##gff-version 3 P07949 UniProtKB Signal peptide 1 28 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 P07949 UniProtKB Chain 29 1114 . . . ID=PRO_0000024450;Note=Proto-oncogene tyrosine-protein kinase receptor Ret P07949 UniProtKB Chain 29 707 . . . ID=PRO_0000415292;Note=Extracellular cell-membrane anchored RET cadherin 120 kDa fragment P07949 UniProtKB Chain 708 1017 . . . ID=PRO_0000415293;Note=Soluble RET kinase fragment P07949 UniProtKB Topological domain 29 635 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P07949 UniProtKB Transmembrane 636 657 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P07949 UniProtKB Topological domain 658 1114 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P07949 UniProtKB Domain 168 272 . . . Note=Cadherin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043 P07949 UniProtKB Domain 724 1016 . . . Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P07949 UniProtKB Active site 874 874 . . . Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10028 P07949 UniProtKB Binding site 730 738 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P07949 UniProtKB Binding site 758 758 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P07949 UniProtKB Binding site 805 807 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:20117004,ECO:0007744|PDB:2X2M;Dbxref=PMID:20117004 P07949 UniProtKB Site 587 588 . . . Note=Breakpoint for translocation to form the TRIM27/RET oncogene P07949 UniProtKB Site 707 708 . . . Note=Cleavage%3B by caspase-3 P07949 UniProtKB Site 712 713 . . . Note=Breakpoint for translocation to form PCM1-RET%3B RET-CCDC6%3B RET-GOLGA5%3B RET-TRIM24 and RET-TRIM33 oncogenes P07949 UniProtKB Site 1017 1018 . . . Note=Cleavage%3B by caspase-3 P07949 UniProtKB Modified residue 696 696 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 P07949 UniProtKB Modified residue 806 806 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14711813;Dbxref=PMID:14711813 P07949 UniProtKB Modified residue 809 809 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14711813;Dbxref=PMID:14711813 P07949 UniProtKB Modified residue 900 900 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14711813,ECO:0000269|PubMed:16928683;Dbxref=PMID:14711813,PMID:16928683 P07949 UniProtKB Modified residue 905 905 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14711813,ECO:0000269|PubMed:16928683,ECO:0000269|PubMed:20117004,ECO:0000269|PubMed:28846099;Dbxref=PMID:14711813,PMID:16928683,PMID:20117004,PMID:28846099 P07949 UniProtKB Modified residue 981 981 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14711813;Dbxref=PMID:14711813 P07949 UniProtKB Modified residue 1015 1015 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11061555;Dbxref=PMID:11061555 P07949 UniProtKB Modified residue 1062 1062 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11061555,ECO:0000269|PubMed:14711813,ECO:0000269|PubMed:28846099;Dbxref=PMID:11061555,PMID:14711813,PMID:28846099 P07949 UniProtKB Modified residue 1090 1090 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14711813;Dbxref=PMID:14711813 P07949 UniProtKB Modified residue 1096 1096 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14711813;Dbxref=PMID:14711813 P07949 UniProtKB Glycosylation 98 98 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P07949 UniProtKB Glycosylation 151 151 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20473317;Dbxref=PMID:20473317 P07949 UniProtKB Glycosylation 199 199 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P07949 UniProtKB Glycosylation 336 336 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P07949 UniProtKB Glycosylation 343 343 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P07949 UniProtKB Glycosylation 361 361 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P07949 UniProtKB Glycosylation 367 367 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P07949 UniProtKB Glycosylation 377 377 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P07949 UniProtKB Glycosylation 394 394 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P07949 UniProtKB Glycosylation 448 448 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P07949 UniProtKB Glycosylation 468 468 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P07949 UniProtKB Glycosylation 554 554 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P07949 UniProtKB Glycosylation 688 688 . . . Note=O-linked (GlcNAc) serine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26237509;Dbxref=PMID:26237509 P07949 UniProtKB Disulfide bond 137 142 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20473317;Dbxref=PMID:20473317 P07949 UniProtKB Alternative sequence 1064 1114 . . . ID=VSP_040735;Note=In isoform 2. MSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS->RISHAFTRF;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:3037315;Dbxref=PMID:14702039,PMID:15489334,PMID:3037315 P07949 UniProtKB Natural variant 20 20 . . . ID=VAR_009459;Note=In HSCR1%3B sporadic form. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7633441;Dbxref=PMID:7633441 P07949 UniProtKB Natural variant 32 32 . . . ID=VAR_006295;Note=In HSCR1%3B familial form. S->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10618407,ECO:0000269|PubMed:8114939;Dbxref=dbSNP:rs76764689,PMID:10618407,PMID:8114939 P07949 UniProtKB Natural variant 40 40 . . . ID=VAR_009492;Note=In HSCR1. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7704557,ECO:0000269|PubMed:9043870;Dbxref=PMID:7704557,PMID:9043870 P07949 UniProtKB Natural variant 64 64 . . . ID=VAR_006296;Note=In HSCR1%3B familial form. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8114939;Dbxref=dbSNP:rs77596424,PMID:8114939 P07949 UniProtKB Natural variant 67 67 . . . ID=VAR_018153;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14566559;Dbxref=dbSNP:rs192489011,PMID:14566559 P07949 UniProtKB Natural variant 77 77 . . . ID=VAR_009460;Note=In HSCR1. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10618407;Dbxref=PMID:10618407 P07949 UniProtKB Natural variant 93 93 . . . ID=VAR_006297;Note=In HSCR1%3B uncertain significance. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7633441;Dbxref=dbSNP:rs1477699803,PMID:7633441 P07949 UniProtKB Natural variant 114 114 . . . ID=VAR_067101;Note=In HSCR1%3B uncertain significance. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22174939;Dbxref=dbSNP:rs747483905,PMID:22174939 P07949 UniProtKB Natural variant 114 114 . . . ID=VAR_018154;Note=R->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12086152,ECO:0000269|PubMed:14566559,ECO:0000269|PubMed:22174939;Dbxref=dbSNP:rs76397662,PMID:12086152,PMID:14566559,PMID:22174939 P07949 UniProtKB Natural variant 142 142 . . . ID=VAR_006298;Note=In HSCR1%3B sporadic form. C->S P07949 UniProtKB Natural variant 145 145 . . . ID=VAR_035711;Note=In HSCR1%3B also in a colorectal cancer sample%3B somatic mutation. V->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16959974,ECO:0000269|PubMed:22174939;Dbxref=dbSNP:rs1588863999,PMID:16959974,PMID:22174939 P07949 UniProtKB Natural variant 155 155 . . . ID=VAR_067102;Note=In HSCR1. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22174939;Dbxref=PMID:22174939 P07949 UniProtKB Natural variant 157 157 . . . ID=VAR_009461;Note=In HSCR1%3B uncertain significance. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.64 P07949 UniProtKB Natural variant 163 163 . . . ID=VAR_041762;Note=In a colorectal adenocarcinoma sample%3B somatic mutation. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs149403911,PMID:17344846 P07949 UniProtKB Natural variant 174 174 . . . ID=VAR_009462;Note=In HSCR1%3B sporadic form. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9094028;Dbxref=PMID:9094028 P07949 UniProtKB Natural variant 175 175 . . . ID=VAR_067103;Note=In HSCR1. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22174939;Dbxref=PMID:22174939 P07949 UniProtKB Natural variant 180 180 . . . ID=VAR_009463;Note=In HSCR1%3B sporadic form. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9090527;Dbxref=PMID:9090527 P07949 UniProtKB Natural variant 197 197 . . . ID=VAR_009464;Note=In HSCR1%3B sporadic form. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9094028;Dbxref=PMID:9094028 P07949 UniProtKB Natural variant 198 198 . . . ID=VAR_044392;Note=In a patient with renal agenesis%3B uncertain significance%3B prevents phosphorylation in response to GDNF. P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18252215;Dbxref=dbSNP:rs76736111,PMID:18252215 P07949 UniProtKB Natural variant 231 231 . . . ID=VAR_006299;Note=In HSCR1%3B familial form. R->H;Dbxref=dbSNP:rs79661516 P07949 UniProtKB Natural variant 251 251 . . . ID=VAR_006300;Note=In HSCR1%3B familial form. E->K;Dbxref=dbSNP:rs562449603 P07949 UniProtKB Natural variant 278 278 . . . ID=VAR_067104;Note=In HSCR1. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22174939;Dbxref=dbSNP:rs541929171,PMID:22174939 P07949 UniProtKB Natural variant 278 278 . . . ID=VAR_041763;Note=Found in two patients with Hirschsprung disease. T->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344846,ECO:0000269|PubMed:22174939;Dbxref=dbSNP:rs35118262,PMID:17344846,PMID:22174939 P07949 UniProtKB Natural variant 278 278 . . . ID=VAR_067105;Note=In HSCR1. T->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22174939;Dbxref=PMID:22174939 P07949 UniProtKB Natural variant 287 287 . . . ID=VAR_006301;Note=In HSCR1%3B sporadic form. R->Q;Dbxref=dbSNP:rs1564491460 P07949 UniProtKB Natural variant 292 292 . . . ID=VAR_041764;Note=Found in patients with Hirschsprung disease%3B uncertain significance. V->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344846,ECO:0000269|PubMed:22174939;Dbxref=dbSNP:rs34682185,PMID:17344846,PMID:22174939 P07949 UniProtKB Natural variant 300 300 . . . ID=VAR_067106;Note=In HSCR1. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22174939;Dbxref=PMID:22174939 P07949 UniProtKB Natural variant 313 313 . . . ID=VAR_009465;Note=In HSCR1. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22174939,ECO:0000269|PubMed:9090527;Dbxref=dbSNP:rs77702891,PMID:22174939,PMID:9090527 P07949 UniProtKB Natural variant 316 316 . . . ID=VAR_067107;Note=In HSCR1. S->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22174939;Dbxref=dbSNP:rs1060499894,PMID:22174939 P07949 UniProtKB Natural variant 330 330 . . . ID=VAR_006302;Note=In HSCR1. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7633441,ECO:0000269|PubMed:8114939;Dbxref=dbSNP:rs80236571,PMID:7633441,PMID:8114939 P07949 UniProtKB Natural variant 339 339 . . . ID=VAR_067108;Note=In HSCR1. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22174939;Dbxref=dbSNP:rs774829203,PMID:22174939 P07949 UniProtKB Natural variant 353 353 . . . ID=VAR_067109;Note=In HSCR1. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22174939;Dbxref=dbSNP:rs1837785429,PMID:22174939 P07949 UniProtKB Natural variant 359 359 . . . ID=VAR_009466;Note=In HSCR1%3B uncertain significance. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.64 P07949 UniProtKB Natural variant 360 360 . . . ID=VAR_067110;Note=In HSCR1. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22174939;Dbxref=dbSNP:rs762472027,PMID:22174939 P07949 UniProtKB Natural variant 360 360 . . . ID=VAR_009467;Note=In HSCR1. R->W;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10618407,ECO:0000269|PubMed:16959974;Dbxref=PMID:10618407,PMID:16959974 P07949 UniProtKB Natural variant 376 376 . . . ID=VAR_044393;Note=In a patient with renal agenesis%3B uncertain significance%3B constitutively phosphorylated%3B expressed only the immature intracellular form. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18252215;Dbxref=PMID:18252215 P07949 UniProtKB Natural variant 393 393 . . . ID=VAR_006303;Note=In HSCR1%3B familial form. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8114939;Dbxref=dbSNP:rs78098482,PMID:8114939 P07949 UniProtKB Natural variant 394 394 . . . ID=VAR_044394;Note=In a patient with renal agenesis%3B uncertain significance%3B prevents phosphorylation in response to GDNF. N->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18252215;Dbxref=PMID:18252215 P07949 UniProtKB Natural variant 394 394 . . . ID=VAR_009468;Note=In HSCR1. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10618407;Dbxref=PMID:10618407 P07949 UniProtKB Natural variant 397 397 . . . ID=VAR_067111;Note=In HSCR1. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22174939;Dbxref=dbSNP:rs183729115,PMID:22174939 P07949 UniProtKB Natural variant 399 399 . . . ID=VAR_006304;Note=In HSCR1%3B sporadic form. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7704557;Dbxref=dbSNP:rs1554818362,PMID:7704557 P07949 UniProtKB Natural variant 412 412 . . . ID=VAR_067112;Note=In HSCR1. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22174939;Dbxref=dbSNP:rs746970700,PMID:22174939 P07949 UniProtKB Natural variant 423 423 . . . ID=VAR_067113;Note=In HSCR1. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22174939;Dbxref=dbSNP:rs767601598,PMID:22174939 P07949 UniProtKB Natural variant 432 432 . . . ID=VAR_018155;Note=Found in a patient with congenital central hypoventilation syndrome%3B uncertain significance. A->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14566559;Dbxref=dbSNP:rs552057730,PMID:14566559 P07949 UniProtKB Natural variant 475 475 . . . ID=VAR_006305;Note=In HSCR1%3B sporadic form. R->Q;Dbxref=dbSNP:rs138624658 P07949 UniProtKB Natural variant 480 480 . . . ID=VAR_067114;Note=In HSCR1. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22174939;Dbxref=dbSNP:rs537874538,PMID:22174939 P07949 UniProtKB Natural variant 489 489 . . . ID=VAR_018156;Note=D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14566559,ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs9282834,PMID:14566559,PMID:17344846 P07949 UniProtKB Natural variant 531 531 . . . ID=VAR_009469;Note=In MTC%3B familial form. C->CEEC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10323403;Dbxref=PMID:10323403 P07949 UniProtKB Natural variant 549 550 . . . ID=VAR_067115;Note=In HSCR1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22174939;Dbxref=PMID:22174939 P07949 UniProtKB Natural variant 593 593 . . . ID=VAR_035712;Note=In a colorectal cancer sample%3B somatic mutation. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 P07949 UniProtKB Natural variant 595 595 . . . ID=VAR_067116;Note=In HSCR1. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22174939;Dbxref=dbSNP:rs1483605155,PMID:22174939 P07949 UniProtKB Natural variant 600 600 . . . ID=VAR_008966;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10612852;Dbxref=dbSNP:rs377767393,PMID:10612852 P07949 UniProtKB Natural variant 609 609 . . . ID=VAR_009470;Note=In MEN2A. C->G;Dbxref=dbSNP:rs77558292 P07949 UniProtKB Natural variant 609 609 . . . ID=VAR_009471;Note=In MEN2A. C->R;Dbxref=dbSNP:rs77558292 P07949 UniProtKB Natural variant 609 609 . . . ID=VAR_006307;Note=In HSCR1%3B familial form. C->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7881414;Dbxref=dbSNP:rs377767396,PMID:7881414 P07949 UniProtKB Natural variant 609 609 . . . ID=VAR_006306;Note=In MTC%2C MEN2A and HSCR1%3B familial and sporadic forms. C->Y;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7633441,ECO:0000269|PubMed:7849720,ECO:0000269|PubMed:9384613,ECO:0000269|Ref.64;Dbxref=dbSNP:rs77939446,PMID:7633441,PMID:7849720,PMID:9384613 P07949 UniProtKB Natural variant 611 611 . . . ID=VAR_009472;Note=In MTC%3B familial form. C->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9677065;Dbxref=dbSNP:rs377767391,PMID:9677065 P07949 UniProtKB Natural variant 611 611 . . . ID=VAR_009473;Note=In MEN2A. C->R;Dbxref=dbSNP:rs377767391 P07949 UniProtKB Natural variant 611 611 . . . ID=VAR_009474;Note=In MEN2A. C->S;Dbxref=dbSNP:rs377767391 P07949 UniProtKB Natural variant 611 611 . . . ID=VAR_006308;Note=In MEN2A and MTC%3B familial form. C->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8103403;Dbxref=dbSNP:rs80069458,PMID:8103403 P07949 UniProtKB Natural variant 611 611 . . . ID=VAR_006309;Note=In MEN2A. C->Y;Dbxref=dbSNP:rs377767397 P07949 UniProtKB Natural variant 618 618 . . . ID=VAR_006312;Note=In MEN2A and MTC%3B familial form. C->F;Dbxref=dbSNP:rs79781594 P07949 UniProtKB Natural variant 618 618 . . . ID=VAR_006310;Note=In MEN2A. C->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8099202;Dbxref=dbSNP:rs76262710,PMID:8099202 P07949 UniProtKB Natural variant 618 618 . . . ID=VAR_006311;Note=In MEN2A%2C MTC and HSCR1. C->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7849720,ECO:0000269|PubMed:7881414,ECO:0000269|PubMed:7915165,ECO:0000269|PubMed:9259198;Dbxref=dbSNP:rs76262710,PMID:7849720,PMID:7881414,PMID:7915165,PMID:9259198 P07949 UniProtKB Natural variant 618 618 . . . ID=VAR_006313;Note=In MEN2A%2C HSCR1 and MTC%3B familial and sporadic forms. C->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7849720,ECO:0000269|PubMed:7860065,ECO:0000269|PubMed:7915165,ECO:0000269|PubMed:8103403,ECO:0000269|PubMed:9384613;Dbxref=dbSNP:rs79781594,PMID:7849720,PMID:7860065,PMID:7915165,PMID:8103403,PMID:9384613 P07949 UniProtKB Natural variant 618 618 . . . ID=VAR_006314;Note=In MEN2A and MTC%3B familial form. C->Y;Dbxref=dbSNP:rs79781594 P07949 UniProtKB Natural variant 620 620 . . . ID=VAR_006318;Note=In MEN2A and MTC%3B familial form. C->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7915165;Dbxref=dbSNP:rs77503355,PMID:7915165 P07949 UniProtKB Natural variant 620 620 . . . ID=VAR_006315;Note=In MEN2A and MTC%3B familial and sporadic forms. C->G;Dbxref=dbSNP:rs77316810 P07949 UniProtKB Natural variant 620 620 . . . ID=VAR_006316;Note=In MEN2A%2C MTC and HSCR1%3B familial and sporadic forms. C->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7633441,ECO:0000269|PubMed:7881414,ECO:0000269|PubMed:7915165,ECO:0000269|PubMed:8103403,ECO:0000269|PubMed:9090527,ECO:0000269|PubMed:9384613,ECO:0000269|Ref.64;Dbxref=dbSNP:rs77316810,PMID:7633441,PMID:7881414,PMID:7915165,PMID:8103403,PMID:9090527,PMID:9384613 P07949 UniProtKB Natural variant 620 620 . . . ID=VAR_006317;Note=In MEN2A and MTC%3B familial form. C->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7849720,ECO:0000269|PubMed:7860065;Dbxref=dbSNP:rs77503355,PMID:7849720,PMID:7860065 P07949 UniProtKB Natural variant 620 620 . . . ID=VAR_009475;Note=In MEN2A and HSCR1. C->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9384613;Dbxref=dbSNP:rs79890926,PMID:9384613 P07949 UniProtKB Natural variant 620 620 . . . ID=VAR_006319;Note=In MEN2A. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8103403;Dbxref=dbSNP:rs77503355,PMID:8103403 P07949 UniProtKB Natural variant 626 626 . . . ID=VAR_009476;Note=In HSCR1%3B sporadic form. Q->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10090908;Dbxref=dbSNP:rs1255575160,PMID:10090908 P07949 UniProtKB Natural variant 630 630 . . . ID=VAR_006320;Note=In MEN2A and MTC%3B familial form. C->F;Dbxref=dbSNP:rs377767405 P07949 UniProtKB Natural variant 630 630 . . . ID=VAR_009477;Note=In MTC%3B sporadic form. C->S;Dbxref=dbSNP:rs377767405 P07949 UniProtKB Natural variant 630 630 . . . ID=VAR_009478;Note=In MTC%3B familial and sporadic forms. C->Y;Dbxref=dbSNP:rs377767405 P07949 UniProtKB Natural variant 631 631 . . . ID=VAR_006321;Note=In thyroid carcinoma%3B somatic mutation. D->G;Dbxref=dbSNP:rs121913308 P07949 UniProtKB Natural variant 632 634 . . . ID=VAR_006322;Note=In MEN2A. ELC->DVR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8099202;Dbxref=dbSNP:rs377767408,PMID:8099202 P07949 UniProtKB Natural variant 634 635 . . . ID=VAR_006329;Note=In MEN2A. CR->WG P07949 UniProtKB Natural variant 634 634 . . . ID=VAR_009479;Note=In MEN2A. C->CHELC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9097963;Dbxref=PMID:9097963 P07949 UniProtKB Natural variant 634 634 . . . ID=VAR_006324;Note=In MEN2A and pheochromocytoma. C->F;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12000816,ECO:0000269|PubMed:7915165,ECO:0000269|PubMed:8099202;Dbxref=dbSNP:rs75996173,PMID:12000816,PMID:7915165,PMID:8099202 P07949 UniProtKB Natural variant 634 634 . . . ID=VAR_006323;Note=In MEN2A and pheochromocytoma. C->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12000816,ECO:0000269|PubMed:7915165,ECO:0000269|PubMed:8099202;Dbxref=dbSNP:rs75076352,PMID:12000816,PMID:7915165,PMID:8099202 P07949 UniProtKB Natural variant 634 634 . . . ID=VAR_006326;Note=In MEN2A%2C pheochromocytoma and MTC%3B familial form%3B also found as somatic mutation in a sporadic thyroid carcinoma. C->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12000816,ECO:0000269|PubMed:7860065,ECO:0000269|PubMed:8103403;Dbxref=dbSNP:rs75076352,PMID:12000816,PMID:7860065,PMID:8103403 P07949 UniProtKB Natural variant 634 634 . . . ID=VAR_006327;Note=In MEN2A%2C pheochromocytoma and MTC%3B familial form. C->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12000816,ECO:0000269|PubMed:8099202;Dbxref=dbSNP:rs75076352,PMID:12000816,PMID:8099202 P07949 UniProtKB Natural variant 634 634 . . . ID=VAR_006328;Note=In MEN2A%2C pheochromocytoma and MTC%3B familial form. C->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12000816;Dbxref=dbSNP:rs77709286,PMID:12000816 P07949 UniProtKB Natural variant 634 634 . . . ID=VAR_006325;Note=In MEN2A%2C pheochromocytoma and MTC%3B familial form. C->Y;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12000816,ECO:0000269|PubMed:7860065,ECO:0000269|PubMed:7915165,ECO:0000269|PubMed:8099202;Dbxref=dbSNP:rs75996173,PMID:12000816,PMID:7860065,PMID:7915165,PMID:8099202 P07949 UniProtKB Natural variant 636 636 . . . ID=VAR_006330;Note=In MEN2A. T->TCRT;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9452064;Dbxref=PMID:9452064 P07949 UniProtKB Natural variant 639 639 . . . ID=VAR_012743;Note=In MTC%3B sporadic form. A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11692159;Dbxref=PMID:11692159 P07949 UniProtKB Natural variant 640 640 . . . ID=VAR_009480;Note=In MEN2A. A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10522989;Dbxref=dbSNP:rs78935588,PMID:10522989 P07949 UniProtKB Natural variant 641 641 . . . ID=VAR_012744;Note=In MTC%3B sporadic form. A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11692159;Dbxref=PMID:11692159 P07949 UniProtKB Natural variant 679 679 . . . ID=VAR_067117;Note=In HSCR1. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22174939;Dbxref=PMID:22174939 P07949 UniProtKB Natural variant 690 690 . . . ID=VAR_006331;Note=In HSCR1%3B sporadic form. S->P P07949 UniProtKB Natural variant 691 691 . . . ID=VAR_006332;Note=G->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14566559,ECO:0000269|PubMed:17344846,ECO:0000269|PubMed:9223675,ECO:0000269|PubMed:9497256;Dbxref=dbSNP:rs1799939,PMID:14566559,PMID:17344846,PMID:9223675,PMID:9497256 P07949 UniProtKB Natural variant 694 694 . . . ID=VAR_067118;Note=In HSCR1. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22174939;Dbxref=dbSNP:rs141185224,PMID:22174939 P07949 UniProtKB Natural variant 749 749 . . . ID=VAR_041765;Note=R->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34288963,PMID:17344846 P07949 UniProtKB Natural variant 762 762 . . . ID=VAR_009481;Note=In HSCR1%3B sporadic form. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7704557;Dbxref=PMID:7704557 P07949 UniProtKB Natural variant 765 765 . . . ID=VAR_009493;Note=In HSCR1. S->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7704557,ECO:0000269|PubMed:8114938,ECO:0000269|PubMed:9043870;Dbxref=dbSNP:rs75075748,PMID:7704557,PMID:8114938,PMID:9043870 P07949 UniProtKB Natural variant 767 767 . . . ID=VAR_006334;Note=In HSCR1%3B sporadic form. S->R P07949 UniProtKB Natural variant 768 768 . . . ID=VAR_006335;Note=In MTC%3B familial and sporadic forms. E->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7784092,ECO:0000269|PubMed:7845675,ECO:0000269|PubMed:8807338;Dbxref=dbSNP:rs78014899,PMID:7784092,PMID:7845675,PMID:8807338 P07949 UniProtKB Natural variant 778 778 . . . ID=VAR_044395;Note=In a patient with renal agenesis%3B uncertain significance%3B constitutively phosphorylated. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18252215;Dbxref=dbSNP:rs75686697,PMID:18252215 P07949 UniProtKB Natural variant 783 783 . . . ID=VAR_067119;Note=In HSCR1. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22174939;Dbxref=dbSNP:rs587778656,PMID:22174939 P07949 UniProtKB Natural variant 790 790 . . . ID=VAR_009482;Note=In MEN2A and MTC%3B familial form. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9506724;Dbxref=dbSNP:rs75030001,PMID:9506724 P07949 UniProtKB Natural variant 791 791 . . . ID=VAR_009483;Note=In HSCR1%2C pheochromocytoma%2C MTC and MEN2A%3B familial form. Y->F;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12000816,ECO:0000269|PubMed:9090527,ECO:0000269|PubMed:9506724;Dbxref=dbSNP:rs77724903,PMID:12000816,PMID:9090527,PMID:9506724 P07949 UniProtKB Natural variant 804 804 . . . ID=VAR_006336;Note=In MTC%3B familial form. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7784092;Dbxref=dbSNP:rs79658334,PMID:7784092 P07949 UniProtKB Natural variant 804 804 . . . ID=VAR_006337;Note=In MTC%3B familial form. V->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10826520,ECO:0000269|PubMed:9452077;Dbxref=dbSNP:rs79658334,PMID:10826520,PMID:9452077 P07949 UniProtKB Natural variant 813 813 . . . ID=VAR_009484;Note=In HSCR1%3B sporadic form. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10090908;Dbxref=dbSNP:rs1318733775,PMID:10090908 P07949 UniProtKB Natural variant 826 826 . . . ID=VAR_041766;Note=Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34617196,PMID:17344846 P07949 UniProtKB Natural variant 830 830 . . . ID=VAR_067120;Note=In HSCR1. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22174939;Dbxref=dbSNP:rs200127630,PMID:22174939 P07949 UniProtKB Natural variant 844 844 . . . ID=VAR_011582;Note=In MTC%3B familial form. R->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10826520,ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55947360,PMID:10826520,PMID:17344846 P07949 UniProtKB Natural variant 873 873 . . . ID=VAR_006338;Note=In HSCR1%3B sporadic form. R->Q;Dbxref=dbSNP:rs1451004715 P07949 UniProtKB Natural variant 883 883 . . . ID=VAR_009485;Note=In MEN2B%3B somatic mutation in sporadic medullary thyroid carcinoma%3B requires 2 nucleotide substitutions. A->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:9294615,ECO:0000269|PubMed:9360560;Dbxref=dbSNP:rs377767429,PMID:9294615,PMID:9360560 P07949 UniProtKB Natural variant 891 891 . . . ID=VAR_009486;Note=In MTC%3B familial form. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9398735;Dbxref=dbSNP:rs75234356,PMID:9398735 P07949 UniProtKB Natural variant 893 893 . . . ID=VAR_006339;Note=In HSCR1%3B sporadic form. F->L P07949 UniProtKB Natural variant 894 894 . . . ID=VAR_044396;Note=In a patient with renal agenesis%3B uncertain significance%3B constitutively phosphorylated%3B expressed only the immature intracellular form. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18252215;Dbxref=PMID:18252215 P07949 UniProtKB Natural variant 897 897 . . . ID=VAR_006340;Note=In HSCR1%3B sporadic form. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7704557,ECO:0000269|PubMed:8114938;Dbxref=dbSNP:rs76087194,PMID:7704557,PMID:8114938 P07949 UniProtKB Natural variant 907 907 . . . ID=VAR_006341;Note=In HSCR1%3B sporadic form. K->E;Dbxref=dbSNP:rs377767430 P07949 UniProtKB Natural variant 907 907 . . . ID=VAR_067121;Note=In HSCR1. K->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22174939;Dbxref=PMID:22174939 P07949 UniProtKB Natural variant 918 918 . . . ID=VAR_006342;Note=In MEN2B and MTC%3B sporadic form%3B somatic mutation%3B also found in a patient with renal agenesis. M->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18252215,ECO:0000269|PubMed:7906417,ECO:0000269|PubMed:7906866,ECO:0000269|PubMed:7911697,ECO:0000269|PubMed:8595427,ECO:0000269|PubMed:8807338;Dbxref=dbSNP:rs74799832,PMID:18252215,PMID:7906417,PMID:7906866,PMID:7911697,PMID:8595427,PMID:8807338 P07949 UniProtKB Natural variant 921 921 . . . ID=VAR_006343;Note=In HSCR1%3B sporadic form. E->K P07949 UniProtKB Natural variant 922 922 . . . ID=VAR_012745;Note=In MTC%3B sporadic form. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11692159;Dbxref=dbSNP:rs377767432,PMID:11692159 P07949 UniProtKB Natural variant 922 922 . . . ID=VAR_009487;Note=S->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8595427;Dbxref=dbSNP:rs377767432,PMID:8595427 P07949 UniProtKB Natural variant 946 946 . . . ID=VAR_006345;Note=In MEN2B and MTC%3B familial form. T->M P07949 UniProtKB Natural variant 961 961 . . . ID=VAR_067122;Note=In HSCR1. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22174939;Dbxref=PMID:22174939 P07949 UniProtKB Natural variant 972 972 . . . ID=VAR_006346;Note=In HSCR1%3B familial form. R->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7704557,ECO:0000269|PubMed:8114938;Dbxref=dbSNP:rs76534745,PMID:7704557,PMID:8114938 P07949 UniProtKB Natural variant 973 973 . . . ID=VAR_006347;Note=In HSCR1%3B familial form. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7704557;Dbxref=PMID:7704557 P07949 UniProtKB Natural variant 980 980 . . . ID=VAR_006348;Note=In HSCR1%3B sporadic form. M->T P07949 UniProtKB Natural variant 982 982 . . . ID=VAR_006349;Note=R->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14566559,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:17344846,ECO:0000269|PubMed:7633441,ECO:0000269|PubMed:9760196;Dbxref=dbSNP:rs17158558,PMID:14566559,PMID:15489334,PMID:17344846,PMID:7633441,PMID:9760196 P07949 UniProtKB Natural variant 1039 1039 . . . ID=VAR_018157;Note=In HSCR1. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9497256;Dbxref=dbSNP:rs79853121,PMID:9497256 P07949 UniProtKB Natural variant 1039 1039 . . . ID=VAR_009488;Note=P->Q;Dbxref=dbSNP:rs79853121 P07949 UniProtKB Natural variant 1049 1049 . . . ID=VAR_044397;Note=In a patient with renal agenesis%3B uncertain significance%3B prevents phosphorylation in response to GDNF. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18252215;Dbxref=dbSNP:rs1490712863,PMID:18252215 P07949 UniProtKB Natural variant 1052 1052 . . . ID=VAR_067123;Note=In HSCR1. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22174939;Dbxref=dbSNP:rs1564501947,PMID:22174939 P07949 UniProtKB Natural variant 1059 1059 . . . ID=VAR_009489;Note=In HSCR1. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10484767,ECO:0000269|Ref.64;Dbxref=PMID:10484767 P07949 UniProtKB Natural variant 1061 1061 . . . ID=VAR_009490;Note=In HSCR1. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10484767,ECO:0000269|Ref.64;Dbxref=dbSNP:rs536486113,PMID:10484767 P07949 UniProtKB Natural variant 1062 1062 . . . ID=VAR_067124;Note=In HSCR1. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22174939;Dbxref=dbSNP:rs587778659,PMID:22174939 P07949 UniProtKB Natural variant 1064 1064 . . . ID=VAR_009491;Note=In HSCR1%3B familial form. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22174939;Dbxref=dbSNP:rs149513065,PMID:22174939 P07949 UniProtKB Natural variant 1067 1067 . . . ID=VAR_044398;Note=In a patient with renal agenesis%3B uncertain significance%3B prevents phosphorylation in response to GDNF. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18252215;Dbxref=dbSNP:rs775583354,PMID:18252215 P07949 UniProtKB Natural variant 1112 1112 . . . ID=VAR_041767;Note=In a bladder transitional cell carcinoma sample%3B somatic mutation. F->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 P07949 UniProtKB Mutagenesis 707 707 . . . Note=Impaired cleavage by caspase-3 and loss of induced cell death. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21357690;Dbxref=PMID:21357690 P07949 UniProtKB Mutagenesis 708 1114 . . . Note=Loss of induced cell death%2C but increased cell aggregation. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21357690;Dbxref=PMID:21357690 P07949 UniProtKB Mutagenesis 758 758 . . . Note=Loss of kinase activity. No effect on interaction with and dissociation from CBLC and CD2AP. K->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18753381,ECO:0000269|PubMed:21357690;Dbxref=PMID:18753381,PMID:21357690 P07949 UniProtKB Mutagenesis 1062 1062 . . . Note=Abolishes GFRAL-mediated MAPK1/MAPK2 phosphorylation. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28953886;Dbxref=PMID:28953886 P07949 UniProtKB Sequence conflict 647 647 . . . Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 P07949 UniProtKB Sequence conflict 664 664 . . . Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 P07949 UniProtKB Sequence conflict 750 750 . . . Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 P07949 UniProtKB Sequence conflict 904 904 . . . Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 P07949 UniProtKB Beta strand 30 32 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2X2U P07949 UniProtKB Beta strand 34 41 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2X2U P07949 UniProtKB Beta strand 49 52 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2X2U P07949 UniProtKB Beta strand 70 73 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2X2U P07949 UniProtKB Helix 75 77 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2X2U P07949 UniProtKB Beta strand 79 82 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2X2U P07949 UniProtKB Beta strand 85 88 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2X2U P07949 UniProtKB Turn 90 92 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2X2U P07949 UniProtKB Beta strand 94 99 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2X2U P07949 UniProtKB Helix 103 111 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2X2U P07949 UniProtKB Beta strand 120 126 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2X2U P07949 UniProtKB Turn 139 141 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2X2U P07949 UniProtKB Beta strand 142 152 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2X2U P07949 UniProtKB Helix 157 159 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2X2U P07949 UniProtKB Helix 162 166 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2X2U P07949 UniProtKB Beta strand 174 178 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2X2U P07949 UniProtKB Beta strand 184 187 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2X2U P07949 UniProtKB Helix 191 196 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2X2U P07949 UniProtKB Beta strand 202 208 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2X2U P07949 UniProtKB Beta strand 212 215 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2X2U P07949 UniProtKB Beta strand 222 227 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2X2U P07949 UniProtKB Turn 231 233 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2X2U P07949 UniProtKB Beta strand 235 245 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2X2U P07949 UniProtKB Beta strand 252 263 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2X2U P07949 UniProtKB Helix 705 710 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA P07949 UniProtKB Turn 715 717 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA P07949 UniProtKB Helix 721 723 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA P07949 UniProtKB Beta strand 724 733 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA P07949 UniProtKB Beta strand 736 744 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA P07949 UniProtKB Helix 746 748 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6NEC P07949 UniProtKB Beta strand 751 759 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA P07949 UniProtKB Helix 766 781 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA P07949 UniProtKB Beta strand 790 794 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA P07949 UniProtKB Beta strand 796 798 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA P07949 UniProtKB Beta strand 801 805 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA P07949 UniProtKB Helix 812 819 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA P07949 UniProtKB Beta strand 822 826 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA P07949 UniProtKB Beta strand 844 846 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6NJA P07949 UniProtKB Helix 848 867 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA P07949 UniProtKB Helix 877 879 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA P07949 UniProtKB Beta strand 880 883 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA P07949 UniProtKB Helix 884 886 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA P07949 UniProtKB Beta strand 887 890 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA P07949 UniProtKB Helix 893 895 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7JU5 P07949 UniProtKB Turn 900 902 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA P07949 UniProtKB Helix 915 917 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA P07949 UniProtKB Helix 920 925 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA P07949 UniProtKB Helix 930 945 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA P07949 UniProtKB Helix 957 959 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA P07949 UniProtKB Helix 960 965 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA P07949 UniProtKB Helix 978 987 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA P07949 UniProtKB Helix 992 994 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA P07949 UniProtKB Helix 998 1010 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7DUA