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P07944

- PBP_STAAU

UniProt

P07944 - PBP_STAAU

Protein

Beta-lactam-inducible penicillin-binding protein

Gene

pbp

Organism
Staphylococcus aureus
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Aug 1988)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei25 – 251PenicillinCurated
    Binding sitei405 – 4051PenicillinCurated

    GO - Molecular functioni

    1. penicillin binding Source: InterPro

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-KW
    4. regulation of cell shape Source: UniProtKB-KW
    5. response to antibiotic Source: UniProtKB-KW

    Keywords - Biological processi

    Antibiotic resistance, Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactam-inducible penicillin-binding protein
    Gene namesi
    Name:pbp
    OrganismiStaphylococcus aureus
    Taxonomic identifieri1280 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 670670Beta-lactam-inducible penicillin-binding proteinPRO_0000195443Add
    BLAST

    Expressioni

    Inductioni

    In the presence of beta-lactam antibiotics, MRSA cells produce this unique PBP in excessively large amounts and can still proliferate, while all the normal PBPs are inactivated (reversible switching ability of PBP formation).

    Structurei

    3D structure databases

    ProteinModelPortaliP07944.
    SMRiP07944. Positions 27-670.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the transpeptidase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0768.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR007887. MecA_N.
    IPR005311. PBP_dimer.
    IPR001460. PCN-bd_Tpept.
    [Graphical view]
    PfamiPF05223. MecA_N. 1 hit.
    PF03717. PBP_dimer. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56519. SSF56519. 1 hit.
    SSF56601. SSF56601. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P07944-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKIKIVPLI LIVVVVGFGI YFYASKDKEI NNTIDAIEDK NFKQVYKDSS    50
    YISKSDNGEV EMTERPIKIY NSLGVKDINI QDRKIKKVSK NKKRVDAQYK 100
    IKTNYGNIDR NVQFNFVKED GMWKLDWDHS VIIPGMQKDQ SIHIENLKSE 150
    RGKILDRNNV ELANTGTHMR LGIVPKNVSK KDYKAIAKEL SISEDYINNK 200
    WIKIGYKMIP SFHFKTVKKM DEYLSDFAKK FHLTTNETES RNYPLGKATS 250
    HLLGYVGPIN SEELKQKEYK GYKDDAVIGK KGLEKLYDKK LQHEDGYRVT 300
    IVRVDDNSNT IAHTLIEKKK KDGKDIQLTI DAKVQKSIYN NMKNDYGSGT 350
    AIHPQTGELL ALVSTPSYDV YPFMYGMSNE EYNKLTEDKK EPLLNKFQIT 400
    TSPGSTQKIL TAMIGLNNKT LDDKTSYKID GKGWQKDKSW GGYNVTRYEV 450
    VNGNIDLKQA IESSDNIFFA RVALELGSKK FEKGMKKLGV GEDIPSDYPF 500
    YNAQISNKNL DNEILLADSG YGQGEILINP VQILSIYSAL ENNGNINAPH 550
    LLKDTKNKVW KKNIISKENI NLLNDGMQQV VNKTHKEDIY RSYANLIGKS 600
    GTAELKMKQG ETGRQIGWFI SYDKDNPNMM MAINVKDVQD KGMASYNAKI 650
    SGKVYDELYE NGNKKYDIDE 670
    Length:670
    Mass (Da):76,463
    Last modified:August 1, 1988 - v1
    Checksum:i2DAA414D35DA993A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00688 Genomic DNA. Translation: CAA68684.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00688 Genomic DNA. Translation: CAA68684.1 .

    3D structure databases

    ProteinModelPortali P07944.
    SMRi P07944. Positions 27-670.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG0768.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR007887. MecA_N.
    IPR005311. PBP_dimer.
    IPR001460. PCN-bd_Tpept.
    [Graphical view ]
    Pfami PF05223. MecA_N. 1 hit.
    PF03717. PBP_dimer. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56519. SSF56519. 1 hit.
    SSF56601. SSF56601. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of an inducible penicillin-target protein in methicillin-resistant Staphylococcus aureus by gene fusion."
      Song M.D., Wachi M., Doi M., Ishino F., Matsuhashi M.
      FEBS Lett. 221:167-171(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiPBP_STAAU
    AccessioniPrimary (citable) accession number: P07944
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: August 1, 1988
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    PBP has extremely low affinity to penicillin and most other beta-lactam antibiotics.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3