07098052G → GG in CAPM2. 1 Publication1
Natural variantiVAR_070982139Missing in CAPM2; also found in a patient with congenital myopathy with fiber-type disproportion. 3 Publications1
Natural variantiVAR_070983202N → K in CAPM2. 1 PublicationCorresponds to variant rs137853307dbSNPEnsembl.1
Arthrogryposis, distal, 2B (DA2B)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. DA2B is characterized by contractures of the hands and feet, and a distinctive face characterized by prominent nasolabial folds, small mouth and downslanting palpebral fissures.
See also OMIM:601680
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070981133R → W in DA2B, NEM4 and DA1A; also found in a patient with congenital myopathy with fiber-type disproportion. 2 PublicationsCorresponds to variant rs137853305dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation, Nemaline myopathy

Organism-specific databases

DisGeNETi7169.
MalaCardsiTPM2.
MIMi108120. phenotype.
601680. phenotype.
609285. phenotype.
OpenTargetsiENSG00000198467.
Orphaneti171881. Cap myopathy.
171439. Childhood-onset nemaline myopathy.
2020. Congenital fiber-type disproportion myopathy.
1146. Digitotalar dysmorphism.
1147. Sheldon-Hall syndrome.
171436. Typical nemaline myopathy.
PharmGKBiPA36691.

Polymorphism and mutation databases

BioMutaiTPM2.
DMDMi136090.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002056271 – 284Tropomyosin beta chainAdd BLAST284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei53Phosphothreonine1 Publication1
Modified residuei61Phosphoserine; by PIK3CGBy similarity1
Cross-linki77Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei79Phosphothreonine1 Publication1
Modified residuei87PhosphoserineBy similarity1
Modified residuei108Phosphothreonine1 Publication1
Modified residuei158Phosphoserine1 Publication1
Modified residuei206Phosphoserine1 Publication1
Modified residuei215PhosphoserineBy similarity1
Modified residuei252Phosphothreonine1 Publication1
Modified residuei261PhosphotyrosineBy similarity1
Modified residuei271PhosphoserineBy similarity1
Modified residuei282Phosphothreonine1 Publication1
Modified residuei283Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylated on Ser-61 by PIK3CG. Phosphorylation on Ser-61 is required for ADRB2 internalization (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP07951.
MaxQBiP07951.
PaxDbiP07951.
PeptideAtlasiP07951.
PRIDEiP07951.

2D gel databases

DOSAC-COBS-2DPAGEP07951.
REPRODUCTION-2DPAGEIPI00220709.
UCD-2DPAGEP07951.

PTM databases

iPTMnetiP07951.
PhosphoSitePlusiP07951.

Expressioni

Tissue specificityi

Present in primary breast cancer tissue, absent from normal breast tissue.1 Publication

Gene expression databases

BgeeiENSG00000198467.
CleanExiHS_TPM2.
ExpressionAtlasiP07951. baseline and differential.
GenevisibleiP07951. HS.

Organism-specific databases

HPAiHPA009066.
HPA047089.
HPA053624.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

GO - Molecular functioni

  • actin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi113022. 121 interactors.
IntActiP07951. 38 interactors.
MINTiMINT-94363.
STRINGi9606.ENSP00000354219.

Structurei

3D structure databases

ProteinModelPortaliP07951.
SMRiP07951.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 284By similarityAdd BLAST284

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1003. Eukaryota.
ENOG410XR5K. LUCA.
GeneTreeiENSGT00550000074494.
HOVERGENiHBG107404.
InParanoidiP07951.
KOiK10374.
OMAiTEPTHEC.
PhylomeDBiP07951.
TreeFamiTF351519.

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P07951-1) [UniParc]FASTAAdd to basket
Also known as: Skeletal muscle

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDAIKKKMQM LKLDKENAID RAEQAEADKK QAEDRCKQLE EEQQALQKKL
60 70 80 90 100
KGTEDEVEKY SESVKEAQEK LEQAEKKATD AEADVASLNR RIQLVEEELD
110 120 130 140 150
RAQERLATAL QKLEEAEKAA DESERGMKVI ENRAMKDEEK MELQEMQLKE
160 170 180 190 200
AKHIAEDSDR KYEEVARKLV ILEGELERSE ERAEVAESKC GDLEEELKIV
210 220 230 240 250
TNNLKSLEAQ ADKYSTKEDK YEEEIKLLEE KLKEAETRAE FAERSVAKLE
260 270 280
KTIDDLEDEV YAQKMKYKAI SEELDNALND ITSL
Length:284
Mass (Da):32,851
Last modified:August 1, 1988 - v1
Checksum:i18E330568E14E0BE
GO
Isoform 2 (identifier: P07951-2) [UniParc]FASTAAdd to basket
Also known as: non-muscle, Fibroblast TM36, Epithelial TMe1

The sequence of this isoform differs from the canonical sequence as follows:
     189-213: KCGDLEEELKIVTNNLKSLEAQADK → RARQLEEELRTMDQALKSLMASEEE
     258-284: DEVYAQKMKYKAISEELDNALNDITSL → ETLASAKEENVEIHQTLDQTLLELNNL

Show »
Length:284
Mass (Da):32,990
Checksum:i584D60A8A4D6E9CA
GO
Isoform 3 (identifier: P07951-3) [UniParc]FASTAAdd to basket
Also known as: non-muscle

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: MDAIKKKMQM...LEQAEKKATD → MAGISSIDAV...ADAERQARER
     189-213: KCGDLEEELKIVTNNLKSLEAQADK → RARQLEEELRTMDQALKSLMASEEE
     258-284: DEVYAQKMKYKAISEELDNALNDITSL → ETLASAKEENVEIHQTLDQTLLELNNL

Show »
Length:248
Mass (Da):28,684
Checksum:iD89A89A37CF9D026
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89N → S in BAD96978 (Ref. 4) Curated1

Mass spectrometryi

Isoform 1 : Molecular mass is 32850.73 Da from positions 1 - 284. Determined by MALDI. 1 Publication
Isoform 2 : Molecular mass is 32989.81 Da from positions 1 - 284. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0714852D → V Probable disease-associated mutation found in patients with undefined congenital myopathy. 1 PublicationCorresponds to variant rs199476145dbSNPEnsembl.1
Natural variantiVAR_0714863A → G in NEM4. 1 Publication1
Natural variantiVAR_0714877Missing in NEM4. 1 Publication1
Natural variantiVAR_07148814D → V in NEM4. 1 Publication1
Natural variantiVAR_07097841E → K in NEM4; also found in a patient with congenital myopathy with fiber-type disproportion and patients with undefined congenital myopathy. 2 PublicationsCorresponds to variant rs137853306dbSNPEnsembl.1
Natural variantiVAR_07097949Missing in CAPM2. 1 Publication1
Natural variantiVAR_07098052G → GG in CAPM2. 1 Publication1
Natural variantiVAR_01608691R → G in DA1A. 1 PublicationCorresponds to variant rs104894127dbSNPEnsembl.1
Natural variantiVAR_07148993Q → H Probable disease-associated mutation found in patients with undefined congenital myopathy. 1 PublicationCorresponds to variant rs727504180dbSNPEnsembl.1
Natural variantiVAR_07149093Q → R in DA1A. 1 PublicationCorresponds to variant rs199476151dbSNPEnsembl.1
Natural variantiVAR_013468117E → A in NEM4. 1 Publication1
Natural variantiVAR_071491117E → K in DA1A; also found in a patient with congenital myopathy with fiber-type disproportion. 1 PublicationCorresponds to variant rs104894129dbSNPEnsembl.1
Natural variantiVAR_071492128K → E Probable disease-associated mutation found in a patient with congenital myopathy with fiber-type disproportion and patients with undefined congenital myopathy. 1 Publication1
Natural variantiVAR_071493133R → P Probable disease-associated mutation found in a patient with congenital myopathy with fiber-type disproportion and patients with undefined congenital myopathy. 1 PublicationCorresponds to variant rs199476152dbSNPEnsembl.1
Natural variantiVAR_070981133R → W in DA2B, NEM4 and DA1A; also found in a patient with congenital myopathy with fiber-type disproportion. 2 PublicationsCorresponds to variant rs137853305dbSNPEnsembl.1
Natural variantiVAR_070982139Missing in CAPM2; also found in a patient with congenital myopathy with fiber-type disproportion. 3 Publications1
Natural variantiVAR_071494143L → P in NEM4; also found in a patient with congenital myopathy with fiber-type disproportion. 1 Publication1
Natural variantiVAR_013469147Q → P in NEM4. 1 PublicationCorresponds to variant rs104894128dbSNPEnsembl.1
Natural variantiVAR_071495148L → P in NEM4; also found in a patient with congenital myopathy with fiber-type disproportion. 1 Publication1
Natural variantiVAR_071496155A → T Probable disease-associated mutation found in patients with undefined congenital myopathy. 1 Publication1
Natural variantiVAR_070983202N → K in CAPM2. 1 PublicationCorresponds to variant rs137853307dbSNPEnsembl.1
Natural variantiVAR_071497218Missing Probable disease-associated mutation in patients with undefined congenital myopathy. 1 Publication1
Natural variantiVAR_071498261Y → C in DA1A; also found in patients with undefined congenital myopathy. 1 Publication1
Natural variantiVAR_052402273E → K.Corresponds to variant rs3180843dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0065941 – 80MDAIK…KKATD → MAGISSIDAVKKKIQSLQQV ADEAEERAEHLQREADAERQ ARER in isoform 3. CuratedAdd BLAST80
Alternative sequenceiVSP_006595189 – 213KCGDL…AQADK → RARQLEEELRTMDQALKSLM ASEEE in isoform 2 and isoform 3. 4 PublicationsAdd BLAST25
Alternative sequenceiVSP_006596258 – 284DEVYA…DITSL → ETLASAKEENVEIHQTLDQT LLELNNL in isoform 2 and isoform 3. 4 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12126 mRNA. Translation: AAA61229.1.
M12125 mRNA. Translation: AAA36773.1.
X06825 mRNA. Translation: CAA29971.1.
M75165 mRNA. Translation: AAB59509.1.
M74817 mRNA. Translation: AAA61230.1.
AK223258 mRNA. Translation: BAD96978.1.
AL133410 Genomic DNA. Translation: CAI10974.1.
AL133410 Genomic DNA. Translation: CAI10977.1.
CH471071 Genomic DNA. Translation: EAW58354.1.
BC011776 mRNA. Translation: AAH11776.1.
AF209746 Genomic DNA. Translation: AAF17621.1.
J05247 Genomic DNA. Translation: AAA51842.1.
CCDSiCCDS6586.1. [P07951-2]
CCDS6587.1. [P07951-1]
PIRiA23562.
S00922.
RefSeqiNP_003280.2. NM_003289.3. [P07951-1]
NP_998839.1. NM_213674.1. [P07951-2]
XP_016870580.1. XM_017015091.1. [P07951-1]
UniGeneiHs.300772.

Genome annotation databases

EnsembliENST00000360958; ENSP00000354219; ENSG00000198467. [P07951-1]
ENST00000378292; ENSP00000367542; ENSG00000198467. [P07951-2]
GeneIDi7169.
KEGGihsa:7169.
UCSCiuc003zxs.4. human. [P07951-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12126 mRNA. Translation: AAA61229.1.
M12125 mRNA. Translation: AAA36773.1.
X06825 mRNA. Translation: CAA29971.1.
M75165 mRNA. Translation: AAB59509.1.
M74817 mRNA. Translation: AAA61230.1.
AK223258 mRNA. Translation: BAD96978.1.
AL133410 Genomic DNA. Translation: CAI10974.1.
AL133410 Genomic DNA. Translation: CAI10977.1.
CH471071 Genomic DNA. Translation: EAW58354.1.
BC011776 mRNA. Translation: AAH11776.1.
AF209746 Genomic DNA. Translation: AAF17621.1.
J05247 Genomic DNA. Translation: AAA51842.1.
CCDSiCCDS6586.1. [P07951-2]
CCDS6587.1. [P07951-1]
PIRiA23562.
S00922.
RefSeqiNP_003280.2. NM_003289.3. [P07951-1]
NP_998839.1. NM_213674.1. [P07951-2]
XP_016870580.1. XM_017015091.1. [P07951-1]
UniGeneiHs.300772.

3D structure databases

ProteinModelPortaliP07951.
SMRiP07951.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113022. 121 interactors.
IntActiP07951. 38 interactors.
MINTiMINT-94363.
STRINGi9606.ENSP00000354219.

PTM databases

iPTMnetiP07951.
PhosphoSitePlusiP07951.

Polymorphism and mutation databases

BioMutaiTPM2.
DMDMi136090.

2D gel databases

DOSAC-COBS-2DPAGEP07951.
REPRODUCTION-2DPAGEIPI00220709.
UCD-2DPAGEP07951.

Proteomic databases

EPDiP07951.
MaxQBiP07951.
PaxDbiP07951.
PeptideAtlasiP07951.
PRIDEiP07951.

Protocols and materials databases

DNASUi7169.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360958; ENSP00000354219; ENSG00000198467. [P07951-1]
ENST00000378292; ENSP00000367542; ENSG00000198467. [P07951-2]
GeneIDi7169.
KEGGihsa:7169.
UCSCiuc003zxs.4. human. [P07951-1]

Organism-specific databases

CTDi7169.
DisGeNETi7169.
GeneCardsiTPM2.
GeneReviewsiTPM2.
HGNCiHGNC:12011. TPM2.
HPAiHPA009066.
HPA047089.
HPA053624.
MalaCardsiTPM2.
MIMi108120. phenotype.
190990. gene.
601680. phenotype.
609285. phenotype.
neXtProtiNX_P07951.
OpenTargetsiENSG00000198467.
Orphaneti171881. Cap myopathy.
171439. Childhood-onset nemaline myopathy.
2020. Congenital fiber-type disproportion myopathy.
1146. Digitotalar dysmorphism.
1147. Sheldon-Hall syndrome.
171436. Typical nemaline myopathy.
PharmGKBiPA36691.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1003. Eukaryota.
ENOG410XR5K. LUCA.
GeneTreeiENSGT00550000074494.
HOVERGENiHBG107404.
InParanoidiP07951.
KOiK10374.
OMAiTEPTHEC.
PhylomeDBiP07951.
TreeFamiTF351519.

Enzyme and pathway databases

BioCyciZFISH:G66-31495-MONOMER.
ReactomeiR-HSA-390522. Striated Muscle Contraction.
R-HSA-445355. Smooth Muscle Contraction.

Miscellaneous databases

ChiTaRSiTPM2. human.
GeneWikiiTPM2.
GenomeRNAii7169.
PROiP07951.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198467.
CleanExiHS_TPM2.
ExpressionAtlasiP07951. baseline and differential.
GenevisibleiP07951. HS.

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPM2_HUMAN
AccessioniPrimary (citable) accession number: P07951
Secondary accession number(s): A6NM85
, P06468, Q13894, Q53FM4, Q5TCU4, Q5TCU7, Q9UH67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 30, 2016
This is version 176 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.