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P07944 (PBP_STAAU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactam-inducible penicillin-binding protein
Gene names
Name:pbp
OrganismStaphylococcus aureus
Taxonomic identifier1280 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length670 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Cell membrane; Single-pass membrane protein Potential.

Induction

In the presence of beta-lactam antibiotics, MRSA cells produce this unique PBP in excessively large amounts and can still proliferate, while all the normal PBPs are inactivated (reversible switching ability of PBP formation).

Miscellaneous

PBP has extremely low affinity to penicillin and most other beta-lactam antibiotics.

Sequence similarities

Belongs to the transpeptidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 670670Beta-lactam-inducible penicillin-binding protein
PRO_0000195443

Regions

Transmembrane4 – 2421Helical; Potential

Sites

Binding site251Penicillin Probable
Binding site4051Penicillin Probable

Sequences

Sequence LengthMass (Da)Tools
P07944 [UniParc].

Last modified August 1, 1988. Version 1.
Checksum: 2DAA414D35DA993A

FASTA67076,463
        10         20         30         40         50         60 
MKKIKIVPLI LIVVVVGFGI YFYASKDKEI NNTIDAIEDK NFKQVYKDSS YISKSDNGEV 

        70         80         90        100        110        120 
EMTERPIKIY NSLGVKDINI QDRKIKKVSK NKKRVDAQYK IKTNYGNIDR NVQFNFVKED 

       130        140        150        160        170        180 
GMWKLDWDHS VIIPGMQKDQ SIHIENLKSE RGKILDRNNV ELANTGTHMR LGIVPKNVSK 

       190        200        210        220        230        240 
KDYKAIAKEL SISEDYINNK WIKIGYKMIP SFHFKTVKKM DEYLSDFAKK FHLTTNETES 

       250        260        270        280        290        300 
RNYPLGKATS HLLGYVGPIN SEELKQKEYK GYKDDAVIGK KGLEKLYDKK LQHEDGYRVT 

       310        320        330        340        350        360 
IVRVDDNSNT IAHTLIEKKK KDGKDIQLTI DAKVQKSIYN NMKNDYGSGT AIHPQTGELL 

       370        380        390        400        410        420 
ALVSTPSYDV YPFMYGMSNE EYNKLTEDKK EPLLNKFQIT TSPGSTQKIL TAMIGLNNKT 

       430        440        450        460        470        480 
LDDKTSYKID GKGWQKDKSW GGYNVTRYEV VNGNIDLKQA IESSDNIFFA RVALELGSKK 

       490        500        510        520        530        540 
FEKGMKKLGV GEDIPSDYPF YNAQISNKNL DNEILLADSG YGQGEILINP VQILSIYSAL 

       550        560        570        580        590        600 
ENNGNINAPH LLKDTKNKVW KKNIISKENI NLLNDGMQQV VNKTHKEDIY RSYANLIGKS 

       610        620        630        640        650        660 
GTAELKMKQG ETGRQIGWFI SYDKDNPNMM MAINVKDVQD KGMASYNAKI SGKVYDELYE 

       670 
NGNKKYDIDE 

« Hide

References

[1]"Evolution of an inducible penicillin-target protein in methicillin-resistant Staphylococcus aureus by gene fusion."
Song M.D., Wachi M., Doi M., Ishino F., Matsuhashi M.
FEBS Lett. 221:167-171(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y00688 Genomic DNA. Translation: CAA68684.1.

3D structure databases

ProteinModelPortalP07944.
SMRP07944. Positions 27-670.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0768.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR007887. MecA_N.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamPF05223. MecA_N. 1 hit.
PF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMSSF56519. SSF56519. 1 hit.
SSF56601. SSF56601. 1 hit.
ProtoNetSearch...

Entry information

Entry namePBP_STAAU
AccessionPrimary (citable) accession number: P07944
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: February 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families